Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q724_LEIMA

TriTrypDb:

LmjF.30.2700 , LMJLV39_300034600 , LMJSD75_300034000

Length:

381

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	6
GO:0042995	cell projection	2	6
GO:0043226	organelle	2	6
GO:0043227	membrane-bounded organelle	3	6
GO:0110165	cellular anatomical entity	1	6
GO:0120025	plasma membrane bounded cell projection	3	6

Expansion

Sequence features

Q4Q724

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q724

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	13	15	PF00675	0.371
CLV_NRD_NRD_1	177	179	PF00675	0.391
CLV_NRD_NRD_1	199	201	PF00675	0.603
CLV_NRD_NRD_1	261	263	PF00675	0.524
CLV_NRD_NRD_1	307	309	PF00675	0.673
CLV_NRD_NRD_1	5	7	PF00675	0.462
CLV_PCSK_KEX2_1	12	14	PF00082	0.400
CLV_PCSK_KEX2_1	177	179	PF00082	0.421
CLV_PCSK_KEX2_1	199	201	PF00082	0.567
CLV_PCSK_KEX2_1	307	309	PF00082	0.673
CLV_PCSK_KEX2_1	5	7	PF00082	0.462
CLV_PCSK_PC7_1	195	201	PF00082	0.506
CLV_PCSK_SKI1_1	183	187	PF00082	0.518
CLV_PCSK_SKI1_1	263	267	PF00082	0.594
CLV_PCSK_SKI1_1	33	37	PF00082	0.352
CLV_PCSK_SKI1_1	369	373	PF00082	0.638
CLV_PCSK_SKI1_1	5	9	PF00082	0.481
DEG_SPOP_SBC_1	150	154	PF00917	0.359
DEG_SPOP_SBC_1	286	290	PF00917	0.524
DEG_SPOP_SBC_1	328	332	PF00917	0.529
DOC_CDC14_PxL_1	220	228	PF14671	0.535
DOC_CYCLIN_yCln2_LP_2	272	275	PF00134	0.624
DOC_PP2B_LxvP_1	272	275	PF13499	0.624
DOC_PP2B_PxIxI_1	236	242	PF00149	0.597
DOC_SPAK_OSR1_1	86	90	PF12202	0.410
DOC_USP7_MATH_1	287	291	PF00917	0.540
DOC_USP7_MATH_1	327	331	PF00917	0.474
DOC_WW_Pin1_4	203	208	PF00397	0.506
DOC_WW_Pin1_4	230	235	PF00397	0.617
DOC_WW_Pin1_4	309	314	PF00397	0.584
LIG_14-3-3_CanoR_1	21	29	PF00244	0.590
LIG_14-3-3_CanoR_1	349	357	PF00244	0.587
LIG_BIR_II_1	1	5	PF00653	0.472
LIG_FHA_1	127	133	PF00498	0.522
LIG_FHA_1	150	156	PF00498	0.373
LIG_FHA_1	23	29	PF00498	0.373
LIG_FHA_1	267	273	PF00498	0.620
LIG_FHA_1	295	301	PF00498	0.610
LIG_FHA_1	373	379	PF00498	0.562
LIG_FHA_2	123	129	PF00498	0.353
LIG_FHA_2	246	252	PF00498	0.663
LIG_FHA_2	318	324	PF00498	0.566
LIG_FHA_2	69	75	PF00498	0.299
LIG_FHA_2	98	104	PF00498	0.396
LIG_LIR_Apic_2	323	327	PF02991	0.492
LIG_LIR_Gen_1	190	198	PF02991	0.416
LIG_LIR_Gen_1	40	47	PF02991	0.339
LIG_LIR_Nem_3	100	104	PF02991	0.327
LIG_LIR_Nem_3	190	196	PF02991	0.413
LIG_LIR_Nem_3	34	38	PF02991	0.402
LIG_LIR_Nem_3	40	45	PF02991	0.328
LIG_LIR_Nem_3	82	88	PF02991	0.351
LIG_MYND_3	223	227	PF01753	0.539
LIG_RPA_C_Fungi	173	185	PF08784	0.448
LIG_SH2_CRK	193	197	PF00017	0.419
LIG_SH2_PTP2	42	45	PF00017	0.315
LIG_SH2_PTP2	88	91	PF00017	0.399
LIG_SH2_STAT5	193	196	PF00017	0.479
LIG_SH2_STAT5	247	250	PF00017	0.538
LIG_SH2_STAT5	337	340	PF00017	0.518
LIG_SH2_STAT5	42	45	PF00017	0.323
LIG_SH2_STAT5	88	91	PF00017	0.548
LIG_SH3_3	201	207	PF00018	0.500
LIG_SH3_3	231	237	PF00018	0.546
LIG_SH3_3	351	357	PF00018	0.607
LIG_SH3_3	373	379	PF00018	0.597
LIG_SH3_3	4	10	PF00018	0.485
LIG_SH3_CIN85_PxpxPR_1	230	235	PF14604	0.630
LIG_SUMO_SIM_par_1	216	222	PF11976	0.572
LIG_TYR_ITIM	191	196	PF00017	0.392
LIG_ULM_U2AF65_1	199	204	PF00076	0.435
LIG_WRC_WIRS_1	32	37	PF05994	0.345
MOD_CDK_SPK_2	230	235	PF00069	0.546
MOD_CDK_SPxxK_3	203	210	PF00069	0.512
MOD_CK1_1	114	120	PF00069	0.444
MOD_CK1_1	225	231	PF00069	0.595
MOD_CK1_1	233	239	PF00069	0.531
MOD_CK1_1	276	282	PF00069	0.583
MOD_CK1_1	294	300	PF00069	0.630
MOD_CK1_1	31	37	PF00069	0.349
MOD_CK2_1	122	128	PF00069	0.350
MOD_CK2_1	133	139	PF00069	0.373
MOD_CK2_1	312	318	PF00069	0.729
MOD_CK2_1	68	74	PF00069	0.307
MOD_Cter_Amidation	260	263	PF01082	0.520
MOD_GlcNHglycan	112	116	PF01048	0.387
MOD_GlcNHglycan	165	168	PF01048	0.407
MOD_GlcNHglycan	282	285	PF01048	0.574
MOD_GlcNHglycan	289	292	PF01048	0.567
MOD_GlcNHglycan	351	354	PF01048	0.621
MOD_GlcNHglycan	53	56	PF01048	0.400
MOD_GSK3_1	122	129	PF00069	0.382
MOD_GSK3_1	150	157	PF00069	0.466
MOD_GSK3_1	187	194	PF00069	0.442
MOD_GSK3_1	273	280	PF00069	0.671
MOD_GSK3_1	287	294	PF00069	0.695
MOD_GSK3_1	295	302	PF00069	0.727
MOD_GSK3_1	365	372	PF00069	0.598
MOD_N-GLC_1	150	155	PF02516	0.395
MOD_N-GLC_1	187	192	PF02516	0.554
MOD_NEK2_1	1	6	PF00069	0.469
MOD_NEK2_1	132	137	PF00069	0.393
MOD_NEK2_1	277	282	PF00069	0.606
MOD_NEK2_1	329	334	PF00069	0.527
MOD_NEK2_1	362	367	PF00069	0.674
MOD_NEK2_1	94	99	PF00069	0.332
MOD_PKA_1	369	375	PF00069	0.598
MOD_PKA_2	198	204	PF00069	0.554
MOD_Plk_1	150	156	PF00069	0.393
MOD_Plk_1	187	193	PF00069	0.493
MOD_Plk_1	317	323	PF00069	0.712
MOD_Plk_2-3	222	228	PF00069	0.594
MOD_Plk_2-3	317	323	PF00069	0.531
MOD_Plk_4	151	157	PF00069	0.350
MOD_Plk_4	268	274	PF00069	0.593
MOD_Plk_4	317	323	PF00069	0.549
MOD_Plk_4	97	103	PF00069	0.380
MOD_ProDKin_1	203	209	PF00069	0.510
MOD_ProDKin_1	230	236	PF00069	0.618
MOD_ProDKin_1	309	315	PF00069	0.575
MOD_SUMO_rev_2	221	230	PF00179	0.594
TRG_ENDOCYTIC_2	193	196	PF00928	0.416
TRG_ENDOCYTIC_2	42	45	PF00928	0.328
TRG_ER_diArg_1	12	14	PF00400	0.337
TRG_ER_diArg_1	177	180	PF00400	0.432
TRG_ER_diArg_1	198	200	PF00400	0.601
TRG_ER_diArg_1	5	7	PF00400	0.397
TRG_Pf-PMV_PEXEL_1	120	124	PF00026	0.360
TRG_Pf-PMV_PEXEL_1	183	187	PF00026	0.358

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB83	Leptomonas seymouri	45%	86%
A0A3Q8IFS9	Leishmania donovani	93%	98%
A4I5U7	Leishmania infantum	93%	98%
E9B142	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	97%