Present in the outer mitochondrial membrane proteome 34

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Present in the outer mitochondrial membrane proteome 31

Species:

Leishmania major

UniProt:

Q4Q753_LEIMA

TriTrypDb:

LmjF.30.2400 , LMJLV39_300031300 , LMJSD75_300030900

Length:

273

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005741	mitochondrial outer membrane	5	2
GO:0016020	membrane	2	3
GO:0019867	outer membrane	3	2
GO:0031090	organelle membrane	3	2
GO:0031966	mitochondrial membrane	4	2
GO:0031968	organelle outer membrane	4	2
GO:0098588	bounding membrane of organelle	4	2
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

Q4Q753

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q753

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	162	164	PF00675	0.365
CLV_PCSK_FUR_1	171	175	PF00082	0.377
CLV_PCSK_KEX2_1	161	163	PF00082	0.352
CLV_PCSK_KEX2_1	173	175	PF00082	0.276
CLV_PCSK_PC1ET2_1	173	175	PF00082	0.301
CLV_PCSK_PC7_1	169	175	PF00082	0.430
CLV_PCSK_SKI1_1	173	177	PF00082	0.301
CLV_PCSK_SKI1_1	71	75	PF00082	0.351
CLV_PCSK_SKI1_1	99	103	PF00082	0.532
DEG_APCC_DBOX_1	98	106	PF00400	0.405
DEG_SPOP_SBC_1	9	13	PF00917	0.716
DEG_SPOP_SBC_1	93	97	PF00917	0.490
DOC_CYCLIN_yCln2_LP_2	85	91	PF00134	0.413
DOC_MAPK_gen_1	171	180	PF00069	0.477
DOC_MAPK_RevD_3	149	163	PF00069	0.330
DOC_PP2B_LxvP_1	85	88	PF13499	0.449
DOC_USP7_MATH_1	131	135	PF00917	0.370
DOC_USP7_MATH_1	187	191	PF00917	0.428
DOC_USP7_MATH_1	246	250	PF00917	0.767
DOC_USP7_MATH_1	9	13	PF00917	0.703
DOC_WW_Pin1_4	251	256	PF00397	0.756
DOC_WW_Pin1_4	94	99	PF00397	0.323
LIG_14-3-3_CanoR_1	108	116	PF00244	0.449
LIG_14-3-3_CanoR_1	186	196	PF00244	0.409
LIG_14-3-3_CanoR_1	222	226	PF00244	0.531
LIG_14-3-3_CanoR_1	261	268	PF00244	0.710
LIG_14-3-3_CanoR_1	28	32	PF00244	0.585
LIG_14-3-3_CanoR_1	71	77	PF00244	0.528
LIG_BIR_II_1	1	5	PF00653	0.752
LIG_BRCT_BRCA1_1	180	184	PF00533	0.242
LIG_BRCT_BRCA1_1	46	50	PF00533	0.578
LIG_deltaCOP1_diTrp_1	136	146	PF00928	0.375
LIG_FHA_1	12	18	PF00498	0.643
LIG_FHA_1	143	149	PF00498	0.385
LIG_FHA_1	170	176	PF00498	0.530
LIG_FHA_1	189	195	PF00498	0.210
LIG_FHA_1	215	221	PF00498	0.368
LIG_FHA_1	24	30	PF00498	0.471
LIG_FHA_1	243	249	PF00498	0.738
LIG_FHA_2	208	214	PF00498	0.365
LIG_GBD_Chelix_1	204	212	PF00786	0.398
LIG_LIR_Apic_2	145	149	PF02991	0.413
LIG_LIR_Apic_2	224	228	PF02991	0.634
LIG_LIR_Gen_1	107	116	PF02991	0.408
LIG_LIR_Gen_1	138	149	PF02991	0.328
LIG_LIR_Gen_1	190	197	PF02991	0.387
LIG_LIR_Nem_3	107	112	PF02991	0.407
LIG_LIR_Nem_3	122	127	PF02991	0.288
LIG_LIR_Nem_3	138	144	PF02991	0.309
LIG_LIR_Nem_3	30	34	PF02991	0.521
LIG_Pex14_1	139	143	PF04695	0.372
LIG_RPA_C_Fungi	157	169	PF08784	0.553
LIG_SH2_STAP1	124	128	PF00017	0.398
LIG_SH2_STAP1	268	272	PF00017	0.765
LIG_SH2_STAT3	45	48	PF00017	0.547
LIG_SH2_STAT5	16	19	PF00017	0.607
LIG_SH2_STAT5	219	222	PF00017	0.393
LIG_SH2_STAT5	72	75	PF00017	0.432
LIG_SH2_STAT5	91	94	PF00017	0.190
LIG_SH3_3	191	197	PF00018	0.327
LIG_SUMO_SIM_anti_2	110	117	PF11976	0.475
LIG_SUMO_SIM_anti_2	83	88	PF11976	0.449
LIG_SUMO_SIM_par_1	110	117	PF11976	0.503
LIG_SUMO_SIM_par_1	207	213	PF11976	0.342
LIG_UBA3_1	152	157	PF00899	0.405
LIG_WRC_WIRS_1	189	194	PF05994	0.385
LIG_WW_3	254	258	PF00397	0.697
MOD_CDK_SPK_2	94	99	PF00069	0.395
MOD_CDK_SPxK_1	251	257	PF00069	0.739
MOD_CK1_1	190	196	PF00069	0.407
MOD_CK1_1	237	243	PF00069	0.628
MOD_CK1_1	260	266	PF00069	0.750
MOD_CK2_1	132	138	PF00069	0.518
MOD_CK2_1	19	25	PF00069	0.487
MOD_CK2_1	207	213	PF00069	0.388
MOD_CK2_1	62	68	PF00069	0.478
MOD_GlcNHglycan	1	4	PF01048	0.741
MOD_GlcNHglycan	166	169	PF01048	0.594
MOD_GSK3_1	119	126	PF00069	0.488
MOD_GSK3_1	147	154	PF00069	0.318
MOD_GSK3_1	19	26	PF00069	0.462
MOD_GSK3_1	234	241	PF00069	0.609
MOD_GSK3_1	242	249	PF00069	0.643
MOD_N-GLC_1	238	243	PF02516	0.729
MOD_NEK2_1	164	169	PF00069	0.621
MOD_NEK2_1	207	212	PF00069	0.374
MOD_NEK2_1	215	220	PF00069	0.352
MOD_NEK2_1	39	44	PF00069	0.463
MOD_NEK2_1	92	97	PF00069	0.417
MOD_PIKK_1	178	184	PF00454	0.488
MOD_PIKK_1	44	50	PF00454	0.552
MOD_PKA_2	107	113	PF00069	0.590
MOD_PKA_2	221	227	PF00069	0.428
MOD_PKA_2	260	266	PF00069	0.779
MOD_PKA_2	27	33	PF00069	0.487
MOD_Plk_4	147	153	PF00069	0.385
MOD_Plk_4	207	213	PF00069	0.367
MOD_Plk_4	215	221	PF00069	0.370
MOD_Plk_4	39	45	PF00069	0.454
MOD_ProDKin_1	251	257	PF00069	0.708
MOD_ProDKin_1	94	100	PF00069	0.394
TRG_ENDOCYTIC_2	31	34	PF00928	0.441
TRG_ER_diArg_1	161	163	PF00400	0.439

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBK1	Leptomonas seymouri	70%	100%
A0A0S4ILA8	Bodo saltans	44%	100%
A0A1X0P1K3	Trypanosomatidae	49%	100%
A0A3S7X3K3	Leishmania donovani	96%	100%
A0A422NWC9	Trypanosoma rangeli	49%	100%
A4HIH1	Leishmania braziliensis	87%	100%
A4I5R8	Leishmania infantum	96%	100%
C9ZR37	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	85%
E9B113	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5AWV4	Trypanosoma cruzi	52%	100%