ADF-H domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q738_LEIMA

TriTrypDb:

LmjF.30.2570 , LMJLV39_300033200 , LMJSD75_300032600

Length:

409

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005856	cytoskeleton	5	2
GO:0005886	plasma membrane	3	2
GO:0016020	membrane	2	2
GO:0030863	cortical cytoskeleton	6	2
GO:0030864	cortical actin cytoskeleton	7	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q738

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q738

Function

Biological processes
Term	Name	Level	Count
GO:0008064	regulation of actin polymerization or depolymerization	6	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0030832	regulation of actin filament length	5	2
GO:0030833	regulation of actin filament polymerization	7	2
GO:0032271	regulation of protein polymerization	6	2
GO:0032535	regulation of cellular component size	4	2
GO:0032956	regulation of actin cytoskeleton organization	5	2
GO:0032970	regulation of actin filament-based process	4	2
GO:0033043	regulation of organelle organization	5	2
GO:0043254	regulation of protein-containing complex assembly	5	2
GO:0044087	regulation of cellular component biogenesis	4	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0051128	regulation of cellular component organization	4	2
GO:0051493	regulation of cytoskeleton organization	6	2
GO:0065007	biological regulation	1	2
GO:0065008	regulation of biological quality	2	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0090066	regulation of anatomical structure size	3	2
GO:0110053	regulation of actin filament organization	6	2
GO:1902903	regulation of supramolecular fiber organization	5	2

Molecular functions
Term	Name	Level	Count
GO:0003779	actin binding	4	10
GO:0005488	binding	1	10
GO:0005515	protein binding	2	10
GO:0008092	cytoskeletal protein binding	3	10
GO:0044877	protein-containing complex binding	2	2
GO:0051015	actin filament binding	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	375	379	PF00656	0.498
CLV_NRD_NRD_1	147	149	PF00675	0.652
CLV_NRD_NRD_1	246	248	PF00675	0.298
CLV_NRD_NRD_1	311	313	PF00675	0.584
CLV_PCSK_FUR_1	145	149	PF00082	0.641
CLV_PCSK_KEX2_1	144	146	PF00082	0.617
CLV_PCSK_KEX2_1	147	149	PF00082	0.655
CLV_PCSK_KEX2_1	246	248	PF00082	0.298
CLV_PCSK_KEX2_1	311	313	PF00082	0.686
CLV_PCSK_KEX2_1	41	43	PF00082	0.420
CLV_PCSK_KEX2_1	59	61	PF00082	0.330
CLV_PCSK_PC1ET2_1	144	146	PF00082	0.594
CLV_PCSK_PC1ET2_1	41	43	PF00082	0.452
CLV_PCSK_PC1ET2_1	59	61	PF00082	0.316
CLV_PCSK_SKI1_1	183	187	PF00082	0.427
CLV_PCSK_SKI1_1	247	251	PF00082	0.315
CLV_PCSK_SKI1_1	302	306	PF00082	0.442
DEG_Kelch_Keap1_1	237	242	PF01344	0.513
DEG_SCF_FBW7_2	162	169	PF00400	0.532
DEG_SCF_TRCP1_1	105	110	PF00400	0.522
DEG_SPOP_SBC_1	371	375	PF00917	0.506
DOC_CKS1_1	163	168	PF01111	0.532
DOC_CKS1_1	305	310	PF01111	0.513
DOC_CYCLIN_yCln2_LP_2	355	361	PF00134	0.585
DOC_MAPK_gen_1	167	177	PF00069	0.579
DOC_MAPK_gen_1	350	359	PF00069	0.668
DOC_MAPK_gen_1	41	48	PF00069	0.360
DOC_MAPK_MEF2A_6	147	156	PF00069	0.681
DOC_MAPK_MEF2A_6	170	179	PF00069	0.482
DOC_MAPK_RevD_3	231	247	PF00069	0.498
DOC_PP1_RVXF_1	233	239	PF00149	0.495
DOC_PP1_RVXF_1	245	252	PF00149	0.424
DOC_PP2B_LxvP_1	355	358	PF13499	0.590
DOC_PP4_FxxP_1	305	308	PF00568	0.501
DOC_USP7_MATH_1	34	38	PF00917	0.564
DOC_USP7_MATH_1	372	376	PF00917	0.668
DOC_USP7_MATH_1	53	57	PF00917	0.490
DOC_WW_Pin1_4	148	153	PF00397	0.612
DOC_WW_Pin1_4	162	167	PF00397	0.558
DOC_WW_Pin1_4	170	175	PF00397	0.632
DOC_WW_Pin1_4	275	280	PF00397	0.562
DOC_WW_Pin1_4	304	309	PF00397	0.504
DOC_WW_Pin1_4	376	381	PF00397	0.676
LIG_14-3-3_CanoR_1	147	152	PF00244	0.656
LIG_14-3-3_CanoR_1	183	189	PF00244	0.355
LIG_14-3-3_CanoR_1	235	239	PF00244	0.446
LIG_14-3-3_CanoR_1	312	321	PF00244	0.534
LIG_14-3-3_CanoR_1	332	336	PF00244	0.468
LIG_14-3-3_CanoR_1	348	358	PF00244	0.642
LIG_APCC_ABBA_1	127	132	PF00400	0.487
LIG_BRCT_BRCA1_1	105	109	PF00533	0.646
LIG_BRCT_BRCA1_1	322	326	PF00533	0.550
LIG_BRCT_BRCA1_1	36	40	PF00533	0.548
LIG_BRCT_BRCA1_1	87	91	PF00533	0.457
LIG_deltaCOP1_diTrp_1	226	234	PF00928	0.492
LIG_FHA_1	149	155	PF00498	0.511
LIG_FHA_1	179	185	PF00498	0.468
LIG_FHA_1	339	345	PF00498	0.656
LIG_FHA_1	350	356	PF00498	0.700
LIG_FHA_1	388	394	PF00498	0.406
LIG_FHA_1	70	76	PF00498	0.513
LIG_FHA_2	305	311	PF00498	0.590
LIG_GBD_Chelix_1	401	409	PF00786	0.347
LIG_GSK3_LRP6_1	162	167	PF00069	0.528
LIG_LIR_Apic_2	303	308	PF02991	0.480
LIG_LIR_Gen_1	194	201	PF02991	0.480
LIG_LIR_Gen_1	88	98	PF02991	0.502
LIG_LIR_Nem_3	194	200	PF02991	0.480
LIG_LIR_Nem_3	228	234	PF02991	0.471
LIG_LIR_Nem_3	281	285	PF02991	0.453
LIG_LIR_Nem_3	88	94	PF02991	0.495
LIG_LYPXL_S_1	269	273	PF13949	0.329
LIG_LYPXL_yS_3	270	273	PF13949	0.529
LIG_PCNA_yPIPBox_3	210	221	PF02747	0.444
LIG_PDZ_Class_3	404	409	PF00595	0.351
LIG_Pex14_2	234	238	PF04695	0.529
LIG_SH2_PTP2	50	53	PF00017	0.453
LIG_SH2_STAP1	282	286	PF00017	0.465
LIG_SH2_STAT5	285	288	PF00017	0.475
LIG_SH2_STAT5	47	50	PF00017	0.345
LIG_SH3_3	157	163	PF00018	0.712
LIG_SH3_3	168	174	PF00018	0.660
LIG_SH3_3	355	361	PF00018	0.678
LIG_SUMO_SIM_anti_2	388	395	PF11976	0.437
LIG_SUMO_SIM_par_1	172	178	PF11976	0.575
LIG_TRAF2_1	225	228	PF00917	0.549
LIG_TRAF2_1	386	389	PF00917	0.469
LIG_UBA3_1	217	222	PF00899	0.477
MOD_CDK_SPK_2	162	167	PF00069	0.528
MOD_CDK_SPxxK_3	148	155	PF00069	0.506
MOD_CDK_SPxxK_3	304	311	PF00069	0.512
MOD_CK1_1	178	184	PF00069	0.601
MOD_CK1_1	367	373	PF00069	0.627
MOD_CK1_1	90	96	PF00069	0.397
MOD_CK2_1	170	176	PF00069	0.683
MOD_CK2_1	199	205	PF00069	0.576
MOD_CK2_1	236	242	PF00069	0.540
MOD_CK2_1	331	337	PF00069	0.471
MOD_CK2_1	383	389	PF00069	0.454
MOD_Cter_Amidation	145	148	PF01082	0.613
MOD_DYRK1A_RPxSP_1	170	174	PF00069	0.652
MOD_GlcNHglycan	105	108	PF01048	0.544
MOD_GlcNHglycan	302	305	PF01048	0.567
MOD_GlcNHglycan	36	39	PF01048	0.599
MOD_GlcNHglycan	374	377	PF01048	0.639
MOD_GSK3_1	103	110	PF00069	0.517
MOD_GSK3_1	201	208	PF00069	0.526
MOD_GSK3_1	300	307	PF00069	0.484
MOD_GSK3_1	320	327	PF00069	0.539
MOD_GSK3_1	349	356	PF00069	0.740
MOD_GSK3_1	367	374	PF00069	0.523
MOD_GSK3_1	383	390	PF00069	0.531
MOD_GSK3_1	65	72	PF00069	0.512
MOD_GSK3_1	81	88	PF00069	0.452
MOD_N-GLC_1	107	112	PF02516	0.492
MOD_N-GLC_1	148	153	PF02516	0.498
MOD_N-GLC_1	191	196	PF02516	0.280
MOD_N-GLC_1	68	73	PF02516	0.511
MOD_NEK2_1	234	239	PF00069	0.432
MOD_NEK2_1	28	33	PF00069	0.382
MOD_NEK2_1	320	325	PF00069	0.572
MOD_NEK2_1	98	103	PF00069	0.565
MOD_NEK2_2	36	41	PF00069	0.472
MOD_PIKK_1	313	319	PF00454	0.456
MOD_PKA_1	147	153	PF00069	0.674
MOD_PKA_2	147	153	PF00069	0.629
MOD_PKA_2	169	175	PF00069	0.590
MOD_PKA_2	234	240	PF00069	0.430
MOD_PKA_2	331	337	PF00069	0.471
MOD_PKA_2	353	359	PF00069	0.645
MOD_PKA_2	8	14	PF00069	0.418
MOD_PKA_2	98	104	PF00069	0.669
MOD_PKB_1	145	153	PF00069	0.662
MOD_Plk_1	107	113	PF00069	0.491
MOD_Plk_1	175	181	PF00069	0.544
MOD_Plk_1	321	327	PF00069	0.561
MOD_Plk_1	364	370	PF00069	0.627
MOD_Plk_1	387	393	PF00069	0.470
MOD_Plk_4	321	327	PF00069	0.488
MOD_Plk_4	331	337	PF00069	0.568
MOD_Plk_4	53	59	PF00069	0.498
MOD_Plk_4	90	96	PF00069	0.425
MOD_Plk_4	98	104	PF00069	0.594
MOD_ProDKin_1	148	154	PF00069	0.617
MOD_ProDKin_1	162	168	PF00069	0.560
MOD_ProDKin_1	170	176	PF00069	0.624
MOD_ProDKin_1	275	281	PF00069	0.562
MOD_ProDKin_1	304	310	PF00069	0.507
MOD_ProDKin_1	376	382	PF00069	0.673
MOD_SUMO_for_1	166	169	PF00179	0.689
MOD_SUMO_rev_2	19	26	PF00179	0.421
TRG_DiLeu_BaEn_1	389	394	PF01217	0.366
TRG_ENDOCYTIC_2	270	273	PF00928	0.495
TRG_ENDOCYTIC_2	30	33	PF00928	0.350
TRG_ER_diArg_1	145	148	PF00400	0.634
TRG_ER_diArg_1	246	248	PF00400	0.510
TRG_ER_diArg_1	311	313	PF00400	0.561
TRG_NES_CRM1_1	92	105	PF08389	0.453
TRG_NLS_MonoExtC_3	143	148	PF00514	0.601

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5G8	Leptomonas seymouri	65%	100%
A0A1X0P342	Trypanosomatidae	39%	100%
A0A3Q8IFZ1	Leishmania donovani	94%	100%
A4HII8	Leishmania braziliensis	82%	100%
A4I5T2	Leishmania infantum	96%	100%
C9ZR53	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	91%
E9B127	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5BMX2	Trypanosoma cruzi	41%	100%