Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q755_LEIMA

TriTrypDb:

LmjF.30.2380 , LMJLV39_300031100 , LMJSD75_300030700

Length:

300

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q755

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q755

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	124	126	PF00675	0.573
CLV_NRD_NRD_1	22	24	PF00675	0.449
CLV_NRD_NRD_1	296	298	PF00675	0.538
CLV_NRD_NRD_1	86	88	PF00675	0.539
CLV_PCSK_FUR_1	84	88	PF00082	0.358
CLV_PCSK_KEX2_1	124	126	PF00082	0.558
CLV_PCSK_KEX2_1	22	24	PF00082	0.452
CLV_PCSK_KEX2_1	231	233	PF00082	0.491
CLV_PCSK_KEX2_1	296	298	PF00082	0.538
CLV_PCSK_KEX2_1	86	88	PF00082	0.439
CLV_PCSK_PC1ET2_1	231	233	PF00082	0.491
CLV_PCSK_SKI1_1	22	26	PF00082	0.491
CLV_PCSK_SKI1_1	35	39	PF00082	0.375
DEG_SPOP_SBC_1	131	135	PF00917	0.531
DOC_PP1_RVXF_1	108	114	PF00149	0.396
DOC_PP1_RVXF_1	33	39	PF00149	0.430
DOC_USP7_MATH_1	131	135	PF00917	0.520
DOC_USP7_MATH_1	200	204	PF00917	0.720
DOC_USP7_MATH_1	3	7	PF00917	0.656
LIG_14-3-3_CanoR_1	124	128	PF00244	0.612
LIG_14-3-3_CanoR_1	178	185	PF00244	0.660
LIG_14-3-3_CanoR_1	199	205	PF00244	0.592
LIG_14-3-3_CanoR_1	22	28	PF00244	0.504
LIG_14-3-3_CanoR_1	84	94	PF00244	0.453
LIG_14-3-3_CterR_2	296	300	PF00244	0.495
LIG_Actin_WH2_2	72	88	PF00022	0.539
LIG_BIR_II_1	1	5	PF00653	0.592
LIG_FHA_1	212	218	PF00498	0.598
LIG_FHA_1	245	251	PF00498	0.409
LIG_FHA_1	281	287	PF00498	0.438
LIG_FHA_1	80	86	PF00498	0.502
LIG_FHA_1	94	100	PF00498	0.433
LIG_FHA_2	153	159	PF00498	0.628
LIG_FHA_2	214	220	PF00498	0.648
LIG_FHA_2	37	43	PF00498	0.530
LIG_FHA_2	86	92	PF00498	0.537
LIG_LIR_Gen_1	275	280	PF02991	0.475
LIG_LIR_Nem_3	275	279	PF02991	0.479
LIG_NRBOX	264	270	PF00104	0.519
LIG_SH2_NCK_1	235	239	PF00017	0.439
LIG_SH3_3	182	188	PF00018	0.453
LIG_Sin3_3	8	15	PF02671	0.374
LIG_SUMO_SIM_anti_2	247	252	PF11976	0.402
LIG_SUMO_SIM_anti_2	62	70	PF11976	0.595
LIG_TRAF2_1	126	129	PF00917	0.612
LIG_TRAF2_1	225	228	PF00917	0.537
LIG_TRAF2_1	275	278	PF00917	0.418
LIG_UBA3_1	146	154	PF00899	0.543
MOD_CK1_1	207	213	PF00069	0.706
MOD_CK2_1	123	129	PF00069	0.551
MOD_CK2_1	152	158	PF00069	0.466
MOD_CK2_1	25	31	PF00069	0.559
MOD_CK2_1	272	278	PF00069	0.530
MOD_CK2_1	36	42	PF00069	0.431
MOD_CK2_1	85	91	PF00069	0.459
MOD_GlcNHglycan	1	4	PF01048	0.597
MOD_GlcNHglycan	194	197	PF01048	0.703
MOD_GlcNHglycan	206	209	PF01048	0.674
MOD_GlcNHglycan	5	9	PF01048	0.513
MOD_GSK3_1	119	126	PF00069	0.535
MOD_GSK3_1	177	184	PF00069	0.543
MOD_GSK3_1	200	207	PF00069	0.617
MOD_GSK3_1	268	275	PF00069	0.475
MOD_NEK2_1	161	166	PF00069	0.537
MOD_NEK2_1	204	209	PF00069	0.571
MOD_NEK2_1	25	30	PF00069	0.496
MOD_NEK2_1	268	273	PF00069	0.460
MOD_NEK2_1	85	90	PF00069	0.601
MOD_NEK2_2	200	205	PF00069	0.728
MOD_PIKK_1	25	31	PF00454	0.513
MOD_PIKK_1	85	91	PF00454	0.518
MOD_PKA_2	123	129	PF00069	0.584
MOD_PKA_2	177	183	PF00069	0.647
MOD_PKA_2	85	91	PF00069	0.448
MOD_Plk_1	152	158	PF00069	0.598
MOD_Plk_1	4	10	PF00069	0.511
MOD_SUMO_for_1	150	153	PF00179	0.559
MOD_SUMO_rev_2	227	233	PF00179	0.635
MOD_SUMO_rev_2	28	37	PF00179	0.563
TRG_DiLeu_BaEn_1	264	269	PF01217	0.490
TRG_DiLeu_BaEn_1	42	47	PF01217	0.546
TRG_ER_diArg_1	123	125	PF00400	0.552
TRG_ER_diArg_1	22	24	PF00400	0.467
TRG_ER_diArg_1	84	87	PF00400	0.441

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDE9	Leptomonas seymouri	47%	96%
A0A0S4ILD4	Bodo saltans	23%	100%
A0A1X0P1M8	Trypanosomatidae	28%	100%
A0A3S7X3N1	Leishmania donovani	92%	100%
A0A422NW57	Trypanosoma rangeli	31%	100%
A4HIG9	Leishmania braziliensis	77%	100%
A4I5R6	Leishmania infantum	92%	100%
C9ZR34	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9B111	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5BGW1	Trypanosoma cruzi	32%	100%