Aminoacyl-tRNA hydrolase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

peptidyl-tRNA hydrolase PTH2, putative

Species:

Leishmania major

UniProt:

Q4Q751_LEIMA

TriTrypDb:

LmjF.30.2420 , LMJLV39_300031500 , LMJSD75_300031100

Length:

166

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	3
GO:0005829	cytosol	2	3
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3
GO:0110165	cellular anatomical entity	1	8
GO:0016020	membrane	2	6

Expansion

Sequence features

Q4Q751

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q751

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	14
GO:0004045	aminoacyl-tRNA hydrolase activity	5	14
GO:0016787	hydrolase activity	2	14
GO:0016788	hydrolase activity, acting on ester bonds	3	14
GO:0052689	carboxylic ester hydrolase activity	4	14
GO:0140098	catalytic activity, acting on RNA	3	14
GO:0140101	catalytic activity, acting on a tRNA	4	14
GO:0140640	catalytic activity, acting on a nucleic acid	2	14

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	110	112	PF00675	0.273
CLV_NRD_NRD_1	121	123	PF00675	0.298
CLV_PCSK_KEX2_1	121	123	PF00082	0.286
CLV_PCSK_SKI1_1	16	20	PF00082	0.248
DEG_Nend_UBRbox_2	1	3	PF02207	0.445
DOC_MAPK_gen_1	121	127	PF00069	0.483
DOC_MAPK_MEF2A_6	100	107	PF00069	0.524
DOC_MAPK_MEF2A_6	138	147	PF00069	0.427
DOC_MAPK_NFAT4_5	100	108	PF00069	0.409
DOC_USP7_MATH_1	120	124	PF00917	0.460
DOC_USP7_MATH_1	137	141	PF00917	0.465
DOC_USP7_MATH_1	149	153	PF00917	0.421
DOC_USP7_MATH_1	57	61	PF00917	0.518
DOC_USP7_MATH_1	69	73	PF00917	0.404
DOC_USP7_UBL2_3	134	138	PF12436	0.363
DOC_USP7_UBL2_3	92	96	PF12436	0.421
LIG_14-3-3_CanoR_1	121	127	PF00244	0.493
LIG_FHA_1	100	106	PF00498	0.409
LIG_FHA_1	157	163	PF00498	0.480
LIG_FHA_2	28	34	PF00498	0.470
LIG_LIR_Gen_1	4	15	PF02991	0.351
LIG_LIR_LC3C_4	102	107	PF02991	0.398
LIG_NRBOX	44	50	PF00104	0.427
LIG_Pex14_1	78	82	PF04695	0.454
LIG_SH2_STAT5	82	85	PF00017	0.470
LIG_SH3_3	133	139	PF00018	0.433
LIG_SH3_3	151	157	PF00018	0.371
LIG_SH3_3	56	62	PF00018	0.459
LIG_SUMO_SIM_anti_2	140	146	PF11976	0.451
LIG_SUMO_SIM_anti_2	33	38	PF11976	0.460
LIG_TRAF2_1	30	33	PF00917	0.470
MOD_CK1_1	60	66	PF00069	0.524
MOD_CK2_1	2	8	PF00069	0.416
MOD_CK2_1	27	33	PF00069	0.431
MOD_CMANNOS	78	81	PF00535	0.254
MOD_GlcNHglycan	39	42	PF01048	0.212
MOD_GlcNHglycan	55	58	PF01048	0.248
MOD_GlcNHglycan	59	62	PF01048	0.228
MOD_GlcNHglycan	71	74	PF01048	0.232
MOD_GSK3_1	53	60	PF00069	0.524
MOD_NEK2_1	125	130	PF00069	0.435
MOD_NEK2_1	19	24	PF00069	0.409
MOD_NEK2_1	37	42	PF00069	0.463
MOD_NEK2_2	91	96	PF00069	0.429
MOD_PKA_2	120	126	PF00069	0.479
MOD_Plk_2-3	2	8	PF00069	0.377
MOD_Plk_2-3	99	105	PF00069	0.454
MOD_SUMO_rev_2	47	56	PF00179	0.418
TRG_DiLeu_BaEn_1	101	106	PF01217	0.363
TRG_ENDOCYTIC_2	7	10	PF00928	0.404

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHT0	Leptomonas seymouri	53%	69%
A0A3Q8IED2	Leishmania donovani	93%	100%
A0A3S7WPI5	Leishmania donovani	31%	100%
A0A422NW74	Trypanosoma rangeli	39%	69%
A4H4Q4	Leishmania braziliensis	28%	75%
A4HIH3	Leishmania braziliensis	73%	87%
A4HSY3	Leishmania infantum	35%	100%
A4I5S0	Leishmania infantum	93%	100%
E9AKW9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9B115	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4QIY6	Leishmania major	30%	100%
Q9Y3E5	Homo sapiens	25%	93%
V5BGW4	Trypanosoma cruzi	35%	68%