Sphingosine-1-phosphate lyase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

sphingosine 1-phosphate lyase

Species:

Leishmania major

UniProt:

Q4Q758_LEIMA

TriTrypDb:

LmjF.30.2350 , LMJLV39_300030800 , LMJSD75_300030400

Length:

537

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005783	endoplasmic reticulum	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	3
GO:0016020	membrane	2	1

Expansion

Sequence features

Q4Q758

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q758

Function

Biological processes
Term	Name	Level	Count
GO:0006066	alcohol metabolic process	3	2
GO:0006082	organic acid metabolic process	3	11
GO:0006576	biogenic amine metabolic process	5	2
GO:0006580	ethanolamine metabolic process	5	2
GO:0006629	lipid metabolic process	3	2
GO:0006643	membrane lipid metabolic process	4	2
GO:0006665	sphingolipid metabolic process	4	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	11
GO:0009056	catabolic process	2	2
GO:0009058	biosynthetic process	2	2
GO:0009308	amine metabolic process	4	2
GO:0009309	amine biosynthetic process	5	2
GO:0009987	cellular process	1	11
GO:0016042	lipid catabolic process	4	2
GO:0019752	carboxylic acid metabolic process	5	11
GO:0030149	sphingolipid catabolic process	5	2
GO:0034308	primary alcohol metabolic process	4	2
GO:0034309	primary alcohol biosynthetic process	5	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0042401	biogenic amine biosynthetic process	6	2
GO:0042439	ethanolamine-containing compound metabolic process	4	2
GO:0043436	oxoacid metabolic process	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	2
GO:0044242	cellular lipid catabolic process	4	2
GO:0044248	cellular catabolic process	3	2
GO:0044249	cellular biosynthetic process	3	2
GO:0044255	cellular lipid metabolic process	3	2
GO:0044271	cellular nitrogen compound biosynthetic process	4	2
GO:0044281	small molecule metabolic process	2	11
GO:0044283	small molecule biosynthetic process	3	2
GO:0046165	alcohol biosynthetic process	4	2
GO:0046335	ethanolamine biosynthetic process	6	2
GO:0046466	membrane lipid catabolic process	5	2
GO:0071704	organic substance metabolic process	2	11
GO:1901160	primary amino compound metabolic process	4	2
GO:1901162	primary amino compound biosynthetic process	5	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1901565	organonitrogen compound catabolic process	4	2
GO:1901566	organonitrogen compound biosynthetic process	4	2
GO:1901575	organic substance catabolic process	3	2
GO:1901576	organic substance biosynthetic process	3	2
GO:1901615	organic hydroxy compound metabolic process	3	2
GO:1901617	organic hydroxy compound biosynthetic process	4	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	11
GO:0008117	sphinganine-1-phosphate aldolase activity	5	8
GO:0016829	lyase activity	2	12
GO:0016830	carbon-carbon lyase activity	3	11
GO:0016832	aldehyde-lyase activity	4	8
GO:0019842	vitamin binding	3	11
GO:0030170	pyridoxal phosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0070279	vitamin B6 binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	154	156	PF00675	0.243
CLV_NRD_NRD_1	63	65	PF00675	0.424
CLV_PCSK_KEX2_1	45	47	PF00082	0.359
CLV_PCSK_PC1ET2_1	45	47	PF00082	0.359
CLV_PCSK_SKI1_1	115	119	PF00082	0.307
CLV_PCSK_SKI1_1	318	322	PF00082	0.337
CLV_PCSK_SKI1_1	398	402	PF00082	0.308
CLV_PCSK_SKI1_1	42	46	PF00082	0.413
CLV_PCSK_SKI1_1	500	504	PF00082	0.468
CLV_PCSK_SKI1_1	528	532	PF00082	0.367
CLV_PCSK_SKI1_1	65	69	PF00082	0.375
DOC_CDC14_PxL_1	232	240	PF14671	0.308
DOC_CKS1_1	466	471	PF01111	0.373
DOC_MAPK_DCC_7	408	418	PF00069	0.177
DOC_MAPK_gen_1	13	22	PF00069	0.324
DOC_MAPK_gen_1	251	260	PF00069	0.258
DOC_MAPK_gen_1	305	315	PF00069	0.389
DOC_MAPK_gen_1	64	73	PF00069	0.594
DOC_MAPK_MEF2A_6	308	315	PF00069	0.389
DOC_PP2B_LxvP_1	58	61	PF13499	0.473
DOC_PP2B_LxvP_1	86	89	PF13499	0.575
DOC_PP2B_PxIxI_1	413	419	PF00149	0.258
DOC_PP4_FxxP_1	298	301	PF00568	0.243
DOC_USP7_MATH_1	145	149	PF00917	0.302
DOC_USP7_MATH_1	366	370	PF00917	0.271
DOC_USP7_MATH_1	422	426	PF00917	0.247
DOC_USP7_MATH_1	428	432	PF00917	0.274
DOC_USP7_MATH_1	44	48	PF00917	0.499
DOC_USP7_MATH_1	89	93	PF00917	0.442
DOC_USP7_MATH_2	274	280	PF00917	0.291
DOC_USP7_UBL2_3	247	251	PF12436	0.282
DOC_USP7_UBL2_3	65	69	PF12436	0.399
DOC_USP7_UBL2_3	75	79	PF12436	0.363
DOC_USP7_UBL2_3	80	84	PF12436	0.355
DOC_WW_Pin1_4	13	18	PF00397	0.453
DOC_WW_Pin1_4	362	367	PF00397	0.258
DOC_WW_Pin1_4	465	470	PF00397	0.365
LIG_14-3-3_CanoR_1	127	136	PF00244	0.242
LIG_14-3-3_CanoR_1	475	483	PF00244	0.312
LIG_14-3-3_CanoR_1	53	59	PF00244	0.493
LIG_APCC_ABBA_1	287	292	PF00400	0.258
LIG_APCC_ABBA_1	299	304	PF00400	0.258
LIG_BIR_III_4	176	180	PF00653	0.258
LIG_BRCT_BRCA1_1	147	151	PF00533	0.302
LIG_BRCT_BRCA1_1	348	352	PF00533	0.258
LIG_eIF4E_1	227	233	PF01652	0.243
LIG_FHA_1	128	134	PF00498	0.211
LIG_FHA_1	16	22	PF00498	0.440
LIG_FHA_1	184	190	PF00498	0.243
LIG_FHA_1	201	207	PF00498	0.243
LIG_FHA_1	239	245	PF00498	0.255
LIG_FHA_1	255	261	PF00498	0.207
LIG_FHA_1	335	341	PF00498	0.260
LIG_FHA_1	405	411	PF00498	0.243
LIG_FHA_1	428	434	PF00498	0.297
LIG_FHA_2	399	405	PF00498	0.264
LIG_GBD_Chelix_1	101	109	PF00786	0.422
LIG_LIR_Gen_1	349	359	PF02991	0.243
LIG_LIR_Nem_3	226	230	PF02991	0.258
LIG_LIR_Nem_3	250	255	PF02991	0.302
LIG_LIR_Nem_3	349	355	PF02991	0.243
LIG_LIR_Nem_3	82	86	PF02991	0.517
LIG_MAD2	69	77	PF02301	0.525
LIG_MYND_3	300	304	PF01753	0.389
LIG_PCNA_PIPBox_1	1	10	PF02747	0.463
LIG_PCNA_PIPBox_1	524	533	PF02747	0.412
LIG_PCNA_yPIPBox_3	520	531	PF02747	0.388
LIG_Pex14_2	298	302	PF04695	0.243
LIG_PTB_Apo_2	529	536	PF02174	0.337
LIG_PTB_Phospho_1	529	535	PF10480	0.334
LIG_SH2_CRK	255	259	PF00017	0.277
LIG_SH2_CRK	363	367	PF00017	0.258
LIG_SH2_GRB2like	7	10	PF00017	0.452
LIG_SH2_NCK_1	255	259	PF00017	0.277
LIG_SH2_PTP2	415	418	PF00017	0.277
LIG_SH2_STAP1	255	259	PF00017	0.302
LIG_SH2_STAT5	227	230	PF00017	0.258
LIG_SH2_STAT5	252	255	PF00017	0.258
LIG_SH2_STAT5	363	366	PF00017	0.258
LIG_SH2_STAT5	392	395	PF00017	0.243
LIG_SH2_STAT5	415	418	PF00017	0.277
LIG_SH2_STAT5	7	10	PF00017	0.568
LIG_SH3_3	208	214	PF00018	0.389
LIG_SH3_3	262	268	PF00018	0.243
LIG_SH3_3	71	77	PF00018	0.485
LIG_SUMO_SIM_anti_2	18	24	PF11976	0.420
LIG_SUMO_SIM_anti_2	462	468	PF11976	0.293
LIG_SUMO_SIM_par_1	18	24	PF11976	0.494
LIG_SUMO_SIM_par_1	235	241	PF11976	0.177
LIG_TRAF2_1	274	277	PF00917	0.337
LIG_TYR_ITIM	253	258	PF00017	0.277
LIG_TYR_ITIM	413	418	PF00017	0.277
LIG_UBA3_1	189	194	PF00899	0.277
LIG_UBA3_1	299	305	PF00899	0.351
LIG_UBA3_1	436	444	PF00899	0.393
LIG_WRC_WIRS_1	347	352	PF05994	0.302
MOD_CK1_1	183	189	PF00069	0.243
MOD_CK1_1	324	330	PF00069	0.243
MOD_CK1_1	506	512	PF00069	0.532
MOD_CK2_1	398	404	PF00069	0.439
MOD_CK2_1	89	95	PF00069	0.386
MOD_Cter_Amidation	497	500	PF01082	0.504
MOD_GlcNHglycan	118	121	PF01048	0.288
MOD_GlcNHglycan	182	185	PF01048	0.243
MOD_GlcNHglycan	262	265	PF01048	0.243
MOD_GlcNHglycan	368	371	PF01048	0.261
MOD_GlcNHglycan	505	509	PF01048	0.509
MOD_GSK3_1	179	186	PF00069	0.243
MOD_GSK3_1	346	353	PF00069	0.326
MOD_GSK3_1	362	369	PF00069	0.227
MOD_GSK3_1	398	405	PF00069	0.310
MOD_GSK3_1	461	468	PF00069	0.291
MOD_GSK3_1	506	513	PF00069	0.439
MOD_NEK2_1	140	145	PF00069	0.251
MOD_NEK2_1	151	156	PF00069	0.229
MOD_NEK2_1	238	243	PF00069	0.389
MOD_NEK2_1	303	308	PF00069	0.389
MOD_NEK2_1	350	355	PF00069	0.343
MOD_NEK2_1	427	432	PF00069	0.340
MOD_NEK2_1	459	464	PF00069	0.270
MOD_NEK2_1	503	508	PF00069	0.587
MOD_NEK2_1	510	515	PF00069	0.514
MOD_NEK2_1	530	535	PF00069	0.219
MOD_NEK2_2	422	427	PF00069	0.258
MOD_PIKK_1	100	106	PF00454	0.401
MOD_PIKK_1	15	21	PF00454	0.407
MOD_PK_1	69	75	PF00069	0.361
MOD_PKA_2	200	206	PF00069	0.313
MOD_PKA_2	402	408	PF00069	0.341
MOD_PKB_1	316	324	PF00069	0.337
MOD_Plk_1	109	115	PF00069	0.417
MOD_Plk_1	518	524	PF00069	0.340
MOD_Plk_4	160	166	PF00069	0.258
MOD_Plk_4	185	191	PF00069	0.258
MOD_Plk_4	207	213	PF00069	0.243
MOD_Plk_4	24	30	PF00069	0.313
MOD_Plk_4	336	342	PF00069	0.253
MOD_Plk_4	422	428	PF00069	0.258
MOD_Plk_4	461	467	PF00069	0.274
MOD_Plk_4	506	512	PF00069	0.421
MOD_Plk_4	530	536	PF00069	0.480
MOD_Plk_4	69	75	PF00069	0.539
MOD_ProDKin_1	13	19	PF00069	0.452
MOD_ProDKin_1	362	368	PF00069	0.258
MOD_ProDKin_1	465	471	PF00069	0.371
MOD_SUMO_rev_2	441	445	PF00179	0.438
MOD_SUMO_rev_2	478	483	PF00179	0.431
MOD_SUMO_rev_2	491	501	PF00179	0.536
MOD_SUMO_rev_2	78	86	PF00179	0.448
TRG_DiLeu_BaEn_1	490	495	PF01217	0.477
TRG_DiLeu_BaEn_1	97	102	PF01217	0.403
TRG_ENDOCYTIC_2	227	230	PF00928	0.243
TRG_ENDOCYTIC_2	255	258	PF00928	0.261
TRG_ENDOCYTIC_2	415	418	PF00928	0.277
TRG_ER_diArg_1	315	318	PF00400	0.337
TRG_NES_CRM1_1	100	114	PF08389	0.476
TRG_Pf-PMV_PEXEL_1	417	421	PF00026	0.286
TRG_Pf-PMV_PEXEL_1	475	479	PF00026	0.327
TRG_Pf-PMV_PEXEL_1	520	524	PF00026	0.386

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IBN8	Leptomonas seymouri	75%	99%
A0A0S4JRW4	Bodo saltans	55%	99%
A0A1X0P362	Trypanosomatidae	65%	100%
A0A3Q8IS31	Leishmania donovani	93%	100%
A0A3R7KL89	Trypanosoma rangeli	63%	100%
A0B9M9	Methanothrix thermoacetophila (strain DSM 6194 / JCM 14653 / NBRC 101360 / PT)	28%	100%
A2STQ3	Methanocorpusculum labreanum (strain ATCC 43576 / DSM 4855 / Z)	28%	100%
A4HIG7	Leishmania braziliensis	85%	100%
A4I5R3	Leishmania infantum	93%	100%
A5ULW4	Methanobrevibacter smithii (strain ATCC 35061 / DSM 861 / OCM 144 / PS)	28%	100%
A6UVR4	Methanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3)	27%	100%
C9ZR31	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	64%	100%
E9B108	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
O95470	Homo sapiens	43%	95%
P54767	Solanum lycopersicum	25%	100%
Q05567	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	38%	91%
Q12VA2	Methanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 / ACE-M)	25%	100%
Q2NHY7	Methanosphaera stadtmanae (strain ATCC 43021 / DSM 3091 / JCM 11832 / MCB-3)	27%	100%
Q42472	Arabidopsis thaliana	23%	100%
Q52RG7	Oryza sativa subsp. japonica	41%	100%
Q54RV9	Dictyostelium discoideum	38%	100%
Q5R4G0	Pongo abelii	42%	95%
Q5WUR6	Legionella pneumophila (strain Lens)	31%	89%
Q5X3A8	Legionella pneumophila (strain Paris)	32%	89%
Q5ZTI6	Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)	32%	89%
Q8CHN6	Rattus norvegicus	40%	95%
Q8PXA5	Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88)	30%	100%
Q8R0X7	Mus musculus	40%	95%
Q8U1P6	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	29%	100%
Q9C509	Arabidopsis thaliana	41%	99%
Q9UZD5	Pyrococcus abyssi (strain GE5 / Orsay)	28%	100%
Q9V7Y2	Drosophila melanogaster	38%	99%
Q9Y194	Caenorhabditis elegans	37%	97%
Q9ZPS3	Arabidopsis thaliana	25%	100%
V5AWV1	Trypanosoma cruzi	62%	86%