Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q731_LEIMA

TriTrypDb:

LmjF.30.2640 , LMJLV39_300033900 , LMJSD75_300033300

Length:

831

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q731

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q731

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	360	364	PF00656	0.376
CLV_MEL_PAP_1	47	53	PF00089	0.432
CLV_NRD_NRD_1	325	327	PF00675	0.395
CLV_NRD_NRD_1	396	398	PF00675	0.370
CLV_NRD_NRD_1	440	442	PF00675	0.404
CLV_NRD_NRD_1	626	628	PF00675	0.674
CLV_NRD_NRD_1	744	746	PF00675	0.784
CLV_NRD_NRD_1	819	821	PF00675	0.585
CLV_PCSK_KEX2_1	253	255	PF00082	0.425
CLV_PCSK_KEX2_1	295	297	PF00082	0.438
CLV_PCSK_KEX2_1	325	327	PF00082	0.395
CLV_PCSK_KEX2_1	396	398	PF00082	0.370
CLV_PCSK_KEX2_1	626	628	PF00082	0.674
CLV_PCSK_KEX2_1	682	684	PF00082	0.783
CLV_PCSK_KEX2_1	743	745	PF00082	0.851
CLV_PCSK_KEX2_1	819	821	PF00082	0.585
CLV_PCSK_PC1ET2_1	253	255	PF00082	0.540
CLV_PCSK_PC1ET2_1	295	297	PF00082	0.438
CLV_PCSK_PC1ET2_1	682	684	PF00082	0.783
CLV_PCSK_SKI1_1	253	257	PF00082	0.417
CLV_PCSK_SKI1_1	296	300	PF00082	0.391
CLV_PCSK_SKI1_1	381	385	PF00082	0.401
CLV_PCSK_SKI1_1	520	524	PF00082	0.686
CLV_PCSK_SKI1_1	826	830	PF00082	0.679
DEG_APCC_DBOX_1	295	303	PF00400	0.389
DEG_APCC_DBOX_1	396	404	PF00400	0.322
DEG_APCC_DBOX_1	519	527	PF00400	0.688
DEG_Nend_UBRbox_2	1	3	PF02207	0.459
DEG_SPOP_SBC_1	283	287	PF00917	0.427
DOC_CDC14_PxL_1	96	104	PF14671	0.524
DOC_CYCLIN_RxL_1	376	388	PF00134	0.391
DOC_CYCLIN_yCln2_LP_2	424	430	PF00134	0.385
DOC_MAPK_DCC_7	313	321	PF00069	0.374
DOC_MAPK_gen_1	119	129	PF00069	0.444
DOC_MAPK_gen_1	253	262	PF00069	0.506
DOC_MAPK_gen_1	396	405	PF00069	0.351
DOC_MAPK_gen_1	417	424	PF00069	0.421
DOC_MAPK_gen_1	527	535	PF00069	0.576
DOC_MAPK_HePTP_8	395	407	PF00069	0.327
DOC_MAPK_MEF2A_6	104	113	PF00069	0.592
DOC_MAPK_MEF2A_6	122	129	PF00069	0.370
DOC_MAPK_MEF2A_6	301	310	PF00069	0.474
DOC_MAPK_MEF2A_6	349	357	PF00069	0.347
DOC_MAPK_MEF2A_6	398	407	PF00069	0.321
DOC_PP2B_LxvP_1	761	764	PF13499	0.739
DOC_SPAK_OSR1_1	50	54	PF12202	0.512
DOC_USP7_MATH_1	138	142	PF00917	0.409
DOC_USP7_MATH_1	226	230	PF00917	0.443
DOC_USP7_MATH_1	239	243	PF00917	0.430
DOC_USP7_MATH_1	283	287	PF00917	0.383
DOC_USP7_MATH_1	370	374	PF00917	0.370
DOC_USP7_MATH_1	386	390	PF00917	0.320
DOC_USP7_MATH_1	446	450	PF00917	0.373
DOC_USP7_MATH_1	460	464	PF00917	0.545
DOC_USP7_MATH_1	537	541	PF00917	0.769
DOC_USP7_MATH_1	569	573	PF00917	0.751
DOC_USP7_MATH_1	619	623	PF00917	0.765
DOC_USP7_MATH_1	690	694	PF00917	0.670
DOC_USP7_MATH_1	706	710	PF00917	0.626
DOC_USP7_MATH_1	768	772	PF00917	0.609
DOC_USP7_MATH_1	798	802	PF00917	0.644
DOC_USP7_MATH_1	806	810	PF00917	0.664
DOC_USP7_UBL2_3	136	140	PF12436	0.558
DOC_WW_Pin1_4	198	203	PF00397	0.536
DOC_WW_Pin1_4	222	227	PF00397	0.487
DOC_WW_Pin1_4	242	247	PF00397	0.343
DOC_WW_Pin1_4	312	317	PF00397	0.386
DOC_WW_Pin1_4	435	440	PF00397	0.429
DOC_WW_Pin1_4	456	461	PF00397	0.523
DOC_WW_Pin1_4	593	598	PF00397	0.677
DOC_WW_Pin1_4	627	632	PF00397	0.699
DOC_WW_Pin1_4	633	638	PF00397	0.740
DOC_WW_Pin1_4	673	678	PF00397	0.802
DOC_WW_Pin1_4	686	691	PF00397	0.587
DOC_WW_Pin1_4	743	748	PF00397	0.775
DOC_WW_Pin1_4	794	799	PF00397	0.678
LIG_14-3-3_CanoR_1	122	126	PF00244	0.442
LIG_14-3-3_CanoR_1	254	264	PF00244	0.492
LIG_14-3-3_CanoR_1	326	336	PF00244	0.450
LIG_14-3-3_CanoR_1	445	451	PF00244	0.375
LIG_14-3-3_CanoR_1	50	54	PF00244	0.522
LIG_14-3-3_CanoR_1	511	515	PF00244	0.611
LIG_14-3-3_CanoR_1	531	536	PF00244	0.579
LIG_14-3-3_CanoR_1	591	597	PF00244	0.569
LIG_14-3-3_CanoR_1	626	630	PF00244	0.743
LIG_14-3-3_CanoR_1	697	701	PF00244	0.772
LIG_14-3-3_CanoR_1	813	819	PF00244	0.576
LIG_Actin_WH2_2	108	124	PF00022	0.428
LIG_Actin_WH2_2	351	369	PF00022	0.390
LIG_AP2alpha_1	193	197	PF02296	0.700
LIG_CtBP_PxDLS_1	777	781	PF00389	0.651
LIG_FHA_1	122	128	PF00498	0.454
LIG_FHA_1	158	164	PF00498	0.543
LIG_FHA_1	250	256	PF00498	0.437
LIG_FHA_1	285	291	PF00498	0.369
LIG_FHA_1	352	358	PF00498	0.402
LIG_FHA_1	582	588	PF00498	0.618
LIG_FHA_1	646	652	PF00498	0.716
LIG_FHA_2	190	196	PF00498	0.692
LIG_FHA_2	206	212	PF00498	0.509
LIG_FHA_2	44	50	PF00498	0.464
LIG_GBD_Chelix_1	379	387	PF00786	0.390
LIG_LIR_Apic_2	602	608	PF02991	0.660
LIG_LIR_Gen_1	147	156	PF02991	0.458
LIG_LIR_Gen_1	189	197	PF02991	0.620
LIG_LIR_Gen_1	263	272	PF02991	0.315
LIG_LIR_Gen_1	56	67	PF02991	0.544
LIG_LIR_Nem_3	147	151	PF02991	0.404
LIG_LIR_Nem_3	189	193	PF02991	0.612
LIG_LIR_Nem_3	263	267	PF02991	0.307
LIG_LIR_Nem_3	56	62	PF02991	0.527
LIG_LIR_Nem_3	789	795	PF02991	0.676
LIG_MAD2	452	460	PF02301	0.458
LIG_NRBOX	174	180	PF00104	0.460
LIG_NRBOX	420	426	PF00104	0.397
LIG_NRBOX	495	501	PF00104	0.406
LIG_PDZ_Class_2	826	831	PF00595	0.651
LIG_Pex14_2	193	197	PF04695	0.700
LIG_PTB_Apo_2	495	502	PF02174	0.465
LIG_SH2_CRK	605	609	PF00017	0.655
LIG_SH2_CRK	792	796	PF00017	0.657
LIG_SH2_PTP2	114	117	PF00017	0.408
LIG_SH2_PTP2	352	355	PF00017	0.431
LIG_SH2_STAP1	164	168	PF00017	0.536
LIG_SH2_STAP1	664	668	PF00017	0.710
LIG_SH2_STAT3	272	275	PF00017	0.437
LIG_SH2_STAT5	114	117	PF00017	0.408
LIG_SH2_STAT5	148	151	PF00017	0.395
LIG_SH2_STAT5	272	275	PF00017	0.389
LIG_SH2_STAT5	352	355	PF00017	0.431
LIG_SH2_STAT5	40	43	PF00017	0.398
LIG_SH2_STAT5	402	405	PF00017	0.342
LIG_SH2_STAT5	432	435	PF00017	0.427
LIG_SH3_1	18	24	PF00018	0.595
LIG_SH3_3	18	24	PF00018	0.495
LIG_SH3_3	450	456	PF00018	0.411
LIG_SH3_3	613	619	PF00018	0.808
LIG_SH3_3	731	737	PF00018	0.623
LIG_SH3_3	757	763	PF00018	0.759
LIG_SUMO_SIM_anti_2	263	269	PF11976	0.307
LIG_SUMO_SIM_anti_2	285	292	PF11976	0.376
LIG_SUMO_SIM_anti_2	305	310	PF11976	0.212
LIG_SUMO_SIM_anti_2	354	360	PF11976	0.353
LIG_SUMO_SIM_anti_2	471	478	PF11976	0.565
LIG_SUMO_SIM_par_1	353	360	PF11976	0.371
LIG_TRAF2_1	754	757	PF00917	0.729
LIG_TYR_ITIM	400	405	PF00017	0.343
LIG_UBA3_1	30	38	PF00899	0.383
LIG_Vh1_VBS_1	273	291	PF01044	0.360
LIG_WRC_WIRS_1	227	232	PF05994	0.431
LIG_WW_3	762	766	PF00397	0.683
MOD_CDC14_SPxK_1	438	441	PF00782	0.425
MOD_CDC14_SPxK_1	689	692	PF00782	0.720
MOD_CDK_SPK_2	456	461	PF00069	0.595
MOD_CDK_SPK_2	633	638	PF00069	0.591
MOD_CDK_SPxK_1	435	441	PF00069	0.429
MOD_CDK_SPxK_1	686	692	PF00069	0.730
MOD_CDK_SPxxK_3	435	442	PF00069	0.425
MOD_CK1_1	174	180	PF00069	0.576
MOD_CK1_1	189	195	PF00069	0.491
MOD_CK1_1	198	204	PF00069	0.561
MOD_CK1_1	225	231	PF00069	0.562
MOD_CK1_1	242	248	PF00069	0.395
MOD_CK1_1	286	292	PF00069	0.296
MOD_CK1_1	359	365	PF00069	0.532
MOD_CK1_1	43	49	PF00069	0.526
MOD_CK1_1	509	515	PF00069	0.599
MOD_CK1_1	518	524	PF00069	0.635
MOD_CK1_1	561	567	PF00069	0.713
MOD_CK1_1	572	578	PF00069	0.688
MOD_CK1_1	579	585	PF00069	0.591
MOD_CK1_1	636	642	PF00069	0.697
MOD_CK1_1	693	699	PF00069	0.684
MOD_CK1_1	801	807	PF00069	0.626
MOD_CK2_1	138	144	PF00069	0.408
MOD_CK2_1	43	49	PF00069	0.423
MOD_Cter_Amidation	624	627	PF01082	0.720
MOD_DYRK1A_RPxSP_1	627	631	PF00069	0.711
MOD_GlcNHglycan	247	250	PF01048	0.489
MOD_GlcNHglycan	296	299	PF01048	0.402
MOD_GlcNHglycan	336	339	PF01048	0.458
MOD_GlcNHglycan	359	362	PF01048	0.495
MOD_GlcNHglycan	388	391	PF01048	0.553
MOD_GlcNHglycan	514	517	PF01048	0.662
MOD_GlcNHglycan	560	563	PF01048	0.653
MOD_GlcNHglycan	621	624	PF01048	0.786
MOD_GlcNHglycan	631	634	PF01048	0.632
MOD_GlcNHglycan	678	681	PF01048	0.686
MOD_GlcNHglycan	708	711	PF01048	0.726
MOD_GlcNHglycan	740	743	PF01048	0.674
MOD_GlcNHglycan	801	804	PF01048	0.630
MOD_GSK3_1	134	141	PF00069	0.435
MOD_GSK3_1	182	189	PF00069	0.560
MOD_GSK3_1	193	200	PF00069	0.642
MOD_GSK3_1	218	225	PF00069	0.621
MOD_GSK3_1	245	252	PF00069	0.559
MOD_GSK3_1	282	289	PF00069	0.327
MOD_GSK3_1	328	335	PF00069	0.452
MOD_GSK3_1	338	345	PF00069	0.362
MOD_GSK3_1	382	389	PF00069	0.370
MOD_GSK3_1	456	463	PF00069	0.518
MOD_GSK3_1	502	509	PF00069	0.520
MOD_GSK3_1	518	525	PF00069	0.692
MOD_GSK3_1	569	576	PF00069	0.736
MOD_GSK3_1	595	602	PF00069	0.689
MOD_GSK3_1	625	632	PF00069	0.674
MOD_GSK3_1	63	70	PF00069	0.449
MOD_GSK3_1	645	652	PF00069	0.717
MOD_GSK3_1	655	662	PF00069	0.612
MOD_GSK3_1	686	693	PF00069	0.639
MOD_GSK3_1	794	801	PF00069	0.626
MOD_N-GLC_1	558	563	PF02516	0.751
MOD_N-GLC_1	649	654	PF02516	0.597
MOD_N-GLC_1	673	678	PF02516	0.694
MOD_N-GLC_1	798	803	PF02516	0.565
MOD_NEK2_1	121	126	PF00069	0.432
MOD_NEK2_1	13	18	PF00069	0.464
MOD_NEK2_1	151	156	PF00069	0.429
MOD_NEK2_1	186	191	PF00069	0.560
MOD_NEK2_1	193	198	PF00069	0.599
MOD_NEK2_1	255	260	PF00069	0.506
MOD_NEK2_1	506	511	PF00069	0.547
MOD_NEK2_1	522	527	PF00069	0.757
MOD_NEK2_1	590	595	PF00069	0.686
MOD_NEK2_1	63	68	PF00069	0.438
MOD_NEK2_2	40	45	PF00069	0.382
MOD_PIKK_1	255	261	PF00454	0.500
MOD_PIKK_1	338	344	PF00454	0.330
MOD_PIKK_1	515	521	PF00454	0.737
MOD_PIKK_1	812	818	PF00454	0.718
MOD_PK_1	659	665	PF00069	0.671
MOD_PKA_1	325	331	PF00069	0.401
MOD_PKA_2	121	127	PF00069	0.436
MOD_PKA_2	325	331	PF00069	0.584
MOD_PKA_2	460	466	PF00069	0.584
MOD_PKA_2	49	55	PF00069	0.478
MOD_PKA_2	510	516	PF00069	0.607
MOD_PKA_2	572	578	PF00069	0.641
MOD_PKA_2	590	596	PF00069	0.542
MOD_PKA_2	625	631	PF00069	0.654
MOD_PKA_2	696	702	PF00069	0.768
MOD_PKA_2	812	818	PF00069	0.602
MOD_PKB_1	529	537	PF00069	0.613
MOD_Plk_1	138	144	PF00069	0.408
MOD_Plk_1	182	188	PF00069	0.640
MOD_Plk_2-3	49	55	PF00069	0.478
MOD_Plk_4	174	180	PF00069	0.589
MOD_Plk_4	2	8	PF00069	0.451
MOD_Plk_4	226	232	PF00069	0.438
MOD_Plk_4	286	292	PF00069	0.296
MOD_Plk_4	379	385	PF00069	0.460
MOD_Plk_4	446	452	PF00069	0.378
MOD_Plk_4	502	508	PF00069	0.505
MOD_Plk_4	54	60	PF00069	0.558
MOD_Plk_4	659	665	PF00069	0.629
MOD_ProDKin_1	198	204	PF00069	0.535
MOD_ProDKin_1	222	228	PF00069	0.488
MOD_ProDKin_1	242	248	PF00069	0.355
MOD_ProDKin_1	312	318	PF00069	0.394
MOD_ProDKin_1	435	441	PF00069	0.429
MOD_ProDKin_1	456	462	PF00069	0.520
MOD_ProDKin_1	593	599	PF00069	0.678
MOD_ProDKin_1	627	633	PF00069	0.700
MOD_ProDKin_1	673	679	PF00069	0.804
MOD_ProDKin_1	686	692	PF00069	0.588
MOD_ProDKin_1	743	749	PF00069	0.775
MOD_ProDKin_1	794	800	PF00069	0.681
MOD_SUMO_for_1	127	130	PF00179	0.473
MOD_SUMO_rev_2	130	138	PF00179	0.451
MOD_SUMO_rev_2	823	828	PF00179	0.580
TRG_DiLeu_BaEn_1	420	425	PF01217	0.403
TRG_DiLeu_BaEn_2	146	152	PF01217	0.444
TRG_DiLeu_BaEn_2	501	507	PF01217	0.485
TRG_DiLeu_BaEn_4	756	762	PF01217	0.670
TRG_DiLeu_BaLyEn_6	462	467	PF01217	0.552
TRG_DiLeu_BaLyEn_6	731	736	PF01217	0.608
TRG_ENDOCYTIC_2	114	117	PF00928	0.408
TRG_ENDOCYTIC_2	148	151	PF00928	0.444
TRG_ENDOCYTIC_2	352	355	PF00928	0.431
TRG_ENDOCYTIC_2	402	405	PF00928	0.342
TRG_ENDOCYTIC_2	792	795	PF00928	0.659
TRG_ER_diArg_1	324	326	PF00400	0.380
TRG_ER_diArg_1	395	397	PF00400	0.373
TRG_ER_diArg_1	526	529	PF00400	0.641
TRG_ER_diArg_1	743	745	PF00400	0.707
TRG_ER_diArg_1	818	820	PF00400	0.581
TRG_NES_CRM1_1	278	294	PF08389	0.383
TRG_NLS_Bipartite_1	235	257	PF00514	0.566
TRG_Pf-PMV_PEXEL_1	45	49	PF00026	0.467
TRG_Pf-PMV_PEXEL_1	820	824	PF00026	0.572

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P525	Leptomonas seymouri	54%	96%
A0A3Q8II38	Leishmania donovani	93%	100%
A4HIJ6	Leishmania braziliensis	73%	100%
A4I5U0	Leishmania infantum	93%	100%
E9B135	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%