TSNAXIP1_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q739_LEIMA

TriTrypDb:

LmjF.30.2560 , LMJLV39_300033000 , LMJSD75_300032500

Length:

1076

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q739

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q739

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	103	107	PF00656	0.730
CLV_C14_Caspase3-7	573	577	PF00656	0.634
CLV_C14_Caspase3-7	654	658	PF00656	0.740
CLV_NRD_NRD_1	1064	1066	PF00675	0.591
CLV_NRD_NRD_1	122	124	PF00675	0.693
CLV_NRD_NRD_1	187	189	PF00675	0.685
CLV_NRD_NRD_1	422	424	PF00675	0.530
CLV_NRD_NRD_1	458	460	PF00675	0.562
CLV_NRD_NRD_1	490	492	PF00675	0.534
CLV_NRD_NRD_1	493	495	PF00675	0.534
CLV_NRD_NRD_1	749	751	PF00675	0.537
CLV_NRD_NRD_1	885	887	PF00675	0.493
CLV_PCSK_FUR_1	491	495	PF00082	0.526
CLV_PCSK_FUR_1	883	887	PF00082	0.481
CLV_PCSK_KEX2_1	1064	1066	PF00082	0.591
CLV_PCSK_KEX2_1	122	124	PF00082	0.693
CLV_PCSK_KEX2_1	255	257	PF00082	0.616
CLV_PCSK_KEX2_1	422	424	PF00082	0.530
CLV_PCSK_KEX2_1	490	492	PF00082	0.534
CLV_PCSK_KEX2_1	493	495	PF00082	0.534
CLV_PCSK_KEX2_1	552	554	PF00082	0.620
CLV_PCSK_KEX2_1	594	596	PF00082	0.765
CLV_PCSK_KEX2_1	749	751	PF00082	0.537
CLV_PCSK_KEX2_1	869	871	PF00082	0.481
CLV_PCSK_KEX2_1	885	887	PF00082	0.382
CLV_PCSK_PC1ET2_1	255	257	PF00082	0.616
CLV_PCSK_PC1ET2_1	552	554	PF00082	0.610
CLV_PCSK_PC1ET2_1	594	596	PF00082	0.677
CLV_PCSK_PC1ET2_1	869	871	PF00082	0.491
CLV_PCSK_PC7_1	418	424	PF00082	0.528
CLV_PCSK_PC7_1	548	554	PF00082	0.713
CLV_PCSK_PC7_1	590	596	PF00082	0.805
CLV_PCSK_SKI1_1	122	126	PF00082	0.712
CLV_PCSK_SKI1_1	278	282	PF00082	0.542
CLV_PCSK_SKI1_1	387	391	PF00082	0.523
CLV_PCSK_SKI1_1	422	426	PF00082	0.510
CLV_PCSK_SKI1_1	429	433	PF00082	0.555
CLV_PCSK_SKI1_1	517	521	PF00082	0.604
CLV_PCSK_SKI1_1	522	526	PF00082	0.640
CLV_PCSK_SKI1_1	886	890	PF00082	0.440
CLV_PCSK_SKI1_1	909	913	PF00082	0.440
CLV_PCSK_SKI1_1	951	955	PF00082	0.564
DEG_Nend_UBRbox_1	1	4	PF02207	0.709
DEG_SCF_FBW7_1	544	550	PF00400	0.678
DEG_SPOP_SBC_1	753	757	PF00917	0.334
DEG_SPOP_SBC_1	790	794	PF00917	0.634
DOC_CDC14_PxL_1	555	563	PF14671	0.687
DOC_CKS1_1	1012	1017	PF01111	0.560
DOC_CKS1_1	544	549	PF01111	0.684
DOC_CYCLIN_RxL_1	120	128	PF00134	0.701
DOC_CYCLIN_RxL_1	203	213	PF00134	0.667
DOC_CYCLIN_RxL_1	253	262	PF00134	0.547
DOC_MAPK_gen_1	143	153	PF00069	0.656
DOC_MAPK_gen_1	375	385	PF00069	0.698
DOC_MAPK_gen_1	610	619	PF00069	0.747
DOC_MAPK_MEF2A_6	146	153	PF00069	0.655
DOC_MAPK_MEF2A_6	719	728	PF00069	0.654
DOC_MAPK_MEF2A_6	940	949	PF00069	0.472
DOC_MAPK_NFAT4_5	940	948	PF00069	0.473
DOC_MAPK_RevD_3	735	750	PF00069	0.557
DOC_PP2B_LxvP_1	108	111	PF13499	0.797
DOC_PP2B_LxvP_1	183	186	PF13499	0.721
DOC_PP2B_LxvP_1	724	727	PF13499	0.643
DOC_PP2B_PxIxI_1	854	860	PF00149	0.399
DOC_PP4_FxxP_1	1041	1044	PF00568	0.495
DOC_PP4_MxPP_1	720	723	PF00568	0.629
DOC_USP7_MATH_1	1001	1005	PF00917	0.361
DOC_USP7_MATH_1	152	156	PF00917	0.767
DOC_USP7_MATH_1	162	166	PF00917	0.753
DOC_USP7_MATH_1	266	270	PF00917	0.625
DOC_USP7_MATH_1	283	287	PF00917	0.380
DOC_USP7_MATH_1	290	294	PF00917	0.503
DOC_USP7_MATH_1	354	358	PF00917	0.649
DOC_USP7_MATH_1	49	53	PF00917	0.785
DOC_USP7_MATH_1	536	540	PF00917	0.758
DOC_USP7_MATH_1	54	58	PF00917	0.735
DOC_USP7_MATH_1	547	551	PF00917	0.583
DOC_USP7_MATH_1	682	686	PF00917	0.798
DOC_USP7_MATH_1	691	695	PF00917	0.712
DOC_USP7_MATH_1	754	758	PF00917	0.413
DOC_USP7_MATH_1	790	794	PF00917	0.614
DOC_USP7_MATH_1	817	821	PF00917	0.597
DOC_USP7_MATH_1	922	926	PF00917	0.443
DOC_WW_Pin1_4	1011	1016	PF00397	0.546
DOC_WW_Pin1_4	168	173	PF00397	0.688
DOC_WW_Pin1_4	19	24	PF00397	0.704
DOC_WW_Pin1_4	543	548	PF00397	0.657
DOC_WW_Pin1_4	588	593	PF00397	0.560
LIG_14-3-3_CanoR_1	1049	1057	PF00244	0.514
LIG_14-3-3_CanoR_1	1064	1068	PF00244	0.633
LIG_14-3-3_CanoR_1	206	211	PF00244	0.699
LIG_14-3-3_CanoR_1	249	254	PF00244	0.587
LIG_14-3-3_CanoR_1	366	372	PF00244	0.683
LIG_14-3-3_CanoR_1	429	435	PF00244	0.574
LIG_14-3-3_CanoR_1	459	467	PF00244	0.569
LIG_14-3-3_CanoR_1	595	602	PF00244	0.814
LIG_14-3-3_CanoR_1	646	652	PF00244	0.671
LIG_14-3-3_CanoR_1	664	671	PF00244	0.684
LIG_14-3-3_CanoR_1	749	753	PF00244	0.508
LIG_14-3-3_CanoR_1	940	944	PF00244	0.534
LIG_14-3-3_CanoR_1	951	960	PF00244	0.503
LIG_14-3-3_CanoR_1	996	1001	PF00244	0.437
LIG_APCC_ABBA_1	274	279	PF00400	0.496
LIG_APCC_ABBA_1	582	587	PF00400	0.708
LIG_BRCT_BRCA1_1	39	43	PF00533	0.682
LIG_CaM_IQ_9	382	397	PF13499	0.527
LIG_Clathr_ClatBox_1	124	128	PF01394	0.730
LIG_CSL_BTD_1	735	738	PF09270	0.571
LIG_EH1_1	620	628	PF00400	0.587
LIG_eIF4E_1	253	259	PF01652	0.524
LIG_FHA_1	1012	1018	PF00498	0.538
LIG_FHA_1	103	109	PF00498	0.716
LIG_FHA_1	1057	1063	PF00498	0.507
LIG_FHA_1	172	178	PF00498	0.666
LIG_FHA_1	209	215	PF00498	0.706
LIG_FHA_1	222	228	PF00498	0.699
LIG_FHA_1	30	36	PF00498	0.661
LIG_FHA_1	380	386	PF00498	0.594
LIG_FHA_1	477	483	PF00498	0.497
LIG_FHA_1	493	499	PF00498	0.567
LIG_FHA_1	539	545	PF00498	0.775
LIG_FHA_1	570	576	PF00498	0.703
LIG_FHA_1	647	653	PF00498	0.791
LIG_FHA_1	72	78	PF00498	0.678
LIG_FHA_1	792	798	PF00498	0.637
LIG_FHA_1	9	15	PF00498	0.713
LIG_FHA_2	107	113	PF00498	0.714
LIG_FHA_2	327	333	PF00498	0.569
LIG_FHA_2	499	505	PF00498	0.560
LIG_FHA_2	571	577	PF00498	0.660
LIG_FHA_2	663	669	PF00498	0.716
LIG_FHA_2	769	775	PF00498	0.572
LIG_FHA_2	809	815	PF00498	0.458
LIG_FHA_2	899	905	PF00498	0.531
LIG_IBAR_NPY_1	275	277	PF08397	0.538
LIG_LIR_Gen_1	293	302	PF02991	0.486
LIG_LIR_Gen_1	40	49	PF02991	0.560
LIG_LIR_Gen_1	426	435	PF02991	0.551
LIG_LIR_Gen_1	469	478	PF02991	0.566
LIG_LIR_Gen_1	927	936	PF02991	0.535
LIG_LIR_Gen_1	944	953	PF02991	0.276
LIG_LIR_Nem_3	279	284	PF02991	0.517
LIG_LIR_Nem_3	286	291	PF02991	0.494
LIG_LIR_Nem_3	293	298	PF02991	0.428
LIG_LIR_Nem_3	40	46	PF02991	0.688
LIG_LIR_Nem_3	426	430	PF02991	0.554
LIG_LIR_Nem_3	442	447	PF02991	0.556
LIG_LIR_Nem_3	550	554	PF02991	0.560
LIG_LIR_Nem_3	556	561	PF02991	0.563
LIG_LIR_Nem_3	927	933	PF02991	0.499
LIG_LIR_Nem_3	944	949	PF02991	0.276
LIG_LYPXL_SIV_4	276	284	PF13949	0.613
LIG_LYPXL_yS_3	558	561	PF13949	0.689
LIG_NRBOX	628	634	PF00104	0.647
LIG_NRBOX	800	806	PF00104	0.567
LIG_PCNA_PIPBox_1	758	767	PF02747	0.453
LIG_Pex14_1	551	555	PF04695	0.692
LIG_SH2_CRK	291	295	PF00017	0.475
LIG_SH2_CRK	302	306	PF00017	0.495
LIG_SH2_CRK	818	822	PF00017	0.526
LIG_SH2_GRB2like	302	305	PF00017	0.553
LIG_SH2_NCK_1	317	321	PF00017	0.651
LIG_SH2_NCK_1	818	822	PF00017	0.597
LIG_SH2_SRC	302	305	PF00017	0.553
LIG_SH2_SRC	465	468	PF00017	0.663
LIG_SH2_STAP1	302	306	PF00017	0.539
LIG_SH2_STAP1	317	321	PF00017	0.527
LIG_SH2_STAP1	427	431	PF00017	0.556
LIG_SH2_STAP1	462	466	PF00017	0.593
LIG_SH2_STAP1	564	568	PF00017	0.644
LIG_SH2_STAP1	78	82	PF00017	0.578
LIG_SH2_STAP1	818	822	PF00017	0.597
LIG_SH2_STAT3	621	624	PF00017	0.600
LIG_SH2_STAT3	772	775	PF00017	0.447
LIG_SH2_STAT5	19	22	PF00017	0.777
LIG_SH2_STAT5	253	256	PF00017	0.543
LIG_SH2_STAT5	465	468	PF00017	0.552
LIG_SH2_STAT5	621	624	PF00017	0.600
LIG_SH2_STAT5	772	775	PF00017	0.550
LIG_SH2_STAT5	946	949	PF00017	0.416
LIG_SH3_3	1009	1015	PF00018	0.535
LIG_SH3_3	1028	1034	PF00018	0.624
LIG_SH3_3	146	152	PF00018	0.729
LIG_SH3_3	20	26	PF00018	0.702
LIG_SH3_3	541	547	PF00018	0.767
LIG_SH3_3	606	612	PF00018	0.799
LIG_SH3_3	685	691	PF00018	0.609
LIG_SH3_3	710	716	PF00018	0.725
LIG_SH3_3	732	738	PF00018	0.573
LIG_SH3_3	849	855	PF00018	0.495
LIG_SH3_3	977	983	PF00018	0.624
LIG_SUMO_SIM_anti_2	408	414	PF11976	0.533
LIG_SUMO_SIM_anti_2	501	507	PF11976	0.565
LIG_SUMO_SIM_anti_2	860	866	PF11976	0.466
LIG_SUMO_SIM_par_1	1006	1011	PF11976	0.526
LIG_SUMO_SIM_par_1	625	630	PF11976	0.570
LIG_SUMO_SIM_par_1	895	901	PF11976	0.522
LIG_SUMO_SIM_par_1	932	938	PF11976	0.536
LIG_SUMO_SIM_par_1	995	1002	PF11976	0.514
LIG_TRAF2_1	1040	1043	PF00917	0.627
LIG_TRAF2_1	329	332	PF00917	0.583
LIG_TRAF2_1	343	346	PF00917	0.564
LIG_TRAF2_1	360	363	PF00917	0.439
LIG_TRAF2_1	512	515	PF00917	0.560
LIG_TRAF2_1	586	589	PF00917	0.662
LIG_TRAF2_1	670	673	PF00917	0.800
LIG_WRC_WIRS_1	946	951	PF05994	0.452
LIG_WW_3	853	857	PF00397	0.472
MOD_CDC14_SPxK_1	591	594	PF00782	0.570
MOD_CDK_SPK_2	543	548	PF00069	0.636
MOD_CDK_SPxK_1	588	594	PF00069	0.565
MOD_CDK_SPxxK_3	588	595	PF00069	0.570
MOD_CK1_1	201	207	PF00069	0.726
MOD_CK1_1	209	215	PF00069	0.739
MOD_CK1_1	24	30	PF00069	0.781
MOD_CK1_1	262	268	PF00069	0.615
MOD_CK1_1	373	379	PF00069	0.629
MOD_CK1_1	57	63	PF00069	0.814
MOD_CK1_1	597	603	PF00069	0.823
MOD_CK1_1	667	673	PF00069	0.607
MOD_CK1_1	675	681	PF00069	0.644
MOD_CK1_1	706	712	PF00069	0.657
MOD_CK1_1	969	975	PF00069	0.637
MOD_CK2_1	326	332	PF00069	0.546
MOD_CK2_1	346	352	PF00069	0.309
MOD_CK2_1	394	400	PF00069	0.618
MOD_CK2_1	662	668	PF00069	0.695
MOD_CK2_1	898	904	PF00069	0.507
MOD_GlcNHglycan	1002	1006	PF01048	0.565
MOD_GlcNHglycan	1068	1071	PF01048	0.691
MOD_GlcNHglycan	112	117	PF01048	0.706
MOD_GlcNHglycan	119	122	PF01048	0.571
MOD_GlcNHglycan	177	180	PF01048	0.743
MOD_GlcNHglycan	237	240	PF01048	0.637
MOD_GlcNHglycan	26	29	PF01048	0.600
MOD_GlcNHglycan	261	264	PF01048	0.664
MOD_GlcNHglycan	268	271	PF01048	0.619
MOD_GlcNHglycan	285	288	PF01048	0.378
MOD_GlcNHglycan	341	344	PF01048	0.509
MOD_GlcNHglycan	52	55	PF01048	0.704
MOD_GlcNHglycan	560	564	PF01048	0.614
MOD_GlcNHglycan	684	688	PF01048	0.802
MOD_GlcNHglycan	705	708	PF01048	0.757
MOD_GlcNHglycan	743	746	PF01048	0.573
MOD_GlcNHglycan	8	11	PF01048	0.728
MOD_GlcNHglycan	918	921	PF01048	0.503
MOD_GlcNHglycan	94	98	PF01048	0.697
MOD_GlcNHglycan	968	971	PF01048	0.698
MOD_GSK3_1	102	109	PF00069	0.772
MOD_GSK3_1	138	145	PF00069	0.780
MOD_GSK3_1	167	174	PF00069	0.713
MOD_GSK3_1	17	24	PF00069	0.741
MOD_GSK3_1	198	205	PF00069	0.699
MOD_GSK3_1	245	252	PF00069	0.526
MOD_GSK3_1	262	269	PF00069	0.603
MOD_GSK3_1	311	318	PF00069	0.585
MOD_GSK3_1	346	353	PF00069	0.612
MOD_GSK3_1	367	374	PF00069	0.767
MOD_GSK3_1	50	57	PF00069	0.778
MOD_GSK3_1	536	543	PF00069	0.726
MOD_GSK3_1	593	600	PF00069	0.831
MOD_GSK3_1	748	755	PF00069	0.534
MOD_GSK3_1	77	84	PF00069	0.636
MOD_GSK3_1	786	793	PF00069	0.677
MOD_GSK3_1	804	811	PF00069	0.325
MOD_N-GLC_1	138	143	PF02516	0.775
MOD_N-GLC_1	221	226	PF02516	0.729
MOD_N-GLC_1	379	384	PF02516	0.553
MOD_N-GLC_1	646	651	PF02516	0.794
MOD_N-GLC_2	1072	1074	PF02516	0.632
MOD_NEK2_1	17	22	PF00069	0.710
MOD_NEK2_1	177	182	PF00069	0.724
MOD_NEK2_1	36	41	PF00069	0.702
MOD_NEK2_1	371	376	PF00069	0.768
MOD_NEK2_1	430	435	PF00069	0.561
MOD_NEK2_1	632	637	PF00069	0.669
MOD_NEK2_1	77	82	PF00069	0.624
MOD_NEK2_1	879	884	PF00069	0.542
MOD_NEK2_1	93	98	PF00069	0.649
MOD_NEK2_1	945	950	PF00069	0.453
MOD_NEK2_2	290	295	PF00069	0.578
MOD_NEK2_2	81	86	PF00069	0.691
MOD_PIKK_1	326	332	PF00454	0.572
MOD_PIKK_1	400	406	PF00454	0.590
MOD_PIKK_1	498	504	PF00454	0.561
MOD_PIKK_1	632	638	PF00454	0.672
MOD_PK_1	1020	1026	PF00069	0.516
MOD_PKA_1	460	466	PF00069	0.555
MOD_PKA_1	594	600	PF00069	0.825
MOD_PKA_2	1048	1054	PF00069	0.508
MOD_PKA_2	1063	1069	PF00069	0.634
MOD_PKA_2	214	220	PF00069	0.665
MOD_PKA_2	394	400	PF00069	0.558
MOD_PKA_2	492	498	PF00069	0.507
MOD_PKA_2	547	553	PF00069	0.650
MOD_PKA_2	569	575	PF00069	0.622
MOD_PKA_2	594	600	PF00069	0.814
MOD_PKA_2	645	651	PF00069	0.689
MOD_PKA_2	691	697	PF00069	0.713
MOD_PKA_2	741	747	PF00069	0.536
MOD_PKA_2	748	754	PF00069	0.451
MOD_PKA_2	85	91	PF00069	0.759
MOD_PKA_2	939	945	PF00069	0.513
MOD_Plk_1	1020	1026	PF00069	0.516
MOD_Plk_1	379	385	PF00069	0.607
MOD_Plk_1	667	673	PF00069	0.692
MOD_Plk_1	914	920	PF00069	0.463
MOD_Plk_2-3	106	112	PF00069	0.674
MOD_Plk_4	214	220	PF00069	0.698
MOD_Plk_4	249	255	PF00069	0.532
MOD_Plk_4	290	296	PF00069	0.485
MOD_Plk_4	430	436	PF00069	0.616
MOD_Plk_4	540	546	PF00069	0.771
MOD_Plk_4	768	774	PF00069	0.534
MOD_Plk_4	77	83	PF00069	0.669
MOD_Plk_4	945	951	PF00069	0.459
MOD_ProDKin_1	1011	1017	PF00069	0.551
MOD_ProDKin_1	168	174	PF00069	0.690
MOD_ProDKin_1	19	25	PF00069	0.705
MOD_ProDKin_1	543	549	PF00069	0.653
MOD_ProDKin_1	588	594	PF00069	0.565
MOD_SUMO_for_1	254	257	PF00179	0.612
MOD_SUMO_rev_2	384	392	PF00179	0.527
MOD_SUMO_rev_2	439	447	PF00179	0.504
MOD_SUMO_rev_2	774	779	PF00179	0.594
TRG_DiLeu_BaEn_1	426	431	PF01217	0.542
TRG_DiLeu_BaLyEn_6	1058	1063	PF01217	0.556
TRG_DiLeu_BaLyEn_6	120	125	PF01217	0.688
TRG_DiLeu_BaLyEn_6	724	729	PF01217	0.607
TRG_ENDOCYTIC_2	291	294	PF00928	0.480
TRG_ENDOCYTIC_2	302	305	PF00928	0.499
TRG_ENDOCYTIC_2	427	430	PF00928	0.558
TRG_ENDOCYTIC_2	558	561	PF00928	0.625
TRG_ENDOCYTIC_2	762	765	PF00928	0.530
TRG_ENDOCYTIC_2	802	805	PF00928	0.584
TRG_ENDOCYTIC_2	818	821	PF00928	0.390
TRG_ENDOCYTIC_2	946	949	PF00928	0.404
TRG_ER_diArg_1	1063	1065	PF00400	0.584
TRG_ER_diArg_1	122	124	PF00400	0.693
TRG_ER_diArg_1	422	424	PF00400	0.530
TRG_ER_diArg_1	490	492	PF00400	0.527
TRG_ER_diArg_1	883	886	PF00400	0.476
TRG_NLS_MonoExtC_3	458	464	PF00514	0.551
TRG_Pf-PMV_PEXEL_1	123	128	PF00026	0.693
TRG_Pf-PMV_PEXEL_1	156	161	PF00026	0.727
TRG_Pf-PMV_PEXEL_1	422	426	PF00026	0.532
TRG_Pf-PMV_PEXEL_1	669	673	PF00026	0.674
TRG_Pf-PMV_PEXEL_1	873	878	PF00026	0.531

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2U2	Leptomonas seymouri	49%	94%
A0A0S4JIU6	Bodo saltans	26%	100%
A0A3Q8IC50	Leishmania donovani	91%	100%
A4HII7	Leishmania braziliensis	70%	99%
A4I686	Leishmania infantum	90%	100%
E9B126	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%