LeishMANIAdb
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TPT domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
TPT domain-containing protein
Gene product:
Triose-phosphate Transporter family, putative
Species:
Leishmania major
UniProt:
Q4Q726_LEIMA
TriTrypDb:
LmjF.30.2680 , LMJLV39_300034400 , LMJSD75_300033800
Length:
325

Annotations

LeishMANIAdb annotations

Related to plant and animal nucleoside-sugar transporters, often localized to the Golgi apparatus.. An expanded family in kinetoplastids, possibly to cover the need for expanded proteoglycan biosynthesis. Localization: Golgi (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 20
NetGPI no yes: 0, no: 20
Cellular components
Term Name Level Count
GO:0005794 Golgi apparatus 5 3
GO:0016020 membrane 2 21
GO:0043226 organelle 2 3
GO:0043227 membrane-bounded organelle 3 3
GO:0043229 intracellular organelle 3 3
GO:0043231 intracellular membrane-bounded organelle 4 3
GO:0110165 cellular anatomical entity 1 21

Expansion

Sequence features

Q4Q726
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q726

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 3
GO:0005338 nucleotide-sugar transmembrane transporter activity 4 3
GO:0015291 secondary active transmembrane transporter activity 4 3
GO:0015297 antiporter activity 5 3
GO:0015932 nucleobase-containing compound transmembrane transporter activity 3 3
GO:0022804 active transmembrane transporter activity 3 3
GO:0022857 transmembrane transporter activity 2 3
GO:1901505 carbohydrate derivative transmembrane transporter activity 3 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 315 317 PF00675 0.468
CLV_NRD_NRD_1 70 72 PF00675 0.354
CLV_PCSK_KEX2_1 119 121 PF00082 0.241
CLV_PCSK_KEX2_1 25 27 PF00082 0.473
CLV_PCSK_KEX2_1 315 317 PF00082 0.329
CLV_PCSK_KEX2_1 70 72 PF00082 0.288
CLV_PCSK_PC1ET2_1 119 121 PF00082 0.273
CLV_PCSK_PC1ET2_1 25 27 PF00082 0.473
CLV_PCSK_SKI1_1 26 30 PF00082 0.477
CLV_PCSK_SKI1_1 60 64 PF00082 0.279
CLV_PCSK_SKI1_1 70 74 PF00082 0.264
DEG_APCC_DBOX_1 119 127 PF00400 0.479
DEG_MDM2_SWIB_1 214 222 PF02201 0.255
DOC_CKS1_1 104 109 PF01111 0.307
DOC_CKS1_1 185 190 PF01111 0.235
DOC_CKS1_1 61 66 PF01111 0.527
DOC_CYCLIN_yCln2_LP_2 104 110 PF00134 0.316
DOC_MAPK_gen_1 119 129 PF00069 0.466
DOC_MAPK_gen_1 272 279 PF00069 0.362
DOC_MAPK_gen_1 315 322 PF00069 0.578
DOC_MAPK_MEF2A_6 102 111 PF00069 0.338
DOC_MAPK_MEF2A_6 272 281 PF00069 0.310
DOC_MAPK_MEF2A_6 315 322 PF00069 0.543
DOC_WW_Pin1_4 103 108 PF00397 0.299
DOC_WW_Pin1_4 184 189 PF00397 0.394
DOC_WW_Pin1_4 239 244 PF00397 0.448
DOC_WW_Pin1_4 307 312 PF00397 0.694
DOC_WW_Pin1_4 60 65 PF00397 0.527
LIG_14-3-3_CanoR_1 298 304 PF00244 0.676
LIG_APCC_ABBA_1 108 113 PF00400 0.193
LIG_APCC_ABBAyCdc20_2 25 31 PF00400 0.255
LIG_BRCT_BRCA1_1 222 226 PF00533 0.309
LIG_BRCT_BRCA1_1 254 258 PF00533 0.407
LIG_BRCT_BRCA1_1 4 8 PF00533 0.409
LIG_BRCT_BRCA1_1 75 79 PF00533 0.254
LIG_deltaCOP1_diTrp_1 145 155 PF00928 0.217
LIG_EH1_1 97 105 PF00400 0.409
LIG_eIF4E_1 251 257 PF01652 0.289
LIG_FHA_1 1 7 PF00498 0.515
LIG_FHA_1 104 110 PF00498 0.300
LIG_FHA_1 13 19 PF00498 0.392
LIG_FHA_1 168 174 PF00498 0.511
LIG_FHA_1 217 223 PF00498 0.342
LIG_FHA_1 239 245 PF00498 0.453
LIG_FHA_1 252 258 PF00498 0.299
LIG_FHA_1 45 51 PF00498 0.401
LIG_FHA_1 90 96 PF00498 0.298
LIG_GBD_Chelix_1 248 256 PF00786 0.365
LIG_IRF3_LxIS_1 69 76 PF10401 0.438
LIG_LIR_Gen_1 216 226 PF02991 0.331
LIG_LIR_Gen_1 233 243 PF02991 0.280
LIG_LIR_Gen_1 261 270 PF02991 0.374
LIG_LIR_Gen_1 288 297 PF02991 0.488
LIG_LIR_Gen_1 35 43 PF02991 0.288
LIG_LIR_Gen_1 5 14 PF02991 0.371
LIG_LIR_Gen_1 96 104 PF02991 0.359
LIG_LIR_Nem_3 113 117 PF02991 0.171
LIG_LIR_Nem_3 145 151 PF02991 0.251
LIG_LIR_Nem_3 211 217 PF02991 0.294
LIG_LIR_Nem_3 233 238 PF02991 0.311
LIG_LIR_Nem_3 261 265 PF02991 0.361
LIG_LIR_Nem_3 288 292 PF02991 0.494
LIG_LIR_Nem_3 35 39 PF02991 0.309
LIG_LIR_Nem_3 5 11 PF02991 0.330
LIG_LIR_Nem_3 76 82 PF02991 0.270
LIG_LIR_Nem_3 96 101 PF02991 0.449
LIG_NRBOX 122 128 PF00104 0.507
LIG_NRBOX 6 12 PF00104 0.409
LIG_PCNA_PIPBox_1 149 158 PF02747 0.235
LIG_PDZ_Class_2 320 325 PF00595 0.705
LIG_Pex14_2 111 115 PF04695 0.345
LIG_Pex14_2 214 218 PF04695 0.262
LIG_Pex14_2 228 232 PF04695 0.354
LIG_Pex14_2 258 262 PF04695 0.290
LIG_Pex14_2 45 49 PF04695 0.236
LIG_PTB_Apo_2 158 165 PF02174 0.289
LIG_PTB_Apo_2 21 28 PF02174 0.394
LIG_PTB_Phospho_1 158 164 PF10480 0.289
LIG_SH2_CRK 98 102 PF00017 0.341
LIG_SH2_NCK_1 289 293 PF00017 0.353
LIG_SH2_STAP1 210 214 PF00017 0.296
LIG_SH2_STAT5 164 167 PF00017 0.289
LIG_SH2_STAT5 251 254 PF00017 0.289
LIG_SH2_STAT5 82 85 PF00017 0.289
LIG_SH3_1 291 297 PF00018 0.613
LIG_SH3_3 194 200 PF00018 0.366
LIG_SH3_3 291 297 PF00018 0.643
LIG_SUMO_SIM_anti_2 124 131 PF11976 0.277
LIG_SUMO_SIM_anti_2 190 196 PF11976 0.273
LIG_SUMO_SIM_anti_2 278 283 PF11976 0.404
LIG_SUMO_SIM_anti_2 37 44 PF11976 0.269
LIG_SUMO_SIM_par_1 218 223 PF11976 0.379
LIG_WRC_WIRS_1 46 51 PF05994 0.202
LIG_WW_2 294 297 PF00397 0.509
MOD_CDK_SPK_2 60 65 PF00069 0.527
MOD_CDK_SPxK_1 60 66 PF00069 0.417
MOD_CK1_1 162 168 PF00069 0.309
MOD_CK1_1 242 248 PF00069 0.448
MOD_CK1_1 299 305 PF00069 0.658
MOD_CK1_1 306 312 PF00069 0.683
MOD_CK1_1 89 95 PF00069 0.309
MOD_CK2_1 287 293 PF00069 0.434
MOD_Cter_Amidation 117 120 PF01082 0.327
MOD_GlcNHglycan 189 192 PF01048 0.260
MOD_GlcNHglycan 265 268 PF01048 0.525
MOD_GSK3_1 121 128 PF00069 0.486
MOD_GSK3_1 2 9 PF00069 0.448
MOD_GSK3_1 216 223 PF00069 0.311
MOD_GSK3_1 238 245 PF00069 0.448
MOD_GSK3_1 298 305 PF00069 0.622
MOD_GSK3_1 34 41 PF00069 0.255
MOD_GSK3_1 89 96 PF00069 0.306
MOD_N-GLC_1 12 17 PF02516 0.409
MOD_N-GLC_1 230 235 PF02516 0.313
MOD_N-GLC_1 86 91 PF02516 0.307
MOD_NEK2_1 12 17 PF00069 0.356
MOD_NEK2_1 252 257 PF00069 0.333
MOD_NEK2_1 34 39 PF00069 0.254
MOD_NEK2_1 45 50 PF00069 0.307
MOD_NEK2_1 6 11 PF00069 0.339
MOD_NEK2_1 91 96 PF00069 0.238
MOD_NEK2_2 210 215 PF00069 0.332
MOD_PK_1 65 71 PF00069 0.457
MOD_PKA_1 65 71 PF00069 0.473
MOD_PKA_2 303 309 PF00069 0.750
MOD_Plk_1 210 216 PF00069 0.254
MOD_Plk_1 230 236 PF00069 0.289
MOD_Plk_1 34 40 PF00069 0.217
MOD_Plk_1 86 92 PF00069 0.299
MOD_Plk_4 122 128 PF00069 0.456
MOD_Plk_4 136 142 PF00069 0.297
MOD_Plk_4 159 165 PF00069 0.318
MOD_Plk_4 2 8 PF00069 0.432
MOD_Plk_4 213 219 PF00069 0.267
MOD_Plk_4 252 258 PF00069 0.280
MOD_Plk_4 35 41 PF00069 0.258
MOD_Plk_4 45 51 PF00069 0.297
MOD_Plk_4 86 92 PF00069 0.320
MOD_Plk_4 93 99 PF00069 0.255
MOD_ProDKin_1 103 109 PF00069 0.299
MOD_ProDKin_1 184 190 PF00069 0.394
MOD_ProDKin_1 239 245 PF00069 0.448
MOD_ProDKin_1 307 313 PF00069 0.693
MOD_ProDKin_1 60 66 PF00069 0.527
TRG_DiLeu_BaLyEn_6 104 109 PF01217 0.192
TRG_ENDOCYTIC_2 289 292 PF00928 0.413
TRG_ENDOCYTIC_2 82 85 PF00928 0.299
TRG_ENDOCYTIC_2 98 101 PF00928 0.298
TRG_ER_diArg_1 69 71 PF00400 0.551
TRG_PTS2 1 34 PF00400 0.417

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P8N6 Leptomonas seymouri 39% 100%
A0A0N1PAW1 Leptomonas seymouri 74% 100%
A0A0S4IKX4 Bodo saltans 36% 100%
A0A0S4JRZ1 Bodo saltans 37% 100%
A0A1X0P276 Trypanosomatidae 67% 100%
A0A1X0P5Z4 Trypanosomatidae 43% 100%
A0A3R7NGZ9 Trypanosoma rangeli 64% 100%
A0A3S7WVL9 Leishmania donovani 37% 100%
A0A3S7X3R1 Leishmania donovani 93% 100%
A0A422NUS0 Trypanosoma rangeli 40% 100%
A4HAA0 Leishmania braziliensis 37% 100%
A4HYI0 Leishmania infantum 37% 100%
A4I5U5 Leishmania infantum 93% 100%
A4IFK2 Bos taurus 34% 100%
C9ZR66 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 58% 100%
E9ASA4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 37% 100%
E9B140 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
F4IHS9 Arabidopsis thaliana 31% 95%
P49131 Flaveria pringlei 25% 80%
P49132 Flaveria trinervia 25% 80%
P49133 Zea mays 26% 79%
Q1JQ66 Danio rerio 35% 100%
Q3E6T0 Arabidopsis thaliana 26% 93%
Q4QD58 Leishmania major 35% 100%
Q550W6 Dictyostelium discoideum 23% 88%
Q5XF09 Arabidopsis thaliana 28% 100%
Q6DBP3 Arabidopsis thaliana 27% 100%
Q6PGC7 Mus musculus 35% 100%
Q7Z769 Homo sapiens 35% 100%
Q8GUJ1 Arabidopsis thaliana 33% 92%
Q8RWW7 Arabidopsis thaliana 30% 96%
Q8RXL8 Arabidopsis thaliana 30% 91%
Q94EI9 Arabidopsis thaliana 26% 96%
Q9C521 Arabidopsis thaliana 26% 97%
Q9C8M1 Arabidopsis thaliana 28% 98%
Q9FDZ5 Arabidopsis thaliana 28% 97%
Q9FG70 Arabidopsis thaliana 27% 82%
Q9FIH5 Arabidopsis thaliana 29% 93%
Q9FTT3 Oryza sativa subsp. japonica 25% 78%
Q9FYE5 Arabidopsis thaliana 27% 100%
Q9LDH3 Arabidopsis thaliana 25% 90%
Q9LFN3 Arabidopsis thaliana 27% 93%
Q9LNH5 Arabidopsis thaliana 28% 89%
Q9LPU2 Arabidopsis thaliana 30% 93%
Q9LRP2 Arabidopsis thaliana 29% 87%
Q9LU76 Arabidopsis thaliana 27% 83%
Q9SFE9 Arabidopsis thaliana 28% 95%
Q9SKJ7 Arabidopsis thaliana 25% 94%
Q9SRE4 Arabidopsis thaliana 29% 94%
Q9SS40 Arabidopsis thaliana 27% 92%
Q9SUV2 Arabidopsis thaliana 27% 93%
Q9SZ96 Arabidopsis thaliana 29% 97%
V5BMW3 Trypanosoma cruzi 60% 100%
V5D4Q6 Trypanosoma cruzi 41% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS