Conserved zinc-finger protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

zinc-finger protein, conserved

Species:

Leishmania major

UniProt:

Q4Q759_LEIMA

TriTrypDb:

LmjF.30.2340 , LMJLV39_300030700 , LMJSD75_300030300

Length:

1197

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q759

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q759

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	18	22	PF00656	0.610
CLV_C14_Caspase3-7	405	409	PF00656	0.799
CLV_C14_Caspase3-7	638	642	PF00656	0.825
CLV_C14_Caspase3-7	922	926	PF00656	0.717
CLV_C14_Caspase3-7	938	942	PF00656	0.588
CLV_NRD_NRD_1	1166	1168	PF00675	0.807
CLV_NRD_NRD_1	1183	1185	PF00675	0.545
CLV_NRD_NRD_1	1195	1197	PF00675	0.524
CLV_NRD_NRD_1	182	184	PF00675	0.684
CLV_NRD_NRD_1	252	254	PF00675	0.576
CLV_NRD_NRD_1	415	417	PF00675	0.841
CLV_NRD_NRD_1	689	691	PF00675	0.718
CLV_NRD_NRD_1	852	854	PF00675	0.769
CLV_NRD_NRD_1	88	90	PF00675	0.603
CLV_NRD_NRD_1	891	893	PF00675	0.758
CLV_NRD_NRD_1	98	100	PF00675	0.663
CLV_PCSK_FUR_1	185	189	PF00082	0.713
CLV_PCSK_KEX2_1	1166	1168	PF00082	0.745
CLV_PCSK_KEX2_1	1183	1185	PF00082	0.532
CLV_PCSK_KEX2_1	1195	1197	PF00082	0.524
CLV_PCSK_KEX2_1	184	186	PF00082	0.687
CLV_PCSK_KEX2_1	187	189	PF00082	0.602
CLV_PCSK_KEX2_1	414	416	PF00082	0.848
CLV_PCSK_KEX2_1	689	691	PF00082	0.718
CLV_PCSK_KEX2_1	852	854	PF00082	0.769
CLV_PCSK_KEX2_1	88	90	PF00082	0.640
CLV_PCSK_KEX2_1	891	893	PF00082	0.758
CLV_PCSK_KEX2_1	98	100	PF00082	0.663
CLV_PCSK_PC1ET2_1	1183	1185	PF00082	0.604
CLV_PCSK_PC1ET2_1	1195	1197	PF00082	0.524
CLV_PCSK_PC1ET2_1	184	186	PF00082	0.687
CLV_PCSK_PC1ET2_1	187	189	PF00082	0.602
CLV_PCSK_PC1ET2_1	852	854	PF00082	0.728
CLV_PCSK_PC7_1	183	189	PF00082	0.708
CLV_PCSK_SKI1_1	1185	1189	PF00082	0.818
CLV_PCSK_SKI1_1	175	179	PF00082	0.425
CLV_PCSK_SKI1_1	208	212	PF00082	0.617
CLV_PCSK_SKI1_1	327	331	PF00082	0.546
CLV_PCSK_SKI1_1	34	38	PF00082	0.726
CLV_PCSK_SKI1_1	387	391	PF00082	0.758
CLV_PCSK_SKI1_1	59	63	PF00082	0.570
CLV_PCSK_SKI1_1	673	677	PF00082	0.735
CLV_Separin_Metazoa	328	332	PF03568	0.628
DEG_SPOP_SBC_1	224	228	PF00917	0.719
DEG_SPOP_SBC_1	653	657	PF00917	0.586
DOC_ANK_TNKS_1	801	808	PF00023	0.601
DOC_CKS1_1	428	433	PF01111	0.818
DOC_CKS1_1	521	526	PF01111	0.628
DOC_CYCLIN_RxL_1	324	332	PF00134	0.594
DOC_MAPK_gen_1	253	261	PF00069	0.604
DOC_MAPK_gen_1	384	392	PF00069	0.762
DOC_MAPK_gen_1	454	463	PF00069	0.714
DOC_MAPK_gen_1	720	727	PF00069	0.761
DOC_MAPK_MEF2A_6	254	263	PF00069	0.599
DOC_MAPK_MEF2A_6	639	648	PF00069	0.600
DOC_MAPK_MEF2A_6	736	745	PF00069	0.683
DOC_MAPK_MEF2A_6	827	834	PF00069	0.830
DOC_PP2B_LxvP_1	380	383	PF13499	0.800
DOC_PP2B_LxvP_1	500	503	PF13499	0.741
DOC_PP2B_LxvP_1	569	572	PF13499	0.712
DOC_PP2B_LxvP_1	743	746	PF13499	0.682
DOC_PP4_FxxP_1	931	934	PF00568	0.681
DOC_USP7_MATH_1	1019	1023	PF00917	0.738
DOC_USP7_MATH_1	1025	1029	PF00917	0.691
DOC_USP7_MATH_1	1098	1102	PF00917	0.660
DOC_USP7_MATH_1	15	19	PF00917	0.462
DOC_USP7_MATH_1	150	154	PF00917	0.663
DOC_USP7_MATH_1	177	181	PF00917	0.640
DOC_USP7_MATH_1	196	200	PF00917	0.648
DOC_USP7_MATH_1	224	228	PF00917	0.796
DOC_USP7_MATH_1	299	303	PF00917	0.688
DOC_USP7_MATH_1	469	473	PF00917	0.633
DOC_USP7_MATH_1	476	480	PF00917	0.689
DOC_USP7_MATH_1	494	498	PF00917	0.508
DOC_USP7_MATH_1	515	519	PF00917	0.656
DOC_USP7_MATH_1	575	579	PF00917	0.764
DOC_USP7_MATH_1	663	667	PF00917	0.593
DOC_USP7_MATH_1	762	766	PF00917	0.748
DOC_USP7_MATH_1	810	814	PF00917	0.774
DOC_USP7_MATH_1	837	841	PF00917	0.707
DOC_USP7_MATH_1	863	867	PF00917	0.609
DOC_USP7_MATH_1	917	921	PF00917	0.629
DOC_USP7_MATH_1	966	970	PF00917	0.607
DOC_WW_Pin1_4	1008	1013	PF00397	0.853
DOC_WW_Pin1_4	1087	1092	PF00397	0.792
DOC_WW_Pin1_4	1138	1143	PF00397	0.721
DOC_WW_Pin1_4	135	140	PF00397	0.767
DOC_WW_Pin1_4	275	280	PF00397	0.610
DOC_WW_Pin1_4	424	429	PF00397	0.823
DOC_WW_Pin1_4	465	470	PF00397	0.764
DOC_WW_Pin1_4	490	495	PF00397	0.767
DOC_WW_Pin1_4	520	525	PF00397	0.634
DOC_WW_Pin1_4	540	545	PF00397	0.837
DOC_WW_Pin1_4	640	645	PF00397	0.764
DOC_WW_Pin1_4	764	769	PF00397	0.673
DOC_WW_Pin1_4	964	969	PF00397	0.714
LIG_14-3-3_CanoR_1	104	112	PF00244	0.400
LIG_14-3-3_CanoR_1	1166	1175	PF00244	0.803
LIG_14-3-3_CanoR_1	1184	1188	PF00244	0.531
LIG_14-3-3_CanoR_1	134	139	PF00244	0.672
LIG_14-3-3_CanoR_1	387	393	PF00244	0.759
LIG_14-3-3_CanoR_1	436	443	PF00244	0.729
LIG_14-3-3_CanoR_1	720	727	PF00244	0.787
LIG_14-3-3_CanoR_1	809	815	PF00244	0.777
LIG_14-3-3_CanoR_1	862	870	PF00244	0.741
LIG_14-3-3_CanoR_1	880	888	PF00244	0.554
LIG_14-3-3_CanoR_1	995	1000	PF00244	0.832
LIG_Actin_WH2_2	318	333	PF00022	0.729
LIG_APCC_ABBA_1	323	328	PF00400	0.644
LIG_BIR_III_2	641	645	PF00653	0.821
LIG_BRCT_BRCA1_1	227	231	PF00533	0.610
LIG_BRCT_BRCA1_1	747	751	PF00533	0.702
LIG_CtBP_PxDLS_1	1054	1058	PF00389	0.622
LIG_EVH1_2	531	535	PF00568	0.649
LIG_FHA_1	31	37	PF00498	0.592
LIG_FHA_1	448	454	PF00498	0.792
LIG_FHA_1	564	570	PF00498	0.806
LIG_FHA_1	641	647	PF00498	0.634
LIG_FHA_1	764	770	PF00498	0.631
LIG_FHA_1	871	877	PF00498	0.701
LIG_FHA_1	92	98	PF00498	0.658
LIG_FHA_2	1009	1015	PF00498	0.647
LIG_FHA_2	1046	1052	PF00498	0.771
LIG_FHA_2	1098	1104	PF00498	0.765
LIG_FHA_2	287	293	PF00498	0.683
LIG_FHA_2	330	336	PF00498	0.622
LIG_FHA_2	636	642	PF00498	0.782
LIG_FHA_2	693	699	PF00498	0.752
LIG_FHA_2	936	942	PF00498	0.773
LIG_Integrin_RGD_1	639	641	PF01839	0.600
LIG_LIR_Apic_2	526	532	PF02991	0.684
LIG_LIR_Apic_2	928	934	PF02991	0.678
LIG_LIR_Gen_1	106	114	PF02991	0.419
LIG_LIR_Gen_1	13	24	PF02991	0.621
LIG_LIR_Gen_1	879	890	PF02991	0.621
LIG_LIR_LC3C_4	421	425	PF02991	0.707
LIG_LIR_Nem_3	1026	1032	PF02991	0.789
LIG_LIR_Nem_3	106	111	PF02991	0.420
LIG_LIR_Nem_3	13	19	PF02991	0.616
LIG_LIR_Nem_3	534	538	PF02991	0.667
LIG_LIR_Nem_3	75	81	PF02991	0.545
LIG_LIR_Nem_3	785	790	PF02991	0.617
LIG_LIR_Nem_3	879	885	PF02991	0.621
LIG_LIR_Nem_3	947	953	PF02991	0.758
LIG_LIR_Nem_3	994	999	PF02991	0.737
LIG_MYND_1	301	305	PF01753	0.608
LIG_PTAP_UEV_1	220	225	PF05743	0.603
LIG_SH2_CRK	529	533	PF00017	0.646
LIG_SH2_CRK	882	886	PF00017	0.602
LIG_SH2_NCK_1	882	886	PF00017	0.602
LIG_SH2_SRC	529	532	PF00017	0.600
LIG_SH2_STAP1	1030	1034	PF00017	0.817
LIG_SH2_STAP1	911	915	PF00017	0.851
LIG_SH2_STAP1	992	996	PF00017	0.598
LIG_SH2_STAT3	121	124	PF00017	0.647
LIG_SH2_STAT5	1030	1033	PF00017	0.815
LIG_SH2_STAT5	281	284	PF00017	0.757
LIG_SH2_STAT5	579	582	PF00017	0.725
LIG_SH2_STAT5	78	81	PF00017	0.638
LIG_SH3_2	528	533	PF14604	0.624
LIG_SH3_3	214	220	PF00018	0.617
LIG_SH3_3	422	428	PF00018	0.806
LIG_SH3_3	46	52	PF00018	0.660
LIG_SH3_3	525	531	PF00018	0.779
LIG_SH3_3	705	711	PF00018	0.606
LIG_SH3_3	800	806	PF00018	0.833
LIG_SH3_3	882	888	PF00018	0.680
LIG_SH3_3	910	916	PF00018	0.773
LIG_SH3_CIN85_PxpxPR_1	379	384	PF14604	0.755
LIG_SUMO_SIM_anti_2	1158	1165	PF11976	0.612
LIG_SUMO_SIM_anti_2	421	427	PF11976	0.787
LIG_SUMO_SIM_par_1	109	116	PF11976	0.589
LIG_SUMO_SIM_par_1	421	427	PF11976	0.828
LIG_TRAF2_1	1048	1051	PF00917	0.853
LIG_TRAF2_1	107	110	PF00917	0.443
LIG_TRAF2_1	316	319	PF00917	0.635
LIG_TRAF2_1	622	625	PF00917	0.589
LIG_WRC_WIRS_1	634	639	PF05994	0.647
LIG_WW_3	530	534	PF00397	0.647
MOD_CDC14_SPxK_1	138	141	PF00782	0.571
MOD_CDK_SPK_2	1138	1143	PF00069	0.721
MOD_CDK_SPxK_1	135	141	PF00069	0.656
MOD_CK1_1	1028	1034	PF00069	0.699
MOD_CK1_1	1170	1176	PF00069	0.756
MOD_CK1_1	137	143	PF00069	0.793
MOD_CK1_1	427	433	PF00069	0.807
MOD_CK1_1	474	480	PF00069	0.692
MOD_CK1_1	495	501	PF00069	0.754
MOD_CK1_1	536	542	PF00069	0.733
MOD_CK1_1	613	619	PF00069	0.714
MOD_CK1_1	656	662	PF00069	0.595
MOD_CK1_1	767	773	PF00069	0.618
MOD_CK1_1	798	804	PF00069	0.845
MOD_CK1_1	842	848	PF00069	0.627
MOD_CK1_1	898	904	PF00069	0.742
MOD_CK2_1	1008	1014	PF00069	0.667
MOD_CK2_1	103	109	PF00069	0.445
MOD_CK2_1	1034	1040	PF00069	0.679
MOD_CK2_1	1045	1051	PF00069	0.662
MOD_CK2_1	1097	1103	PF00069	0.764
MOD_CK2_1	286	292	PF00069	0.835
MOD_CK2_1	313	319	PF00069	0.676
MOD_CK2_1	329	335	PF00069	0.548
MOD_CK2_1	399	405	PF00069	0.663
MOD_CK2_1	415	421	PF00069	0.741
MOD_CK2_1	505	511	PF00069	0.593
MOD_CK2_1	654	660	PF00069	0.735
MOD_CK2_1	692	698	PF00069	0.787
MOD_CK2_1	890	896	PF00069	0.776
MOD_GlcNHglycan	105	108	PF01048	0.429
MOD_GlcNHglycan	1074	1077	PF01048	0.763
MOD_GlcNHglycan	1100	1103	PF01048	0.768
MOD_GlcNHglycan	1132	1135	PF01048	0.775
MOD_GlcNHglycan	198	201	PF01048	0.718
MOD_GlcNHglycan	221	224	PF01048	0.725
MOD_GlcNHglycan	227	230	PF01048	0.699
MOD_GlcNHglycan	306	309	PF01048	0.641
MOD_GlcNHglycan	340	343	PF01048	0.718
MOD_GlcNHglycan	352	355	PF01048	0.653
MOD_GlcNHglycan	473	476	PF01048	0.695
MOD_GlcNHglycan	497	500	PF01048	0.748
MOD_GlcNHglycan	525	528	PF01048	0.646
MOD_GlcNHglycan	534	538	PF01048	0.588
MOD_GlcNHglycan	573	576	PF01048	0.747
MOD_GlcNHglycan	598	601	PF01048	0.670
MOD_GlcNHglycan	604	607	PF01048	0.634
MOD_GlcNHglycan	615	618	PF01048	0.540
MOD_GlcNHglycan	665	668	PF01048	0.688
MOD_GlcNHglycan	747	750	PF01048	0.794
MOD_GlcNHglycan	753	756	PF01048	0.720
MOD_GlcNHglycan	790	793	PF01048	0.636
MOD_GlcNHglycan	865	868	PF01048	0.804
MOD_GlcNHglycan	882	885	PF01048	0.589
MOD_GlcNHglycan	892	895	PF01048	0.675
MOD_GlcNHglycan	903	906	PF01048	0.622
MOD_GlcNHglycan	968	971	PF01048	0.667
MOD_GSK3_1	1028	1035	PF00069	0.714
MOD_GSK3_1	1166	1173	PF00069	0.760
MOD_GSK3_1	1183	1190	PF00069	0.562
MOD_GSK3_1	196	203	PF00069	0.738
MOD_GSK3_1	219	226	PF00069	0.776
MOD_GSK3_1	415	422	PF00069	0.753
MOD_GSK3_1	465	472	PF00069	0.648
MOD_GSK3_1	490	497	PF00069	0.689
MOD_GSK3_1	536	543	PF00069	0.627
MOD_GSK3_1	571	578	PF00069	0.720
MOD_GSK3_1	609	616	PF00069	0.723
MOD_GSK3_1	652	659	PF00069	0.680
MOD_GSK3_1	688	695	PF00069	0.696
MOD_GSK3_1	763	770	PF00069	0.672
MOD_GSK3_1	810	817	PF00069	0.860
MOD_GSK3_1	839	846	PF00069	0.719
MOD_GSK3_1	876	883	PF00069	0.750
MOD_GSK3_1	991	998	PF00069	0.742
MOD_NEK2_1	1119	1124	PF00069	0.751
MOD_NEK2_1	1187	1192	PF00069	0.600
MOD_NEK2_1	163	168	PF00069	0.465
MOD_NEK2_1	306	311	PF00069	0.777
MOD_NEK2_1	329	334	PF00069	0.577
MOD_NEK2_1	504	509	PF00069	0.637
MOD_NEK2_1	547	552	PF00069	0.783
MOD_NEK2_1	654	659	PF00069	0.732
MOD_NEK2_1	72	77	PF00069	0.522
MOD_NEK2_1	814	819	PF00069	0.744
MOD_NEK2_1	870	875	PF00069	0.712
MOD_NEK2_1	876	881	PF00069	0.699
MOD_NEK2_1	935	940	PF00069	0.656
MOD_NEK2_2	1081	1086	PF00069	0.699
MOD_NEK2_2	200	205	PF00069	0.672
MOD_PIKK_1	1167	1173	PF00454	0.814
MOD_PIKK_1	306	312	PF00454	0.620
MOD_PIKK_1	436	442	PF00454	0.786
MOD_PIKK_1	564	570	PF00454	0.729
MOD_PIKK_1	573	579	PF00454	0.599
MOD_PIKK_1	692	698	PF00454	0.672
MOD_PIKK_1	720	726	PF00454	0.762
MOD_PIKK_1	771	777	PF00454	0.729
MOD_PK_1	415	421	PF00069	0.730
MOD_PKA_1	1166	1172	PF00069	0.796
MOD_PKA_1	1183	1189	PF00069	0.539
MOD_PKA_1	415	421	PF00069	0.833
MOD_PKA_2	1002	1008	PF00069	0.770
MOD_PKA_2	103	109	PF00069	0.441
MOD_PKA_2	1098	1104	PF00069	0.662
MOD_PKA_2	1130	1136	PF00069	0.770
MOD_PKA_2	1166	1172	PF00069	0.718
MOD_PKA_2	1183	1189	PF00069	0.523
MOD_PKA_2	344	350	PF00069	0.692
MOD_PKA_2	357	363	PF00069	0.669
MOD_PKA_2	383	389	PF00069	0.718
MOD_PKA_2	415	421	PF00069	0.833
MOD_PKA_2	688	694	PF00069	0.770
MOD_PKA_2	771	777	PF00069	0.634
MOD_PKA_2	795	801	PF00069	0.808
MOD_PKA_2	861	867	PF00069	0.744
MOD_PKA_2	890	896	PF00069	0.710
MOD_PKA_2	974	980	PF00069	0.708
MOD_PKB_1	132	140	PF00069	0.635
MOD_Plk_1	1025	1031	PF00069	0.702
MOD_Plk_1	1081	1087	PF00069	0.700
MOD_Plk_1	318	324	PF00069	0.523
MOD_Plk_1	37	43	PF00069	0.572
MOD_Plk_1	609	615	PF00069	0.769
MOD_Plk_1	843	849	PF00069	0.730
MOD_Plk_1	935	941	PF00069	0.800
MOD_Plk_4	1025	1031	PF00069	0.764
MOD_Plk_4	1183	1189	PF00069	0.615
MOD_Plk_4	15	21	PF00069	0.694
MOD_Plk_4	235	241	PF00069	0.763
MOD_Plk_4	277	283	PF00069	0.748
MOD_Plk_4	318	324	PF00069	0.523
MOD_Plk_4	419	425	PF00069	0.726
MOD_Plk_4	505	511	PF00069	0.695
MOD_Plk_4	575	581	PF00069	0.713
MOD_ProDKin_1	1008	1014	PF00069	0.857
MOD_ProDKin_1	1087	1093	PF00069	0.791
MOD_ProDKin_1	1138	1144	PF00069	0.725
MOD_ProDKin_1	135	141	PF00069	0.773
MOD_ProDKin_1	275	281	PF00069	0.616
MOD_ProDKin_1	424	430	PF00069	0.822
MOD_ProDKin_1	465	471	PF00069	0.765
MOD_ProDKin_1	490	496	PF00069	0.762
MOD_ProDKin_1	520	526	PF00069	0.632
MOD_ProDKin_1	540	546	PF00069	0.838
MOD_ProDKin_1	640	646	PF00069	0.767
MOD_ProDKin_1	764	770	PF00069	0.672
MOD_ProDKin_1	964	970	PF00069	0.714
MOD_SUMO_rev_2	29	39	PF00179	0.732
MOD_SUMO_rev_2	477	485	PF00179	0.752
MOD_SUMO_rev_2	895	904	PF00179	0.855
TRG_DiLeu_BaEn_1	318	323	PF01217	0.753
TRG_DiLeu_BaEn_4	109	115	PF01217	0.511
TRG_DiLeu_BaEn_4	318	324	PF01217	0.749
TRG_ENDOCYTIC_2	672	675	PF00928	0.597
TRG_ENDOCYTIC_2	882	885	PF00928	0.607
TRG_ER_diArg_1	1165	1167	PF00400	0.627
TRG_ER_diArg_1	182	185	PF00400	0.689
TRG_ER_diArg_1	414	416	PF00400	0.843
TRG_ER_diArg_1	5	8	PF00400	0.666
TRG_ER_diArg_1	890	892	PF00400	0.673
TRG_ER_diArg_1	97	99	PF00400	0.667
TRG_ER_diLys_1	1194	1197	PF00400	0.814
TRG_NLS_Bipartite_1	1166	1187	PF00514	0.790
TRG_NLS_MonoCore_2	1181	1186	PF00514	0.680
TRG_NLS_MonoExtC_3	182	187	PF00514	0.686
TRG_NLS_MonoExtN_4	1182	1187	PF00514	0.598
TRG_NLS_MonoExtN_4	183	188	PF00514	0.702
TRG_Pf-PMV_PEXEL_1	126	130	PF00026	0.602
TRG_Pf-PMV_PEXEL_1	66	70	PF00026	0.576
TRG_Pf-PMV_PEXEL_1	874	878	PF00026	0.748

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IF13	Leishmania donovani	80%	100%
A4HIG6	Leishmania braziliensis	49%	100%
E9B107	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%