Conserved zinc-finger protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

zinc-finger protein, conserved

Species:

Leishmania major

UniProt:

Q4Q768_LEIMA

TriTrypDb:

LmjF.30.2250 , LMJLV39_300029700 , LMJSD75_300029400

Length:

371

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	10
GO:0030684	preribosome	3	2
GO:0030687	preribosome, large subunit precursor	4	2
GO:0032991	protein-containing complex	1	2
GO:0110165	cellular anatomical entity	1	10
GO:1990904	ribonucleoprotein complex	2	2

Expansion

Sequence features

Q4Q768

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q768

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	2
GO:0022613	ribonucleoprotein complex biogenesis	4	2
GO:0042273	ribosomal large subunit biogenesis	5	2
GO:0044085	cellular component biogenesis	3	2
GO:0071840	cellular component organization or biogenesis	2	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0005488	binding	1	12
GO:0008270	zinc ion binding	6	10
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0046914	transition metal ion binding	5	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	122	124	PF00675	0.571
CLV_NRD_NRD_1	200	202	PF00675	0.254
CLV_NRD_NRD_1	32	34	PF00675	0.499
CLV_NRD_NRD_1	91	93	PF00675	0.547
CLV_PCSK_KEX2_1	122	124	PF00082	0.571
CLV_PCSK_KEX2_1	280	282	PF00082	0.563
CLV_PCSK_KEX2_1	285	287	PF00082	0.555
CLV_PCSK_KEX2_1	304	306	PF00082	0.525
CLV_PCSK_KEX2_1	31	33	PF00082	0.488
CLV_PCSK_KEX2_1	339	341	PF00082	0.591
CLV_PCSK_KEX2_1	95	97	PF00082	0.629
CLV_PCSK_PC1ET2_1	280	282	PF00082	0.622
CLV_PCSK_PC1ET2_1	285	287	PF00082	0.611
CLV_PCSK_PC1ET2_1	304	306	PF00082	0.545
CLV_PCSK_PC1ET2_1	339	341	PF00082	0.595
CLV_PCSK_PC1ET2_1	95	97	PF00082	0.629
CLV_PCSK_PC7_1	281	287	PF00082	0.578
CLV_PCSK_SKI1_1	157	161	PF00082	0.349
CLV_PCSK_SKI1_1	235	239	PF00082	0.249
CLV_PCSK_SKI1_1	281	285	PF00082	0.613
CLV_Separin_Metazoa	15	19	PF03568	0.546
DOC_ANK_TNKS_1	30	37	PF00023	0.470
DOC_MAPK_gen_1	201	209	PF00069	0.462
DOC_MAPK_MEF2A_6	345	354	PF00069	0.545
DOC_MAPK_NFAT4_5	345	353	PF00069	0.628
DOC_PP4_FxxP_1	181	184	PF00568	0.454
DOC_USP7_MATH_1	338	342	PF00917	0.584
DOC_USP7_MATH_1	99	103	PF00917	0.480
DOC_USP7_UBL2_3	139	143	PF12436	0.633
DOC_USP7_UBL2_3	275	279	PF12436	0.703
DOC_USP7_UBL2_3	358	362	PF12436	0.524
DOC_WW_Pin1_4	236	241	PF00397	0.540
DOC_WW_Pin1_4	59	64	PF00397	0.605
LIG_14-3-3_CanoR_1	214	219	PF00244	0.516
LIG_14-3-3_CanoR_1	38	47	PF00244	0.508
LIG_14-3-3_CanoR_1	85	91	PF00244	0.466
LIG_BIR_II_1	1	5	PF00653	0.484
LIG_BIR_III_2	135	139	PF00653	0.679
LIG_DLG_GKlike_1	214	221	PF00625	0.531
LIG_FHA_1	164	170	PF00498	0.487
LIG_FHA_1	180	186	PF00498	0.460
LIG_FHA_1	313	319	PF00498	0.602
LIG_FHA_1	354	360	PF00498	0.661
LIG_FHA_1	4	10	PF00498	0.489
LIG_FHA_1	85	91	PF00498	0.452
LIG_GBD_Chelix_1	199	207	PF00786	0.331
LIG_Integrin_RGD_1	133	135	PF01839	0.764
LIG_Integrin_RGD_1	265	267	PF01839	0.667
LIG_LIR_Apic_2	180	184	PF02991	0.450
LIG_LIR_Gen_1	215	224	PF02991	0.448
LIG_LIR_Gen_1	239	250	PF02991	0.458
LIG_LIR_Gen_1	73	80	PF02991	0.480
LIG_LIR_Nem_3	215	221	PF02991	0.465
LIG_LIR_Nem_3	239	245	PF02991	0.458
LIG_LIR_Nem_3	73	77	PF02991	0.465
LIG_PCNA_PIPBox_1	192	201	PF02747	0.503
LIG_PCNA_yPIPBox_3	192	202	PF02747	0.503
LIG_SH2_STAP1	246	250	PF00017	0.476
LIG_SH2_STAP1	65	69	PF00017	0.515
LIG_SH2_STAT5	198	201	PF00017	0.454
LIG_SH3_CIN85_PxpxPR_1	291	296	PF14604	0.679
LIG_TRAF2_1	319	322	PF00917	0.559
LIG_UBA3_1	195	202	PF00899	0.460
LIG_WRC_WIRS_1	178	183	PF05994	0.503
MOD_CK1_1	106	112	PF00069	0.527
MOD_CK1_1	217	223	PF00069	0.480
MOD_CK1_1	353	359	PF00069	0.558
MOD_CK1_1	76	82	PF00069	0.465
MOD_CK2_1	216	222	PF00069	0.532
MOD_CK2_1	45	51	PF00069	0.541
MOD_Cter_Amidation	277	280	PF01082	0.706
MOD_GlcNHglycan	114	117	PF01048	0.567
MOD_GlcNHglycan	340	343	PF01048	0.571
MOD_GSK3_1	108	115	PF00069	0.521
MOD_GSK3_1	163	170	PF00069	0.561
MOD_GSK3_1	212	219	PF00069	0.502
MOD_GSK3_1	59	66	PF00069	0.586
MOD_GSK3_1	79	86	PF00069	0.323
MOD_GSK3_1	99	106	PF00069	0.481
MOD_NEK2_1	107	112	PF00069	0.549
MOD_NEK2_1	25	30	PF00069	0.467
MOD_NEK2_1	350	355	PF00069	0.532
MOD_NEK2_2	70	75	PF00069	0.465
MOD_PIKK_1	38	44	PF00454	0.547
MOD_PKA_2	295	301	PF00069	0.618
MOD_PKA_2	45	51	PF00069	0.549
MOD_PKA_2	84	90	PF00069	0.465
MOD_PKA_2	99	105	PF00069	0.490
MOD_PKB_1	214	222	PF00069	0.531
MOD_Plk_1	350	356	PF00069	0.630
MOD_Plk_4	103	109	PF00069	0.595
MOD_ProDKin_1	236	242	PF00069	0.540
MOD_ProDKin_1	59	65	PF00069	0.596
MOD_SUMO_for_1	284	287	PF00179	0.691
MOD_SUMO_rev_2	53	62	PF00179	0.613
TRG_DiLeu_BaEn_1	322	327	PF01217	0.514
TRG_DiLeu_BaLyEn_6	232	237	PF01217	0.540
TRG_ENDOCYTIC_2	242	245	PF00928	0.454
TRG_ER_diArg_1	291	294	PF00400	0.590
TRG_ER_diArg_1	30	33	PF00400	0.454
TRG_NLS_MonoExtN_4	277	283	PF00514	0.468
TRG_Pf-PMV_PEXEL_1	316	321	PF00026	0.567
TRG_Pf-PMV_PEXEL_1	38	42	PF00026	0.516

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3A3	Leptomonas seymouri	76%	99%
A0A0S4ILF0	Bodo saltans	46%	100%
A0A1X0P2R4	Trypanosomatidae	54%	100%
A0A3Q8IFW9	Leishmania donovani	94%	100%
A0A422NW52	Trypanosoma rangeli	52%	100%
A4HIF7	Leishmania braziliensis	82%	100%
A4I5Q3	Leishmania infantum	94%	100%
C9ZR22	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
E9B0Z8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
G0S920	Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)	26%	69%
O59811	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	80%
Q06709	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	86%
Q8H1G5	Arabidopsis thaliana	23%	92%
Q9ZQ18	Arabidopsis thaliana	23%	94%
V5BC84	Trypanosoma cruzi	54%	100%