Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q723_LEIMA

TriTrypDb:

LmjF.30.2710 , LMJLV39_300034700 , LMJSD75_300034100

Length:

932

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q723

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q723

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	738	742	PF00656	0.593
CLV_NRD_NRD_1	119	121	PF00675	0.651
CLV_NRD_NRD_1	134	136	PF00675	0.588
CLV_NRD_NRD_1	171	173	PF00675	0.654
CLV_NRD_NRD_1	226	228	PF00675	0.661
CLV_NRD_NRD_1	288	290	PF00675	0.763
CLV_NRD_NRD_1	477	479	PF00675	0.495
CLV_NRD_NRD_1	498	500	PF00675	0.491
CLV_NRD_NRD_1	524	526	PF00675	0.624
CLV_NRD_NRD_1	642	644	PF00675	0.712
CLV_NRD_NRD_1	829	831	PF00675	0.518
CLV_PCSK_FUR_1	169	173	PF00082	0.716
CLV_PCSK_KEX2_1	134	136	PF00082	0.685
CLV_PCSK_KEX2_1	171	173	PF00082	0.698
CLV_PCSK_KEX2_1	226	228	PF00082	0.661
CLV_PCSK_KEX2_1	288	290	PF00082	0.658
CLV_PCSK_KEX2_1	449	451	PF00082	0.737
CLV_PCSK_KEX2_1	524	526	PF00082	0.665
CLV_PCSK_KEX2_1	829	831	PF00082	0.518
CLV_PCSK_PC1ET2_1	449	451	PF00082	0.670
CLV_PCSK_SKI1_1	137	141	PF00082	0.673
CLV_PCSK_SKI1_1	20	24	PF00082	0.452
CLV_PCSK_SKI1_1	25	29	PF00082	0.452
CLV_PCSK_SKI1_1	288	292	PF00082	0.754
CLV_PCSK_SKI1_1	30	34	PF00082	0.461
CLV_PCSK_SKI1_1	492	496	PF00082	0.474
CLV_PCSK_SKI1_1	595	599	PF00082	0.549
CLV_PCSK_SKI1_1	683	687	PF00082	0.515
DEG_Nend_UBRbox_2	1	3	PF02207	0.565
DEG_SCF_FBW7_2	417	423	PF00400	0.616
DEG_SCF_TRCP1_1	876	882	PF00400	0.674
DEG_SPOP_SBC_1	631	635	PF00917	0.623
DEG_SPOP_SBC_1	69	73	PF00917	0.661
DEG_SPOP_SBC_1	88	92	PF00917	0.541
DOC_ANK_TNKS_1	460	467	PF00023	0.520
DOC_ANK_TNKS_1	501	508	PF00023	0.614
DOC_CKS1_1	290	295	PF01111	0.700
DOC_CKS1_1	417	422	PF01111	0.604
DOC_CYCLIN_yCln2_LP_2	844	850	PF00134	0.611
DOC_MAPK_JIP1_4	774	780	PF00069	0.613
DOC_MAPK_MEF2A_6	59	68	PF00069	0.638
DOC_PP2B_LxvP_1	294	297	PF13499	0.734
DOC_PP2B_LxvP_1	610	613	PF13499	0.568
DOC_PP2B_LxvP_1	687	690	PF13499	0.523
DOC_PP2B_LxvP_1	920	923	PF13499	0.651
DOC_PP4_FxxP_1	331	334	PF00568	0.670
DOC_PP4_FxxP_1	809	812	PF00568	0.587
DOC_USP7_MATH_1	109	113	PF00917	0.707
DOC_USP7_MATH_1	185	189	PF00917	0.614
DOC_USP7_MATH_1	439	443	PF00917	0.608
DOC_USP7_MATH_1	506	510	PF00917	0.516
DOC_USP7_MATH_1	631	635	PF00917	0.616
DOC_USP7_MATH_1	70	74	PF00917	0.703
DOC_USP7_MATH_1	856	860	PF00917	0.666
DOC_USP7_UBL2_3	50	54	PF12436	0.479
DOC_USP7_UBL2_3	500	504	PF12436	0.575
DOC_USP7_UBL2_3	508	512	PF12436	0.600
DOC_WW_Pin1_4	128	133	PF00397	0.653
DOC_WW_Pin1_4	162	167	PF00397	0.600
DOC_WW_Pin1_4	289	294	PF00397	0.794
DOC_WW_Pin1_4	307	312	PF00397	0.654
DOC_WW_Pin1_4	330	335	PF00397	0.677
DOC_WW_Pin1_4	338	343	PF00397	0.783
DOC_WW_Pin1_4	352	357	PF00397	0.571
DOC_WW_Pin1_4	370	375	PF00397	0.765
DOC_WW_Pin1_4	382	387	PF00397	0.574
DOC_WW_Pin1_4	416	421	PF00397	0.586
DOC_WW_Pin1_4	435	440	PF00397	0.679
DOC_WW_Pin1_4	451	456	PF00397	0.572
DOC_WW_Pin1_4	460	465	PF00397	0.650
DOC_WW_Pin1_4	608	613	PF00397	0.649
DOC_WW_Pin1_4	652	657	PF00397	0.617
DOC_WW_Pin1_4	811	816	PF00397	0.603
DOC_WW_Pin1_4	83	88	PF00397	0.791
DOC_WW_Pin1_4	879	884	PF00397	0.748
DOC_WW_Pin1_4	94	99	PF00397	0.670
LIG_14-3-3_CanoR_1	114	120	PF00244	0.608
LIG_14-3-3_CanoR_1	288	293	PF00244	0.731
LIG_14-3-3_CanoR_1	301	305	PF00244	0.626
LIG_14-3-3_CanoR_1	450	455	PF00244	0.714
LIG_14-3-3_CanoR_1	595	600	PF00244	0.586
LIG_14-3-3_CanoR_1	632	640	PF00244	0.631
LIG_14-3-3_CanoR_1	683	688	PF00244	0.503
LIG_14-3-3_CanoR_1	744	750	PF00244	0.645
LIG_APCC_ABBA_1	400	405	PF00400	0.612
LIG_BIR_III_4	247	251	PF00653	0.672
LIG_deltaCOP1_diTrp_1	720	726	PF00928	0.413
LIG_FHA_1	123	129	PF00498	0.722
LIG_FHA_1	201	207	PF00498	0.605
LIG_FHA_1	260	266	PF00498	0.614
LIG_FHA_1	289	295	PF00498	0.757
LIG_FHA_1	314	320	PF00498	0.689
LIG_FHA_1	387	393	PF00498	0.635
LIG_FHA_1	429	435	PF00498	0.680
LIG_FHA_1	680	686	PF00498	0.593
LIG_FHA_1	775	781	PF00498	0.719
LIG_FHA_1	818	824	PF00498	0.590
LIG_FHA_1	839	845	PF00498	0.530
LIG_FHA_1	88	94	PF00498	0.691
LIG_FHA_2	140	146	PF00498	0.681
LIG_FHA_2	156	162	PF00498	0.732
LIG_FHA_2	236	242	PF00498	0.629
LIG_FHA_2	452	458	PF00498	0.715
LIG_FHA_2	526	532	PF00498	0.615
LIG_FHA_2	596	602	PF00498	0.558
LIG_FHA_2	637	643	PF00498	0.627
LIG_FHA_2	667	673	PF00498	0.547
LIG_FHA_2	893	899	PF00498	0.710
LIG_FHA_2	914	920	PF00498	0.588
LIG_Integrin_isoDGR_2	805	807	PF01839	0.616
LIG_Integrin_isoDGR_2	853	855	PF01839	0.596
LIG_Integrin_RGD_1	763	765	PF01839	0.646
LIG_LIR_Apic_2	329	334	PF02991	0.665
LIG_LIR_Apic_2	58	64	PF02991	0.619
LIG_LIR_Gen_1	421	430	PF02991	0.668
LIG_LIR_Gen_1	720	730	PF02991	0.423
LIG_LIR_Gen_1	915	923	PF02991	0.605
LIG_LIR_Nem_3	341	347	PF02991	0.647
LIG_LIR_Nem_3	421	427	PF02991	0.629
LIG_LIR_Nem_3	592	597	PF02991	0.568
LIG_LIR_Nem_3	605	610	PF02991	0.595
LIG_LIR_Nem_3	720	726	PF02991	0.413
LIG_LIR_Nem_3	915	920	PF02991	0.615
LIG_MYND_1	352	356	PF01753	0.630
LIG_MYND_1	398	402	PF01753	0.602
LIG_MYND_1	614	618	PF01753	0.615
LIG_SH2_CRK	344	348	PF00017	0.633
LIG_SH2_CRK	424	428	PF00017	0.630
LIG_SH2_CRK	8	12	PF00017	0.506
LIG_SH2_CRK	848	852	PF00017	0.654
LIG_SH2_NCK_1	424	428	PF00017	0.630
LIG_SH2_PTP2	383	386	PF00017	0.677
LIG_SH2_SRC	6	9	PF00017	0.549
LIG_SH2_STAT3	260	263	PF00017	0.602
LIG_SH2_STAT5	383	386	PF00017	0.677
LIG_SH2_STAT5	6	9	PF00017	0.549
LIG_SH2_STAT5	606	609	PF00017	0.594
LIG_SH3_2	534	539	PF14604	0.691
LIG_SH3_3	279	285	PF00018	0.680
LIG_SH3_3	287	293	PF00018	0.655
LIG_SH3_3	396	402	PF00018	0.612
LIG_SH3_3	414	420	PF00018	0.601
LIG_SH3_3	456	462	PF00018	0.626
LIG_SH3_3	531	537	PF00018	0.627
LIG_SH3_3	611	617	PF00018	0.597
LIG_SH3_3	63	69	PF00018	0.728
LIG_SH3_3	809	815	PF00018	0.613
LIG_SH3_3	820	826	PF00018	0.578
LIG_SH3_3	844	850	PF00018	0.648
LIG_SH3_3	90	96	PF00018	0.649
LIG_SH3_4	626	633	PF00018	0.551
LIG_SUMO_SIM_par_1	412	419	PF11976	0.603
LIG_SUMO_SIM_par_1	776	781	PF11976	0.608
LIG_SUMO_SIM_par_1	9	17	PF11976	0.480
LIG_TRAF2_1	474	477	PF00917	0.516
LIG_TRAF2_1	670	673	PF00917	0.597
LIG_TRAF2_1	837	840	PF00917	0.552
LIG_WRC_WIRS_1	661	666	PF05994	0.642
LIG_WRC_WIRS_1	746	751	PF05994	0.532
LIG_WRC_WIRS_1	914	919	PF05994	0.675
MOD_CDC14_SPxK_1	131	134	PF00782	0.632
MOD_CDK_SPK_2	382	387	PF00069	0.683
MOD_CDK_SPxK_1	128	134	PF00069	0.630
MOD_CDK_SPxK_1	289	295	PF00069	0.628
MOD_CDK_SPxK_1	416	422	PF00069	0.583
MOD_CDK_SPxxK_3	128	135	PF00069	0.658
MOD_CDK_SPxxK_3	162	169	PF00069	0.591
MOD_CDK_SPxxK_3	370	377	PF00069	0.710
MOD_CDK_SPxxK_3	451	458	PF00069	0.698
MOD_CK1_1	235	241	PF00069	0.757
MOD_CK1_1	246	252	PF00069	0.772
MOD_CK1_1	264	270	PF00069	0.493
MOD_CK1_1	299	305	PF00069	0.663
MOD_CK1_1	320	326	PF00069	0.597
MOD_CK1_1	435	441	PF00069	0.617
MOD_CK1_1	634	640	PF00069	0.632
MOD_CK1_1	654	660	PF00069	0.572
MOD_CK1_1	666	672	PF00069	0.526
MOD_CK1_1	679	685	PF00069	0.602
MOD_CK1_1	72	78	PF00069	0.634
MOD_CK1_1	747	753	PF00069	0.651
MOD_CK1_1	894	900	PF00069	0.572
MOD_CK1_1	97	103	PF00069	0.632
MOD_CK2_1	139	145	PF00069	0.634
MOD_CK2_1	155	161	PF00069	0.726
MOD_CK2_1	235	241	PF00069	0.624
MOD_CK2_1	451	457	PF00069	0.795
MOD_CK2_1	595	601	PF00069	0.592
MOD_CK2_1	630	636	PF00069	0.692
MOD_CK2_1	666	672	PF00069	0.629
MOD_CK2_1	714	720	PF00069	0.380
MOD_CK2_1	773	779	PF00069	0.670
MOD_CK2_1	834	840	PF00069	0.585
MOD_CK2_1	892	898	PF00069	0.711
MOD_CK2_1	913	919	PF00069	0.585
MOD_Cter_Amidation	169	172	PF01082	0.656
MOD_Cter_Amidation	217	220	PF01082	0.665
MOD_DYRK1A_RPxSP_1	289	293	PF00069	0.656
MOD_GlcNHglycan	111	114	PF01048	0.618
MOD_GlcNHglycan	142	145	PF01048	0.713
MOD_GlcNHglycan	148	152	PF01048	0.654
MOD_GlcNHglycan	180	183	PF01048	0.653
MOD_GlcNHglycan	238	241	PF01048	0.673
MOD_GlcNHglycan	247	251	PF01048	0.817
MOD_GlcNHglycan	298	301	PF01048	0.796
MOD_GlcNHglycan	319	322	PF01048	0.637
MOD_GlcNHglycan	368	371	PF01048	0.683
MOD_GlcNHglycan	410	414	PF01048	0.749
MOD_GlcNHglycan	434	437	PF01048	0.686
MOD_GlcNHglycan	441	444	PF01048	0.771
MOD_GlcNHglycan	508	511	PF01048	0.672
MOD_GlcNHglycan	550	553	PF01048	0.702
MOD_GlcNHglycan	669	672	PF01048	0.564
MOD_GlcNHglycan	728	731	PF01048	0.489
MOD_GlcNHglycan	737	740	PF01048	0.557
MOD_GlcNHglycan	74	77	PF01048	0.723
MOD_GlcNHglycan	752	755	PF01048	0.598
MOD_GlcNHglycan	820	823	PF01048	0.720
MOD_GlcNHglycan	860	863	PF01048	0.705
MOD_GlcNHglycan	868	871	PF01048	0.733
MOD_GlcNHglycan	876	879	PF01048	0.738
MOD_GSK3_1	135	142	PF00069	0.732
MOD_GSK3_1	173	180	PF00069	0.675
MOD_GSK3_1	185	192	PF00069	0.692
MOD_GSK3_1	232	239	PF00069	0.620
MOD_GSK3_1	295	302	PF00069	0.756
MOD_GSK3_1	313	320	PF00069	0.664
MOD_GSK3_1	366	373	PF00069	0.721
MOD_GSK3_1	382	389	PF00069	0.577
MOD_GSK3_1	418	425	PF00069	0.665
MOD_GSK3_1	428	435	PF00069	0.658
MOD_GSK3_1	444	451	PF00069	0.613
MOD_GSK3_1	460	467	PF00069	0.632
MOD_GSK3_1	608	615	PF00069	0.626
MOD_GSK3_1	630	637	PF00069	0.698
MOD_GSK3_1	647	654	PF00069	0.532
MOD_GSK3_1	660	667	PF00069	0.560
MOD_GSK3_1	679	686	PF00069	0.492
MOD_GSK3_1	68	75	PF00069	0.618
MOD_GSK3_1	745	752	PF00069	0.724
MOD_GSK3_1	79	86	PF00069	0.676
MOD_GSK3_1	813	820	PF00069	0.630
MOD_GSK3_1	830	837	PF00069	0.381
MOD_GSK3_1	874	881	PF00069	0.741
MOD_GSK3_1	97	104	PF00069	0.564
MOD_N-GLC_1	115	120	PF02516	0.669
MOD_N-GLC_1	208	213	PF02516	0.680
MOD_N-GLC_1	403	408	PF02516	0.651
MOD_N-GLC_1	451	456	PF02516	0.657
MOD_N-GLC_1	79	84	PF02516	0.675
MOD_NEK2_1	101	106	PF00069	0.663
MOD_NEK2_1	498	503	PF00069	0.572
MOD_NEK2_1	664	669	PF00069	0.625
MOD_NEK2_1	749	754	PF00069	0.696
MOD_NEK2_1	913	918	PF00069	0.619
MOD_NEK2_2	115	120	PF00069	0.680
MOD_NEK2_2	671	676	PF00069	0.524
MOD_OFUCOSY	231	236	PF10250	0.662
MOD_PIKK_1	259	265	PF00454	0.599
MOD_PIKK_1	714	720	PF00454	0.380
MOD_PIKK_1	79	85	PF00454	0.674
MOD_PIKK_1	813	819	PF00454	0.662
MOD_PIKK_1	830	836	PF00454	0.381
MOD_PK_1	422	428	PF00069	0.666
MOD_PKA_1	226	232	PF00069	0.663
MOD_PKA_1	288	294	PF00069	0.731
MOD_PKA_1	830	836	PF00069	0.508
MOD_PKA_2	185	191	PF00069	0.665
MOD_PKA_2	226	232	PF00069	0.640
MOD_PKA_2	288	294	PF00069	0.672
MOD_PKA_2	300	306	PF00069	0.535
MOD_PKA_2	386	392	PF00069	0.580
MOD_PKA_2	498	504	PF00069	0.576
MOD_PKA_2	631	637	PF00069	0.647
MOD_PKA_2	857	863	PF00069	0.646
MOD_Plk_1	115	121	PF00069	0.694
MOD_Plk_1	208	214	PF00069	0.707
MOD_Plk_1	409	415	PF00069	0.603
MOD_Plk_1	422	428	PF00069	0.593
MOD_Plk_1	671	677	PF00069	0.524
MOD_Plk_2-3	636	642	PF00069	0.604
MOD_Plk_4	422	428	PF00069	0.666
MOD_Plk_4	602	608	PF00069	0.611
MOD_Plk_4	660	666	PF00069	0.541
MOD_ProDKin_1	128	134	PF00069	0.656
MOD_ProDKin_1	162	168	PF00069	0.597
MOD_ProDKin_1	289	295	PF00069	0.798
MOD_ProDKin_1	307	313	PF00069	0.653
MOD_ProDKin_1	330	336	PF00069	0.676
MOD_ProDKin_1	338	344	PF00069	0.785
MOD_ProDKin_1	352	358	PF00069	0.575
MOD_ProDKin_1	370	376	PF00069	0.764
MOD_ProDKin_1	382	388	PF00069	0.564
MOD_ProDKin_1	416	422	PF00069	0.588
MOD_ProDKin_1	435	441	PF00069	0.680
MOD_ProDKin_1	451	457	PF00069	0.574
MOD_ProDKin_1	460	466	PF00069	0.645
MOD_ProDKin_1	608	614	PF00069	0.648
MOD_ProDKin_1	652	658	PF00069	0.617
MOD_ProDKin_1	811	817	PF00069	0.602
MOD_ProDKin_1	83	89	PF00069	0.791
MOD_ProDKin_1	879	885	PF00069	0.750
MOD_ProDKin_1	94	100	PF00069	0.671
MOD_SUMO_for_1	46	49	PF00179	0.464
MOD_SUMO_for_1	494	497	PF00179	0.472
MOD_SUMO_for_1	511	514	PF00179	0.603
MOD_SUMO_rev_2	475	481	PF00179	0.502
MOD_SUMO_rev_2	73	82	PF00179	0.585
TRG_DiLeu_BaEn_4	672	678	PF01217	0.594
TRG_ENDOCYTIC_2	344	347	PF00928	0.634
TRG_ENDOCYTIC_2	424	427	PF00928	0.670
TRG_ENDOCYTIC_2	606	609	PF00928	0.663
TRG_ENDOCYTIC_2	848	851	PF00928	0.653
TRG_ER_diArg_1	134	137	PF00400	0.688
TRG_ER_diArg_1	168	171	PF00400	0.751
TRG_ER_diArg_1	226	228	PF00400	0.661
TRG_ER_diArg_1	287	289	PF00400	0.701
TRG_ER_diArg_1	523	525	PF00400	0.626
TRG_ER_diArg_1	828	830	PF00400	0.523
TRG_Pf-PMV_PEXEL_1	830	834	PF00026	0.506

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXH7	Leptomonas seymouri	41%	100%
A0A3S5H7N6	Leishmania donovani	92%	100%
A4HIK3	Leishmania braziliensis	68%	100%
A4I5U8	Leishmania infantum	93%	100%
E9B143	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%