Reticulon-like protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

reticulon domain protein, 22 kDa potentially aggravating protein (paple22)

Species:

Leishmania major

UniProt:

Q4Q737_LEIMA

TriTrypDb:

LmjF.30.2580 , LMJLV39_300033300 , LMJSD75_300032700

Length:

197

Annotations

LeishMANIAdb annotations

Similar to reticulons (structural ER membrane proteins) of multicellular animals.. The toplology is difficult to assess, likely owing to the fact that these proteins are curvature-inducing. Localization: ER (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	2
GO:0005789	endoplasmic reticulum membrane	4	11
GO:0016020	membrane	2	11
GO:0031090	organelle membrane	3	11
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

Q4Q737

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q737

Function

Biological processes
Term	Name	Level	Count
GO:0009605	response to external stimulus	2	10
GO:0009607	response to biotic stimulus	2	10
GO:0009617	response to bacterium	3	10
GO:0043207	response to external biotic stimulus	3	10
GO:0044419	biological process involved in interspecies interaction between organisms	1	10
GO:0050896	response to stimulus	1	10
GO:0051707	response to other organism	2	10

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	193	195	PF00675	0.497
CLV_PCSK_KEX2_1	68	70	PF00082	0.374
CLV_PCSK_PC1ET2_1	68	70	PF00082	0.374
CLV_PCSK_SKI1_1	6	10	PF00082	0.470
CLV_PCSK_SKI1_1	76	80	PF00082	0.231
DEG_MDM2_SWIB_1	32	40	PF02201	0.414
DOC_MAPK_gen_1	68	74	PF00069	0.597
DOC_PP4_FxxP_1	143	146	PF00568	0.347
DOC_USP7_MATH_1	22	26	PF00917	0.548
DOC_USP7_MATH_1	85	89	PF00917	0.576
LIG_14-3-3_CanoR_1	21	29	PF00244	0.539
LIG_14-3-3_CanoR_1	69	75	PF00244	0.528
LIG_APCC_ABBA_1	38	43	PF00400	0.492
LIG_BIR_II_1	1	5	PF00653	0.672
LIG_BRCT_BRCA1_1	111	115	PF00533	0.446
LIG_BRCT_BRCA1_1	29	33	PF00533	0.375
LIG_EH1_1	114	122	PF00400	0.446
LIG_FHA_1	11	17	PF00498	0.514
LIG_FHA_1	116	122	PF00498	0.385
LIG_FHA_1	131	137	PF00498	0.316
LIG_FHA_1	142	148	PF00498	0.298
LIG_FHA_1	45	51	PF00498	0.452
LIG_FHA_1	92	98	PF00498	0.560
LIG_FHA_2	10	16	PF00498	0.622
LIG_FHA_2	103	109	PF00498	0.535
LIG_FHA_2	174	180	PF00498	0.595
LIG_LIR_Apic_2	18	22	PF02991	0.564
LIG_LIR_Gen_1	34	44	PF02991	0.392
LIG_LIR_Gen_1	83	93	PF02991	0.574
LIG_LIR_Nem_3	105	109	PF02991	0.530
LIG_LIR_Nem_3	30	35	PF02991	0.391
LIG_LIR_Nem_3	7	11	PF02991	0.631
LIG_LIR_Nem_3	83	89	PF02991	0.545
LIG_MLH1_MIPbox_1	29	33	PF16413	0.375
LIG_Pex14_2	124	128	PF04695	0.428
LIG_Pex14_2	29	33	PF04695	0.425
LIG_SH2_STAP1	109	113	PF00017	0.604
LIG_SH2_STAP1	166	170	PF00017	0.611
LIG_SH2_STAT5	170	173	PF00017	0.615
LIG_SH2_STAT5	44	47	PF00017	0.297
LIG_SH3_3	69	75	PF00018	0.597
LIG_SUMO_SIM_anti_2	130	138	PF11976	0.374
LIG_SUMO_SIM_anti_2	55	60	PF11976	0.492
LIG_SUMO_SIM_par_1	98	105	PF11976	0.555
LIG_WRC_WIRS_1	29	34	PF05994	0.375
LIG_WRC_WIRS_1	46	51	PF05994	0.367
MOD_CK1_1	130	136	PF00069	0.346
MOD_CK1_1	180	186	PF00069	0.672
MOD_CK1_1	31	37	PF00069	0.423
MOD_CK1_1	99	105	PF00069	0.525
MOD_CK2_1	173	179	PF00069	0.633
MOD_CK2_1	180	186	PF00069	0.612
MOD_GlcNHglycan	1	4	PF01048	0.525
MOD_GlcNHglycan	111	114	PF01048	0.367
MOD_GlcNHglycan	24	27	PF01048	0.370
MOD_GSK3_1	173	180	PF00069	0.670
MOD_GSK3_1	27	34	PF00069	0.428
MOD_GSK3_1	44	51	PF00069	0.374
MOD_NEK2_1	115	120	PF00069	0.439
MOD_NEK2_1	129	134	PF00069	0.277
MOD_NEK2_1	173	178	PF00069	0.650
MOD_NEK2_1	96	101	PF00069	0.502
MOD_NEK2_2	85	90	PF00069	0.542
MOD_PK_1	181	187	PF00069	0.659
MOD_PK_1	52	58	PF00069	0.492
MOD_PKA_1	181	187	PF00069	0.714
MOD_Plk_1	130	136	PF00069	0.345
MOD_Plk_1	42	48	PF00069	0.384
MOD_Plk_1	97	103	PF00069	0.574
MOD_Plk_4	116	122	PF00069	0.353
MOD_Plk_4	130	136	PF00069	0.288
MOD_Plk_4	28	34	PF00069	0.374
MOD_Plk_4	45	51	PF00069	0.417
MOD_Plk_4	52	58	PF00069	0.365
MOD_SUMO_rev_2	191	196	PF00179	0.718
MOD_SUMO_rev_2	2	11	PF00179	0.714
TRG_ENDOCYTIC_2	170	173	PF00928	0.664
TRG_ENDOCYTIC_2	86	89	PF00928	0.554

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P527	Leptomonas seymouri	56%	100%
A0A0S4JFE7	Bodo saltans	31%	100%
A0A1X0P1J2	Trypanosomatidae	36%	100%
A0A3Q8IFS1	Leishmania donovani	93%	100%
A0A3R7L2P9	Trypanosoma rangeli	34%	100%
A4HII9	Leishmania braziliensis	74%	100%
C9ZR54	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9B128	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q28D16	Xenopus tropicalis	21%	92%
Q9NJS2	Leishmania infantum	93%	100%