Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q743_LEIMA

TriTrypDb:

LmjF.30.2520 , LMJLV39_300032600 , LMJSD75_300032100

Length:

349

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4Q743

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q743

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	104	106	PF00675	0.509
CLV_NRD_NRD_1	246	248	PF00675	0.598
CLV_PCSK_KEX2_1	104	106	PF00082	0.509
CLV_PCSK_KEX2_1	246	248	PF00082	0.575
CLV_PCSK_SKI1_1	107	111	PF00082	0.541
CLV_PCSK_SKI1_1	183	187	PF00082	0.373
CLV_PCSK_SKI1_1	225	229	PF00082	0.536
CLV_PCSK_SKI1_1	268	272	PF00082	0.500
CLV_PCSK_SKI1_1	338	342	PF00082	0.520
DEG_COP1_1	273	280	PF00400	0.566
DEG_SPOP_SBC_1	29	33	PF00917	0.311
DOC_CKS1_1	113	118	PF01111	0.533
DOC_CYCLIN_yClb5_NLxxxL_5	51	60	PF00134	0.628
DOC_MAPK_MEF2A_6	163	172	PF00069	0.488
DOC_MAPK_MEF2A_6	212	219	PF00069	0.320
DOC_PP2B_LxvP_1	199	202	PF13499	0.429
DOC_PP2B_LxvP_1	290	293	PF13499	0.593
DOC_PP2B_LxvP_1	302	305	PF13499	0.750
DOC_PP4_FxxP_1	334	337	PF00568	0.474
DOC_USP7_MATH_1	108	112	PF00917	0.444
DOC_USP7_MATH_1	120	124	PF00917	0.505
DOC_USP7_MATH_1	29	33	PF00917	0.459
DOC_USP7_MATH_1	293	297	PF00917	0.589
DOC_USP7_MATH_1	309	313	PF00917	0.578
DOC_USP7_MATH_1	330	334	PF00917	0.452
DOC_USP7_MATH_1	77	81	PF00917	0.518
DOC_USP7_MATH_1	91	95	PF00917	0.270
DOC_WW_Pin1_4	112	117	PF00397	0.500
DOC_WW_Pin1_4	191	196	PF00397	0.528
DOC_WW_Pin1_4	211	216	PF00397	0.239
DOC_WW_Pin1_4	245	250	PF00397	0.497
DOC_WW_Pin1_4	333	338	PF00397	0.449
LIG_14-3-3_CanoR_1	107	116	PF00244	0.452
LIG_14-3-3_CanoR_1	122	131	PF00244	0.476
LIG_14-3-3_CanoR_1	153	157	PF00244	0.450
LIG_14-3-3_CanoR_1	190	195	PF00244	0.592
LIG_14-3-3_CanoR_1	225	230	PF00244	0.483
LIG_Actin_WH2_2	140	155	PF00022	0.480
LIG_Actin_WH2_2	215	232	PF00022	0.507
LIG_BRCT_BRCA1_1	311	315	PF00533	0.608
LIG_BRCT_BRCA1_1	79	83	PF00533	0.363
LIG_eIF4E_1	180	186	PF01652	0.490
LIG_FHA_1	172	178	PF00498	0.412
LIG_FHA_1	212	218	PF00498	0.457
LIG_FHA_1	272	278	PF00498	0.552
LIG_FHA_1	299	305	PF00498	0.637
LIG_FHA_1	339	345	PF00498	0.522
LIG_FHA_1	34	40	PF00498	0.518
LIG_FHA_2	134	140	PF00498	0.474
LIG_FHA_2	70	76	PF00498	0.565
LIG_GBD_Chelix_1	34	42	PF00786	0.296
LIG_Integrin_isoDGR_2	257	259	PF01839	0.461
LIG_LIR_Apic_2	110	116	PF02991	0.528
LIG_LIR_Apic_2	3	8	PF02991	0.586
LIG_LIR_Apic_2	333	337	PF02991	0.505
LIG_LIR_Gen_1	329	337	PF02991	0.422
LIG_LIR_Gen_1	67	78	PF02991	0.549
LIG_LIR_Nem_3	329	334	PF02991	0.386
LIG_LIR_Nem_3	67	73	PF02991	0.501
LIG_MLH1_MIPbox_1	80	84	PF16413	0.468
LIG_PDZ_Class_2	344	349	PF00595	0.446
LIG_Rb_LxCxE_1	228	244	PF01857	0.575
LIG_SH2_CRK	70	74	PF00017	0.546
LIG_SH2_NCK_1	113	117	PF00017	0.530
LIG_SH2_NCK_1	26	30	PF00017	0.493
LIG_SH2_NCK_1	5	9	PF00017	0.681
LIG_SH2_SRC	5	8	PF00017	0.684
LIG_SH2_STAP1	187	191	PF00017	0.560
LIG_SH3_3	125	131	PF00018	0.392
LIG_SH3_3	274	280	PF00018	0.573
LIG_SH3_3	342	348	PF00018	0.486
LIG_SUMO_SIM_anti_2	98	103	PF11976	0.403
LIG_SUMO_SIM_par_1	143	148	PF11976	0.432
LIG_SUMO_SIM_par_1	196	203	PF11976	0.432
LIG_SxIP_EBH_1	122	133	PF03271	0.474
LIG_WRC_WIRS_1	172	177	PF05994	0.440
MOD_CDC14_SPxK_1	248	251	PF00782	0.459
MOD_CDK_SPK_2	333	338	PF00069	0.525
MOD_CDK_SPxK_1	245	251	PF00069	0.497
MOD_CK1_1	103	109	PF00069	0.397
MOD_CK1_1	193	199	PF00069	0.519
MOD_CK1_1	211	217	PF00069	0.274
MOD_CK1_1	285	291	PF00069	0.539
MOD_CK1_1	33	39	PF00069	0.373
MOD_CK1_1	333	339	PF00069	0.535
MOD_CK1_1	95	101	PF00069	0.449
MOD_CK2_1	120	126	PF00069	0.381
MOD_CK2_1	133	139	PF00069	0.345
MOD_CK2_1	313	319	PF00069	0.627
MOD_CK2_1	60	66	PF00069	0.524
MOD_CK2_1	69	75	PF00069	0.533
MOD_GlcNHglycan	284	287	PF01048	0.539
MOD_GlcNHglycan	295	298	PF01048	0.641
MOD_GlcNHglycan	311	314	PF01048	0.511
MOD_GlcNHglycan	315	318	PF01048	0.526
MOD_GlcNHglycan	60	63	PF01048	0.593
MOD_GSK3_1	103	110	PF00069	0.490
MOD_GSK3_1	186	193	PF00069	0.524
MOD_GSK3_1	241	248	PF00069	0.617
MOD_GSK3_1	278	285	PF00069	0.515
MOD_GSK3_1	29	36	PF00069	0.471
MOD_GSK3_1	305	312	PF00069	0.613
MOD_GSK3_1	326	333	PF00069	0.462
MOD_GSK3_1	60	67	PF00069	0.521
MOD_GSK3_1	91	98	PF00069	0.457
MOD_N-GLC_1	338	343	PF02516	0.512
MOD_NEK2_1	152	157	PF00069	0.490
MOD_NEK2_1	186	191	PF00069	0.518
MOD_NEK2_1	241	246	PF00069	0.569
MOD_NEK2_1	34	39	PF00069	0.334
MOD_NEK2_1	60	65	PF00069	0.517
MOD_NEK2_1	78	83	PF00069	0.401
MOD_NEK2_2	108	113	PF00069	0.471
MOD_PIKK_1	147	153	PF00454	0.554
MOD_PIKK_1	339	345	PF00454	0.536
MOD_PKA_2	103	109	PF00069	0.427
MOD_PKA_2	152	158	PF00069	0.448
MOD_PKA_2	293	299	PF00069	0.684
MOD_PKB_1	105	113	PF00069	0.540
MOD_Plk_1	147	153	PF00069	0.496
MOD_Plk_1	318	324	PF00069	0.489
MOD_Plk_4	171	177	PF00069	0.453
MOD_Plk_4	194	200	PF00069	0.446
MOD_Plk_4	278	284	PF00069	0.461
MOD_Plk_4	285	291	PF00069	0.444
MOD_Plk_4	30	36	PF00069	0.379
MOD_Plk_4	97	103	PF00069	0.444
MOD_ProDKin_1	112	118	PF00069	0.501
MOD_ProDKin_1	191	197	PF00069	0.528
MOD_ProDKin_1	211	217	PF00069	0.232
MOD_ProDKin_1	245	251	PF00069	0.497
MOD_ProDKin_1	333	339	PF00069	0.456
TRG_ENDOCYTIC_2	70	73	PF00928	0.561
TRG_ER_diArg_1	104	107	PF00400	0.547
TRG_Pf-PMV_PEXEL_1	122	126	PF00026	0.544

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZP9	Leptomonas seymouri	74%	99%
A0A1X0P1L9	Trypanosomatidae	43%	100%
A0A3Q8IF23	Leishmania donovani	94%	100%
A0A3R7LJF8	Trypanosoma rangeli	42%	100%
A4HII3	Leishmania braziliensis	85%	87%
A4I5S6	Leishmania infantum	94%	100%
C9ZR45	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9B122	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
V5CKN5	Trypanosoma cruzi	46%	100%