AAA family ATPase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

AAA family ATPase-like protein

Species:

Leishmania major

UniProt:

Q4Q741_LEIMA

TriTrypDb:

LmjF.30.2540 , LMJLV39_300032800 , LMJSD75_300032300

Length:

807

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q741

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q741

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	15
GO:0003824	catalytic activity	1	15
GO:0005488	binding	1	15
GO:0005524	ATP binding	5	15
GO:0016462	pyrophosphatase activity	5	15
GO:0016787	hydrolase activity	2	15
GO:0016817	hydrolase activity, acting on acid anhydrides	3	15
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	15
GO:0016887	ATP hydrolysis activity	7	15
GO:0017076	purine nucleotide binding	4	15
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	15
GO:0030554	adenyl nucleotide binding	5	15
GO:0032553	ribonucleotide binding	3	15
GO:0032555	purine ribonucleotide binding	4	15
GO:0032559	adenyl ribonucleotide binding	5	15
GO:0035639	purine ribonucleoside triphosphate binding	4	15
GO:0036094	small molecule binding	2	15
GO:0043167	ion binding	2	15
GO:0043168	anion binding	3	15
GO:0097159	organic cyclic compound binding	2	15
GO:0097367	carbohydrate derivative binding	2	15
GO:1901265	nucleoside phosphate binding	3	15
GO:1901363	heterocyclic compound binding	2	15

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	158	162	PF00656	0.502
CLV_C14_Caspase3-7	638	642	PF00656	0.283
CLV_C14_Caspase3-7	662	666	PF00656	0.283
CLV_C14_Caspase3-7	688	692	PF00656	0.402
CLV_C14_Caspase3-7	738	742	PF00656	0.395
CLV_NRD_NRD_1	178	180	PF00675	0.395
CLV_NRD_NRD_1	457	459	PF00675	0.566
CLV_NRD_NRD_1	702	704	PF00675	0.263
CLV_PCSK_KEX2_1	178	180	PF00082	0.374
CLV_PCSK_KEX2_1	216	218	PF00082	0.507
CLV_PCSK_KEX2_1	457	459	PF00082	0.585
CLV_PCSK_KEX2_1	525	527	PF00082	0.549
CLV_PCSK_KEX2_1	702	704	PF00082	0.316
CLV_PCSK_PC1ET2_1	216	218	PF00082	0.507
CLV_PCSK_PC1ET2_1	525	527	PF00082	0.546
CLV_PCSK_SKI1_1	142	146	PF00082	0.578
CLV_PCSK_SKI1_1	195	199	PF00082	0.417
CLV_PCSK_SKI1_1	200	204	PF00082	0.383
CLV_PCSK_SKI1_1	573	577	PF00082	0.246
CLV_PCSK_SKI1_1	585	589	PF00082	0.299
CLV_PCSK_SKI1_1	621	625	PF00082	0.283
CLV_PCSK_SKI1_1	675	679	PF00082	0.359
DEG_APCC_DBOX_1	199	207	PF00400	0.376
DEG_APCC_DBOX_1	449	457	PF00400	0.427
DEG_COP1_1	158	167	PF00400	0.434
DEG_Nend_UBRbox_1	1	4	PF02207	0.476
DEG_SCF_TRCP1_1	270	275	PF00400	0.461
DEG_SPOP_SBC_1	246	250	PF00917	0.483
DOC_CDC14_PxL_1	705	713	PF14671	0.436
DOC_CYCLIN_yClb1_LxF_4	675	681	PF00134	0.333
DOC_MAPK_DCC_7	44	53	PF00069	0.412
DOC_MAPK_gen_1	44	53	PF00069	0.512
DOC_MAPK_gen_1	525	531	PF00069	0.514
DOC_MAPK_gen_1	674	681	PF00069	0.359
DOC_MAPK_gen_1	696	706	PF00069	0.283
DOC_MAPK_MEF2A_6	184	192	PF00069	0.457
DOC_MAPK_MEF2A_6	46	55	PF00069	0.493
DOC_MAPK_MEF2A_6	628	636	PF00069	0.283
DOC_MAPK_MEF2A_6	699	708	PF00069	0.283
DOC_PP1_RVXF_1	323	330	PF00149	0.473
DOC_PP2B_LxvP_1	436	439	PF13499	0.476
DOC_PP2B_LxvP_1	569	572	PF13499	0.334
DOC_SPAK_OSR1_1	526	530	PF12202	0.510
DOC_USP7_MATH_1	246	250	PF00917	0.516
DOC_USP7_MATH_1	254	258	PF00917	0.714
DOC_USP7_MATH_1	29	33	PF00917	0.623
DOC_USP7_MATH_1	314	318	PF00917	0.536
DOC_USP7_MATH_1	356	360	PF00917	0.418
DOC_USP7_MATH_1	465	469	PF00917	0.422
DOC_USP7_MATH_1	501	505	PF00917	0.381
DOC_USP7_MATH_1	581	585	PF00917	0.257
DOC_USP7_MATH_1	593	597	PF00917	0.346
DOC_USP7_MATH_1	764	768	PF00917	0.331
DOC_USP7_UBL2_3	15	19	PF12436	0.658
DOC_WW_Pin1_4	20	25	PF00397	0.509
DOC_WW_Pin1_4	216	221	PF00397	0.583
DOC_WW_Pin1_4	255	260	PF00397	0.669
DOC_WW_Pin1_4	5	10	PF00397	0.590
DOC_WW_Pin1_4	567	572	PF00397	0.364
DOC_WW_Pin1_4	628	633	PF00397	0.359
LIG_14-3-3_CanoR_1	142	147	PF00244	0.364
LIG_14-3-3_CanoR_1	178	182	PF00244	0.410
LIG_14-3-3_CanoR_1	191	197	PF00244	0.369
LIG_14-3-3_CanoR_1	297	303	PF00244	0.423
LIG_14-3-3_CanoR_1	355	361	PF00244	0.483
LIG_14-3-3_CanoR_1	383	389	PF00244	0.368
LIG_14-3-3_CanoR_1	408	414	PF00244	0.300
LIG_14-3-3_CanoR_1	502	507	PF00244	0.394
LIG_14-3-3_CanoR_1	513	521	PF00244	0.510
LIG_14-3-3_CanoR_1	649	657	PF00244	0.249
LIG_14-3-3_CanoR_1	714	722	PF00244	0.391
LIG_Actin_WH2_2	442	459	PF00022	0.565
LIG_BRCT_BRCA1_1	560	564	PF00533	0.404
LIG_deltaCOP1_diTrp_1	172	177	PF00928	0.493
LIG_deltaCOP1_diTrp_1	554	562	PF00928	0.460
LIG_deltaCOP1_diTrp_1	789	796	PF00928	0.333
LIG_FHA_1	191	197	PF00498	0.515
LIG_FHA_1	279	285	PF00498	0.429
LIG_FHA_1	322	328	PF00498	0.448
LIG_FHA_1	343	349	PF00498	0.438
LIG_FHA_1	491	497	PF00498	0.406
LIG_FHA_2	481	487	PF00498	0.311
LIG_FHA_2	506	512	PF00498	0.541
LIG_FHA_2	533	539	PF00498	0.341
LIG_FHA_2	546	552	PF00498	0.268
LIG_FHA_2	660	666	PF00498	0.296
LIG_FHA_2	708	714	PF00498	0.552
LIG_FHA_2	742	748	PF00498	0.293
LIG_FHA_2	768	774	PF00498	0.242
LIG_LIR_Gen_1	170	181	PF02991	0.418
LIG_LIR_Gen_1	328	336	PF02991	0.450
LIG_LIR_Gen_1	533	543	PF02991	0.403
LIG_LIR_Gen_1	561	572	PF02991	0.477
LIG_LIR_Gen_1	719	729	PF02991	0.328
LIG_LIR_Gen_1	754	764	PF02991	0.227
LIG_LIR_LC3C_4	281	284	PF02991	0.416
LIG_LIR_Nem_3	170	176	PF02991	0.434
LIG_LIR_Nem_3	274	279	PF02991	0.550
LIG_LIR_Nem_3	328	332	PF02991	0.372
LIG_LIR_Nem_3	533	539	PF02991	0.388
LIG_LIR_Nem_3	561	567	PF02991	0.417
LIG_LIR_Nem_3	719	725	PF02991	0.306
LIG_LIR_Nem_3	754	760	PF02991	0.227
LIG_LIR_Nem_3	88	93	PF02991	0.495
LIG_MYND_1	130	134	PF01753	0.405
LIG_PCNA_yPIPBox_3	478	491	PF02747	0.342
LIG_Pex14_1	173	177	PF04695	0.486
LIG_SH2_CRK	578	582	PF00017	0.283
LIG_SH2_CRK	94	98	PF00017	0.392
LIG_SH2_PTP2	187	190	PF00017	0.479
LIG_SH2_PTP2	705	708	PF00017	0.283
LIG_SH2_STAT5	187	190	PF00017	0.424
LIG_SH2_STAT5	326	329	PF00017	0.431
LIG_SH2_STAT5	705	708	PF00017	0.283
LIG_SH2_STAT5	735	738	PF00017	0.227
LIG_SH2_STAT5	743	746	PF00017	0.227
LIG_SH3_2	709	714	PF14604	0.333
LIG_SH3_3	128	134	PF00018	0.361
LIG_SH3_3	526	532	PF00018	0.412
LIG_SH3_3	600	606	PF00018	0.227
LIG_SH3_3	691	697	PF00018	0.252
LIG_SH3_3	703	709	PF00018	0.333
LIG_SUMO_SIM_anti_2	747	754	PF11976	0.227
LIG_SUMO_SIM_par_1	119	125	PF11976	0.475
LIG_SUMO_SIM_par_1	204	209	PF11976	0.477
LIG_SUMO_SIM_par_1	280	286	PF11976	0.289
LIG_SUMO_SIM_par_1	396	402	PF11976	0.486
LIG_SUMO_SIM_par_1	432	437	PF11976	0.394
LIG_SUMO_SIM_par_1	468	477	PF11976	0.451
LIG_TRAF2_1	670	673	PF00917	0.265
LIG_TRFH_1	567	571	PF08558	0.350
LIG_TYR_ITIM	185	190	PF00017	0.456
LIG_TYR_ITSM	86	93	PF00017	0.491
MOD_CDK_SPK_2	10	15	PF00069	0.650
MOD_CDK_SPxK_1	567	573	PF00069	0.384
MOD_CK1_1	166	172	PF00069	0.587
MOD_CK1_1	241	247	PF00069	0.468
MOD_CK1_1	271	277	PF00069	0.517
MOD_CK1_1	341	347	PF00069	0.424
MOD_CK1_1	379	385	PF00069	0.476
MOD_CK1_1	412	418	PF00069	0.296
MOD_CK1_1	432	438	PF00069	0.294
MOD_CK1_1	530	536	PF00069	0.444
MOD_CK1_1	767	773	PF00069	0.343
MOD_CK1_1	8	14	PF00069	0.619
MOD_CK2_1	166	172	PF00069	0.615
MOD_CK2_1	241	247	PF00069	0.586
MOD_CK2_1	707	713	PF00069	0.439
MOD_CK2_1	741	747	PF00069	0.232
MOD_Cter_Amidation	214	217	PF01082	0.482
MOD_DYRK1A_RPxSP_1	628	632	PF00069	0.359
MOD_GlcNHglycan	102	105	PF01048	0.645
MOD_GlcNHglycan	241	244	PF01048	0.613
MOD_GlcNHglycan	249	252	PF01048	0.640
MOD_GlcNHglycan	270	273	PF01048	0.606
MOD_GlcNHglycan	316	319	PF01048	0.515
MOD_GlcNHglycan	358	361	PF01048	0.489
MOD_GlcNHglycan	378	381	PF01048	0.334
MOD_GlcNHglycan	411	414	PF01048	0.290
MOD_GlcNHglycan	439	442	PF01048	0.395
MOD_GlcNHglycan	515	518	PF01048	0.434
MOD_GlcNHglycan	541	544	PF01048	0.439
MOD_GlcNHglycan	79	82	PF01048	0.423
MOD_GSK3_1	163	170	PF00069	0.500
MOD_GSK3_1	241	248	PF00069	0.539
MOD_GSK3_1	268	275	PF00069	0.640
MOD_GSK3_1	314	321	PF00069	0.676
MOD_GSK3_1	338	345	PF00069	0.405
MOD_GSK3_1	356	363	PF00069	0.343
MOD_GSK3_1	375	382	PF00069	0.326
MOD_GSK3_1	501	508	PF00069	0.536
MOD_GSK3_1	558	565	PF00069	0.448
MOD_GSK3_1	655	662	PF00069	0.257
MOD_GSK3_1	737	744	PF00069	0.227
MOD_LATS_1	798	804	PF00433	0.457
MOD_N-GLC_1	567	572	PF02516	0.480
MOD_N-GLC_1	593	598	PF02516	0.283
MOD_NEK2_1	100	105	PF00069	0.408
MOD_NEK2_1	177	182	PF00069	0.555
MOD_NEK2_1	190	195	PF00069	0.439
MOD_NEK2_1	239	244	PF00069	0.555
MOD_NEK2_1	429	434	PF00069	0.465
MOD_NEK2_1	490	495	PF00069	0.366
MOD_NEK2_1	527	532	PF00069	0.378
MOD_NEK2_1	67	72	PF00069	0.517
MOD_NEK2_1	731	736	PF00069	0.381
MOD_NEK2_1	86	91	PF00069	0.296
MOD_PIKK_1	190	196	PF00454	0.409
MOD_PIKK_1	480	486	PF00454	0.320
MOD_PIKK_1	655	661	PF00454	0.227
MOD_PKA_1	800	806	PF00069	0.647
MOD_PKA_2	100	106	PF00069	0.563
MOD_PKA_2	177	183	PF00069	0.390
MOD_PKA_2	190	196	PF00069	0.270
MOD_PKA_2	356	362	PF00069	0.465
MOD_PKA_2	501	507	PF00069	0.517
MOD_Plk_1	121	127	PF00069	0.415
MOD_Plk_1	206	212	PF00069	0.535
MOD_Plk_1	491	497	PF00069	0.248
MOD_Plk_1	527	533	PF00069	0.404
MOD_Plk_1	593	599	PF00069	0.359
MOD_Plk_4	278	284	PF00069	0.424
MOD_Plk_4	344	350	PF00069	0.387
MOD_Plk_4	360	366	PF00069	0.479
MOD_Plk_4	384	390	PF00069	0.382
MOD_Plk_4	424	430	PF00069	0.396
MOD_Plk_4	491	497	PF00069	0.253
MOD_Plk_4	558	564	PF00069	0.449
MOD_Plk_4	583	589	PF00069	0.289
MOD_Plk_4	731	737	PF00069	0.190
MOD_ProDKin_1	20	26	PF00069	0.507
MOD_ProDKin_1	216	222	PF00069	0.582
MOD_ProDKin_1	255	261	PF00069	0.670
MOD_ProDKin_1	5	11	PF00069	0.593
MOD_ProDKin_1	567	573	PF00069	0.362
MOD_ProDKin_1	628	634	PF00069	0.359
MOD_SUMO_for_1	14	17	PF00179	0.510
MOD_SUMO_rev_2	209	218	PF00179	0.604
MOD_SUMO_rev_2	538	548	PF00179	0.388
MOD_SUMO_rev_2	672	677	PF00179	0.226
TRG_ENDOCYTIC_2	187	190	PF00928	0.345
TRG_ENDOCYTIC_2	705	708	PF00928	0.283
TRG_ENDOCYTIC_2	90	93	PF00928	0.503
TRG_ENDOCYTIC_2	94	97	PF00928	0.471
TRG_ER_diArg_1	177	179	PF00400	0.365
TRG_ER_diArg_1	456	458	PF00400	0.363
TRG_ER_diArg_1	702	704	PF00400	0.390
TRG_ER_diArg_1	781	784	PF00400	0.357
TRG_Pf-PMV_PEXEL_1	621	625	PF00026	0.359
TRG_Pf-PMV_PEXEL_1	655	659	PF00026	0.227
TRG_PTS1	804	807	PF00515	0.477

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2H1	Leptomonas seymouri	66%	88%
A0A1X0P1J4	Trypanosomatidae	49%	100%
A0A3Q8IS46	Leishmania donovani	92%	83%
A0A3R7M308	Trypanosoma rangeli	48%	100%
A0A3S7X0L3	Leishmania donovani	31%	100%
A4HFM9	Leishmania braziliensis	32%	100%
A4HII5	Leishmania braziliensis	80%	85%
A4I2Q7	Leishmania infantum	31%	100%
A4I5S8	Leishmania infantum	92%	77%
C9ZR48	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9AD83	Leishmania major	31%	100%
E9AZ07	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9B124	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
P32794	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	100%
Q07844	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	96%
V5AUZ1	Trypanosoma cruzi	49%	100%