EF-hand domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q733_LEIMA

TriTrypDb:

LmjF.30.2620 , LMJLV39_300033700 , LMJSD75_300033100

Length:

719

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q733

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q733

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	153	157	PF00656	0.591
CLV_C14_Caspase3-7	585	589	PF00656	0.659
CLV_NRD_NRD_1	389	391	PF00675	0.503
CLV_NRD_NRD_1	638	640	PF00675	0.710
CLV_NRD_NRD_1	644	646	PF00675	0.647
CLV_NRD_NRD_1	665	667	PF00675	0.701
CLV_NRD_NRD_1	701	703	PF00675	0.650
CLV_PCSK_FUR_1	663	667	PF00082	0.683
CLV_PCSK_KEX2_1	130	132	PF00082	0.746
CLV_PCSK_KEX2_1	248	250	PF00082	0.617
CLV_PCSK_KEX2_1	389	391	PF00082	0.503
CLV_PCSK_KEX2_1	601	603	PF00082	0.683
CLV_PCSK_KEX2_1	644	646	PF00082	0.697
CLV_PCSK_KEX2_1	665	667	PF00082	0.701
CLV_PCSK_KEX2_1	701	703	PF00082	0.650
CLV_PCSK_PC1ET2_1	130	132	PF00082	0.746
CLV_PCSK_PC1ET2_1	248	250	PF00082	0.617
CLV_PCSK_PC1ET2_1	601	603	PF00082	0.683
CLV_PCSK_SKI1_1	360	364	PF00082	0.525
CLV_PCSK_SKI1_1	389	393	PF00082	0.535
CLV_PCSK_SKI1_1	441	445	PF00082	0.520
DEG_APCC_DBOX_1	488	496	PF00400	0.562
DEG_Nend_UBRbox_2	1	3	PF02207	0.733
DEG_SPOP_SBC_1	17	21	PF00917	0.619
DEG_SPOP_SBC_1	220	224	PF00917	0.722
DOC_CDC14_PxL_1	559	567	PF14671	0.746
DOC_CKS1_1	413	418	PF01111	0.553
DOC_CYCLIN_RxL_1	506	516	PF00134	0.542
DOC_MAPK_DCC_7	557	567	PF00069	0.714
DOC_MAPK_gen_1	198	207	PF00069	0.661
DOC_MAPK_gen_1	397	404	PF00069	0.595
DOC_MAPK_gen_1	509	519	PF00069	0.553
DOC_PP1_RVXF_1	363	369	PF00149	0.489
DOC_PP2B_LxvP_1	565	568	PF13499	0.740
DOC_SPAK_OSR1_1	673	677	PF12202	0.714
DOC_USP7_MATH_1	149	153	PF00917	0.780
DOC_USP7_MATH_1	154	158	PF00917	0.709
DOC_USP7_MATH_1	161	165	PF00917	0.627
DOC_USP7_MATH_1	17	21	PF00917	0.619
DOC_USP7_MATH_1	180	184	PF00917	0.569
DOC_USP7_MATH_1	221	225	PF00917	0.737
DOC_USP7_MATH_1	298	302	PF00917	0.757
DOC_USP7_MATH_1	305	309	PF00917	0.754
DOC_USP7_MATH_1	34	38	PF00917	0.786
DOC_USP7_MATH_1	649	653	PF00917	0.792
DOC_USP7_MATH_1	90	94	PF00917	0.728
DOC_USP7_MATH_2	23	29	PF00917	0.686
DOC_USP7_UBL2_3	292	296	PF12436	0.593
DOC_USP7_UBL2_3	626	630	PF12436	0.767
DOC_WW_Pin1_4	227	232	PF00397	0.802
DOC_WW_Pin1_4	241	246	PF00397	0.586
DOC_WW_Pin1_4	41	46	PF00397	0.620
DOC_WW_Pin1_4	412	417	PF00397	0.615
DOC_WW_Pin1_4	66	71	PF00397	0.729
LIG_14-3-3_CanoR_1	200	206	PF00244	0.600
LIG_14-3-3_CanoR_1	277	287	PF00244	0.705
LIG_14-3-3_CanoR_1	352	356	PF00244	0.552
LIG_14-3-3_CanoR_1	577	583	PF00244	0.723
LIG_Actin_WH2_2	406	424	PF00022	0.587
LIG_APCC_ABBA_1	511	516	PF00400	0.547
LIG_APCC_ABBAyCdc20_2	102	108	PF00400	0.605
LIG_BRCT_BRCA1_1	353	357	PF00533	0.613
LIG_BRCT_BRCA1_1	436	440	PF00533	0.531
LIG_BRCT_BRCA1_1	670	674	PF00533	0.698
LIG_Clathr_ClatBox_1	517	521	PF01394	0.487
LIG_eIF4E_1	514	520	PF01652	0.544
LIG_FHA_1	485	491	PF00498	0.576
LIG_FHA_1	506	512	PF00498	0.589
LIG_FHA_1	617	623	PF00498	0.594
LIG_FHA_2	206	212	PF00498	0.554
LIG_FHA_2	437	443	PF00498	0.518
LIG_FHA_2	55	61	PF00498	0.734
LIG_FHA_2	583	589	PF00498	0.668
LIG_FHA_2	657	663	PF00498	0.761
LIG_FHA_2	67	73	PF00498	0.698
LIG_LIR_Gen_1	367	375	PF02991	0.492
LIG_LIR_Gen_1	456	463	PF02991	0.572
LIG_LIR_Nem_3	367	371	PF02991	0.483
LIG_LIR_Nem_3	437	443	PF02991	0.518
LIG_LIR_Nem_3	456	460	PF02991	0.565
LIG_LIR_Nem_3	609	615	PF02991	0.705
LIG_LYPXL_yS_3	612	615	PF13949	0.706
LIG_NRBOX	406	412	PF00104	0.589
LIG_PCNA_yPIPBox_3	680	694	PF02747	0.681
LIG_SH2_NCK_1	109	113	PF00017	0.790
LIG_SH2_NCK_1	336	340	PF00017	0.540
LIG_SH2_SRC	109	112	PF00017	0.790
LIG_SH2_STAP1	216	220	PF00017	0.651
LIG_SH2_STAP1	514	518	PF00017	0.549
LIG_SH2_STAP1	546	550	PF00017	0.737
LIG_SH2_STAT3	332	335	PF00017	0.554
LIG_SH2_STAT3	716	719	PF00017	0.652
LIG_SH2_STAT5	212	215	PF00017	0.708
LIG_SH2_STAT5	332	335	PF00017	0.587
LIG_SH3_1	475	481	PF00018	0.530
LIG_SH3_1	557	563	PF00018	0.708
LIG_SH3_2	167	172	PF14604	0.586
LIG_SH3_3	164	170	PF00018	0.746
LIG_SH3_3	261	267	PF00018	0.644
LIG_SH3_3	475	481	PF00018	0.530
LIG_SH3_3	557	563	PF00018	0.722
LIG_SH3_3	679	685	PF00018	0.789
LIG_SUMO_SIM_anti_2	409	415	PF11976	0.517
LIG_SUMO_SIM_par_1	266	272	PF11976	0.718
LIG_TRAF2_1	23	26	PF00917	0.668
LIG_TRAF2_1	69	72	PF00917	0.640
LIG_UBA3_1	391	399	PF00899	0.534
LIG_UBA3_1	459	468	PF00899	0.498
LIG_UBA3_1	708	717	PF00899	0.623
MOD_CDK_SPxxK_3	241	248	PF00069	0.711
MOD_CK1_1	150	156	PF00069	0.712
MOD_CK1_1	174	180	PF00069	0.758
MOD_CK1_1	201	207	PF00069	0.619
MOD_CK1_1	219	225	PF00069	0.646
MOD_CK1_1	244	250	PF00069	0.781
MOD_CK1_1	252	258	PF00069	0.682
MOD_CK1_1	280	286	PF00069	0.766
MOD_CK1_1	308	314	PF00069	0.715
MOD_CK1_1	331	337	PF00069	0.679
MOD_CK1_1	41	47	PF00069	0.770
MOD_CK1_1	584	590	PF00069	0.729
MOD_CK1_1	616	622	PF00069	0.625
MOD_CK1_1	661	667	PF00069	0.740
MOD_CK1_1	95	101	PF00069	0.615
MOD_CK2_1	154	160	PF00069	0.759
MOD_CK2_1	32	38	PF00069	0.848
MOD_CK2_1	417	423	PF00069	0.583
MOD_CK2_1	54	60	PF00069	0.784
MOD_CK2_1	66	72	PF00069	0.636
MOD_CK2_1	95	101	PF00069	0.718
MOD_Cter_Amidation	128	131	PF01082	0.602
MOD_GlcNHglycan	149	152	PF01048	0.747
MOD_GlcNHglycan	163	166	PF01048	0.641
MOD_GlcNHglycan	173	176	PF01048	0.623
MOD_GlcNHglycan	283	286	PF01048	0.707
MOD_GlcNHglycan	318	321	PF01048	0.676
MOD_GlcNHglycan	381	384	PF01048	0.525
MOD_GlcNHglycan	64	67	PF01048	0.823
MOD_GSK3_1	150	157	PF00069	0.721
MOD_GSK3_1	201	208	PF00069	0.621
MOD_GSK3_1	216	223	PF00069	0.657
MOD_GSK3_1	249	256	PF00069	0.715
MOD_GSK3_1	269	276	PF00069	0.672
MOD_GSK3_1	277	284	PF00069	0.712
MOD_GSK3_1	292	299	PF00069	0.636
MOD_GSK3_1	30	37	PF00069	0.832
MOD_GSK3_1	308	315	PF00069	0.686
MOD_GSK3_1	331	338	PF00069	0.654
MOD_GSK3_1	40	47	PF00069	0.608
MOD_GSK3_1	607	614	PF00069	0.721
MOD_GSK3_1	62	69	PF00069	0.797
MOD_GSK3_1	707	714	PF00069	0.666
MOD_GSK3_1	71	78	PF00069	0.718
MOD_N-GLC_1	249	254	PF02516	0.704
MOD_N-GLC_1	607	612	PF02516	0.673
MOD_NEK2_1	278	283	PF00069	0.688
MOD_NEK2_1	40	45	PF00069	0.726
MOD_NEK2_1	436	441	PF00069	0.472
MOD_NEK2_1	615	620	PF00069	0.712
MOD_NEK2_1	92	97	PF00069	0.668
MOD_NEK2_2	417	422	PF00069	0.594
MOD_PIKK_1	174	180	PF00454	0.743
MOD_PIKK_1	331	337	PF00454	0.552
MOD_PIKK_1	707	713	PF00454	0.726
MOD_PIKK_1	75	81	PF00454	0.690
MOD_PIKK_1	92	98	PF00454	0.667
MOD_PKA_1	130	136	PF00069	0.679
MOD_PKA_1	292	298	PF00069	0.603
MOD_PKA_2	130	136	PF00069	0.749
MOD_PKA_2	144	150	PF00069	0.607
MOD_PKA_2	171	177	PF00069	0.607
MOD_PKA_2	252	258	PF00069	0.776
MOD_PKA_2	278	284	PF00069	0.746
MOD_PKA_2	351	357	PF00069	0.615
MOD_PKA_2	576	582	PF00069	0.757
MOD_PKA_2	616	622	PF00069	0.625
MOD_PKB_1	277	285	PF00069	0.627
MOD_Plk_1	249	255	PF00069	0.701
MOD_Plk_1	328	334	PF00069	0.649
MOD_Plk_1	70	76	PF00069	0.734
MOD_Plk_2-3	400	406	PF00069	0.536
MOD_Plk_4	328	334	PF00069	0.583
MOD_Plk_4	711	717	PF00069	0.680
MOD_ProDKin_1	227	233	PF00069	0.805
MOD_ProDKin_1	241	247	PF00069	0.586
MOD_ProDKin_1	41	47	PF00069	0.620
MOD_ProDKin_1	412	418	PF00069	0.613
MOD_ProDKin_1	66	72	PF00069	0.729
MOD_SUMO_rev_2	47	57	PF00179	0.786
TRG_DiLeu_BaEn_1	515	520	PF01217	0.544
TRG_DiLeu_BaEn_2	422	428	PF01217	0.538
TRG_ENDOCYTIC_2	457	460	PF00928	0.562
TRG_ENDOCYTIC_2	514	517	PF00928	0.554
TRG_ENDOCYTIC_2	612	615	PF00928	0.706
TRG_ER_diArg_1	389	391	PF00400	0.499
TRG_ER_diArg_1	450	453	PF00400	0.521
TRG_ER_diArg_1	644	647	PF00400	0.708
TRG_ER_diArg_1	663	666	PF00400	0.510
TRG_ER_diArg_1	701	703	PF00400	0.650
TRG_Pf-PMV_PEXEL_1	475	480	PF00026	0.497
TRG_Pf-PMV_PEXEL_1	701	705	PF00026	0.625

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IEY6	Leishmania donovani	89%	100%
A4HIJ3	Leishmania braziliensis	58%	98%
A4I5T8	Leishmania infantum	89%	100%
E9B132	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%