SH3 domain protein-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SH3 domain protein-like protein

Species:

Leishmania major

UniProt:

Q4Q725_LEIMA

TriTrypDb:

LmjF.30.2690 , LMJLV39_300034500 , LMJSD75_300033900

Length:

294

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q725

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q725

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	189	191	PF00675	0.482
CLV_NRD_NRD_1	219	221	PF00675	0.421
CLV_NRD_NRD_1	48	50	PF00675	0.297
CLV_PCSK_KEX2_1	189	191	PF00082	0.484
CLV_PCSK_KEX2_1	47	49	PF00082	0.297
CLV_PCSK_SKI1_1	100	104	PF00082	0.588
CLV_PCSK_SKI1_1	163	167	PF00082	0.547
CLV_PCSK_SKI1_1	281	285	PF00082	0.667
DEG_Nend_UBRbox_1	1	4	PF02207	0.374
DEG_SPOP_SBC_1	144	148	PF00917	0.730
DOC_CKS1_1	87	92	PF01111	0.661
DOC_CYCLIN_RxL_1	160	167	PF00134	0.612
DOC_PP2B_LxvP_1	257	260	PF13499	0.640
DOC_USP7_MATH_1	144	148	PF00917	0.668
DOC_USP7_MATH_1	260	264	PF00917	0.702
DOC_USP7_MATH_1	63	67	PF00917	0.481
DOC_USP7_MATH_1	72	76	PF00917	0.608
DOC_WW_Pin1_4	123	128	PF00397	0.678
DOC_WW_Pin1_4	131	136	PF00397	0.626
DOC_WW_Pin1_4	149	154	PF00397	0.620
DOC_WW_Pin1_4	263	268	PF00397	0.647
DOC_WW_Pin1_4	285	290	PF00397	0.659
DOC_WW_Pin1_4	82	87	PF00397	0.637
LIG_14-3-3_CanoR_1	189	197	PF00244	0.463
LIG_FHA_1	135	141	PF00498	0.715
LIG_FHA_1	217	223	PF00498	0.515
LIG_FHA_1	263	269	PF00498	0.629
LIG_FHA_1	27	33	PF00498	0.410
LIG_FHA_2	108	114	PF00498	0.595
LIG_LIR_Apic_2	250	256	PF02991	0.492
LIG_LIR_Gen_1	180	191	PF02991	0.468
LIG_LIR_Gen_1	35	42	PF02991	0.279
LIG_LIR_Nem_3	180	186	PF02991	0.406
LIG_LIR_Nem_3	35	40	PF02991	0.311
LIG_MYND_1	127	131	PF01753	0.626
LIG_PCNA_yPIPBox_3	163	177	PF02747	0.521
LIG_PDZ_Class_2	289	294	PF00595	0.641
LIG_PTB_Apo_2	176	183	PF02174	0.529
LIG_PTB_Phospho_1	176	182	PF10480	0.530
LIG_SH2_CRK	253	257	PF00017	0.522
LIG_SH2_GRB2like	182	185	PF00017	0.462
LIG_SH2_STAT3	182	185	PF00017	0.462
LIG_SH2_STAT5	182	185	PF00017	0.518
LIG_SH2_STAT5	3	6	PF00017	0.394
LIG_SH2_STAT5	56	59	PF00017	0.466
MOD_CDC14_SPxK_1	85	88	PF00782	0.650
MOD_CDK_SPK_2	285	290	PF00069	0.635
MOD_CDK_SPxK_1	263	269	PF00069	0.651
MOD_CDK_SPxK_1	82	88	PF00069	0.658
MOD_CK1_1	134	140	PF00069	0.590
MOD_CK1_1	262	268	PF00069	0.639
MOD_CK2_1	196	202	PF00069	0.418
MOD_CK2_1	58	64	PF00069	0.509
MOD_GlcNHglycan	117	120	PF01048	0.575
MOD_GlcNHglycan	191	194	PF01048	0.493
MOD_GlcNHglycan	198	201	PF01048	0.469
MOD_GlcNHglycan	213	217	PF01048	0.476
MOD_GlcNHglycan	253	256	PF01048	0.593
MOD_GlcNHglycan	262	265	PF01048	0.628
MOD_GlcNHglycan	276	279	PF01048	0.598
MOD_GlcNHglycan	59	63	PF01048	0.547
MOD_GlcNHglycan	69	72	PF01048	0.655
MOD_GlcNHglycan	74	77	PF01048	0.615
MOD_GlcNHglycan	96	100	PF01048	0.619
MOD_GSK3_1	103	110	PF00069	0.594
MOD_GSK3_1	131	138	PF00069	0.599
MOD_GSK3_1	145	152	PF00069	0.626
MOD_GSK3_1	212	219	PF00069	0.428
MOD_GSK3_1	247	254	PF00069	0.526
MOD_GSK3_1	259	266	PF00069	0.600
MOD_GSK3_1	63	70	PF00069	0.496
MOD_GSK3_1	77	84	PF00069	0.641
MOD_N-GLC_1	104	109	PF02516	0.720
MOD_N-GLC_1	115	120	PF02516	0.596
MOD_NEK2_1	103	108	PF00069	0.684
MOD_NEK2_2	145	150	PF00069	0.440
MOD_PKA_1	189	195	PF00069	0.533
MOD_PKA_2	189	195	PF00069	0.451
MOD_Plk_1	104	110	PF00069	0.624
MOD_Plk_1	135	141	PF00069	0.679
MOD_Plk_1	16	22	PF00069	0.282
MOD_Plk_1	212	218	PF00069	0.443
MOD_Plk_4	16	22	PF00069	0.472
MOD_Plk_4	52	58	PF00069	0.413
MOD_ProDKin_1	123	129	PF00069	0.680
MOD_ProDKin_1	131	137	PF00069	0.627
MOD_ProDKin_1	149	155	PF00069	0.617
MOD_ProDKin_1	263	269	PF00069	0.653
MOD_ProDKin_1	285	291	PF00069	0.660
MOD_ProDKin_1	82	88	PF00069	0.640
MOD_SUMO_for_1	177	180	PF00179	0.401
MOD_SUMO_for_1	21	24	PF00179	0.440
MOD_SUMO_for_1	38	41	PF00179	0.184
MOD_SUMO_rev_2	238	245	PF00179	0.436
TRG_AP2beta_CARGO_1	180	190	PF09066	0.411
TRG_DiLeu_BaEn_4	13	19	PF01217	0.410
TRG_ENDOCYTIC_2	3	6	PF00928	0.426
TRG_ER_diArg_1	233	236	PF00400	0.457
TRG_ER_diArg_1	47	49	PF00400	0.325
TRG_Pf-PMV_PEXEL_1	163	167	PF00026	0.600
TRG_Pf-PMV_PEXEL_1	220	224	PF00026	0.428

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2T5	Leptomonas seymouri	59%	92%
A0A1X0P1K4	Trypanosomatidae	39%	100%
A0A3Q8IG02	Leishmania donovani	92%	100%
A0A422NLQ1	Trypanosoma rangeli	39%	100%
A4HIK1	Leishmania braziliensis	80%	100%
A4I5U6	Leishmania infantum	91%	100%
C9ZR67	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9B141	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5BX71	Trypanosoma cruzi	44%	100%