Phospholipid-transporting ATPase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phospholipid-translocating P-type ATPase (flippase), putative

Species:

Leishmania major

UniProt:

Q4Q767_LEIMA

TriTrypDb:

LmjF.30.2260 , LMJLV39_300029800 , LMJSD75_300029500

Length:

1279

Annotations

LeishMANIAdb annotations

Eukaryotic P-ATPase protein, its closest animal relatives (ATP11A) are involved in phospholipid transport.. Localization: Endosomal (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

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Cellular components
Term	Name	Level	Count
GO:0005886	plasma membrane	3	2
GO:0016020	membrane	2	18
GO:0110165	cellular anatomical entity	1	18

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Expansion

Sequence features

Q4Q767

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q767

Function

Show entries

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	13
GO:0006869	lipid transport	5	13
GO:0009987	cellular process	1	2
GO:0015748	organophosphate ester transport	5	13
GO:0015914	phospholipid transport	6	13
GO:0016043	cellular component organization	3	2
GO:0034204	lipid translocation	4	2
GO:0045332	phospholipid translocation	5	2
GO:0051179	localization	1	13
GO:0051234	establishment of localization	2	13

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	18
GO:0000287	magnesium ion binding	5	13
GO:0003824	catalytic activity	1	17
GO:0004518	nuclease activity	4	1
GO:0004519	endonuclease activity	5	1
GO:0004521	RNA endonuclease activity	5	1
GO:0004526	ribonuclease P activity	6	1
GO:0004540	RNA nuclease activity	4	1
GO:0004549	tRNA-specific ribonuclease activity	5	1
GO:0005215	transporter activity	1	17

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	151	155	PF00656	0.478
CLV_C14_Caspase3-7	597	601	PF00656	0.368
CLV_C14_Caspase3-7	836	840	PF00656	0.691
CLV_C14_Caspase3-7	939	943	PF00656	0.450
CLV_NRD_NRD_1	101	103	PF00675	0.306
CLV_NRD_NRD_1	1180	1182	PF00675	0.506
CLV_NRD_NRD_1	1227	1229	PF00675	0.361
CLV_NRD_NRD_1	1235	1237	PF00675	0.368
CLV_NRD_NRD_1	1261	1263	PF00675	0.498
CLV_NRD_NRD_1	177	179	PF00675	0.405

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKQ9	Leptomonas seymouri	29%	85%
A0A0N1PF54	Leptomonas seymouri	61%	98%
A0A0S4ITW3	Bodo saltans	41%	92%
A0A1X0P1Z0	Trypanosomatidae	49%	100%
A0A1X0PA06	Trypanosomatidae	30%	99%
A0A3Q8IFQ5	Leishmania donovani	93%	100%
A0A3Q8INM6	Leishmania donovani	28%	100%
A0A3R7NV92	Trypanosoma rangeli	31%	100%
A0A3S5IS27	Trypanosoma rangeli	48%	100%
A4H7E2	Leishmania braziliensis	28%	100%

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