DnaJ domain protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DnaJ domain protein-like protein

Species:

Leishmania major

UniProt:

Q4Q748_LEIMA

TriTrypDb:

LmjF.30.2450 , LMJLV39_300031800 , LMJSD75_300031400

Length:

336

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0031207	Sec62/Sec63 complex	3	2
GO:0032991	protein-containing complex	1	2
GO:0098796	membrane protein complex	2	2
GO:0140534	endoplasmic reticulum protein-containing complex	2	2
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

Q4Q748

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q748

Function

Biological processes
Term	Name	Level	Count
GO:0006605	protein targeting	5	2
GO:0006612	protein targeting to membrane	5	2
GO:0006613	cotranslational protein targeting to membrane	6	2
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	7	2
GO:0006620	post-translational protein targeting to endoplasmic reticulum membrane	6	2
GO:0006810	transport	3	2
GO:0006886	intracellular protein transport	4	2
GO:0008104	protein localization	4	2
GO:0009987	cellular process	1	2
GO:0015031	protein transport	4	2
GO:0033036	macromolecule localization	2	2
GO:0033365	protein localization to organelle	5	2
GO:0045047	protein targeting to ER	6	2
GO:0045184	establishment of protein localization	3	2
GO:0046907	intracellular transport	3	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0051668	localization within membrane	3	2
GO:0070727	cellular macromolecule localization	3	2
GO:0070972	protein localization to endoplasmic reticulum	6	2
GO:0071702	organic substance transport	4	2
GO:0071705	nitrogen compound transport	4	2
GO:0072594	establishment of protein localization to organelle	4	2
GO:0072599	establishment of protein localization to endoplasmic reticulum	5	2
GO:0072657	protein localization to membrane	4	2
GO:0090150	establishment of protein localization to membrane	4	2

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	2
GO:0008320	protein transmembrane transporter activity	3	2
GO:0022857	transmembrane transporter activity	2	2
GO:0022884	macromolecule transmembrane transporter activity	3	2
GO:0140318	protein transporter activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	151	153	PF00675	0.648
CLV_NRD_NRD_1	198	200	PF00675	0.570
CLV_NRD_NRD_1	259	261	PF00675	0.404
CLV_NRD_NRD_1	8	10	PF00675	0.706
CLV_NRD_NRD_1	97	99	PF00675	0.693
CLV_PCSK_KEX2_1	151	153	PF00082	0.648
CLV_PCSK_KEX2_1	197	199	PF00082	0.578
CLV_PCSK_KEX2_1	250	252	PF00082	0.391
CLV_PCSK_KEX2_1	261	263	PF00082	0.353
CLV_PCSK_KEX2_1	8	10	PF00082	0.706
CLV_PCSK_KEX2_1	97	99	PF00082	0.695
CLV_PCSK_PC1ET2_1	250	252	PF00082	0.391
CLV_PCSK_PC1ET2_1	261	263	PF00082	0.353
CLV_PCSK_SKI1_1	173	177	PF00082	0.656
CLV_PCSK_SKI1_1	198	202	PF00082	0.580
CLV_PCSK_SKI1_1	24	28	PF00082	0.399
CLV_PCSK_SKI1_1	321	325	PF00082	0.466
CLV_PCSK_SKI1_1	62	66	PF00082	0.531
CLV_PCSK_SKI1_1	8	12	PF00082	0.689
DEG_Nend_Nbox_1	1	3	PF02207	0.485
DOC_ANK_TNKS_1	150	157	PF00023	0.417
DOC_CYCLIN_RxL_1	193	206	PF00134	0.422
DOC_CYCLIN_RxL_1	5	15	PF00134	0.483
DOC_CYCLIN_RxL_1	59	67	PF00134	0.331
DOC_MAPK_gen_1	282	289	PF00069	0.653
DOC_MAPK_MEF2A_6	235	244	PF00069	0.363
DOC_MAPK_RevD_3	238	251	PF00069	0.411
DOC_PP2B_LxvP_1	73	76	PF13499	0.448
DOC_USP7_MATH_1	76	80	PF00917	0.530
DOC_USP7_UBL2_3	28	32	PF12436	0.249
DOC_USP7_UBL2_3	62	66	PF12436	0.331
DOC_WW_Pin1_4	150	155	PF00397	0.364
DOC_WW_Pin1_4	311	316	PF00397	0.666
LIG_14-3-3_CanoR_1	212	220	PF00244	0.450
LIG_Actin_WH2_2	50	68	PF00022	0.249
LIG_AP2alpha_2	15	17	PF02296	0.267
LIG_DCNL_PONY_1	1	4	PF03556	0.437
LIG_EVH1_2	315	319	PF00568	0.724
LIG_FHA_2	133	139	PF00498	0.422
LIG_FHA_2	25	31	PF00498	0.299
LIG_LIR_Gen_1	165	176	PF02991	0.344
LIG_LIR_Gen_1	327	334	PF02991	0.634
LIG_LIR_Gen_1	67	78	PF02991	0.354
LIG_LIR_Nem_3	15	20	PF02991	0.270
LIG_LIR_Nem_3	165	171	PF02991	0.336
LIG_LIR_Nem_3	317	323	PF02991	0.608
LIG_LIR_Nem_3	327	333	PF02991	0.578
LIG_LIR_Nem_3	67	73	PF02991	0.346
LIG_SH2_CRK	237	241	PF00017	0.335
LIG_SH2_CRK	320	324	PF00017	0.689
LIG_SH2_CRK	330	334	PF00017	0.694
LIG_SH2_CRK	61	65	PF00017	0.251
LIG_SH2_NCK_1	330	334	PF00017	0.645
LIG_SH2_STAP1	237	241	PF00017	0.335
LIG_SH2_STAP1	330	334	PF00017	0.722
LIG_SH2_STAT3	158	161	PF00017	0.317
LIG_SH2_STAT5	158	161	PF00017	0.410
LIG_SH2_STAT5	246	249	PF00017	0.282
LIG_SH2_STAT5	330	333	PF00017	0.656
LIG_SH3_3	307	313	PF00018	0.636
LIG_SH3_3	320	326	PF00018	0.672
LIG_Sin3_3	293	300	PF02671	0.577
LIG_TRAF2_1	135	138	PF00917	0.422
LIG_TRAF2_1	268	271	PF00917	0.553
LIG_TYR_ITIM	318	323	PF00017	0.615
LIG_WRC_WIRS_1	183	188	PF05994	0.393
MOD_CDK_SPxxK_3	150	157	PF00069	0.374
MOD_CK1_1	115	121	PF00069	0.605
MOD_CK1_1	123	129	PF00069	0.548
MOD_CK1_1	132	138	PF00069	0.440
MOD_CK1_1	48	54	PF00069	0.329
MOD_CK2_1	132	138	PF00069	0.413
MOD_CK2_1	164	170	PF00069	0.417
MOD_CK2_1	24	30	PF00069	0.267
MOD_CK2_1	311	317	PF00069	0.678
MOD_GlcNHglycan	115	118	PF01048	0.781
MOD_GlcNHglycan	122	125	PF01048	0.714
MOD_GlcNHglycan	142	145	PF01048	0.564
MOD_GlcNHglycan	186	189	PF01048	0.644
MOD_GlcNHglycan	222	225	PF01048	0.625
MOD_GlcNHglycan	47	50	PF01048	0.493
MOD_GSK3_1	112	119	PF00069	0.549
MOD_GSK3_1	146	153	PF00069	0.356
MOD_GSK3_1	20	27	PF00069	0.267
MOD_GSK3_1	249	256	PF00069	0.579
MOD_GSK3_1	324	331	PF00069	0.596
MOD_NEK2_1	101	106	PF00069	0.489
MOD_NEK2_1	20	25	PF00069	0.213
MOD_NEK2_1	253	258	PF00069	0.616
MOD_NEK2_1	287	292	PF00069	0.527
MOD_NEK2_1	319	324	PF00069	0.642
MOD_NEK2_1	4	9	PF00069	0.471
MOD_PKA_2	101	107	PF00069	0.514
MOD_Plk_1	164	170	PF00069	0.452
MOD_Plk_1	208	214	PF00069	0.467
MOD_Plk_2-3	164	170	PF00069	0.398
MOD_Plk_4	164	170	PF00069	0.384
MOD_Plk_4	328	334	PF00069	0.724
MOD_ProDKin_1	150	156	PF00069	0.364
MOD_ProDKin_1	311	317	PF00069	0.669
MOD_SUMO_for_1	192	195	PF00179	0.436
MOD_SUMO_for_1	52	55	PF00179	0.331
MOD_SUMO_rev_2	150	159	PF00179	0.400
MOD_SUMO_rev_2	185	194	PF00179	0.366
TRG_AP2beta_CARGO_1	15	24	PF09066	0.249
TRG_DiLeu_BaLyEn_6	171	176	PF01217	0.430
TRG_DiLeu_BaLyEn_6	6	11	PF01217	0.465
TRG_ENDOCYTIC_2	183	186	PF00928	0.402
TRG_ENDOCYTIC_2	237	240	PF00928	0.283
TRG_ENDOCYTIC_2	266	269	PF00928	0.531
TRG_ENDOCYTIC_2	320	323	PF00928	0.693
TRG_ENDOCYTIC_2	330	333	PF00928	0.691
TRG_ENDOCYTIC_2	35	38	PF00928	0.273
TRG_ENDOCYTIC_2	61	64	PF00928	0.251
TRG_ENDOCYTIC_2	70	73	PF00928	0.349
TRG_ER_diArg_1	196	199	PF00400	0.335
TRG_ER_diArg_1	8	10	PF00400	0.509
TRG_NLS_Bipartite_1	250	264	PF00514	0.589
TRG_Pf-PMV_PEXEL_1	199	204	PF00026	0.527
TRG_Pf-PMV_PEXEL_1	8	13	PF00026	0.650

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCM1	Leptomonas seymouri	72%	100%
A0A0S4IL99	Bodo saltans	42%	100%
A0A1X0P2Q0	Trypanosomatidae	50%	100%
A0A3S7X3P0	Leishmania donovani	94%	100%
A4HIH6	Leishmania braziliensis	81%	100%
A4I5S3	Leishmania infantum	94%	100%
C9ZR42	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9B118	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5AWW0	Trypanosoma cruzi	47%	100%