SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SET domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4Q761_LEIMA

TriTrypDb:

LmjF.30.2320 , LMJLV39_300030500 , LMJSD75_300030100

Length:

354

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4Q761

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q761

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	19	21	PF00675	0.405
CLV_NRD_NRD_1	294	296	PF00675	0.283
CLV_NRD_NRD_1	303	305	PF00675	0.314
CLV_NRD_NRD_1	77	79	PF00675	0.220
CLV_PCSK_FUR_1	300	304	PF00082	0.244
CLV_PCSK_KEX2_1	19	21	PF00082	0.407
CLV_PCSK_KEX2_1	294	296	PF00082	0.257
CLV_PCSK_KEX2_1	302	304	PF00082	0.253
CLV_PCSK_KEX2_1	77	79	PF00082	0.220
CLV_PCSK_SKI1_1	26	30	PF00082	0.298
DOC_CDC14_PxL_1	228	236	PF14671	0.461
DOC_CYCLIN_yCln2_LP_2	41	47	PF00134	0.479
DOC_MAPK_gen_1	247	255	PF00069	0.473
DOC_MAPK_gen_1	302	313	PF00069	0.550
DOC_MAPK_gen_1	77	85	PF00069	0.513
DOC_MAPK_MEF2A_6	36	45	PF00069	0.456
DOC_MAPK_NFAT4_5	36	44	PF00069	0.530
DOC_PP2B_LxvP_1	251	254	PF13499	0.536
DOC_PP2B_LxvP_1	41	44	PF13499	0.532
DOC_PP2B_LxvP_1	53	56	PF13499	0.543
DOC_USP7_MATH_1	293	297	PF00917	0.485
DOC_USP7_MATH_1	98	102	PF00917	0.416
DOC_WW_Pin1_4	129	134	PF00397	0.465
DOC_WW_Pin1_4	280	285	PF00397	0.536
DOC_WW_Pin1_4	61	66	PF00397	0.463
LIG_14-3-3_CanoR_1	104	108	PF00244	0.433
LIG_14-3-3_CanoR_1	159	165	PF00244	0.425
LIG_14-3-3_CanoR_1	174	181	PF00244	0.457
LIG_14-3-3_CanoR_1	294	298	PF00244	0.531
LIG_14-3-3_CanoR_1	61	65	PF00244	0.515
LIG_APCC_ABBA_1	83	88	PF00400	0.496
LIG_BIR_II_1	1	5	PF00653	0.448
LIG_BRCT_BRCA1_1	171	175	PF00533	0.496
LIG_deltaCOP1_diTrp_1	88	96	PF00928	0.536
LIG_FHA_1	174	180	PF00498	0.461
LIG_FHA_1	235	241	PF00498	0.540
LIG_FHA_2	49	55	PF00498	0.534
LIG_FHA_2	67	73	PF00498	0.456
LIG_Integrin_RGD_1	337	339	PF01839	0.472
LIG_LIR_Gen_1	233	243	PF02991	0.522
LIG_LIR_Gen_1	88	98	PF02991	0.536
LIG_LIR_Nem_3	224	228	PF02991	0.445
LIG_LIR_Nem_3	233	238	PF02991	0.448
LIG_LIR_Nem_3	88	93	PF02991	0.536
LIG_Pex14_1	347	351	PF04695	0.434
LIG_Pex14_1	92	96	PF04695	0.536
LIG_Pex14_2	86	90	PF04695	0.496
LIG_RPA_C_Fungi	289	301	PF08784	0.234
LIG_SH2_CRK	47	51	PF00017	0.410
LIG_SH2_NCK_1	193	197	PF00017	0.306
LIG_SH2_SRC	148	151	PF00017	0.355
LIG_SH2_STAP1	148	152	PF00017	0.355
LIG_SH2_STAT5	146	149	PF00017	0.279
LIG_SH2_STAT5	184	187	PF00017	0.320
LIG_SH2_STAT5	244	247	PF00017	0.296
LIG_SH2_STAT5	351	354	PF00017	0.494
LIG_SH2_STAT5	47	50	PF00017	0.297
LIG_SH3_3	266	272	PF00018	0.297
LIG_SH3_5	180	184	PF00018	0.330
LIG_SUMO_SIM_par_1	236	242	PF11976	0.306
LIG_SUMO_SIM_par_1	286	291	PF11976	0.210
LIG_TYR_ITIM	45	50	PF00017	0.410
MOD_CK1_1	106	112	PF00069	0.278
MOD_CK1_1	155	161	PF00069	0.416
MOD_CK1_1	191	197	PF00069	0.355
MOD_CK1_1	257	263	PF00069	0.355
MOD_CK1_1	265	271	PF00069	0.452
MOD_CK2_1	129	135	PF00069	0.297
MOD_CK2_1	194	200	PF00069	0.331
MOD_CK2_1	66	72	PF00069	0.377
MOD_DYRK1A_RPxSP_1	61	65	PF00069	0.282
MOD_GlcNHglycan	100	103	PF01048	0.438
MOD_GlcNHglycan	108	111	PF01048	0.356
MOD_GlcNHglycan	154	157	PF01048	0.421
MOD_GlcNHglycan	197	200	PF01048	0.423
MOD_GlcNHglycan	290	293	PF01048	0.368
MOD_GlcNHglycan	319	322	PF01048	0.737
MOD_GlcNHglycan	96	99	PF01048	0.418
MOD_GSK3_1	105	112	PF00069	0.312
MOD_GSK3_1	169	176	PF00069	0.391
MOD_GSK3_1	191	198	PF00069	0.436
MOD_GSK3_1	230	237	PF00069	0.395
MOD_GSK3_1	327	334	PF00069	0.663
MOD_GSK3_1	94	101	PF00069	0.318
MOD_N-GLC_1	265	270	PF02516	0.296
MOD_N-GLC_1	331	336	PF02516	0.597
MOD_N-GLC_2	278	280	PF02516	0.355
MOD_NEK2_1	127	132	PF00069	0.410
MOD_NEK2_1	152	157	PF00069	0.448
MOD_NEK2_1	234	239	PF00069	0.374
MOD_NEK2_1	245	250	PF00069	0.382
MOD_NEK2_1	255	260	PF00069	0.361
MOD_NEK2_1	317	322	PF00069	0.653
MOD_NEK2_1	39	44	PF00069	0.340
MOD_NEK2_1	66	71	PF00069	0.265
MOD_NEK2_2	188	193	PF00069	0.414
MOD_PIKK_1	48	54	PF00454	0.355
MOD_PKA_2	103	109	PF00069	0.255
MOD_PKA_2	173	179	PF00069	0.306
MOD_PKA_2	293	299	PF00069	0.404
MOD_PKA_2	315	321	PF00069	0.566
MOD_PKA_2	60	66	PF00069	0.444
MOD_PKA_2	94	100	PF00069	0.313
MOD_Plk_1	265	271	PF00069	0.388
MOD_Plk_1	309	315	PF00069	0.302
MOD_Plk_2-3	230	236	PF00069	0.397
MOD_Plk_2-3	309	315	PF00069	0.322
MOD_Plk_4	188	194	PF00069	0.414
MOD_Plk_4	230	236	PF00069	0.324
MOD_Plk_4	239	245	PF00069	0.273
MOD_Plk_4	265	271	PF00069	0.378
MOD_Plk_4	331	337	PF00069	0.751
MOD_ProDKin_1	129	135	PF00069	0.311
MOD_ProDKin_1	280	286	PF00069	0.410
MOD_ProDKin_1	61	67	PF00069	0.309
TRG_DiLeu_BaLyEn_6	251	256	PF01217	0.305
TRG_DiLeu_BaLyEn_6	62	67	PF01217	0.282
TRG_ENDOCYTIC_2	47	50	PF00928	0.325
TRG_ER_diArg_1	19	22	PF00400	0.444
TRG_ER_diArg_1	246	249	PF00400	0.279
TRG_ER_diArg_1	299	302	PF00400	0.315
TRG_ER_diArg_1	303	305	PF00400	0.326
TRG_ER_diArg_1	76	78	PF00400	0.248
TRG_Pf-PMV_PEXEL_1	226	230	PF00026	0.410

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDQ4	Leptomonas seymouri	51%	97%
A0A1X0P1P8	Trypanosomatidae	38%	100%
A0A3Q8IEW5	Leishmania donovani	90%	100%
A0A3R7MQP1	Trypanosoma rangeli	39%	100%
A4HIG4	Leishmania braziliensis	76%	99%
A4I5R0	Leishmania infantum	90%	100%
C9ZR29	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9B105	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	99%
V5BLC5	Trypanosoma cruzi	41%	72%