Histone lysine methyltransferase, SET

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4Q770_LEIMA

TriTrypDb:

LmjF.30.2230 , LMJLV39_300029500 , LMJSD75_300029200

Length:

251

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q770

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q770

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	3	5	PF00675	0.523
CLV_NRD_NRD_1	44	46	PF00675	0.551
CLV_PCSK_KEX2_1	155	157	PF00082	0.487
CLV_PCSK_KEX2_1	2	4	PF00082	0.558
CLV_PCSK_KEX2_1	44	46	PF00082	0.551
CLV_PCSK_PC1ET2_1	155	157	PF00082	0.537
CLV_PCSK_SKI1_1	4	8	PF00082	0.582
DEG_APCC_KENBOX_2	31	35	PF00400	0.401
DEG_Nend_UBRbox_1	1	4	PF02207	0.569
DOC_CYCLIN_RxL_1	1	10	PF00134	0.621
DOC_MAPK_gen_1	2	8	PF00069	0.540
DOC_PP1_RVXF_1	42	49	PF00149	0.499
DOC_PP2B_LxvP_1	232	235	PF13499	0.538
DOC_USP7_MATH_1	160	164	PF00917	0.697
DOC_USP7_UBL2_3	28	32	PF12436	0.423
DOC_WW_Pin1_4	105	110	PF00397	0.704
DOC_WW_Pin1_4	125	130	PF00397	0.352
LIG_14-3-3_CanoR_1	12	19	PF00244	0.523
LIG_14-3-3_CanoR_1	141	146	PF00244	0.545
LIG_Actin_WH2_2	227	245	PF00022	0.441
LIG_BRCT_BRCA1_1	163	167	PF00533	0.628
LIG_BRCT_BRCA1_1	185	189	PF00533	0.423
LIG_Clathr_ClatBox_1	166	170	PF01394	0.334
LIG_eIF4E_1	30	36	PF01652	0.556
LIG_FHA_1	8	14	PF00498	0.495
LIG_FHA_2	149	155	PF00498	0.424
LIG_FHA_2	239	245	PF00498	0.378
LIG_LIR_Apic_2	170	174	PF02991	0.427
LIG_LIR_Gen_1	118	129	PF02991	0.593
LIG_LIR_Gen_1	14	24	PF02991	0.426
LIG_LIR_Gen_1	140	149	PF02991	0.483
LIG_LIR_Gen_1	200	209	PF02991	0.609
LIG_LIR_Nem_3	118	124	PF02991	0.607
LIG_LIR_Nem_3	140	145	PF02991	0.443
LIG_LIR_Nem_3	200	204	PF02991	0.530
LIG_LIR_Nem_3	60	66	PF02991	0.541
LIG_LYPXL_L_2	225	234	PF13949	0.442
LIG_MLH1_MIPbox_1	164	168	PF16413	0.601
LIG_PDZ_Class_2	246	251	PF00595	0.443
LIG_Pex14_2	167	171	PF04695	0.477
LIG_SH2_STAT3	67	70	PF00017	0.404
LIG_SH2_STAT5	64	67	PF00017	0.403
LIG_TRAF2_1	76	79	PF00917	0.543
LIG_WRC_WIRS_1	142	147	PF05994	0.520
LIG_WRC_WIRS_1	198	203	PF05994	0.576
LIG_WRC_WIRS_1	246	251	PF05994	0.520
LIG_WRC_WIRS_1	66	71	PF05994	0.411
MOD_CDC14_SPxK_1	112	115	PF00782	0.652
MOD_CDK_SPxK_1	109	115	PF00069	0.655
MOD_CDK_SPxxK_3	109	116	PF00069	0.703
MOD_CK1_1	128	134	PF00069	0.496
MOD_CK1_1	200	206	PF00069	0.520
MOD_CK2_1	148	154	PF00069	0.447
MOD_CK2_1	238	244	PF00069	0.418
MOD_GlcNHglycan	102	106	PF01048	0.473
MOD_GlcNHglycan	158	161	PF01048	0.618
MOD_GlcNHglycan	84	87	PF01048	0.799
MOD_GSK3_1	105	112	PF00069	0.676
MOD_GSK3_1	156	163	PF00069	0.661
MOD_GSK3_1	179	186	PF00069	0.455
MOD_GSK3_1	238	245	PF00069	0.375
MOD_GSK3_1	65	72	PF00069	0.506
MOD_GSK3_1	7	14	PF00069	0.526
MOD_GSK3_1	97	104	PF00069	0.675
MOD_N-GLC_1	160	165	PF02516	0.674
MOD_NEK2_1	242	247	PF00069	0.495
MOD_NEK2_1	65	70	PF00069	0.404
MOD_NEK2_1	7	12	PF00069	0.547
MOD_NEK2_2	238	243	PF00069	0.332
MOD_PKA_2	11	17	PF00069	0.511
MOD_PKA_2	183	189	PF00069	0.434
MOD_PKA_2	242	248	PF00069	0.455
MOD_PKB_1	139	147	PF00069	0.528
MOD_Plk_1	238	244	PF00069	0.430
MOD_Plk_4	162	168	PF00069	0.395
MOD_Plk_4	184	190	PF00069	0.584
MOD_Plk_4	200	206	PF00069	0.327
MOD_Plk_4	34	40	PF00069	0.413
MOD_ProDKin_1	105	111	PF00069	0.703
MOD_ProDKin_1	125	131	PF00069	0.341
MOD_SUMO_for_1	114	117	PF00179	0.759
TRG_DiLeu_BaEn_4	78	84	PF01217	0.578
TRG_ENDOCYTIC_2	63	66	PF00928	0.406
TRG_ER_diArg_1	1	4	PF00400	0.569
TRG_ER_diArg_1	44	47	PF00400	0.486
TRG_Pf-PMV_PEXEL_1	4	9	PF00026	0.587

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P919	Leptomonas seymouri	53%	100%
A0A0N1I9X1	Leptomonas seymouri	48%	100%
A0A3S7X3I9	Leishmania donovani	93%	100%
A4HIF5	Leishmania braziliensis	77%	100%
A4I5Q1	Leishmania infantum	92%	100%
E9B0Z6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%