Putative RNA-binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA-binding protein, putative

Species:

Leishmania major

UniProt:

Q4Q734_LEIMA

TriTrypDb:

LmjF.30.2610 , LMJLV39_300033600 , LMJSD75_300033000

Length:

216

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q734

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q734

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0003723	RNA binding	4	10
GO:0005488	binding	1	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	58	60	PF00675	0.587
CLV_PCSK_KEX2_1	150	152	PF00082	0.457
CLV_PCSK_KEX2_1	33	35	PF00082	0.613
CLV_PCSK_PC1ET2_1	150	152	PF00082	0.457
CLV_PCSK_PC1ET2_1	33	35	PF00082	0.574
CLV_PCSK_SKI1_1	143	147	PF00082	0.253
CLV_PCSK_SKI1_1	93	97	PF00082	0.253
DOC_PP1_RVXF_1	91	97	PF00149	0.453
DOC_USP7_MATH_1	66	70	PF00917	0.623
DOC_USP7_UBL2_3	146	150	PF12436	0.445
DOC_WD40_RPTOR_TOS_1	19	24	PF00400	0.480
LIG_14-3-3_CanoR_1	104	108	PF00244	0.470
LIG_14-3-3_CanoR_1	86	94	PF00244	0.460
LIG_BIR_II_1	1	5	PF00653	0.634
LIG_BRCT_BRCA1_1	192	196	PF00533	0.620
LIG_FHA_1	116	122	PF00498	0.493
LIG_FHA_2	86	92	PF00498	0.453
LIG_IBAR_NPY_1	197	199	PF08397	0.649
LIG_LIR_Gen_1	118	126	PF02991	0.556
LIG_LIR_Nem_3	118	123	PF02991	0.539
LIG_LIR_Nem_3	193	199	PF02991	0.647
LIG_SH2_STAT5	120	123	PF00017	0.463
LIG_SUMO_SIM_anti_2	103	110	PF11976	0.545
LIG_TRAF2_1	38	41	PF00917	0.520
LIG_TRAF2_1	47	50	PF00917	0.474
MOD_CK1_1	69	75	PF00069	0.527
MOD_CK2_1	35	41	PF00069	0.514
MOD_GlcNHglycan	13	16	PF01048	0.683
MOD_GlcNHglycan	50	53	PF01048	0.634
MOD_GlcNHglycan	68	71	PF01048	0.531
MOD_GSK3_1	65	72	PF00069	0.603
MOD_N-GLC_1	74	79	PF02516	0.402
MOD_NEK2_1	48	53	PF00069	0.573
MOD_NEK2_1	95	100	PF00069	0.499
MOD_PIKK_1	190	196	PF00454	0.637
MOD_PKA_2	103	109	PF00069	0.399
MOD_PKA_2	58	64	PF00069	0.550
MOD_PKA_2	85	91	PF00069	0.468
MOD_Plk_1	74	80	PF00069	0.396
MOD_Plk_2-3	17	23	PF00069	0.576
MOD_Plk_4	103	109	PF00069	0.453
MOD_Plk_4	74	80	PF00069	0.396
MOD_SUMO_for_1	53	56	PF00179	0.646
TRG_ENDOCYTIC_2	120	123	PF00928	0.480
TRG_ER_diArg_1	169	172	PF00400	0.637
TRG_Pf-PMV_PEXEL_1	46	50	PF00026	0.526

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I450	Leptomonas seymouri	76%	100%
A0A0S4JLX4	Bodo saltans	51%	94%
A0A1X0P1L3	Trypanosomatidae	62%	100%
A0A3Q8IJK6	Leishmania donovani	97%	100%
A4HIJ2	Leishmania braziliensis	90%	100%
A4I5T6	Leishmania infantum	97%	100%
A6NDY0	Homo sapiens	31%	78%
B0BNE4	Rattus norvegicus	35%	80%
E9B131	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
Q28ZX3	Drosophila pseudoobscura pseudoobscura	33%	96%
Q54ZS8	Dictyostelium discoideum	28%	97%
Q5XFR0	Mus musculus	31%	79%
Q7KNF2	Drosophila melanogaster	32%	96%
Q93VI4	Arabidopsis thaliana	34%	95%
Q9FJN9	Arabidopsis thaliana	33%	98%
V5B7C6	Trypanosoma cruzi	60%	94%