Tubulin-tyrosine ligase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tubulin-tyrosine ligase-like protein

Species:

Leishmania major

UniProt:

Q4Q765_LEIMA

TriTrypDb:

LmjF.30.2280 , LMJLV39_300030000 , LMJSD75_300029700

Length:

704

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

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Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	3
GO:0042995	cell projection	2	3
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0110165	cellular anatomical entity	1	3
GO:0120025	plasma membrane bounded cell projection	3	3

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Expansion

Sequence features

Q4Q765

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q765

Function

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Biological processes
Term	Name	Level	Count
GO:0000226	microtubule cytoskeleton organization	3	3
GO:0006807	nitrogen compound metabolic process	2	18
GO:0006996	organelle organization	4	3
GO:0007010	cytoskeleton organization	5	3
GO:0007017	microtubule-based process	2	3
GO:0008152	metabolic process	1	18
GO:0009987	cellular process	1	3
GO:0016043	cellular component organization	3	3
GO:0018095	protein polyglutamylation	7	3
GO:0018193	peptidyl-amino acid modification	5	3

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003824	catalytic activity	1	18
GO:0004835	tubulin-tyrosine ligase activity	3	3
GO:0005488	binding	1	8
GO:0005515	protein binding	2	3
GO:0005524	ATP binding	5	7
GO:0008092	cytoskeletal protein binding	3	3
GO:0015631	tubulin binding	4	3
GO:0016874	ligase activity	2	18
GO:0016879	ligase activity, forming carbon-nitrogen bonds	3	5

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	356	360	PF00656	0.529
CLV_C14_Caspase3-7	453	457	PF00656	0.429
CLV_NRD_NRD_1	109	111	PF00675	0.429
CLV_NRD_NRD_1	190	192	PF00675	0.296
CLV_NRD_NRD_1	205	207	PF00675	0.231
CLV_NRD_NRD_1	285	287	PF00675	0.293
CLV_NRD_NRD_1	305	307	PF00675	0.241
CLV_NRD_NRD_1	413	415	PF00675	0.439
CLV_NRD_NRD_1	473	475	PF00675	0.319
CLV_NRD_NRD_1	503	505	PF00675	0.349

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1Q6	Leptomonas seymouri	57%	98%
A0A0S4ISF0	Bodo saltans	37%	100%
A0A1X0NV49	Trypanosomatidae	24%	66%
A0A1X0P1M0	Trypanosomatidae	40%	100%
A0A3Q8IDL7	Leishmania donovani	26%	100%
A0A3Q8IEC1	Leishmania donovani	93%	100%
A0A3R7LAU2	Trypanosoma rangeli	24%	75%
A0A3S5IS28	Trypanosoma rangeli	43%	100%
A4HIG0	Leishmania braziliensis	76%	99%
A4HYN9	Leishmania infantum	26%	100%

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