Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q727_LEIMA

TriTrypDb:

LmjF.30.2670 , LMJLV39_300034300 , LMJSD75_300033700

Length:

368

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 9, no: 1
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

Q4Q727

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q727

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	109	113	PF00656	0.366
CLV_C14_Caspase3-7	274	278	PF00656	0.636
CLV_MEL_PAP_1	196	202	PF00089	0.515
CLV_NRD_NRD_1	10	12	PF00675	0.642
CLV_NRD_NRD_1	292	294	PF00675	0.545
CLV_PCSK_KEX2_1	10	12	PF00082	0.641
CLV_PCSK_KEX2_1	292	294	PF00082	0.497
CLV_PCSK_KEX2_1	319	321	PF00082	0.445
CLV_PCSK_PC1ET2_1	319	321	PF00082	0.445
CLV_PCSK_SKI1_1	186	190	PF00082	0.555
CLV_PCSK_SKI1_1	292	296	PF00082	0.536
DEG_APCC_DBOX_1	292	300	PF00400	0.262
DOC_AGCK_PIF_1	143	148	PF00069	0.282
DOC_ANK_TNKS_1	198	205	PF00023	0.322
DOC_CKS1_1	286	291	PF01111	0.361
DOC_CYCLIN_RxL_1	289	298	PF00134	0.254
DOC_MAPK_gen_1	172	181	PF00069	0.392
DOC_MAPK_gen_1	292	299	PF00069	0.296
DOC_MAPK_gen_1	319	325	PF00069	0.638
DOC_MAPK_MEF2A_6	172	181	PF00069	0.400
DOC_MAPK_MEF2A_6	292	301	PF00069	0.278
DOC_PP4_FxxP_1	165	168	PF00568	0.290
DOC_USP7_MATH_1	161	165	PF00917	0.330
DOC_USP7_MATH_1	266	270	PF00917	0.547
DOC_USP7_MATH_1	284	288	PF00917	0.476
DOC_USP7_MATH_1	307	311	PF00917	0.355
DOC_USP7_MATH_1	363	367	PF00917	0.691
DOC_USP7_MATH_1	5	9	PF00917	0.544
DOC_WW_Pin1_4	138	143	PF00397	0.449
DOC_WW_Pin1_4	173	178	PF00397	0.399
DOC_WW_Pin1_4	234	239	PF00397	0.293
DOC_WW_Pin1_4	241	246	PF00397	0.372
DOC_WW_Pin1_4	285	290	PF00397	0.535
LIG_14-3-3_CanoR_1	100	107	PF00244	0.432
LIG_14-3-3_CanoR_1	134	143	PF00244	0.368
LIG_14-3-3_CanoR_1	144	149	PF00244	0.231
LIG_14-3-3_CanoR_1	215	223	PF00244	0.456
LIG_BIR_II_1	1	5	PF00653	0.595
LIG_CtBP_PxDLS_1	82	86	PF00389	0.408
LIG_eIF4E_1	217	223	PF01652	0.357
LIG_FHA_1	174	180	PF00498	0.458
LIG_FHA_1	286	292	PF00498	0.475
LIG_FHA_1	96	102	PF00498	0.310
LIG_FHA_2	124	130	PF00498	0.310
LIG_FHA_2	216	222	PF00498	0.441
LIG_IRF3_LxIS_1	291	298	PF10401	0.331
LIG_LIR_Apic_2	162	168	PF02991	0.307
LIG_LIR_Apic_2	58	63	PF02991	0.371
LIG_LIR_Gen_1	298	308	PF02991	0.388
LIG_LIR_Gen_1	355	363	PF02991	0.706
LIG_LIR_Nem_3	141	146	PF02991	0.395
LIG_LIR_Nem_3	182	188	PF02991	0.394
LIG_LIR_Nem_3	298	303	PF02991	0.332
LIG_LIR_Nem_3	355	360	PF02991	0.681
LIG_NRBOX	24	30	PF00104	0.536
LIG_NRBOX	290	296	PF00104	0.346
LIG_Pex14_2	145	149	PF04695	0.365
LIG_Pex14_2	52	56	PF04695	0.423
LIG_Pex3_1	291	302	PF04882	0.296
LIG_PTB_Apo_2	93	100	PF02174	0.370
LIG_PTB_Phospho_1	93	99	PF10480	0.365
LIG_REV1ctd_RIR_1	146	152	PF16727	0.287
LIG_SH2_CRK	235	239	PF00017	0.352
LIG_SH2_CRK	357	361	PF00017	0.753
LIG_SH2_CRK	60	64	PF00017	0.306
LIG_SH2_GRB2like	94	97	PF00017	0.367
LIG_SH2_SRC	94	97	PF00017	0.367
LIG_SH2_STAT3	247	250	PF00017	0.295
LIG_SH2_STAT5	184	187	PF00017	0.296
LIG_SH2_STAT5	217	220	PF00017	0.388
LIG_SH2_STAT5	235	238	PF00017	0.292
LIG_SH2_STAT5	247	250	PF00017	0.369
LIG_SH2_STAT5	315	318	PF00017	0.680
LIG_SH2_STAT5	94	97	PF00017	0.367
LIG_SH3_1	174	180	PF00018	0.341
LIG_SH3_3	174	180	PF00018	0.338
LIG_SH3_3	185	191	PF00018	0.277
LIG_SH3_3	29	35	PF00018	0.519
LIG_SH3_3	38	44	PF00018	0.434
LIG_SUMO_SIM_anti_2	21	27	PF11976	0.522
LIG_SUMO_SIM_anti_2	72	78	PF11976	0.301
LIG_SUMO_SIM_par_1	24	30	PF11976	0.526
LIG_SUMO_SIM_par_1	293	298	PF11976	0.403
LIG_WRC_WIRS_1	145	150	PF05994	0.294
MOD_CDK_SPxK_1	138	144	PF00069	0.326
MOD_CDK_SPxxK_3	285	292	PF00069	0.433
MOD_CK1_1	269	275	PF00069	0.563
MOD_CK1_1	278	284	PF00069	0.534
MOD_CK2_1	123	129	PF00069	0.362
MOD_CK2_1	234	240	PF00069	0.451
MOD_CK2_1	251	257	PF00069	0.404
MOD_Cter_Amidation	317	320	PF01082	0.442
MOD_Cter_Amidation	8	11	PF01082	0.576
MOD_GlcNHglycan	20	23	PF01048	0.568
MOD_GlcNHglycan	200	203	PF01048	0.629
MOD_GlcNHglycan	211	214	PF01048	0.589
MOD_GlcNHglycan	218	221	PF01048	0.565
MOD_GlcNHglycan	226	229	PF01048	0.568
MOD_GlcNHglycan	273	276	PF01048	0.827
MOD_GlcNHglycan	309	312	PF01048	0.410
MOD_GlcNHglycan	330	333	PF01048	0.361
MOD_GlcNHglycan	5	8	PF01048	0.633
MOD_GSK3_1	134	141	PF00069	0.480
MOD_GSK3_1	266	273	PF00069	0.499
MOD_GSK3_1	278	285	PF00069	0.526
MOD_GSK3_1	95	102	PF00069	0.416
MOD_N-GLC_1	266	271	PF02516	0.728
MOD_N-GLC_1	95	100	PF02516	0.472
MOD_NEK2_1	18	23	PF00069	0.475
MOD_NEK2_1	233	238	PF00069	0.320
MOD_NEK2_1	239	244	PF00069	0.380
MOD_NEK2_1	295	300	PF00069	0.310
MOD_NEK2_1	347	352	PF00069	0.663
MOD_PIKK_1	246	252	PF00454	0.378
MOD_PIKK_1	282	288	PF00454	0.511
MOD_PIKK_1	347	353	PF00454	0.707
MOD_PKA_2	198	204	PF00069	0.336
MOD_PKA_2	278	284	PF00069	0.583
MOD_PKA_2	99	105	PF00069	0.420
MOD_Plk_1	161	167	PF00069	0.404
MOD_Plk_1	95	101	PF00069	0.296
MOD_Plk_2-3	203	209	PF00069	0.346
MOD_Plk_4	161	167	PF00069	0.351
MOD_Plk_4	179	185	PF00069	0.390
MOD_Plk_4	27	33	PF00069	0.539
MOD_ProDKin_1	138	144	PF00069	0.445
MOD_ProDKin_1	173	179	PF00069	0.399
MOD_ProDKin_1	234	240	PF00069	0.303
MOD_ProDKin_1	241	247	PF00069	0.363
MOD_ProDKin_1	285	291	PF00069	0.527
MOD_SUMO_rev_2	201	210	PF00179	0.457
TRG_DiLeu_BaEn_1	72	77	PF01217	0.271
TRG_DiLeu_BaLyEn_6	14	19	PF01217	0.567
TRG_DiLeu_BaLyEn_6	290	295	PF01217	0.440
TRG_ENDOCYTIC_2	314	317	PF00928	0.610
TRG_ENDOCYTIC_2	357	360	PF00928	0.711
TRG_ER_diArg_1	10	13	PF00400	0.555
TRG_ER_diArg_1	133	136	PF00400	0.389
TRG_ER_diArg_1	291	293	PF00400	0.449

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVT9	Leptomonas seymouri	46%	97%
A0A1X0P1M4	Trypanosomatidae	33%	94%
A0A3S7X3V1	Leishmania donovani	92%	100%
A0A422NM26	Trypanosoma rangeli	35%	96%
A4HIK0	Leishmania braziliensis	68%	100%
A4I5U4	Leishmania infantum	92%	100%
C9ZR64	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9B139	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5DNY7	Trypanosoma cruzi	35%	88%