Tubulin-tyrosine ligase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tubulin-tyrosine ligase-like protein

Species:

Leishmania major

UniProt:

Q4Q765_LEIMA

TriTrypDb:

LmjF.30.2280 , LMJLV39_300030000 , LMJSD75_300029700

Length:

704

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	3
GO:0042995	cell projection	2	3
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0110165	cellular anatomical entity	1	3
GO:0120025	plasma membrane bounded cell projection	3	3

Expansion

Sequence features

Q4Q765

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q765

Function

Biological processes
Term	Name	Level	Count
GO:0000226	microtubule cytoskeleton organization	3	3
GO:0006807	nitrogen compound metabolic process	2	18
GO:0006996	organelle organization	4	3
GO:0007010	cytoskeleton organization	5	3
GO:0007017	microtubule-based process	2	3
GO:0008152	metabolic process	1	18
GO:0009987	cellular process	1	3
GO:0016043	cellular component organization	3	3
GO:0018095	protein polyglutamylation	7	3
GO:0018193	peptidyl-amino acid modification	5	3
GO:0018200	peptidyl-glutamic acid modification	6	3
GO:0019538	protein metabolic process	3	18
GO:0036211	protein modification process	4	18
GO:0043170	macromolecule metabolic process	3	18
GO:0043412	macromolecule modification	4	18
GO:0044238	primary metabolic process	2	18
GO:0071704	organic substance metabolic process	2	18
GO:0071840	cellular component organization or biogenesis	2	3
GO:1901564	organonitrogen compound metabolic process	3	18

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003824	catalytic activity	1	18
GO:0005488	binding	1	8
GO:0005515	protein binding	2	3
GO:0005524	ATP binding	5	7
GO:0008092	cytoskeletal protein binding	3	3
GO:0015631	tubulin binding	4	3
GO:0016874	ligase activity	2	18
GO:0016879	ligase activity, forming carbon-nitrogen bonds	3	5
GO:0016881	acid-amino acid ligase activity	4	5
GO:0017076	purine nucleotide binding	4	7
GO:0030554	adenyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032559	adenyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0070739	protein-glutamic acid ligase activity	3	3
GO:0070740	tubulin-glutamic acid ligase activity	4	3
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:0140096	catalytic activity, acting on a protein	2	5
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7
GO:0004835	tubulin-tyrosine ligase activity	3	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	356	360	PF00656	0.529
CLV_C14_Caspase3-7	453	457	PF00656	0.429
CLV_NRD_NRD_1	109	111	PF00675	0.429
CLV_NRD_NRD_1	190	192	PF00675	0.296
CLV_NRD_NRD_1	205	207	PF00675	0.231
CLV_NRD_NRD_1	285	287	PF00675	0.293
CLV_NRD_NRD_1	305	307	PF00675	0.241
CLV_NRD_NRD_1	413	415	PF00675	0.439
CLV_NRD_NRD_1	473	475	PF00675	0.319
CLV_NRD_NRD_1	503	505	PF00675	0.349
CLV_NRD_NRD_1	55	57	PF00675	0.439
CLV_NRD_NRD_1	566	568	PF00675	0.391
CLV_PCSK_KEX2_1	109	111	PF00082	0.369
CLV_PCSK_KEX2_1	182	184	PF00082	0.286
CLV_PCSK_KEX2_1	190	192	PF00082	0.285
CLV_PCSK_KEX2_1	285	287	PF00082	0.343
CLV_PCSK_KEX2_1	413	415	PF00082	0.460
CLV_PCSK_KEX2_1	473	475	PF00082	0.296
CLV_PCSK_KEX2_1	503	505	PF00082	0.348
CLV_PCSK_PC1ET2_1	182	184	PF00082	0.288
CLV_PCSK_SKI1_1	190	194	PF00082	0.336
CLV_PCSK_SKI1_1	253	257	PF00082	0.283
CLV_PCSK_SKI1_1	285	289	PF00082	0.262
CLV_PCSK_SKI1_1	404	408	PF00082	0.330
CLV_PCSK_SKI1_1	423	427	PF00082	0.468
CLV_PCSK_SKI1_1	594	598	PF00082	0.540
CLV_Separin_Metazoa	132	136	PF03568	0.600
DEG_APCC_DBOX_1	225	233	PF00400	0.368
DEG_Nend_Nbox_1	1	3	PF02207	0.624
DEG_SPOP_SBC_1	342	346	PF00917	0.445
DOC_ANK_TNKS_1	566	573	PF00023	0.433
DOC_CKS1_1	138	143	PF01111	0.486
DOC_CYCLIN_yCln2_LP_2	585	591	PF00134	0.512
DOC_MAPK_FxFP_2	60	63	PF00069	0.436
DOC_MAPK_gen_1	182	189	PF00069	0.527
DOC_MAPK_gen_1	306	314	PF00069	0.466
DOC_MAPK_MEF2A_6	182	189	PF00069	0.431
DOC_MAPK_MEF2A_6	306	314	PF00069	0.467
DOC_MAPK_MEF2A_6	617	624	PF00069	0.459
DOC_MAPK_NFAT4_5	307	315	PF00069	0.466
DOC_PP2B_LxvP_1	143	146	PF13499	0.418
DOC_PP2B_LxvP_1	426	429	PF13499	0.540
DOC_PP2B_LxvP_1	662	665	PF13499	0.572
DOC_PP2B_LxvP_1	99	102	PF13499	0.323
DOC_PP4_FxxP_1	60	63	PF00568	0.407
DOC_USP7_MATH_1	147	151	PF00917	0.593
DOC_USP7_MATH_1	208	212	PF00917	0.539
DOC_USP7_MATH_1	235	239	PF00917	0.514
DOC_USP7_MATH_1	315	319	PF00917	0.451
DOC_USP7_MATH_1	342	346	PF00917	0.535
DOC_USP7_MATH_1	37	41	PF00917	0.674
DOC_USP7_MATH_1	389	393	PF00917	0.739
DOC_USP7_MATH_1	671	675	PF00917	0.533
DOC_USP7_MATH_1	687	691	PF00917	0.523
DOC_USP7_MATH_2	223	229	PF00917	0.462
DOC_WW_Pin1_4	137	142	PF00397	0.540
DOC_WW_Pin1_4	199	204	PF00397	0.446
DOC_WW_Pin1_4	28	33	PF00397	0.691
DOC_WW_Pin1_4	344	349	PF00397	0.723
DOC_WW_Pin1_4	39	44	PF00397	0.449
DOC_WW_Pin1_4	50	55	PF00397	0.505
LIG_14-3-3_CanoR_1	161	169	PF00244	0.419
LIG_14-3-3_CanoR_1	199	203	PF00244	0.509
LIG_14-3-3_CanoR_1	212	216	PF00244	0.532
LIG_14-3-3_CanoR_1	285	293	PF00244	0.521
LIG_14-3-3_CanoR_1	423	429	PF00244	0.663
LIG_14-3-3_CanoR_1	56	61	PF00244	0.422
LIG_Actin_WH2_2	34	51	PF00022	0.585
LIG_BIR_III_4	456	460	PF00653	0.402
LIG_BRCT_BRCA1_1	126	130	PF00533	0.526
LIG_BRCT_BRCA1_1	540	544	PF00533	0.536
LIG_BRCT_BRCA1_1	58	62	PF00533	0.380
LIG_BRCT_BRCA1_1	655	659	PF00533	0.563
LIG_EH_1	525	529	PF12763	0.462
LIG_eIF4E_1	296	302	PF01652	0.440
LIG_eIF4E_1	688	694	PF01652	0.413
LIG_FHA_1	138	144	PF00498	0.657
LIG_FHA_1	282	288	PF00498	0.538
LIG_FHA_1	430	436	PF00498	0.563
LIG_FHA_1	486	492	PF00498	0.525
LIG_FHA_1	548	554	PF00498	0.448
LIG_FHA_1	600	606	PF00498	0.635
LIG_FHA_1	697	703	PF00498	0.399
LIG_FHA_2	200	206	PF00498	0.525
LIG_GBD_Chelix_1	483	491	PF00786	0.251
LIG_GBD_Chelix_1	553	561	PF00786	0.291
LIG_Integrin_RGD_1	381	383	PF01839	0.594
LIG_Integrin_RGD_1	458	460	PF01839	0.325
LIG_LIR_Apic_2	219	223	PF02991	0.465
LIG_LIR_Apic_2	59	63	PF02991	0.427
LIG_LIR_Gen_1	127	134	PF02991	0.452
LIG_LIR_Gen_1	211	221	PF02991	0.457
LIG_LIR_Gen_1	267	275	PF02991	0.536
LIG_LIR_Nem_3	267	271	PF02991	0.471
LIG_LIR_Nem_3	317	322	PF02991	0.466
LIG_LIR_Nem_3	401	406	PF02991	0.395
LIG_LIR_Nem_3	510	515	PF02991	0.498
LIG_LIR_Nem_3	656	662	PF02991	0.632
LIG_LIR_Nem_3	93	99	PF02991	0.325
LIG_MLH1_MIPbox_1	58	62	PF16413	0.479
LIG_MYND_3	535	539	PF01753	0.505
LIG_PDZ_Class_2	699	704	PF00595	0.442
LIG_Pex14_2	634	638	PF04695	0.332
LIG_SH2_CRK	319	323	PF00017	0.478
LIG_SH2_NCK_1	339	343	PF00017	0.518
LIG_SH2_PTP2	313	316	PF00017	0.430
LIG_SH2_SRC	454	457	PF00017	0.499
LIG_SH2_STAP1	97	101	PF00017	0.324
LIG_SH2_STAT3	291	294	PF00017	0.475
LIG_SH2_STAT3	688	691	PF00017	0.410
LIG_SH2_STAT3	73	76	PF00017	0.515
LIG_SH2_STAT5	291	294	PF00017	0.461
LIG_SH2_STAT5	296	299	PF00017	0.452
LIG_SH2_STAT5	313	316	PF00017	0.439
LIG_SH2_STAT5	415	418	PF00017	0.553
LIG_SH2_STAT5	454	457	PF00017	0.505
LIG_SH2_STAT5	47	50	PF00017	0.419
LIG_SH2_STAT5	511	514	PF00017	0.498
LIG_SH2_STAT5	61	64	PF00017	0.310
LIG_SH2_STAT5	681	684	PF00017	0.453
LIG_SH3_3	358	364	PF00018	0.476
LIG_SH3_3	502	508	PF00018	0.513
LIG_SUMO_SIM_anti_2	227	234	PF11976	0.368
LIG_SUMO_SIM_anti_2	604	609	PF11976	0.539
LIG_SUMO_SIM_par_1	298	304	PF11976	0.448
LIG_SUMO_SIM_par_1	424	432	PF11976	0.537
LIG_SUMO_SIM_par_1	528	534	PF11976	0.483
LIG_UBA3_1	271	278	PF00899	0.517
LIG_WW_1	70	73	PF00397	0.459
MOD_CDC14_SPxK_1	53	56	PF00782	0.522
MOD_CDK_SPxK_1	50	56	PF00069	0.510
MOD_CDK_SPxxK_3	199	206	PF00069	0.446
MOD_CDK_SPxxK_3	50	57	PF00069	0.528
MOD_CK1_1	211	217	PF00069	0.528
MOD_CK1_1	228	234	PF00069	0.361
MOD_CK1_1	247	253	PF00069	0.482
MOD_CK1_1	25	31	PF00069	0.634
MOD_CK1_1	281	287	PF00069	0.544
MOD_CK1_1	340	346	PF00069	0.512
MOD_CK1_1	375	381	PF00069	0.757
MOD_CK1_1	424	430	PF00069	0.690
MOD_CK1_1	461	467	PF00069	0.644
MOD_CK1_1	537	543	PF00069	0.444
MOD_CK1_1	644	650	PF00069	0.644
MOD_CK1_1	655	661	PF00069	0.689
MOD_CK1_1	79	85	PF00069	0.394
MOD_CK1_1	88	94	PF00069	0.354
MOD_CK2_1	199	205	PF00069	0.525
MOD_CK2_1	507	513	PF00069	0.505
MOD_CK2_1	89	95	PF00069	0.404
MOD_Cter_Amidation	304	307	PF01082	0.283
MOD_Cter_Amidation	411	414	PF01082	0.403
MOD_GlcNHglycan	374	377	PF01048	0.751
MOD_GlcNHglycan	387	390	PF01048	0.649
MOD_GlcNHglycan	541	544	PF01048	0.294
MOD_GlcNHglycan	643	646	PF01048	0.709
MOD_GlcNHglycan	654	658	PF01048	0.692
MOD_GlcNHglycan	659	662	PF01048	0.610
MOD_GSK3_1	22	29	PF00069	0.639
MOD_GSK3_1	255	262	PF00069	0.537
MOD_GSK3_1	337	344	PF00069	0.549
MOD_GSK3_1	385	392	PF00069	0.785
MOD_GSK3_1	458	465	PF00069	0.525
MOD_GSK3_1	534	541	PF00069	0.465
MOD_GSK3_1	571	578	PF00069	0.585
MOD_GSK3_1	639	646	PF00069	0.502
MOD_GSK3_1	653	660	PF00069	0.716
MOD_GSK3_1	692	699	PF00069	0.519
MOD_GSK3_1	75	82	PF00069	0.474
MOD_GSK3_1	85	92	PF00069	0.387
MOD_N-GLC_1	407	412	PF02516	0.402
MOD_N-GLC_1	576	581	PF02516	0.575
MOD_NEK2_1	162	167	PF00069	0.458
MOD_NEK2_1	197	202	PF00069	0.524
MOD_NEK2_1	23	28	PF00069	0.717
MOD_NEK2_1	287	292	PF00069	0.511
MOD_NEK2_1	444	449	PF00069	0.377
MOD_NEK2_1	521	526	PF00069	0.499
MOD_NEK2_1	538	543	PF00069	0.451
MOD_NEK2_1	575	580	PF00069	0.572
MOD_NEK2_1	643	648	PF00069	0.658
MOD_NEK2_1	653	658	PF00069	0.688
MOD_NEK2_1	87	92	PF00069	0.340
MOD_NEK2_2	124	129	PF00069	0.355
MOD_PIKK_1	255	261	PF00454	0.462
MOD_PIKK_1	576	582	PF00454	0.462
MOD_PIKK_1	645	651	PF00454	0.689
MOD_PIKK_1	687	693	PF00454	0.367
MOD_PKA_1	473	479	PF00069	0.344
MOD_PKA_1	56	62	PF00069	0.388
MOD_PKA_2	198	204	PF00069	0.415
MOD_PKA_2	211	217	PF00069	0.502
MOD_PKA_2	225	231	PF00069	0.502
MOD_PKA_2	247	253	PF00069	0.444
MOD_PKA_2	281	287	PF00069	0.444
MOD_PKA_2	473	479	PF00069	0.320
MOD_PKB_1	402	410	PF00069	0.513
MOD_Plk_1	407	413	PF00069	0.419
MOD_Plk_1	459	465	PF00069	0.647
MOD_Plk_1	521	527	PF00069	0.530
MOD_Plk_1	576	582	PF00069	0.572
MOD_Plk_1	696	702	PF00069	0.399
MOD_Plk_4	211	217	PF00069	0.481
MOD_Plk_4	225	231	PF00069	0.465
MOD_Plk_4	287	293	PF00069	0.537
MOD_Plk_4	30	36	PF00069	0.555
MOD_Plk_4	320	326	PF00069	0.451
MOD_Plk_4	507	513	PF00069	0.505
MOD_Plk_4	56	62	PF00069	0.355
MOD_Plk_4	571	577	PF00069	0.614
MOD_Plk_4	677	683	PF00069	0.495
MOD_ProDKin_1	137	143	PF00069	0.536
MOD_ProDKin_1	199	205	PF00069	0.446
MOD_ProDKin_1	28	34	PF00069	0.690
MOD_ProDKin_1	344	350	PF00069	0.725
MOD_ProDKin_1	39	45	PF00069	0.439
MOD_ProDKin_1	50	56	PF00069	0.506
MOD_SUMO_for_1	651	654	PF00179	0.527
MOD_SUMO_rev_2	273	280	PF00179	0.519
MOD_SUMO_rev_2	563	570	PF00179	0.552
TRG_DiLeu_BaEn_1	225	230	PF01217	0.483
TRG_DiLeu_BaEn_1	298	303	PF01217	0.465
TRG_DiLeu_BaEn_1	482	487	PF01217	0.552
TRG_DiLeu_BaEn_1	689	694	PF01217	0.378
TRG_DiLeu_BaLyEn_6	138	143	PF01217	0.529
TRG_DiLeu_BaLyEn_6	297	302	PF01217	0.445
TRG_DiLeu_BaLyEn_6	99	104	PF01217	0.325
TRG_ENDOCYTIC_2	169	172	PF00928	0.485
TRG_ENDOCYTIC_2	213	216	PF00928	0.465
TRG_ENDOCYTIC_2	313	316	PF00928	0.449
TRG_ENDOCYTIC_2	319	322	PF00928	0.468
TRG_ENDOCYTIC_2	415	418	PF00928	0.528
TRG_ENDOCYTIC_2	511	514	PF00928	0.487
TRG_ENDOCYTIC_2	96	99	PF00928	0.306
TRG_ER_diArg_1	108	110	PF00400	0.421
TRG_ER_diArg_1	189	191	PF00400	0.535
TRG_ER_diArg_1	285	287	PF00400	0.543
TRG_ER_diArg_1	413	415	PF00400	0.512
TRG_ER_diArg_1	473	475	PF00400	0.295
TRG_ER_diArg_1	502	504	PF00400	0.474
TRG_ER_diArg_1	622	625	PF00400	0.488
TRG_ER_diArg_1	63	66	PF00400	0.445

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1Q6	Leptomonas seymouri	57%	98%
A0A0S4ISF0	Bodo saltans	37%	100%
A0A1X0NV49	Trypanosomatidae	24%	66%
A0A1X0P1M0	Trypanosomatidae	40%	100%
A0A3Q8IDL7	Leishmania donovani	26%	100%
A0A3Q8IEC1	Leishmania donovani	93%	100%
A0A3R7LAU2	Trypanosoma rangeli	24%	75%
A0A3S5IS28	Trypanosoma rangeli	43%	100%
A4HIG0	Leishmania braziliensis	76%	99%
A4HYN9	Leishmania infantum	26%	100%
A4I5Q6	Leishmania infantum	93%	100%
A4Q9F0	Mus musculus	25%	77%
C9ZR25	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
C9ZYH1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9AUL7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9B101	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QCW7	Leishmania major	25%	97%
Q6ZT98	Homo sapiens	25%	79%
Q8NHH1	Homo sapiens	23%	88%
V5BLC0	Trypanosoma cruzi	41%	100%
V5BVF5	Trypanosoma cruzi	26%	100%
V5C123	Trypanosoma cruzi	24%	75%