N-acetyltransferase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q736_LEIMA

TriTrypDb:

LmjF.30.2590 , LMJLV39_300033400 , LMJSD75_300032800

Length:

493

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

Q4Q736

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q736

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009056	catabolic process	2	12
GO:0009057	macromolecule catabolic process	4	12
GO:0019538	protein metabolic process	3	12
GO:0030163	protein catabolic process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901565	organonitrogen compound catabolic process	4	12
GO:1901575	organic substance catabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0008914	leucyltransferase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016746	acyltransferase activity	3	12
GO:0016755	aminoacyltransferase activity	3	12
GO:0140096	catalytic activity, acting on a protein	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	12	16	PF00656	0.612
CLV_C14_Caspase3-7	65	69	PF00656	0.571
CLV_NRD_NRD_1	105	107	PF00675	0.676
CLV_NRD_NRD_1	282	284	PF00675	0.375
CLV_NRD_NRD_1	288	290	PF00675	0.332
CLV_NRD_NRD_1	340	342	PF00675	0.425
CLV_NRD_NRD_1	454	456	PF00675	0.423
CLV_PCSK_KEX2_1	282	284	PF00082	0.400
CLV_PCSK_KEX2_1	288	290	PF00082	0.318
CLV_PCSK_KEX2_1	322	324	PF00082	0.483
CLV_PCSK_KEX2_1	340	342	PF00082	0.320
CLV_PCSK_KEX2_1	454	456	PF00082	0.423
CLV_PCSK_PC1ET2_1	322	324	PF00082	0.483
CLV_PCSK_SKI1_1	178	182	PF00082	0.559
CLV_PCSK_SKI1_1	272	276	PF00082	0.678
CLV_PCSK_SKI1_1	341	345	PF00082	0.388
CLV_PCSK_SKI1_1	449	453	PF00082	0.427
CLV_PCSK_SKI1_1	47	51	PF00082	0.582
CLV_PCSK_SKI1_1	67	71	PF00082	0.744
CLV_PCSK_SKI1_1	8	12	PF00082	0.519
CLV_PCSK_SKI1_1	89	93	PF00082	0.640
CLV_Separin_Metazoa	219	223	PF03568	0.323
DEG_SPOP_SBC_1	137	141	PF00917	0.531
DEG_SPOP_SBC_1	254	258	PF00917	0.626
DOC_CKS1_1	3	8	PF01111	0.566
DOC_MAPK_gen_1	288	299	PF00069	0.444
DOC_PP4_FxxP_1	232	235	PF00568	0.425
DOC_USP7_MATH_1	253	257	PF00917	0.783
DOC_USP7_MATH_1	265	269	PF00917	0.425
DOC_USP7_MATH_1	274	278	PF00917	0.647
DOC_USP7_MATH_1	349	353	PF00917	0.482
DOC_USP7_MATH_1	464	468	PF00917	0.498
DOC_USP7_MATH_1	76	80	PF00917	0.576
DOC_WW_Pin1_4	2	7	PF00397	0.568
DOC_WW_Pin1_4	246	251	PF00397	0.557
LIG_14-3-3_CanoR_1	158	163	PF00244	0.619
LIG_14-3-3_CanoR_1	240	244	PF00244	0.398
LIG_14-3-3_CanoR_1	272	281	PF00244	0.589
LIG_14-3-3_CanoR_1	313	318	PF00244	0.516
LIG_14-3-3_CanoR_1	323	327	PF00244	0.473
LIG_14-3-3_CanoR_1	420	426	PF00244	0.517
LIG_14-3-3_CanoR_1	89	96	PF00244	0.663
LIG_APCC_ABBA_1	478	483	PF00400	0.398
LIG_BIR_III_2	461	465	PF00653	0.427
LIG_BRCT_BRCA1_1	168	172	PF00533	0.496
LIG_BRCT_BRCA1_1	40	44	PF00533	0.577
LIG_Clathr_ClatBox_1	365	369	PF01394	0.437
LIG_CtBP_PxDLS_1	154	158	PF00389	0.668
LIG_FHA_1	138	144	PF00498	0.582
LIG_FHA_1	175	181	PF00498	0.573
LIG_FHA_1	198	204	PF00498	0.443
LIG_FHA_1	240	246	PF00498	0.559
LIG_FHA_1	273	279	PF00498	0.537
LIG_FHA_1	302	308	PF00498	0.479
LIG_FHA_1	373	379	PF00498	0.426
LIG_FHA_1	409	415	PF00498	0.305
LIG_FHA_1	48	54	PF00498	0.591
LIG_FHA_1	483	489	PF00498	0.610
LIG_FHA_2	10	16	PF00498	0.610
LIG_LIR_Gen_1	293	300	PF02991	0.364
LIG_LIR_Gen_1	329	335	PF02991	0.367
LIG_LIR_Nem_3	186	191	PF02991	0.435
LIG_LIR_Nem_3	293	299	PF02991	0.367
LIG_LIR_Nem_3	329	334	PF02991	0.378
LIG_LIR_Nem_3	393	397	PF02991	0.361
LIG_LIR_Nem_3	424	430	PF02991	0.442
LIG_LIR_Nem_3	439	445	PF02991	0.403
LIG_NRBOX	213	219	PF00104	0.328
LIG_PCNA_TLS_4	403	412	PF02747	0.465
LIG_PCNA_yPIPBox_3	282	291	PF02747	0.414
LIG_PCNA_yPIPBox_3	67	81	PF02747	0.571
LIG_Pex14_1	426	430	PF04695	0.330
LIG_Pex14_2	172	176	PF04695	0.476
LIG_Pex14_2	438	442	PF04695	0.468
LIG_Pex14_2	452	456	PF04695	0.264
LIG_Rb_LxCxE_1	362	377	PF01857	0.424
LIG_SH2_CRK	211	215	PF00017	0.305
LIG_SH2_PTP2	191	194	PF00017	0.435
LIG_SH2_PTP2	296	299	PF00017	0.297
LIG_SH2_SRC	191	194	PF00017	0.480
LIG_SH2_STAP1	241	245	PF00017	0.408
LIG_SH2_STAP1	423	427	PF00017	0.346
LIG_SH2_STAT3	317	320	PF00017	0.489
LIG_SH2_STAT5	123	126	PF00017	0.504
LIG_SH2_STAT5	191	194	PF00017	0.506
LIG_SH2_STAT5	241	244	PF00017	0.438
LIG_SH2_STAT5	296	299	PF00017	0.437
LIG_SH2_STAT5	394	397	PF00017	0.449
LIG_SH2_STAT5	423	426	PF00017	0.357
LIG_SH2_STAT5	471	474	PF00017	0.329
LIG_SH3_1	190	196	PF00018	0.339
LIG_SH3_2	3	8	PF14604	0.521
LIG_SH3_3	168	174	PF00018	0.532
LIG_SH3_3	190	196	PF00018	0.475
LIG_SH3_3	244	250	PF00018	0.515
LIG_SH3_3	442	448	PF00018	0.484
LIG_SUMO_SIM_anti_2	216	222	PF11976	0.427
LIG_SUMO_SIM_par_1	296	304	PF11976	0.335
LIG_TYR_ITIM	209	214	PF00017	0.294
LIG_UBA3_1	365	373	PF00899	0.441
LIG_WRC_WIRS_1	406	411	PF05994	0.400
MOD_CDK_SPxK_1	2	8	PF00069	0.526
MOD_CK1_1	136	142	PF00069	0.598
MOD_CK1_1	268	274	PF00069	0.468
MOD_CK1_1	79	85	PF00069	0.596
MOD_CK2_1	213	219	PF00069	0.467
MOD_DYRK1A_RPxSP_1	2	6	PF00069	0.499
MOD_GlcNHglycan	135	138	PF01048	0.567
MOD_GlcNHglycan	262	265	PF01048	0.568
MOD_GlcNHglycan	267	270	PF01048	0.495
MOD_GlcNHglycan	292	295	PF01048	0.451
MOD_GlcNHglycan	345	348	PF01048	0.499
MOD_GlcNHglycan	456	459	PF01048	0.479
MOD_GlcNHglycan	485	488	PF01048	0.522
MOD_GlcNHglycan	82	85	PF01048	0.654
MOD_GlcNHglycan	98	101	PF01048	0.464
MOD_GSK3_1	11	18	PF00069	0.769
MOD_GSK3_1	133	140	PF00069	0.596
MOD_GSK3_1	268	275	PF00069	0.489
MOD_GSK3_1	34	41	PF00069	0.585
MOD_GSK3_1	395	402	PF00069	0.360
MOD_GSK3_1	76	83	PF00069	0.564
MOD_N-GLC_1	272	277	PF02516	0.425
MOD_NEK2_1	197	202	PF00069	0.459
MOD_NEK2_1	38	43	PF00069	0.531
MOD_NEK2_1	488	493	PF00069	0.667
MOD_NEK2_2	274	279	PF00069	0.484
MOD_PIKK_1	349	355	PF00454	0.547
MOD_PKA_1	282	288	PF00069	0.364
MOD_PKA_1	322	328	PF00069	0.439
MOD_PKA_1	454	460	PF00069	0.349
MOD_PKA_2	166	172	PF00069	0.656
MOD_PKA_2	239	245	PF00069	0.406
MOD_PKA_2	282	288	PF00069	0.425
MOD_PKA_2	322	328	PF00069	0.577
MOD_PKA_2	399	405	PF00069	0.503
MOD_PKA_2	454	460	PF00069	0.398
MOD_Plk_1	392	398	PF00069	0.302
MOD_Plk_1	464	470	PF00069	0.430
MOD_Plk_1	47	53	PF00069	0.521
MOD_Plk_4	110	116	PF00069	0.420
MOD_Plk_4	166	172	PF00069	0.533
MOD_Plk_4	274	280	PF00069	0.477
MOD_Plk_4	322	328	PF00069	0.362
MOD_Plk_4	34	40	PF00069	0.672
MOD_Plk_4	392	398	PF00069	0.348
MOD_Plk_4	405	411	PF00069	0.474
MOD_Plk_4	421	427	PF00069	0.324
MOD_Plk_4	48	54	PF00069	0.594
MOD_Plk_4	76	82	PF00069	0.564
MOD_ProDKin_1	2	8	PF00069	0.571
MOD_ProDKin_1	246	252	PF00069	0.566
MOD_SUMO_rev_2	41	49	PF00179	0.688
TRG_DiLeu_BaEn_1	66	71	PF01217	0.610
TRG_DiLeu_BaLyEn_6	361	366	PF01217	0.400
TRG_ENDOCYTIC_2	211	214	PF00928	0.302
TRG_ENDOCYTIC_2	296	299	PF00928	0.423
TRG_ENDOCYTIC_2	427	430	PF00928	0.316
TRG_ER_diArg_1	281	283	PF00400	0.404
TRG_ER_diArg_1	287	289	PF00400	0.374
TRG_ER_diArg_1	453	455	PF00400	0.425
TRG_Pf-PMV_PEXEL_1	364	369	PF00026	0.364

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBI6	Leptomonas seymouri	47%	99%
A0A1X0P1I4	Trypanosomatidae	34%	100%
A0A1X0P1L0	Trypanosomatidae	34%	100%
A0A3R7NR23	Trypanosoma rangeli	31%	100%
A0A3S5H7N5	Leishmania donovani	91%	100%
A4HIJ0	Leishmania braziliensis	73%	100%
A4I5T4	Leishmania infantum	91%	100%
C9ZR56	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9B129	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5DNZ0	Trypanosoma cruzi	32%	100%