DUF155 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Uncharacterised ACR, YagE family COG1723, putative

Species:

Leishmania major

UniProt:

Q4Q771_LEIMA

TriTrypDb:

LmjF.30.2220 , LMJLV39_300029400 , LMJSD75_300029100

Length:

539

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	12
GO:0016020	membrane	2	11
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

Q4Q771

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q771

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	209	213	PF00656	0.700
CLV_NRD_NRD_1	175	177	PF00675	0.415
CLV_NRD_NRD_1	190	192	PF00675	0.471
CLV_NRD_NRD_1	207	209	PF00675	0.442
CLV_NRD_NRD_1	223	225	PF00675	0.481
CLV_NRD_NRD_1	263	265	PF00675	0.371
CLV_NRD_NRD_1	436	438	PF00675	0.338
CLV_NRD_NRD_1	505	507	PF00675	0.339
CLV_PCSK_FUR_1	173	177	PF00082	0.475
CLV_PCSK_KEX2_1	175	177	PF00082	0.419
CLV_PCSK_KEX2_1	190	192	PF00082	0.473
CLV_PCSK_KEX2_1	207	209	PF00082	0.442
CLV_PCSK_KEX2_1	223	225	PF00082	0.485
CLV_PCSK_KEX2_1	263	265	PF00082	0.386
CLV_PCSK_KEX2_1	435	437	PF00082	0.335
CLV_PCSK_KEX2_1	505	507	PF00082	0.347
CLV_PCSK_PC1ET2_1	435	437	PF00082	0.393
CLV_PCSK_PC7_1	171	177	PF00082	0.401
CLV_PCSK_SKI1_1	175	179	PF00082	0.430
CLV_PCSK_SKI1_1	190	194	PF00082	0.484
CLV_PCSK_SKI1_1	368	372	PF00082	0.330
CLV_PCSK_SKI1_1	416	420	PF00082	0.284
CLV_PCSK_SKI1_1	91	95	PF00082	0.552
DEG_APCC_DBOX_1	114	122	PF00400	0.649
DEG_APCC_DBOX_1	170	178	PF00400	0.666
DEG_APCC_DBOX_1	250	258	PF00400	0.626
DEG_APCC_DBOX_1	505	513	PF00400	0.475
DEG_Nend_UBRbox_2	1	3	PF02207	0.710
DEG_ODPH_VHL_1	88	101	PF01847	0.715
DEG_SCF_FBW7_1	64	71	PF00400	0.804
DOC_CDC14_PxL_1	462	470	PF14671	0.551
DOC_CKS1_1	349	354	PF01111	0.511
DOC_CKS1_1	419	424	PF01111	0.578
DOC_CYCLIN_RxL_1	114	124	PF00134	0.662
DOC_CYCLIN_RxL_1	171	182	PF00134	0.676
DOC_CYCLIN_RxL_1	368	376	PF00134	0.557
DOC_CYCLIN_yCln2_LP_2	419	425	PF00134	0.562
DOC_MAPK_gen_1	115	123	PF00069	0.663
DOC_MAPK_gen_1	435	447	PF00069	0.563
DOC_MAPK_MEF2A_6	115	123	PF00069	0.601
DOC_MAPK_MEF2A_6	387	394	PF00069	0.475
DOC_MAPK_RevD_3	162	176	PF00069	0.584
DOC_PP1_RVXF_1	369	376	PF00149	0.530
DOC_PP1_RVXF_1	482	488	PF00149	0.562
DOC_USP7_MATH_1	214	218	PF00917	0.731
DOC_USP7_MATH_1	385	389	PF00917	0.516
DOC_USP7_MATH_1	451	455	PF00917	0.540
DOC_USP7_MATH_1	68	72	PF00917	0.741
DOC_USP7_MATH_2	422	428	PF00917	0.378
DOC_WW_Pin1_4	163	168	PF00397	0.573
DOC_WW_Pin1_4	190	195	PF00397	0.675
DOC_WW_Pin1_4	348	353	PF00397	0.518
DOC_WW_Pin1_4	418	423	PF00397	0.578
DOC_WW_Pin1_4	64	69	PF00397	0.737
DOC_WW_Pin1_4	94	99	PF00397	0.759
LIG_14-3-3_CanoR_1	104	114	PF00244	0.541
LIG_14-3-3_CanoR_1	264	274	PF00244	0.590
LIG_14-3-3_CanoR_1	416	422	PF00244	0.562
LIG_14-3-3_CanoR_1	484	488	PF00244	0.592
LIG_14-3-3_CanoR_1	78	88	PF00244	0.764
LIG_14-3-3_CanoR_1	91	100	PF00244	0.759
LIG_BRCT_BRCA1_1	29	33	PF00533	0.704
LIG_BRCT_BRCA1_1	513	517	PF00533	0.335
LIG_Clathr_ClatBox_1	521	525	PF01394	0.413
LIG_deltaCOP1_diTrp_1	460	467	PF00928	0.486
LIG_EH1_1	516	524	PF00400	0.327
LIG_FHA_1	114	120	PF00498	0.672
LIG_FHA_1	125	131	PF00498	0.598
LIG_FHA_1	180	186	PF00498	0.721
LIG_FHA_1	39	45	PF00498	0.727
LIG_FHA_1	424	430	PF00498	0.569
LIG_FHA_1	528	534	PF00498	0.494
LIG_FHA_1	94	100	PF00498	0.713
LIG_FHA_2	129	135	PF00498	0.618
LIG_FHA_2	207	213	PF00498	0.767
LIG_FHA_2	419	425	PF00498	0.579
LIG_FHA_2	492	498	PF00498	0.605
LIG_LIR_Apic_2	376	381	PF02991	0.467
LIG_LIR_Apic_2	460	466	PF02991	0.479
LIG_LIR_Gen_1	158	167	PF02991	0.627
LIG_LIR_Gen_1	242	252	PF02991	0.524
LIG_LIR_Gen_1	280	288	PF02991	0.557
LIG_LIR_Gen_1	424	432	PF02991	0.460
LIG_LIR_Gen_1	514	524	PF02991	0.343
LIG_LIR_Nem_3	148	152	PF02991	0.608
LIG_LIR_Nem_3	158	162	PF02991	0.618
LIG_LIR_Nem_3	242	248	PF02991	0.518
LIG_LIR_Nem_3	280	286	PF02991	0.574
LIG_LIR_Nem_3	405	410	PF02991	0.533
LIG_LIR_Nem_3	424	428	PF02991	0.386
LIG_LIR_Nem_3	514	520	PF02991	0.343
LIG_MYND_1	86	90	PF01753	0.773
LIG_NRBOX	517	523	PF00104	0.362
LIG_PCNA_PIPBox_1	327	336	PF02747	0.475
LIG_PCNA_yPIPBox_3	324	334	PF02747	0.457
LIG_Pex14_1	141	145	PF04695	0.560
LIG_Pex14_1	467	471	PF04695	0.477
LIG_SH2_CRK	149	153	PF00017	0.568
LIG_SH2_CRK	159	163	PF00017	0.544
LIG_SH2_CRK	245	249	PF00017	0.521
LIG_SH2_NCK_1	245	249	PF00017	0.584
LIG_SH2_NCK_1	472	476	PF00017	0.562
LIG_SH2_STAP1	145	149	PF00017	0.638
LIG_SH2_STAP1	245	249	PF00017	0.517
LIG_SH2_STAT5	155	158	PF00017	0.542
LIG_SH2_STAT5	378	381	PF00017	0.465
LIG_SH2_STAT5	406	409	PF00017	0.536
LIG_SH3_1	191	197	PF00018	0.582
LIG_SH3_3	108	114	PF00018	0.633
LIG_SH3_3	161	167	PF00018	0.633
LIG_SH3_3	191	197	PF00018	0.582
LIG_SH3_3	225	231	PF00018	0.760
LIG_SH3_3	346	352	PF00018	0.575
LIG_SH3_3	84	90	PF00018	0.770
LIG_SUMO_SIM_par_1	358	363	PF11976	0.578
LIG_SUMO_SIM_par_1	388	393	PF11976	0.491
LIG_SUMO_SIM_par_1	519	525	PF11976	0.343
LIG_TYR_ITIM	243	248	PF00017	0.515
LIG_UBA3_1	495	503	PF00899	0.552
LIG_UBA3_1	99	107	PF00899	0.586
LIG_WRC_WIRS_1	391	396	PF05994	0.562
MOD_CK1_1	158	164	PF00069	0.658
MOD_CK1_1	179	185	PF00069	0.679
MOD_CK1_1	198	204	PF00069	0.792
MOD_CK1_1	229	235	PF00069	0.727
MOD_CK1_1	25	31	PF00069	0.647
MOD_CK1_1	483	489	PF00069	0.629
MOD_CK1_1	71	77	PF00069	0.729
MOD_CK2_1	128	134	PF00069	0.596
MOD_CK2_1	418	424	PF00069	0.578
MOD_CK2_1	491	497	PF00069	0.602
MOD_Cter_Amidation	205	208	PF01082	0.502
MOD_Cter_Amidation	503	506	PF01082	0.427
MOD_GlcNHglycan	218	221	PF01048	0.570
MOD_GlcNHglycan	231	234	PF01048	0.479
MOD_GlcNHglycan	311	314	PF01048	0.317
MOD_GlcNHglycan	352	355	PF01048	0.222
MOD_GlcNHglycan	4	7	PF01048	0.586
MOD_GlcNHglycan	400	403	PF01048	0.337
MOD_GlcNHglycan	453	456	PF01048	0.327
MOD_GlcNHglycan	50	53	PF01048	0.592
MOD_GlcNHglycan	70	73	PF01048	0.536
MOD_GSK3_1	124	131	PF00069	0.600
MOD_GSK3_1	193	200	PF00069	0.788
MOD_GSK3_1	222	229	PF00069	0.727
MOD_GSK3_1	23	30	PF00069	0.735
MOD_GSK3_1	239	246	PF00069	0.433
MOD_GSK3_1	390	397	PF00069	0.488
MOD_GSK3_1	483	490	PF00069	0.632
MOD_GSK3_1	60	67	PF00069	0.761
MOD_GSK3_1	68	75	PF00069	0.597
MOD_N-GLC_1	124	129	PF02516	0.490
MOD_N-GLC_1	478	483	PF02516	0.316
MOD_NEK2_1	121	126	PF00069	0.672
MOD_NEK2_1	22	27	PF00069	0.717
MOD_NEK2_1	286	291	PF00069	0.499
MOD_NEK2_1	298	303	PF00069	0.463
MOD_NEK2_1	311	316	PF00069	0.482
MOD_NEK2_1	392	397	PF00069	0.475
MOD_NEK2_1	398	403	PF00069	0.475
MOD_NEK2_1	528	533	PF00069	0.463
MOD_NEK2_1	79	84	PF00069	0.697
MOD_NEK2_1	93	98	PF00069	0.712
MOD_NEK2_2	256	261	PF00069	0.606
MOD_PIKK_1	214	220	PF00454	0.798
MOD_PIKK_1	25	31	PF00454	0.718
MOD_PK_1	176	182	PF00069	0.683
MOD_PKA_2	206	212	PF00069	0.701
MOD_PKA_2	222	228	PF00069	0.754
MOD_PKA_2	483	489	PF00069	0.629
MOD_Plk_1	423	429	PF00069	0.378
MOD_Plk_1	60	66	PF00069	0.781
MOD_Plk_2-3	424	430	PF00069	0.424
MOD_Plk_4	158	164	PF00069	0.616
MOD_Plk_4	256	262	PF00069	0.566
MOD_Plk_4	424	430	PF00069	0.424
MOD_Plk_4	483	489	PF00069	0.603
MOD_Plk_4	491	497	PF00069	0.605
MOD_ProDKin_1	163	169	PF00069	0.574
MOD_ProDKin_1	190	196	PF00069	0.679
MOD_ProDKin_1	348	354	PF00069	0.518
MOD_ProDKin_1	418	424	PF00069	0.578
MOD_ProDKin_1	64	70	PF00069	0.736
MOD_ProDKin_1	94	100	PF00069	0.760
TRG_DiLeu_BaEn_1	19	24	PF01217	0.622
TRG_DiLeu_BaEn_1	424	429	PF01217	0.562
TRG_DiLeu_BaLyEn_6	114	119	PF01217	0.659
TRG_DiLeu_BaLyEn_6	95	100	PF01217	0.781
TRG_ENDOCYTIC_2	149	152	PF00928	0.570
TRG_ENDOCYTIC_2	159	162	PF00928	0.558
TRG_ENDOCYTIC_2	245	248	PF00928	0.517
TRG_ENDOCYTIC_2	471	474	PF00928	0.465
TRG_ENDOCYTIC_2	507	510	PF00928	0.562
TRG_ER_diArg_1	114	117	PF00400	0.638
TRG_ER_diArg_1	171	174	PF00400	0.575
TRG_ER_diArg_1	175	177	PF00400	0.610
TRG_ER_diArg_1	189	191	PF00400	0.631
TRG_ER_diArg_1	436	438	PF00400	0.564
TRG_ER_diArg_1	505	507	PF00400	0.548
TRG_Pf-PMV_PEXEL_1	91	95	PF00026	0.480

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8P4	Leptomonas seymouri	70%	79%
A0A0S4IQM3	Bodo saltans	41%	100%
A0A1X0P1X6	Trypanosomatidae	46%	82%
A0A3Q8IS20	Leishmania donovani	94%	100%
A0A422NW98	Trypanosoma rangeli	42%	87%
A4HIF4	Leishmania braziliensis	79%	84%
A4I5Q0	Leishmania infantum	94%	100%
C9ZR20	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	83%
E9B0Z5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5BGV1	Trypanosoma cruzi	43%	86%