SAM_MT_RSMB_NOP domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q762_LEIMA

TriTrypDb:

LmjF.30.2310 , LMJLV39_300030400 , LMJSD75_300030000

Length:

464

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q762

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q762

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	1
GO:0032259	methylation	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0008168	methyltransferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016741	transferase activity, transferring one-carbon groups	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	187	191	PF00656	0.467
CLV_NRD_NRD_1	119	121	PF00675	0.442
CLV_NRD_NRD_1	175	177	PF00675	0.463
CLV_NRD_NRD_1	237	239	PF00675	0.361
CLV_NRD_NRD_1	240	242	PF00675	0.369
CLV_NRD_NRD_1	36	38	PF00675	0.579
CLV_NRD_NRD_1	372	374	PF00675	0.512
CLV_NRD_NRD_1	392	394	PF00675	0.599
CLV_NRD_NRD_1	67	69	PF00675	0.428
CLV_PCSK_FUR_1	117	121	PF00082	0.470
CLV_PCSK_FUR_1	238	242	PF00082	0.448
CLV_PCSK_KEX2_1	117	119	PF00082	0.375
CLV_PCSK_KEX2_1	175	177	PF00082	0.463
CLV_PCSK_KEX2_1	237	239	PF00082	0.361
CLV_PCSK_KEX2_1	240	242	PF00082	0.369
CLV_PCSK_KEX2_1	250	252	PF00082	0.352
CLV_PCSK_KEX2_1	35	37	PF00082	0.557
CLV_PCSK_KEX2_1	372	374	PF00082	0.508
CLV_PCSK_KEX2_1	391	393	PF00082	0.501
CLV_PCSK_KEX2_1	67	69	PF00082	0.442
CLV_PCSK_PC1ET2_1	250	252	PF00082	0.370
CLV_PCSK_PC1ET2_1	391	393	PF00082	0.525
CLV_PCSK_PC7_1	31	37	PF00082	0.553
CLV_PCSK_SKI1_1	119	123	PF00082	0.430
CLV_PCSK_SKI1_1	164	168	PF00082	0.334
CLV_PCSK_SKI1_1	250	254	PF00082	0.383
CLV_PCSK_SKI1_1	271	275	PF00082	0.396
CLV_PCSK_SKI1_1	31	35	PF00082	0.442
CLV_PCSK_SKI1_1	373	377	PF00082	0.519
CLV_PCSK_SKI1_1	400	404	PF00082	0.505
CLV_Separin_Metazoa	338	342	PF03568	0.390
DEG_APCC_DBOX_1	391	399	PF00400	0.370
DEG_SCF_FBW7_1	196	202	PF00400	0.540
DOC_CKS1_1	165	170	PF01111	0.466
DOC_CKS1_1	183	188	PF01111	0.271
DOC_CKS1_1	196	201	PF01111	0.422
DOC_CYCLIN_yClb5_NLxxxL_5	37	45	PF00134	0.441
DOC_MAPK_gen_1	175	183	PF00069	0.507
DOC_MAPK_gen_1	248	255	PF00069	0.395
DOC_MAPK_gen_1	35	43	PF00069	0.515
DOC_MAPK_MEF2A_6	164	172	PF00069	0.448
DOC_MAPK_MEF2A_6	36	45	PF00069	0.576
DOC_MAPK_MEF2A_6	405	412	PF00069	0.373
DOC_MAPK_NFAT4_5	405	413	PF00069	0.374
DOC_MAPK_RevD_3	21	36	PF00069	0.529
DOC_PP1_RVXF_1	407	413	PF00149	0.428
DOC_PP4_FxxP_1	78	81	PF00568	0.327
DOC_USP7_MATH_1	192	196	PF00917	0.405
DOC_WW_Pin1_4	164	169	PF00397	0.465
DOC_WW_Pin1_4	182	187	PF00397	0.269
DOC_WW_Pin1_4	195	200	PF00397	0.413
LIG_14-3-3_CanoR_1	222	232	PF00244	0.427
LIG_14-3-3_CanoR_1	414	419	PF00244	0.447
LIG_AP2alpha_1	144	148	PF02296	0.424
LIG_APCC_ABBA_1	145	150	PF00400	0.438
LIG_APCC_ABBAyCdc20_2	372	378	PF00400	0.327
LIG_BRCT_BRCA1_1	102	106	PF00533	0.353
LIG_BRCT_BRCA1_1	148	152	PF00533	0.317
LIG_BRCT_BRCA1_1	429	433	PF00533	0.343
LIG_BRCT_BRCA1_1	49	53	PF00533	0.435
LIG_BRCT_BRCA1_2	49	55	PF00533	0.358
LIG_FHA_1	1	7	PF00498	0.518
LIG_FHA_1	127	133	PF00498	0.356
LIG_FHA_1	165	171	PF00498	0.401
LIG_FHA_1	183	189	PF00498	0.346
LIG_FHA_1	196	202	PF00498	0.446
LIG_FHA_1	224	230	PF00498	0.430
LIG_FHA_1	286	292	PF00498	0.390
LIG_FHA_1	351	357	PF00498	0.528
LIG_FHA_1	90	96	PF00498	0.548
LIG_FHA_2	185	191	PF00498	0.479
LIG_FHA_2	252	258	PF00498	0.400
LIG_FHA_2	279	285	PF00498	0.360
LIG_GBD_Chelix_1	395	403	PF00786	0.411
LIG_KLC1_Yacidic_2	319	324	PF13176	0.333
LIG_LIR_Apic_2	213	219	PF02991	0.433
LIG_LIR_Gen_1	142	152	PF02991	0.303
LIG_LIR_Gen_1	333	344	PF02991	0.438
LIG_LIR_Gen_1	430	439	PF02991	0.336
LIG_LIR_Nem_3	127	133	PF02991	0.360
LIG_LIR_Nem_3	142	147	PF02991	0.226
LIG_LIR_Nem_3	149	155	PF02991	0.309
LIG_LIR_Nem_3	333	339	PF02991	0.431
LIG_LIR_Nem_3	430	436	PF02991	0.349
LIG_PCNA_yPIPBox_3	19	33	PF02747	0.314
LIG_PDZ_Class_3	459	464	PF00595	0.508
LIG_Pex14_2	144	148	PF04695	0.349
LIG_Pex14_2	412	416	PF04695	0.480
LIG_REV1ctd_RIR_1	104	114	PF16727	0.329
LIG_SH2_CRK	130	134	PF00017	0.325
LIG_SH2_SRC	136	139	PF00017	0.410
LIG_SH2_SRC	207	210	PF00017	0.453
LIG_SH2_SRC	79	82	PF00017	0.455
LIG_SH2_STAP1	136	140	PF00017	0.468
LIG_SH2_STAT5	207	210	PF00017	0.400
LIG_SH2_STAT5	322	325	PF00017	0.329
LIG_SH2_STAT5	437	440	PF00017	0.475
LIG_SH3_3	2	8	PF00018	0.468
LIG_SH3_3	420	426	PF00018	0.385
LIG_SH3_3	436	442	PF00018	0.198
LIG_SUMO_SIM_par_1	251	257	PF11976	0.405
LIG_TRAF2_1	358	361	PF00917	0.448
MOD_CK1_1	139	145	PF00069	0.400
MOD_CK1_1	195	201	PF00069	0.547
MOD_CK1_1	210	216	PF00069	0.464
MOD_CK1_1	451	457	PF00069	0.480
MOD_CK2_1	278	284	PF00069	0.482
MOD_Cter_Amidation	248	251	PF01082	0.427
MOD_GlcNHglycan	209	212	PF01048	0.404
MOD_GlcNHglycan	257	261	PF01048	0.342
MOD_GlcNHglycan	294	297	PF01048	0.523
MOD_GlcNHglycan	429	432	PF01048	0.418
MOD_GlcNHglycan	450	453	PF01048	0.472
MOD_GSK3_1	122	129	PF00069	0.551
MOD_GSK3_1	195	202	PF00069	0.411
MOD_GSK3_1	294	301	PF00069	0.396
MOD_GSK3_1	427	434	PF00069	0.412
MOD_GSK3_1	450	457	PF00069	0.546
MOD_LATS_1	326	332	PF00433	0.406
MOD_N-GLC_1	292	297	PF02516	0.431
MOD_NEK2_1	148	153	PF00069	0.313
MOD_NEK2_1	329	334	PF00069	0.523
MOD_NEK2_1	339	344	PF00069	0.441
MOD_NEK2_1	448	453	PF00069	0.634
MOD_NEK2_1	89	94	PF00069	0.480
MOD_PIKK_1	122	128	PF00454	0.546
MOD_PK_1	414	420	PF00069	0.480
MOD_PKA_2	192	198	PF00069	0.510
MOD_PKA_2	236	242	PF00069	0.421
MOD_PKA_2	448	454	PF00069	0.470
MOD_Plk_1	278	284	PF00069	0.431
MOD_Plk_1	69	75	PF00069	0.431
MOD_Plk_2-3	184	190	PF00069	0.488
MOD_Plk_2-3	279	285	PF00069	0.456
MOD_Plk_4	139	145	PF00069	0.318
MOD_Plk_4	148	154	PF00069	0.327
MOD_Plk_4	192	198	PF00069	0.375
MOD_Plk_4	251	257	PF00069	0.439
MOD_Plk_4	271	277	PF00069	0.264
MOD_Plk_4	294	300	PF00069	0.422
MOD_Plk_4	350	356	PF00069	0.361
MOD_Plk_4	69	75	PF00069	0.458
MOD_ProDKin_1	164	170	PF00069	0.466
MOD_ProDKin_1	182	188	PF00069	0.270
MOD_ProDKin_1	195	201	PF00069	0.417
MOD_SUMO_for_1	54	57	PF00179	0.476
MOD_SUMO_rev_2	378	384	PF00179	0.485
TRG_DiLeu_BaLyEn_6	165	170	PF01217	0.453
TRG_DiLeu_BaLyEn_6	420	425	PF01217	0.530
TRG_ENDOCYTIC_2	130	133	PF00928	0.324
TRG_ER_diArg_1	117	120	PF00400	0.410
TRG_ER_diArg_1	237	240	PF00400	0.355
TRG_ER_diArg_1	312	315	PF00400	0.504
TRG_ER_diArg_1	35	37	PF00400	0.602
TRG_ER_diArg_1	371	373	PF00400	0.514
TRG_ER_diArg_1	392	394	PF00400	0.619
TRG_ER_diArg_1	66	68	PF00400	0.467
TRG_NLS_Bipartite_1	373	395	PF00514	0.432
TRG_NLS_MonoExtN_4	389	395	PF00514	0.408
TRG_Pf-PMV_PEXEL_1	120	124	PF00026	0.546
TRG_Pf-PMV_PEXEL_1	393	397	PF00026	0.445

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P922	Leptomonas seymouri	72%	100%
A0A1X0P2C1	Trypanosomatidae	47%	100%
A0A3S7X3J4	Leishmania donovani	94%	100%
A0A422NW63	Trypanosoma rangeli	47%	100%
A4HIG3	Leishmania braziliensis	88%	100%
A4I5Q9	Leishmania infantum	94%	100%
C9ZR28	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9B104	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5BGV8	Trypanosoma cruzi	45%	100%