TPR_REGION domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q749_LEIMA

TriTrypDb:

LmjF.30.2440 , LMJLV39_300031700 , LMJSD75_300031300

Length:

777

Annotations

LeishMANIAdb annotations

Might be a conserved chaperone protein, probably not transmembrane.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q749

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q749

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	10
GO:0009987	cellular process	1	10

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	10
GO:0005515	protein binding	2	10
GO:0030544	Hsp70 protein binding	4	10
GO:0031072	heat shock protein binding	3	10
GO:0051879	Hsp90 protein binding	4	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	214	218	PF00656	0.451
CLV_C14_Caspase3-7	229	233	PF00656	0.588
CLV_C14_Caspase3-7	239	243	PF00656	0.396
CLV_C14_Caspase3-7	732	736	PF00656	0.718
CLV_NRD_NRD_1	353	355	PF00675	0.621
CLV_NRD_NRD_1	509	511	PF00675	0.412
CLV_NRD_NRD_1	515	517	PF00675	0.415
CLV_NRD_NRD_1	522	524	PF00675	0.427
CLV_NRD_NRD_1	570	572	PF00675	0.520
CLV_NRD_NRD_1	673	675	PF00675	0.588
CLV_NRD_NRD_1	760	762	PF00675	0.498
CLV_PCSK_FUR_1	671	675	PF00082	0.597
CLV_PCSK_KEX2_1	355	357	PF00082	0.579
CLV_PCSK_KEX2_1	509	511	PF00082	0.412
CLV_PCSK_KEX2_1	514	516	PF00082	0.417
CLV_PCSK_KEX2_1	522	524	PF00082	0.429
CLV_PCSK_KEX2_1	570	572	PF00082	0.520
CLV_PCSK_KEX2_1	671	673	PF00082	0.586
CLV_PCSK_PC1ET2_1	355	357	PF00082	0.592
CLV_PCSK_PC1ET2_1	514	516	PF00082	0.465
CLV_PCSK_PC7_1	510	516	PF00082	0.419
CLV_PCSK_SKI1_1	397	401	PF00082	0.705
CLV_PCSK_SKI1_1	499	503	PF00082	0.354
CLV_PCSK_SKI1_1	606	610	PF00082	0.428
CLV_Separin_Metazoa	94	98	PF03568	0.451
DEG_APCC_DBOX_1	467	475	PF00400	0.462
DEG_APCC_DBOX_1	498	506	PF00400	0.449
DEG_COP1_1	27	36	PF00400	0.411
DEG_Nend_Nbox_1	1	3	PF02207	0.528
DEG_SPOP_SBC_1	701	705	PF00917	0.787
DEG_SPOP_SBC_1	715	719	PF00917	0.806
DEG_SPOP_SBC_1	730	734	PF00917	0.586
DOC_CKS1_1	624	629	PF01111	0.662
DOC_CYCLIN_RxL_1	472	480	PF00134	0.452
DOC_CYCLIN_yCln2_LP_2	459	465	PF00134	0.481
DOC_MAPK_gen_1	108	116	PF00069	0.410
DOC_MAPK_gen_1	257	264	PF00069	0.315
DOC_MAPK_gen_1	283	291	PF00069	0.400
DOC_MAPK_gen_1	339	349	PF00069	0.466
DOC_MAPK_gen_1	759	768	PF00069	0.755
DOC_MAPK_MEF2A_6	257	264	PF00069	0.372
DOC_MAPK_MEF2A_6	481	488	PF00069	0.487
DOC_MAPK_MEF2A_6	499	507	PF00069	0.205
DOC_MAPK_MEF2A_6	761	770	PF00069	0.779
DOC_MAPK_RevD_3	500	515	PF00069	0.508
DOC_PP2B_LxvP_1	118	121	PF13499	0.335
DOC_PP2B_LxvP_1	31	34	PF13499	0.468
DOC_PP4_FxxP_1	633	636	PF00568	0.644
DOC_PP4_FxxP_1	649	652	PF00568	0.659
DOC_PP4_MxPP_1	742	745	PF00568	0.679
DOC_USP7_MATH_1	132	136	PF00917	0.427
DOC_USP7_MATH_1	208	212	PF00917	0.418
DOC_USP7_MATH_1	22	26	PF00917	0.584
DOC_USP7_MATH_1	223	227	PF00917	0.513
DOC_USP7_MATH_1	378	382	PF00917	0.447
DOC_USP7_MATH_1	545	549	PF00917	0.768
DOC_USP7_MATH_1	550	554	PF00917	0.755
DOC_USP7_MATH_1	619	623	PF00917	0.680
DOC_USP7_MATH_1	695	699	PF00917	0.795
DOC_USP7_MATH_1	701	705	PF00917	0.743
DOC_USP7_MATH_1	729	733	PF00917	0.727
DOC_WW_Pin1_4	219	224	PF00397	0.544
DOC_WW_Pin1_4	371	376	PF00397	0.481
DOC_WW_Pin1_4	410	415	PF00397	0.586
DOC_WW_Pin1_4	421	426	PF00397	0.551
DOC_WW_Pin1_4	428	433	PF00397	0.530
DOC_WW_Pin1_4	555	560	PF00397	0.746
DOC_WW_Pin1_4	623	628	PF00397	0.666
DOC_WW_Pin1_4	635	640	PF00397	0.765
LIG_14-3-3_CanoR_1	108	118	PF00244	0.402
LIG_14-3-3_CanoR_1	189	194	PF00244	0.479
LIG_14-3-3_CanoR_1	286	292	PF00244	0.397
LIG_14-3-3_CanoR_1	397	405	PF00244	0.542
LIG_14-3-3_CanoR_1	456	460	PF00244	0.403
LIG_14-3-3_CanoR_1	509	517	PF00244	0.650
LIG_14-3-3_CanoR_1	606	612	PF00244	0.638
LIG_14-3-3_CanoR_1	690	697	PF00244	0.783
LIG_Actin_WH2_2	173	191	PF00022	0.436
LIG_APCC_ABBA_1	260	265	PF00400	0.407
LIG_APCC_ABBAyCdc20_2	259	265	PF00400	0.405
LIG_BIR_III_2	217	221	PF00653	0.467
LIG_BIR_III_2	242	246	PF00653	0.474
LIG_BRCT_BRCA1_1	257	261	PF00533	0.380
LIG_BRCT_BRCA1_1	621	625	PF00533	0.685
LIG_CtBP_PxDLS_1	490	494	PF00389	0.301
LIG_FHA_1	115	121	PF00498	0.386
LIG_FHA_1	372	378	PF00498	0.490
LIG_FHA_1	422	428	PF00498	0.596
LIG_FHA_1	483	489	PF00498	0.482
LIG_FHA_1	577	583	PF00498	0.669
LIG_FHA_1	60	66	PF00498	0.448
LIG_FHA_1	658	664	PF00498	0.737
LIG_FHA_1	767	773	PF00498	0.774
LIG_FHA_2	189	195	PF00498	0.451
LIG_FHA_2	227	233	PF00498	0.594
LIG_FHA_2	237	243	PF00498	0.425
LIG_FHA_2	398	404	PF00498	0.460
LIG_FHA_2	438	444	PF00498	0.548
LIG_FHA_2	537	543	PF00498	0.772
LIG_FHA_2	624	630	PF00498	0.668
LIG_FHA_2	694	700	PF00498	0.716
LIG_Integrin_isoDGR_2	88	90	PF01839	0.534
LIG_LIR_Apic_2	622	627	PF02991	0.699
LIG_LIR_Apic_2	632	636	PF02991	0.701
LIG_LIR_Apic_2	647	652	PF02991	0.632
LIG_LIR_Gen_1	131	137	PF02991	0.482
LIG_LIR_Gen_1	184	193	PF02991	0.457
LIG_LIR_Gen_1	258	267	PF02991	0.365
LIG_LIR_Gen_1	344	353	PF02991	0.456
LIG_LIR_Gen_1	610	619	PF02991	0.614
LIG_LIR_Nem_3	112	118	PF02991	0.438
LIG_LIR_Nem_3	131	136	PF02991	0.469
LIG_LIR_Nem_3	147	153	PF02991	0.507
LIG_LIR_Nem_3	184	188	PF02991	0.475
LIG_LIR_Nem_3	258	264	PF02991	0.359
LIG_LIR_Nem_3	344	349	PF02991	0.438
LIG_LIR_Nem_3	458	463	PF02991	0.468
LIG_LIR_Nem_3	539	543	PF02991	0.763
LIG_LIR_Nem_3	610	614	PF02991	0.583
LIG_LIR_Nem_3	615	621	PF02991	0.565
LIG_LIR_Nem_3	622	628	PF02991	0.559
LIG_LIR_Nem_3	80	86	PF02991	0.360
LIG_LYPXL_yS_3	83	86	PF13949	0.409
LIG_MLH1_MIPbox_1	621	625	PF16413	0.687
LIG_PDZ_Class_3	772	777	PF00595	0.741
LIG_Pex14_1	284	288	PF04695	0.360
LIG_Pex14_2	201	205	PF04695	0.467
LIG_PTB_Apo_2	326	333	PF02174	0.309
LIG_PTB_Phospho_1	326	332	PF10480	0.307
LIG_Rb_LxCxE_1	366	381	PF01857	0.481
LIG_Rb_pABgroove_1	588	596	PF01858	0.498
LIG_RPA_C_Fungi	504	516	PF08784	0.606
LIG_SH2_CRK	133	137	PF00017	0.629
LIG_SH2_CRK	150	154	PF00017	0.688
LIG_SH2_CRK	594	598	PF00017	0.452
LIG_SH2_CRK	618	622	PF00017	0.585
LIG_SH2_NCK_1	133	137	PF00017	0.624
LIG_SH2_NCK_1	666	670	PF00017	0.644
LIG_SH2_SRC	215	218	PF00017	0.562
LIG_SH2_SRC	618	621	PF00017	0.453
LIG_SH2_SRC	650	653	PF00017	0.666
LIG_SH2_STAP1	317	321	PF00017	0.580
LIG_SH2_STAT3	332	335	PF00017	0.365
LIG_SH2_STAT5	115	118	PF00017	0.521
LIG_SH2_STAT5	215	218	PF00017	0.607
LIG_SH2_STAT5	288	291	PF00017	0.411
LIG_SH2_STAT5	333	336	PF00017	0.572
LIG_SH2_STAT5	346	349	PF00017	0.347
LIG_SH2_STAT5	448	451	PF00017	0.558
LIG_SH2_STAT5	620	623	PF00017	0.470
LIG_SH2_STAT5	624	627	PF00017	0.488
LIG_SH2_STAT5	650	653	PF00017	0.520
LIG_SH2_STAT5	654	657	PF00017	0.551
LIG_SH2_STAT5	666	669	PF00017	0.614
LIG_SH3_2	559	564	PF14604	0.565
LIG_SH3_3	217	223	PF00018	0.696
LIG_SH3_3	30	36	PF00018	0.634
LIG_SH3_3	556	562	PF00018	0.691
LIG_SH3_3	633	639	PF00018	0.726
LIG_SUMO_SIM_anti_2	485	490	PF11976	0.448
LIG_SUMO_SIM_par_1	626	632	PF11976	0.638
LIG_SUMO_SIM_par_1	747	753	PF11976	0.744
LIG_SUMO_SIM_par_1	768	773	PF11976	0.748
LIG_TYR_ITIM	592	597	PF00017	0.487
LIG_WRC_WIRS_1	630	635	PF05994	0.597
MOD_CDK_SPxxK_3	557	564	PF00069	0.577
MOD_CK1_1	109	115	PF00069	0.602
MOD_CK1_1	123	129	PF00069	0.409
MOD_CK1_1	226	232	PF00069	0.741
MOD_CK1_1	554	560	PF00069	0.568
MOD_CK1_1	644	650	PF00069	0.637
MOD_CK1_1	679	685	PF00069	0.669
MOD_CK1_1	689	695	PF00069	0.752
MOD_CK1_1	705	711	PF00069	0.741
MOD_CK1_1	713	719	PF00069	0.797
MOD_CK2_1	188	194	PF00069	0.542
MOD_CK2_1	208	214	PF00069	0.511
MOD_CK2_1	21	27	PF00069	0.627
MOD_CK2_1	397	403	PF00069	0.702
MOD_CK2_1	693	699	PF00069	0.701
MOD_GlcNHglycan	146	149	PF01048	0.688
MOD_GlcNHglycan	225	228	PF01048	0.720
MOD_GlcNHglycan	232	236	PF01048	0.710
MOD_GlcNHglycan	239	242	PF01048	0.682
MOD_GlcNHglycan	24	27	PF01048	0.680
MOD_GlcNHglycan	511	514	PF01048	0.600
MOD_GlcNHglycan	548	551	PF01048	0.650
MOD_GlcNHglycan	621	624	PF01048	0.559
MOD_GlcNHglycan	677	681	PF01048	0.789
MOD_GlcNHglycan	79	82	PF01048	0.522
MOD_GlcNHglycan	91	94	PF01048	0.426
MOD_GSK3_1	119	126	PF00069	0.439
MOD_GSK3_1	219	226	PF00069	0.683
MOD_GSK3_1	299	306	PF00069	0.528
MOD_GSK3_1	364	371	PF00069	0.575
MOD_GSK3_1	428	435	PF00069	0.792
MOD_GSK3_1	447	454	PF00069	0.539
MOD_GSK3_1	473	480	PF00069	0.563
MOD_GSK3_1	546	553	PF00069	0.638
MOD_GSK3_1	619	626	PF00069	0.627
MOD_GSK3_1	635	642	PF00069	0.496
MOD_GSK3_1	689	696	PF00069	0.581
MOD_GSK3_1	701	708	PF00069	0.648
MOD_GSK3_1	710	717	PF00069	0.790
MOD_GSK3_1	73	80	PF00069	0.600
MOD_GSK3_1	96	103	PF00069	0.442
MOD_LATS_1	534	540	PF00433	0.668
MOD_N-GLC_1	359	364	PF02516	0.510
MOD_N-GLC_1	77	82	PF02516	0.627
MOD_NEK2_1	1	6	PF00069	0.709
MOD_NEK2_1	114	119	PF00069	0.478
MOD_NEK2_1	188	193	PF00069	0.497
MOD_NEK2_1	38	43	PF00069	0.598
MOD_NEK2_1	477	482	PF00069	0.560
MOD_NEK2_1	503	508	PF00069	0.381
MOD_NEK2_1	551	556	PF00069	0.699
MOD_NEK2_1	59	64	PF00069	0.582
MOD_NEK2_1	686	691	PF00069	0.729
MOD_NEK2_1	700	705	PF00069	0.679
MOD_NEK2_1	79	84	PF00069	0.255
MOD_NEK2_2	378	383	PF00069	0.592
MOD_OFUCOSY	119	124	PF10250	0.498
MOD_OFUCOSY	159	166	PF10250	0.676
MOD_PIKK_1	333	339	PF00454	0.529
MOD_PIKK_1	451	457	PF00454	0.661
MOD_PIKK_1	50	56	PF00454	0.549
MOD_PIKK_1	551	557	PF00454	0.719
MOD_PIKK_1	612	618	PF00454	0.532
MOD_PIKK_1	70	76	PF00454	0.261
MOD_PKA_1	509	515	PF00069	0.621
MOD_PKA_2	188	194	PF00069	0.568
MOD_PKA_2	455	461	PF00069	0.489
MOD_PKA_2	509	515	PF00069	0.559
MOD_PKA_2	689	695	PF00069	0.713
MOD_PKA_2	705	711	PF00069	0.548
MOD_PKA_2	89	95	PF00069	0.431
MOD_PKA_2	96	102	PF00069	0.438
MOD_Plk_1	139	145	PF00069	0.671
MOD_Plk_1	231	237	PF00069	0.705
MOD_Plk_1	359	365	PF00069	0.622
MOD_Plk_1	38	44	PF00069	0.703
MOD_Plk_1	565	571	PF00069	0.628
MOD_Plk_2-3	693	699	PF00069	0.753
MOD_Plk_4	100	106	PF00069	0.491
MOD_Plk_4	364	370	PF00069	0.580
MOD_Plk_4	378	384	PF00069	0.568
MOD_Plk_4	455	461	PF00069	0.519
MOD_Plk_4	59	65	PF00069	0.550
MOD_Plk_4	644	650	PF00069	0.610
MOD_ProDKin_1	219	225	PF00069	0.710
MOD_ProDKin_1	371	377	PF00069	0.613
MOD_ProDKin_1	410	416	PF00069	0.762
MOD_ProDKin_1	421	427	PF00069	0.716
MOD_ProDKin_1	428	434	PF00069	0.694
MOD_ProDKin_1	555	561	PF00069	0.702
MOD_ProDKin_1	623	629	PF00069	0.593
MOD_ProDKin_1	635	641	PF00069	0.733
MOD_SUMO_for_1	601	604	PF00179	0.568
MOD_SUMO_rev_2	588	593	PF00179	0.553
MOD_SUMO_rev_2	595	603	PF00179	0.520
MOD_SUMO_rev_2	719	728	PF00179	0.555
TRG_ENDOCYTIC_2	115	118	PF00928	0.523
TRG_ENDOCYTIC_2	133	136	PF00928	0.642
TRG_ENDOCYTIC_2	150	153	PF00928	0.690
TRG_ENDOCYTIC_2	288	291	PF00928	0.497
TRG_ENDOCYTIC_2	346	349	PF00928	0.496
TRG_ENDOCYTIC_2	460	463	PF00928	0.584
TRG_ENDOCYTIC_2	594	597	PF00928	0.458
TRG_ENDOCYTIC_2	611	614	PF00928	0.438
TRG_ENDOCYTIC_2	618	621	PF00928	0.450
TRG_ENDOCYTIC_2	83	86	PF00928	0.441
TRG_ER_diArg_1	256	259	PF00400	0.369
TRG_ER_diArg_1	353	356	PF00400	0.535
TRG_ER_diArg_1	509	511	PF00400	0.537
TRG_ER_diArg_1	515	517	PF00400	0.552
TRG_ER_diArg_1	569	571	PF00400	0.661
TRG_ER_diArg_1	671	674	PF00400	0.766
TRG_Pf-PMV_PEXEL_1	515	519	PF00026	0.577
TRG_Pf-PMV_PEXEL_1	523	528	PF00026	0.608
TRG_Pf-PMV_PEXEL_1	673	677	PF00026	0.663

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3V6	Leptomonas seymouri	55%	90%
A0A0S4IQF5	Bodo saltans	29%	100%
A0A1X0P352	Trypanosomatidae	31%	100%
A0A3Q8IJJ7	Leishmania donovani	93%	99%
A0A3R7NPX7	Trypanosoma rangeli	31%	100%
A4HIH5	Leishmania braziliensis	75%	100%
A4I5S2	Leishmania infantum	93%	99%
C9ZR41	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9B117	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5BC99	Trypanosoma cruzi	30%	100%