Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q728_LEIMA

TriTrypDb:

LmjF.30.2660 , LMJLV39_300034200 , LMJSD75_300033600

Length:

503

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q728

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q728

PDB structure(s): 7aih_Aj , 7am2_Aj , 7ane_Aj

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	140	142	PF00675	0.552
CLV_NRD_NRD_1	195	197	PF00675	0.634
CLV_NRD_NRD_1	257	259	PF00675	0.461
CLV_NRD_NRD_1	31	33	PF00675	0.439
CLV_NRD_NRD_1	338	340	PF00675	0.372
CLV_NRD_NRD_1	389	391	PF00675	0.370
CLV_NRD_NRD_1	39	41	PF00675	0.416
CLV_NRD_NRD_1	417	419	PF00675	0.431
CLV_NRD_NRD_1	475	477	PF00675	0.421
CLV_NRD_NRD_1	79	81	PF00675	0.416
CLV_PCSK_FUR_1	37	41	PF00082	0.416
CLV_PCSK_KEX2_1	195	197	PF00082	0.599
CLV_PCSK_KEX2_1	257	259	PF00082	0.449
CLV_PCSK_KEX2_1	338	340	PF00082	0.372
CLV_PCSK_KEX2_1	37	39	PF00082	0.413
CLV_PCSK_KEX2_1	416	418	PF00082	0.432
CLV_PCSK_KEX2_1	475	477	PF00082	0.419
CLV_PCSK_PC1ET2_1	416	418	PF00082	0.521
CLV_PCSK_PC7_1	412	418	PF00082	0.515
CLV_PCSK_SKI1_1	105	109	PF00082	0.449
CLV_PCSK_SKI1_1	11	15	PF00082	0.396
CLV_PCSK_SKI1_1	33	37	PF00082	0.425
CLV_PCSK_SKI1_1	396	400	PF00082	0.364
CLV_PCSK_SKI1_1	443	447	PF00082	0.405
CLV_Separin_Metazoa	430	434	PF03568	0.427
DEG_Nend_UBRbox_4	1	3	PF02207	0.443
DEG_SPOP_SBC_1	148	152	PF00917	0.736
DOC_AGCK_PIF_2	351	356	PF00069	0.339
DOC_CDC14_PxL_1	15	23	PF14671	0.397
DOC_CDC14_PxL_1	330	338	PF14671	0.351
DOC_MAPK_DCC_7	57	66	PF00069	0.387
DOC_MAPK_gen_1	195	201	PF00069	0.508
DOC_MAPK_gen_1	335	344	PF00069	0.405
DOC_MAPK_gen_1	37	47	PF00069	0.418
DOC_MAPK_gen_1	377	386	PF00069	0.520
DOC_MAPK_MEF2A_6	11	18	PF00069	0.395
DOC_MAPK_RevD_3	381	397	PF00069	0.461
DOC_PP1_RVXF_1	345	352	PF00149	0.353
DOC_PP2B_LxvP_1	449	452	PF13499	0.421
DOC_PP2B_LxvP_1	67	70	PF13499	0.379
DOC_PP4_FxxP_1	72	75	PF00568	0.398
DOC_USP7_MATH_1	147	151	PF00917	0.755
DOC_USP7_MATH_1	93	97	PF00917	0.601
DOC_USP7_UBL2_3	490	494	PF12436	0.548
DOC_WW_Pin1_4	349	354	PF00397	0.342
DOC_WW_Pin1_4	424	429	PF00397	0.383
DOC_WW_Pin1_4	432	437	PF00397	0.407
DOC_WW_Pin1_4	59	64	PF00397	0.414
DOC_WW_Pin1_4	75	80	PF00397	0.392
LIG_14-3-3_CanoR_1	109	115	PF00244	0.391
LIG_14-3-3_CanoR_1	133	138	PF00244	0.545
LIG_14-3-3_CanoR_1	37	47	PF00244	0.479
LIG_14-3-3_CanoR_1	407	412	PF00244	0.398
LIG_BRCT_BRCA1_1	8	12	PF00533	0.417
LIG_CtBP_PxDLS_1	20	24	PF00389	0.401
LIG_EH1_1	326	334	PF00400	0.350
LIG_eIF4E_1	114	120	PF01652	0.531
LIG_eIF4E_1	60	66	PF01652	0.385
LIG_FHA_1	158	164	PF00498	0.600
LIG_FHA_1	172	178	PF00498	0.615
LIG_FHA_1	257	263	PF00498	0.456
LIG_FHA_1	40	46	PF00498	0.421
LIG_FHA_1	47	53	PF00498	0.397
LIG_FHA_2	165	171	PF00498	0.715
LIG_FHA_2	306	312	PF00498	0.409
LIG_FHA_2	425	431	PF00498	0.380
LIG_IBAR_NPY_1	472	474	PF08397	0.440
LIG_LIR_Apic_2	58	63	PF02991	0.382
LIG_LIR_Gen_1	345	356	PF02991	0.350
LIG_LIR_Gen_1	9	20	PF02991	0.391
LIG_LIR_Nem_3	108	114	PF02991	0.410
LIG_LIR_Nem_3	167	171	PF02991	0.656
LIG_LIR_Nem_3	225	230	PF02991	0.373
LIG_LIR_Nem_3	345	351	PF02991	0.356
LIG_LIR_Nem_3	355	359	PF02991	0.341
LIG_LIR_Nem_3	489	495	PF02991	0.428
LIG_LIR_Nem_3	9	15	PF02991	0.421
LIG_MAD2	465	473	PF02301	0.472
LIG_PCNA_yPIPBox_3	455	467	PF02747	0.573
LIG_PDZ_Class_2	498	503	PF00595	0.588
LIG_Pex14_2	340	344	PF04695	0.410
LIG_REV1ctd_RIR_1	396	406	PF16727	0.388
LIG_SH2_CRK	227	231	PF00017	0.368
LIG_SH2_CRK	356	360	PF00017	0.517
LIG_SH2_NCK_1	234	238	PF00017	0.382
LIG_SH2_NCK_1	356	360	PF00017	0.441
LIG_SH2_PTP2	198	201	PF00017	0.402
LIG_SH2_STAP1	111	115	PF00017	0.391
LIG_SH2_STAP1	234	238	PF00017	0.402
LIG_SH2_STAP1	356	360	PF00017	0.335
LIG_SH2_STAP1	447	451	PF00017	0.437
LIG_SH2_STAT5	111	114	PF00017	0.416
LIG_SH2_STAT5	198	201	PF00017	0.418
LIG_SH2_STAT5	213	216	PF00017	0.389
LIG_SH2_STAT5	350	353	PF00017	0.334
LIG_SH2_STAT5	495	498	PF00017	0.440
LIG_SH3_3	13	19	PF00018	0.396
LIG_SH3_3	191	197	PF00018	0.539
LIG_SH3_3	277	283	PF00018	0.500
LIG_SH3_3	67	73	PF00018	0.381
LIG_SH3_3	87	93	PF00018	0.622
LIG_SUMO_SIM_anti_2	162	167	PF11976	0.683
LIG_SUMO_SIM_anti_2	311	318	PF11976	0.337
LIG_SUMO_SIM_par_1	12	17	PF11976	0.402
LIG_SUMO_SIM_par_1	19	24	PF11976	0.440
LIG_TRFH_1	66	70	PF08558	0.383
LIG_TYR_ITIM	224	229	PF00017	0.496
MOD_CDC14_SPxK_1	78	81	PF00782	0.410
MOD_CDK_SPK_2	75	80	PF00069	0.402
MOD_CDK_SPxK_1	75	81	PF00069	0.404
MOD_CK1_1	151	157	PF00069	0.720
MOD_CK1_1	28	34	PF00069	0.443
MOD_CK1_1	323	329	PF00069	0.386
MOD_CK1_1	41	47	PF00069	0.420
MOD_CK2_1	305	311	PF00069	0.409
MOD_CK2_1	424	430	PF00069	0.382
MOD_Cter_Amidation	336	339	PF01082	0.357
MOD_GlcNHglycan	151	154	PF01048	0.725
MOD_GlcNHglycan	277	280	PF01048	0.475
MOD_GlcNHglycan	322	325	PF01048	0.384
MOD_GlcNHglycan	476	479	PF01048	0.375
MOD_GSK3_1	105	112	PF00069	0.418
MOD_GSK3_1	147	154	PF00069	0.678
MOD_GSK3_1	21	28	PF00069	0.407
MOD_GSK3_1	256	263	PF00069	0.488
MOD_GSK3_1	295	302	PF00069	0.512
MOD_GSK3_1	420	427	PF00069	0.400
MOD_GSK3_1	46	53	PF00069	0.419
MOD_GSK3_1	474	481	PF00069	0.372
MOD_GSK3_1	55	62	PF00069	0.413
MOD_NEK2_1	110	115	PF00069	0.405
MOD_NEK2_1	14	19	PF00069	0.391
MOD_NEK2_1	21	26	PF00069	0.412
MOD_NEK2_1	256	261	PF00069	0.410
MOD_NEK2_1	262	267	PF00069	0.378
MOD_NEK2_1	275	280	PF00069	0.246
MOD_NEK2_1	320	325	PF00069	0.482
MOD_NEK2_1	55	60	PF00069	0.395
MOD_NEK2_1	6	11	PF00069	0.411
MOD_NEK2_2	305	310	PF00069	0.465
MOD_PIKK_1	478	484	PF00454	0.555
MOD_PIKK_1	6	12	PF00454	0.387
MOD_PKA_1	38	44	PF00069	0.419
MOD_PKA_2	25	31	PF00069	0.451
MOD_PKA_2	256	262	PF00069	0.425
MOD_PKA_2	38	44	PF00069	0.443
MOD_PKA_2	474	480	PF00069	0.451
MOD_PKB_1	37	45	PF00069	0.419
MOD_Plk_2-3	164	170	PF00069	0.626
MOD_Plk_4	110	116	PF00069	0.412
MOD_Plk_4	305	311	PF00069	0.439
MOD_Plk_4	41	47	PF00069	0.420
MOD_Plk_4	50	56	PF00069	0.392
MOD_ProDKin_1	349	355	PF00069	0.348
MOD_ProDKin_1	424	430	PF00069	0.382
MOD_ProDKin_1	432	438	PF00069	0.407
MOD_ProDKin_1	59	65	PF00069	0.417
MOD_ProDKin_1	75	81	PF00069	0.395
MOD_SUMO_for_1	115	118	PF00179	0.440
MOD_SUMO_for_1	205	208	PF00179	0.415
MOD_SUMO_for_1	445	448	PF00179	0.420
MOD_SUMO_rev_2	392	399	PF00179	0.376
TRG_DiLeu_BaEn_1	312	317	PF01217	0.444
TRG_DiLeu_BaLyEn_6	328	333	PF01217	0.351
TRG_DiLeu_BaLyEn_6	60	65	PF01217	0.400
TRG_ENDOCYTIC_2	198	201	PF00928	0.402
TRG_ENDOCYTIC_2	226	229	PF00928	0.388
TRG_ENDOCYTIC_2	356	359	PF00928	0.522
TRG_ENDOCYTIC_2	442	445	PF00928	0.435
TRG_ER_diArg_1	194	196	PF00400	0.631
TRG_ER_diArg_1	256	258	PF00400	0.455
TRG_ER_diArg_1	338	340	PF00400	0.372
TRG_ER_diArg_1	37	40	PF00400	0.416
TRG_ER_diArg_1	474	476	PF00400	0.448
TRG_NES_CRM1_1	285	299	PF08389	0.323
TRG_Pf-PMV_PEXEL_1	385	389	PF00026	0.455

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P524	Leptomonas seymouri	79%	100%
A0A0S4JJI8	Bodo saltans	54%	100%
A0A1X0P1I0	Trypanosomatidae	62%	100%
A0A3Q8IC59	Leishmania donovani	95%	100%
A0A3S5IRF5	Trypanosoma rangeli	65%	100%
A4HIJ9	Leishmania braziliensis	87%	100%
A4I5U3	Leishmania infantum	95%	100%
C9ZR63	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	64%	100%
E9B138	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	97%
V5BSI7	Trypanosoma cruzi	64%	100%