Mitochondrial carrier protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q769_LEIMA

TriTrypDb:

LmjF.30.2240 , LMJLV39_300029600 , LMJSD75_300029300

Length:

306

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005739	mitochondrion	5	2
GO:0016020	membrane	2	10
GO:0020023	kinetoplast	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

Q4Q769

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q769

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	127	129	PF00675	0.678
CLV_NRD_NRD_1	173	175	PF00675	0.323
CLV_NRD_NRD_1	211	213	PF00675	0.556
CLV_NRD_NRD_1	67	69	PF00675	0.333
CLV_PCSK_FUR_1	209	213	PF00082	0.442
CLV_PCSK_KEX2_1	127	129	PF00082	0.700
CLV_PCSK_KEX2_1	173	175	PF00082	0.325
CLV_PCSK_KEX2_1	211	213	PF00082	0.556
CLV_PCSK_KEX2_1	67	69	PF00082	0.333
CLV_PCSK_PC7_1	207	213	PF00082	0.443
CLV_PCSK_SKI1_1	138	142	PF00082	0.595
CLV_PCSK_SKI1_1	143	147	PF00082	0.583
CLV_PCSK_SKI1_1	18	22	PF00082	0.437
CLV_PCSK_SKI1_1	267	271	PF00082	0.585
CLV_PCSK_SKI1_1	28	32	PF00082	0.456
CLV_PCSK_SKI1_1	59	63	PF00082	0.410
CLV_PCSK_SKI1_1	97	101	PF00082	0.313
DEG_Nend_Nbox_1	1	3	PF02207	0.668
DOC_CKS1_1	150	155	PF01111	0.384
DOC_MAPK_gen_1	138	148	PF00069	0.371
DOC_MAPK_MEF2A_6	275	284	PF00069	0.282
DOC_PP2B_LxvP_1	293	296	PF13499	0.550
DOC_PP4_FxxP_1	78	81	PF00568	0.535
DOC_USP7_UBL2_3	24	28	PF12436	0.651
DOC_WW_Pin1_4	149	154	PF00397	0.391
DOC_WW_Pin1_4	23	28	PF00397	0.685
DOC_WW_Pin1_4	267	272	PF00397	0.408
LIG_Actin_WH2_2	262	277	PF00022	0.431
LIG_deltaCOP1_diTrp_1	217	222	PF00928	0.691
LIG_eIF4E_1	150	156	PF01652	0.296
LIG_FHA_1	134	140	PF00498	0.368
LIG_FHA_1	150	156	PF00498	0.296
LIG_FHA_1	224	230	PF00498	0.596
LIG_FHA_1	268	274	PF00498	0.399
LIG_FHA_1	99	105	PF00498	0.384
LIG_FHA_2	165	171	PF00498	0.344
LIG_FHA_2	27	33	PF00498	0.644
LIG_LIR_Gen_1	164	172	PF02991	0.480
LIG_LIR_Gen_1	286	295	PF02991	0.416
LIG_LIR_Nem_3	164	169	PF02991	0.389
LIG_LIR_Nem_3	177	183	PF02991	0.522
LIG_LIR_Nem_3	221	225	PF02991	0.549
LIG_LIR_Nem_3	286	290	PF02991	0.416
LIG_LIR_Nem_3	6	12	PF02991	0.581
LIG_MYND_1	292	296	PF01753	0.447
LIG_MYND_3	87	91	PF01753	0.663
LIG_PCNA_yPIPBox_3	138	149	PF02747	0.453
LIG_Pex14_2	162	166	PF04695	0.447
LIG_Pex14_2	74	78	PF04695	0.581
LIG_PTB_Apo_2	155	162	PF02174	0.335
LIG_PTB_Phospho_1	155	161	PF10480	0.335
LIG_SH2_CRK	150	154	PF00017	0.380
LIG_SH2_CRK	79	83	PF00017	0.574
LIG_SH2_CRK	9	13	PF00017	0.641
LIG_SH2_NCK_1	150	154	PF00017	0.380
LIG_SH2_STAP1	225	229	PF00017	0.587
LIG_SH2_STAT5	150	153	PF00017	0.374
LIG_SH2_STAT5	161	164	PF00017	0.319
LIG_SH2_STAT5	225	228	PF00017	0.589
LIG_SH2_STAT5	79	82	PF00017	0.507
LIG_SH3_3	112	118	PF00018	0.512
LIG_SH3_3	179	185	PF00018	0.530
LIG_SH3_3	243	249	PF00018	0.418
LIG_WRC_WIRS_1	284	289	PF05994	0.441
LIG_WRC_WIRS_1	99	104	PF05994	0.355
MOD_CDK_SPK_2	23	28	PF00069	0.685
MOD_CK1_1	126	132	PF00069	0.403
MOD_CK1_1	133	139	PF00069	0.387
MOD_CK2_1	164	170	PF00069	0.348
MOD_Cter_Amidation	65	68	PF01082	0.417
MOD_GlcNHglycan	250	253	PF01048	0.571
MOD_GlcNHglycan	262	265	PF01048	0.594
MOD_GlcNHglycan	287	290	PF01048	0.398
MOD_GSK3_1	126	133	PF00069	0.383
MOD_GSK3_1	224	231	PF00069	0.577
MOD_GSK3_1	238	245	PF00069	0.434
MOD_GSK3_1	28	35	PF00069	0.624
MOD_GSK3_1	93	100	PF00069	0.653
MOD_N-GLC_1	141	146	PF02516	0.665
MOD_N-GLC_1	218	223	PF02516	0.477
MOD_NEK2_1	123	128	PF00069	0.408
MOD_NEK2_1	148	153	PF00069	0.370
MOD_NEK2_1	283	288	PF00069	0.441
MOD_NEK2_1	98	103	PF00069	0.424
MOD_NEK2_2	161	166	PF00069	0.454
MOD_PKA_2	126	132	PF00069	0.470
MOD_Plk_1	141	147	PF00069	0.495
MOD_Plk_1	218	224	PF00069	0.653
MOD_Plk_4	141	147	PF00069	0.411
MOD_Plk_4	161	167	PF00069	0.377
MOD_Plk_4	255	261	PF00069	0.413
MOD_Plk_4	269	275	PF00069	0.347
MOD_Plk_4	32	38	PF00069	0.606
MOD_Plk_4	98	104	PF00069	0.351
MOD_ProDKin_1	149	155	PF00069	0.384
MOD_ProDKin_1	23	29	PF00069	0.680
MOD_ProDKin_1	267	273	PF00069	0.403
TRG_DiLeu_BaLyEn_6	289	294	PF01217	0.447
TRG_ENDOCYTIC_2	79	82	PF00928	0.525
TRG_ENDOCYTIC_2	9	12	PF00928	0.643
TRG_ER_diArg_1	172	174	PF00400	0.516
TRG_ER_diArg_1	208	211	PF00400	0.774
TRG_ER_diArg_1	67	69	PF00400	0.546

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8P6	Leptomonas seymouri	76%	100%
A0A0S4IQI4	Bodo saltans	55%	100%
A0A1X0P365	Trypanosomatidae	55%	100%
A0A3Q8IC29	Leishmania donovani	93%	100%
A4HIF6	Leishmania braziliensis	82%	100%
A4I5Q2	Leishmania infantum	93%	100%
C9ZR21	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
E9B0Z7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5BLB5	Trypanosoma cruzi	52%	100%