DUF1691 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q742_LEIMA

TriTrypDb:

LmjF.30.2530 , LMJLV39_300032700 , LMJSD75_300032200

Length:

202

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

Q4Q742

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q742

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	22	26	PF00656	0.565
CLV_NRD_NRD_1	148	150	PF00675	0.447
CLV_NRD_NRD_1	194	196	PF00675	0.630
CLV_NRD_NRD_1	34	36	PF00675	0.635
CLV_PCSK_KEX2_1	148	150	PF00082	0.447
CLV_PCSK_KEX2_1	194	196	PF00082	0.605
CLV_PCSK_KEX2_1	34	36	PF00082	0.635
CLV_PCSK_SKI1_1	186	190	PF00082	0.599
CLV_PCSK_SKI1_1	38	42	PF00082	0.435
DEG_APCC_DBOX_1	37	45	PF00400	0.435
DOC_MAPK_gen_1	146	155	PF00069	0.633
DOC_MAPK_MEF2A_6	148	157	PF00069	0.627
DOC_PP4_FxxP_1	46	49	PF00568	0.336
DOC_USP7_MATH_1	121	125	PF00917	0.421
DOC_USP7_MATH_1	5	9	PF00917	0.472
DOC_WW_Pin1_4	54	59	PF00397	0.310
LIG_14-3-3_CanoR_1	12	21	PF00244	0.463
LIG_14-3-3_CanoR_1	35	41	PF00244	0.339
LIG_14-3-3_CanoR_1	75	83	PF00244	0.484
LIG_14-3-3_CterR_2	198	202	PF00244	0.495
LIG_BIR_II_1	1	5	PF00653	0.502
LIG_BIR_III_4	25	29	PF00653	0.417
LIG_BRCT_BRCA1_1	123	127	PF00533	0.383
LIG_BRCT_BRCA1_1	128	132	PF00533	0.310
LIG_BRCT_BRCA1_1	77	81	PF00533	0.469
LIG_deltaCOP1_diTrp_1	142	152	PF00928	0.621
LIG_FHA_1	115	121	PF00498	0.284
LIG_FHA_1	142	148	PF00498	0.688
LIG_FHA_2	20	26	PF00498	0.570
LIG_Integrin_RGD_1	23	25	PF01839	0.692
LIG_LIR_Gen_1	151	160	PF02991	0.631
LIG_LIR_Gen_1	79	90	PF02991	0.329
LIG_LIR_Nem_3	107	112	PF02991	0.453
LIG_LIR_Nem_3	151	155	PF02991	0.608
LIG_LIR_Nem_3	2	6	PF02991	0.466
LIG_LIR_Nem_3	25	30	PF02991	0.453
LIG_LIR_Nem_3	32	36	PF02991	0.379
LIG_LIR_Nem_3	78	83	PF02991	0.477
LIG_LIR_Nem_3	89	95	PF02991	0.336
LIG_LYPXL_S_1	132	136	PF13949	0.310
LIG_LYPXL_yS_3	133	136	PF13949	0.310
LIG_MLH1_MIPbox_1	77	81	PF16413	0.466
LIG_MYND_1	111	115	PF01753	0.397
LIG_Pex14_2	81	85	PF04695	0.310
LIG_SH2_CRK	187	191	PF00017	0.457
LIG_SH2_CRK	33	37	PF00017	0.457
LIG_SH2_GRB2like	82	85	PF00017	0.336
LIG_SH2_STAT5	112	115	PF00017	0.410
LIG_SH2_STAT5	13	16	PF00017	0.467
LIG_SH2_STAT5	3	6	PF00017	0.450
LIG_SH2_STAT5	82	85	PF00017	0.336
LIG_SH3_3	137	143	PF00018	0.635
LIG_SH3_3	163	169	PF00018	0.457
LIG_SH3_3	52	58	PF00018	0.362
LIG_TYR_ITIM	131	136	PF00017	0.421
MOD_CDK_SPxxK_3	54	61	PF00069	0.310
MOD_CK1_1	19	25	PF00069	0.507
MOD_CK1_1	8	14	PF00069	0.478
MOD_GlcNHglycan	18	21	PF01048	0.645
MOD_GlcNHglycan	7	10	PF01048	0.658
MOD_GSK3_1	8	15	PF00069	0.479
MOD_NEK2_1	126	131	PF00069	0.310
MOD_NEK2_1	60	65	PF00069	0.665
MOD_NEK2_1	85	90	PF00069	0.336
MOD_PIKK_1	13	19	PF00454	0.502
MOD_PIKK_1	60	66	PF00454	0.623
MOD_PKA_2	11	17	PF00069	0.520
MOD_Plk_4	68	74	PF00069	0.617
MOD_ProDKin_1	54	60	PF00069	0.310
MOD_SUMO_rev_2	63	71	PF00179	0.663
TRG_DiLeu_BaLyEn_6	55	60	PF01217	0.336
TRG_ENDOCYTIC_2	133	136	PF00928	0.310
TRG_ENDOCYTIC_2	187	190	PF00928	0.475
TRG_ENDOCYTIC_2	33	36	PF00928	0.427
TRG_ENDOCYTIC_2	82	85	PF00928	0.322
TRG_ENDOCYTIC_2	92	95	PF00928	0.292
TRG_ER_diArg_1	147	149	PF00400	0.687
TRG_ER_diArg_1	33	35	PF00400	0.462

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HT69	Leptomonas seymouri	75%	98%
A0A0S4KH82	Bodo saltans	46%	100%
A0A1X0P1K1	Trypanosomatidae	55%	100%
A0A3S7X3P8	Leishmania donovani	92%	100%
A4HII4	Leishmania braziliensis	83%	100%
A4I5S7	Leishmania infantum	92%	100%
C9ZR46	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	97%
E9B123	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%