Conserved zinc-finger protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

zinc-finger protein, conserved

Species:

Leishmania major

UniProt:

Q4Q757_LEIMA

TriTrypDb:

LmjF.30.2360 , LMJLV39_300030900 , LMJSD75_300030500

Length:

546

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0110165	cellular anatomical entity	1	2
GO:0120025	plasma membrane bounded cell projection	3	2

Expansion

Sequence features

Q4Q757

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q757

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	13
GO:0008270	zinc ion binding	6	13
GO:0043167	ion binding	2	13
GO:0043169	cation binding	3	13
GO:0046872	metal ion binding	4	13
GO:0046914	transition metal ion binding	5	13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	254	258	PF00656	0.484
CLV_C14_Caspase3-7	473	477	PF00656	0.662
CLV_NRD_NRD_1	246	248	PF00675	0.492
CLV_NRD_NRD_1	264	266	PF00675	0.477
CLV_NRD_NRD_1	33	35	PF00675	0.348
CLV_NRD_NRD_1	487	489	PF00675	0.600
CLV_PCSK_KEX2_1	119	121	PF00082	0.465
CLV_PCSK_KEX2_1	246	248	PF00082	0.568
CLV_PCSK_KEX2_1	264	266	PF00082	0.553
CLV_PCSK_KEX2_1	295	297	PF00082	0.617
CLV_PCSK_KEX2_1	33	35	PF00082	0.348
CLV_PCSK_KEX2_1	487	489	PF00082	0.600
CLV_PCSK_PC1ET2_1	119	121	PF00082	0.465
CLV_PCSK_PC1ET2_1	295	297	PF00082	0.615
CLV_PCSK_PC7_1	115	121	PF00082	0.524
CLV_PCSK_SKI1_1	247	251	PF00082	0.525
CLV_PCSK_SKI1_1	34	38	PF00082	0.402
CLV_PCSK_SKI1_1	4	8	PF00082	0.479
CLV_PCSK_SKI1_1	418	422	PF00082	0.629
DEG_APCC_DBOX_1	245	253	PF00400	0.507
DEG_APCC_DBOX_1	264	272	PF00400	0.566
DOC_CKS1_1	376	381	PF01111	0.626
DOC_CYCLIN_yClb1_LxF_4	379	384	PF00134	0.501
DOC_CYCLIN_yCln2_LP_2	15	21	PF00134	0.307
DOC_CYCLIN_yCln2_LP_2	376	382	PF00134	0.606
DOC_MAPK_MEF2A_6	170	179	PF00069	0.436
DOC_PP1_RVXF_1	379	385	PF00149	0.507
DOC_PP1_RVXF_1	495	501	PF00149	0.446
DOC_PP4_FxxP_1	44	47	PF00568	0.284
DOC_USP7_MATH_1	538	542	PF00917	0.444
DOC_WW_Pin1_4	342	347	PF00397	0.526
DOC_WW_Pin1_4	375	380	PF00397	0.565
DOC_WW_Pin1_4	480	485	PF00397	0.495
LIG_14-3-3_CanoR_1	211	215	PF00244	0.529
LIG_14-3-3_CanoR_1	246	250	PF00244	0.528
LIG_14-3-3_CanoR_1	296	304	PF00244	0.569
LIG_14-3-3_CanoR_1	353	360	PF00244	0.738
LIG_14-3-3_CanoR_1	381	385	PF00244	0.472
LIG_14-3-3_CanoR_1	4	12	PF00244	0.356
LIG_14-3-3_CanoR_1	432	438	PF00244	0.509
LIG_Actin_WH2_2	387	404	PF00022	0.448
LIG_Actin_WH2_2	494	512	PF00022	0.461
LIG_APCC_ABBA_1	102	107	PF00400	0.427
LIG_APCC_ABBA_1	166	171	PF00400	0.436
LIG_BRCT_BRCA1_1	130	134	PF00533	0.620
LIG_BRCT_BRCA1_1	40	44	PF00533	0.413
LIG_BRCT_BRCA1_1	444	448	PF00533	0.537
LIG_FHA_1	174	180	PF00498	0.539
LIG_FHA_1	27	33	PF00498	0.377
LIG_FHA_1	381	387	PF00498	0.517
LIG_FHA_1	481	487	PF00498	0.485
LIG_FHA_1	5	11	PF00498	0.323
LIG_FHA_2	287	293	PF00498	0.562
LIG_FHA_2	325	331	PF00498	0.591
LIG_KLC1_Yacidic_2	70	74	PF13176	0.544
LIG_LIR_Apic_2	41	47	PF02991	0.287
LIG_LIR_Gen_1	217	227	PF02991	0.454
LIG_LIR_Gen_1	228	239	PF02991	0.440
LIG_LIR_Gen_1	419	429	PF02991	0.524
LIG_LIR_Gen_1	69	77	PF02991	0.619
LIG_LIR_Nem_3	217	223	PF02991	0.457
LIG_LIR_Nem_3	228	234	PF02991	0.434
LIG_LIR_Nem_3	419	424	PF02991	0.528
LIG_LIR_Nem_3	445	451	PF02991	0.477
LIG_LIR_Nem_3	69	75	PF02991	0.573
LIG_PDZ_Class_2	541	546	PF00595	0.425
LIG_Rb_pABgroove_1	496	504	PF01858	0.419
LIG_SH2_CRK	502	506	PF00017	0.566
LIG_SH2_NCK_1	220	224	PF00017	0.458
LIG_SH2_PTP2	72	75	PF00017	0.490
LIG_SH2_SRC	64	67	PF00017	0.483
LIG_SH2_SRC	72	75	PF00017	0.536
LIG_SH2_STAP1	216	220	PF00017	0.591
LIG_SH2_STAT3	162	165	PF00017	0.357
LIG_SH2_STAT5	105	108	PF00017	0.415
LIG_SH2_STAT5	162	165	PF00017	0.375
LIG_SH2_STAT5	267	270	PF00017	0.567
LIG_SH2_STAT5	482	485	PF00017	0.554
LIG_SH2_STAT5	72	75	PF00017	0.544
LIG_SH3_2	136	141	PF14604	0.252
LIG_SH3_3	133	139	PF00018	0.403
LIG_SUMO_SIM_anti_2	540	546	PF11976	0.397
LIG_SUMO_SIM_par_1	317	323	PF11976	0.641
MOD_CDK_SPK_2	342	347	PF00069	0.526
MOD_CDK_SPxK_1	375	381	PF00069	0.587
MOD_CDK_SPxxK_3	480	487	PF00069	0.456
MOD_CK1_1	128	134	PF00069	0.647
MOD_CK1_1	26	32	PF00069	0.385
MOD_CK1_1	355	361	PF00069	0.761
MOD_CK1_1	456	462	PF00069	0.591
MOD_CK2_1	191	197	PF00069	0.544
MOD_CK2_1	270	276	PF00069	0.519
MOD_CK2_1	286	292	PF00069	0.451
MOD_CK2_1	317	323	PF00069	0.710
MOD_CK2_1	49	55	PF00069	0.521
MOD_GlcNHglycan	116	119	PF01048	0.480
MOD_GlcNHglycan	254	257	PF01048	0.478
MOD_GlcNHglycan	350	353	PF01048	0.678
MOD_GlcNHglycan	354	357	PF01048	0.658
MOD_GlcNHglycan	405	408	PF01048	0.553
MOD_GlcNHglycan	92	95	PF01048	0.562
MOD_GSK3_1	210	217	PF00069	0.603
MOD_GSK3_1	270	277	PF00069	0.538
MOD_GSK3_1	34	41	PF00069	0.411
MOD_GSK3_1	348	355	PF00069	0.654
MOD_GSK3_1	440	447	PF00069	0.517
MOD_GSK3_1	452	459	PF00069	0.617
MOD_N-GLC_1	274	279	PF02516	0.526
MOD_N-GLC_1	340	345	PF02516	0.714
MOD_N-GLC_1	348	353	PF02516	0.739
MOD_N-GLC_1	358	363	PF02516	0.722
MOD_N-GLC_1	38	43	PF02516	0.458
MOD_N-GLC_1	513	518	PF02516	0.499
MOD_NEK2_1	127	132	PF00069	0.639
MOD_NEK2_1	150	155	PF00069	0.395
MOD_NEK2_1	173	178	PF00069	0.570
MOD_NEK2_1	260	265	PF00069	0.518
MOD_NEK2_1	324	329	PF00069	0.589
MOD_NEK2_1	348	353	PF00069	0.762
MOD_NEK2_1	380	385	PF00069	0.490
MOD_NEK2_1	48	53	PF00069	0.479
MOD_NEK2_2	366	371	PF00069	0.497
MOD_PIKK_1	150	156	PF00454	0.391
MOD_PIKK_1	295	301	PF00454	0.647
MOD_PIKK_1	408	414	PF00454	0.538
MOD_PIKK_1	453	459	PF00454	0.658
MOD_PK_1	270	276	PF00069	0.505
MOD_PK_1	440	446	PF00069	0.506
MOD_PKA_1	295	301	PF00069	0.513
MOD_PKA_2	114	120	PF00069	0.573
MOD_PKA_2	210	216	PF00069	0.533
MOD_PKA_2	245	251	PF00069	0.502
MOD_PKA_2	252	258	PF00069	0.453
MOD_PKA_2	295	301	PF00069	0.619
MOD_PKA_2	352	358	PF00069	0.791
MOD_PKA_2	380	386	PF00069	0.477
MOD_PKA_2	77	83	PF00069	0.606
MOD_Plk_1	274	280	PF00069	0.500
MOD_Plk_1	322	328	PF00069	0.615
MOD_Plk_1	358	364	PF00069	0.638
MOD_Plk_1	390	396	PF00069	0.462
MOD_Plk_2-3	191	197	PF00069	0.573
MOD_Plk_2-3	334	340	PF00069	0.675
MOD_Plk_4	191	197	PF00069	0.513
MOD_Plk_4	210	216	PF00069	0.391
MOD_Plk_4	274	280	PF00069	0.563
MOD_Plk_4	366	372	PF00069	0.685
MOD_Plk_4	390	396	PF00069	0.536
MOD_Plk_4	444	450	PF00069	0.450
MOD_Plk_4	540	546	PF00069	0.364
MOD_ProDKin_1	342	348	PF00069	0.527
MOD_ProDKin_1	375	381	PF00069	0.561
MOD_ProDKin_1	480	486	PF00069	0.494
TRG_ENDOCYTIC_2	220	223	PF00928	0.459
TRG_ENDOCYTIC_2	502	505	PF00928	0.559
TRG_ENDOCYTIC_2	72	75	PF00928	0.620
TRG_ER_diArg_1	245	247	PF00400	0.601
TRG_ER_diArg_1	32	34	PF00400	0.411
TRG_ER_diArg_1	399	402	PF00400	0.587
TRG_ER_diArg_1	486	488	PF00400	0.593
TRG_ER_diArg_1	497	500	PF00400	0.496
TRG_Pf-PMV_PEXEL_1	34	38	PF00026	0.346
TRG_Pf-PMV_PEXEL_1	499	503	PF00026	0.411

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9X5	Leptomonas seymouri	68%	99%
A0A0S4IQV6	Bodo saltans	44%	98%
A0A0S4JR35	Bodo saltans	24%	91%
A0A1X0P2R0	Trypanosomatidae	51%	95%
A0A3Q8IC39	Leishmania donovani	95%	100%
A0A3R7M632	Trypanosoma rangeli	52%	97%
A4HIG8	Leishmania braziliensis	80%	100%
A4I5R4	Leishmania infantum	95%	100%
C9ZR32	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	97%
E9B109	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5DCZ6	Trypanosoma cruzi	53%	97%