Ubiquitin-like domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q729_LEIMA

TriTrypDb:

LmjF.30.2650 , LMJLV39_300034100 , LMJSD75_300033500

Length:

156

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	2
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

Q4Q729

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q729

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	147	151	PF00656	0.586
CLV_NRD_NRD_1	28	30	PF00675	0.421
CLV_PCSK_FUR_1	23	27	PF00082	0.323
CLV_PCSK_KEX2_1	25	27	PF00082	0.328
CLV_PCSK_KEX2_1	28	30	PF00082	0.386
CLV_PCSK_PC1ET2_1	25	27	PF00082	0.444
CLV_PCSK_SKI1_1	29	33	PF00082	0.472
DOC_MAPK_gen_1	23	33	PF00069	0.349
LIG_14-3-3_CanoR_1	55	61	PF00244	0.392
LIG_14-3-3_CanoR_1	68	76	PF00244	0.469
LIG_APCC_ABBA_1	31	36	PF00400	0.348
LIG_BRCT_BRCA1_1	53	57	PF00533	0.480
LIG_BRCT_BRCA1_1	72	76	PF00533	0.280
LIG_FHA_1	11	17	PF00498	0.544
LIG_FHA_1	147	153	PF00498	0.537
LIG_FHA_1	28	34	PF00498	0.392
LIG_FHA_1	57	63	PF00498	0.343
LIG_FHA_1	64	70	PF00498	0.386
LIG_FHA_2	145	151	PF00498	0.583
LIG_FHA_2	99	105	PF00498	0.537
LIG_LIR_Gen_1	100	111	PF02991	0.399
LIG_LIR_Nem_3	100	106	PF02991	0.304
LIG_LIR_Nem_3	85	91	PF02991	0.423
LIG_MYND_1	118	122	PF01753	0.479
LIG_PDZ_Class_2	151	156	PF00595	0.562
LIG_SH2_STAP1	58	62	PF00017	0.354
LIG_SH2_STAT3	64	67	PF00017	0.496
LIG_SH2_STAT5	21	24	PF00017	0.351
LIG_SH2_STAT5	34	37	PF00017	0.343
LIG_SH2_STAT5	58	61	PF00017	0.342
LIG_SUMO_SIM_anti_2	149	156	PF11976	0.530
MOD_CK1_1	70	76	PF00069	0.394
MOD_CK2_1	98	104	PF00069	0.535
MOD_GlcNHglycan	76	79	PF01048	0.390
MOD_GSK3_1	125	132	PF00069	0.630
MOD_GSK3_1	142	149	PF00069	0.707
MOD_GSK3_1	63	70	PF00069	0.441
MOD_GSK3_1	74	81	PF00069	0.530
MOD_GSK3_1	89	96	PF00069	0.374
MOD_NEK2_1	1	6	PF00069	0.645
MOD_NEK2_1	129	134	PF00069	0.505
MOD_NEK2_1	76	81	PF00069	0.374
MOD_PIKK_1	63	69	PF00454	0.358
MOD_PKA_2	27	33	PF00069	0.478
MOD_PKA_2	67	73	PF00069	0.485
MOD_Plk_1	70	76	PF00069	0.392
MOD_Plk_2-3	98	104	PF00069	0.473
MOD_Plk_4	71	77	PF00069	0.373
MOD_Plk_4	98	104	PF00069	0.578
TRG_ENDOCYTIC_2	21	24	PF00928	0.362
TRG_ENDOCYTIC_2	34	37	PF00928	0.386
TRG_ER_diArg_1	26	29	PF00400	0.382
TRG_NLS_MonoExtC_3	24	29	PF00514	0.464
TRG_NLS_MonoExtN_4	23	29	PF00514	0.462

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5G5	Leptomonas seymouri	72%	100%
A0A3Q8IS54	Leishmania donovani	96%	100%
A0A3R7LZP3	Trypanosoma rangeli	51%	99%
A4HIJ8	Leishmania braziliensis	74%	100%
A4I5U2	Leishmania infantum	96%	100%
C9ZR62	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	98%
E9B137	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5DP06	Trypanosoma cruzi	48%	99%