Myotubularin phosphatase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Stabilization of polarity axis, putative

Species:

Leishmania major

UniProt:

Q4Q721_LEIMA

TriTrypDb:

LmjF.30.2730 , LMJLV39_300034900 , LMJSD75_300034300

Length:

880

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005886	plasma membrane	3	2
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q721

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q721

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	2
GO:0051179	localization	1	2
GO:0051641	cellular localization	2	2
GO:0051666	actin cortical patch localization	3	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	347	351	PF00656	0.739
CLV_C14_Caspase3-7	397	401	PF00656	0.553
CLV_C14_Caspase3-7	759	763	PF00656	0.527
CLV_NRD_NRD_1	265	267	PF00675	0.753
CLV_NRD_NRD_1	404	406	PF00675	0.577
CLV_NRD_NRD_1	52	54	PF00675	0.731
CLV_NRD_NRD_1	555	557	PF00675	0.346
CLV_NRD_NRD_1	583	585	PF00675	0.336
CLV_NRD_NRD_1	640	642	PF00675	0.593
CLV_NRD_NRD_1	816	818	PF00675	0.449
CLV_PCSK_KEX2_1	265	267	PF00082	0.613
CLV_PCSK_KEX2_1	398	400	PF00082	0.476
CLV_PCSK_KEX2_1	404	406	PF00082	0.564
CLV_PCSK_KEX2_1	455	457	PF00082	0.486
CLV_PCSK_KEX2_1	52	54	PF00082	0.731
CLV_PCSK_KEX2_1	816	818	PF00082	0.449
CLV_PCSK_PC1ET2_1	398	400	PF00082	0.532
CLV_PCSK_PC1ET2_1	455	457	PF00082	0.486
CLV_PCSK_SKI1_1	13	17	PF00082	0.511
CLV_PCSK_SKI1_1	207	211	PF00082	0.602
CLV_PCSK_SKI1_1	386	390	PF00082	0.521
CLV_PCSK_SKI1_1	452	456	PF00082	0.495
CLV_PCSK_SKI1_1	549	553	PF00082	0.346
CLV_PCSK_SKI1_1	584	588	PF00082	0.335
CLV_PCSK_SKI1_1	688	692	PF00082	0.470
CLV_PCSK_SKI1_1	812	816	PF00082	0.446
DEG_APCC_DBOX_1	385	393	PF00400	0.548
DEG_APCC_DBOX_1	523	531	PF00400	0.513
DEG_COP1_1	56	65	PF00400	0.739
DOC_ANK_TNKS_1	264	271	PF00023	0.604
DOC_CKS1_1	248	253	PF01111	0.721
DOC_CKS1_1	287	292	PF01111	0.556
DOC_CYCLIN_yClb5_NLxxxL_5	200	209	PF00134	0.466
DOC_MAPK_gen_1	584	592	PF00069	0.520
DOC_MAPK_gen_1	707	715	PF00069	0.459
DOC_MAPK_gen_1	816	822	PF00069	0.464
DOC_MAPK_MEF2A_6	584	592	PF00069	0.545
DOC_MAPK_MEF2A_6	60	67	PF00069	0.637
DOC_MAPK_MEF2A_6	707	715	PF00069	0.459
DOC_MAPK_MEF2A_6	771	779	PF00069	0.491
DOC_MAPK_RevD_3	541	557	PF00069	0.539
DOC_PP1_RVXF_1	384	391	PF00149	0.582
DOC_PP2B_LxvP_1	335	338	PF13499	0.752
DOC_PP4_FxxP_1	308	311	PF00568	0.598
DOC_PP4_FxxP_1	679	682	PF00568	0.599
DOC_USP7_MATH_1	225	229	PF00917	0.694
DOC_USP7_MATH_1	242	246	PF00917	0.772
DOC_USP7_MATH_1	269	273	PF00917	0.819
DOC_USP7_MATH_1	342	346	PF00917	0.825
DOC_USP7_MATH_1	35	39	PF00917	0.613
DOC_USP7_MATH_1	394	398	PF00917	0.478
DOC_USP7_MATH_1	41	45	PF00917	0.597
DOC_USP7_MATH_1	588	592	PF00917	0.546
DOC_USP7_MATH_1	750	754	PF00917	0.490
DOC_USP7_MATH_1	859	863	PF00917	0.469
DOC_USP7_MATH_2	91	97	PF00917	0.669
DOC_WW_Pin1_4	247	252	PF00397	0.745
DOC_WW_Pin1_4	286	291	PF00397	0.581
DOC_WW_Pin1_4	302	307	PF00397	0.653
DOC_WW_Pin1_4	511	516	PF00397	0.531
DOC_WW_Pin1_4	789	794	PF00397	0.638
DOC_WW_Pin1_4	831	836	PF00397	0.604
LIG_14-3-3_CanoR_1	124	129	PF00244	0.712
LIG_14-3-3_CanoR_1	207	213	PF00244	0.716
LIG_14-3-3_CanoR_1	377	387	PF00244	0.570
LIG_14-3-3_CanoR_1	40	50	PF00244	0.525
LIG_14-3-3_CanoR_1	524	528	PF00244	0.513
LIG_14-3-3_CanoR_1	746	755	PF00244	0.607
LIG_Actin_WH2_2	687	703	PF00022	0.492
LIG_BRCT_BRCA1_1	126	130	PF00533	0.696
LIG_BRCT_BRCA1_1	304	308	PF00533	0.587
LIG_Clathr_ClatBox_1	419	423	PF01394	0.436
LIG_eIF4E_1	525	531	PF01652	0.546
LIG_eIF4E_1	61	67	PF01652	0.605
LIG_FAT_LD_1	205	213	PF03623	0.475
LIG_FHA_1	10	16	PF00498	0.520
LIG_FHA_1	134	140	PF00498	0.561
LIG_FHA_1	211	217	PF00498	0.731
LIG_FHA_1	363	369	PF00498	0.771
LIG_FHA_1	407	413	PF00498	0.523
LIG_FHA_1	44	50	PF00498	0.569
LIG_FHA_1	477	483	PF00498	0.516
LIG_FHA_1	536	542	PF00498	0.452
LIG_FHA_1	641	647	PF00498	0.714
LIG_FHA_1	656	662	PF00498	0.551
LIG_FHA_1	689	695	PF00498	0.350
LIG_FHA_1	70	76	PF00498	0.720
LIG_FHA_1	719	725	PF00498	0.446
LIG_FHA_1	764	770	PF00498	0.543
LIG_FHA_2	278	284	PF00498	0.734
LIG_FHA_2	632	638	PF00498	0.546
LIG_FHA_2	69	75	PF00498	0.716
LIG_FHA_2	80	86	PF00498	0.557
LIG_FHA_2	805	811	PF00498	0.506
LIG_LIR_Apic_2	305	311	PF02991	0.592
LIG_LIR_Apic_2	418	424	PF02991	0.460
LIG_LIR_Gen_1	179	187	PF02991	0.584
LIG_LIR_Gen_1	25	34	PF02991	0.542
LIG_LIR_Gen_1	717	728	PF02991	0.460
LIG_LIR_Nem_3	179	185	PF02991	0.577
LIG_LIR_Nem_3	25	29	PF02991	0.541
LIG_LIR_Nem_3	423	429	PF02991	0.453
LIG_LIR_Nem_3	519	525	PF02991	0.503
LIG_LIR_Nem_3	717	723	PF02991	0.400
LIG_NRBOX	204	210	PF00104	0.544
LIG_NRBOX	538	544	PF00104	0.616
LIG_NRBOX	797	803	PF00104	0.473
LIG_Pex14_1	421	425	PF04695	0.453
LIG_PTB_Apo_2	607	614	PF02174	0.520
LIG_PTB_Apo_2	689	696	PF02174	0.426
LIG_PTB_Apo_2	734	741	PF02174	0.538
LIG_PTB_Phospho_1	689	695	PF10480	0.459
LIG_PTB_Phospho_1	734	740	PF10480	0.531
LIG_SH2_CRK	180	184	PF00017	0.560
LIG_SH2_CRK	458	462	PF00017	0.451
LIG_SH2_CRK	485	489	PF00017	0.541
LIG_SH2_CRK	687	691	PF00017	0.469
LIG_SH2_CRK	720	724	PF00017	0.442
LIG_SH2_GRB2like	497	500	PF00017	0.473
LIG_SH2_GRB2like	727	730	PF00017	0.536
LIG_SH2_GRB2like	871	874	PF00017	0.469
LIG_SH2_NCK_1	458	462	PF00017	0.451
LIG_SH2_NCK_1	498	502	PF00017	0.583
LIG_SH2_PTP2	589	592	PF00017	0.546
LIG_SH2_SRC	727	730	PF00017	0.536
LIG_SH2_SRC	871	874	PF00017	0.469
LIG_SH2_STAP1	126	130	PF00017	0.682
LIG_SH2_STAP1	180	184	PF00017	0.575
LIG_SH2_STAP1	720	724	PF00017	0.442
LIG_SH2_STAT5	187	190	PF00017	0.668
LIG_SH2_STAT5	198	201	PF00017	0.502
LIG_SH2_STAT5	26	29	PF00017	0.692
LIG_SH2_STAT5	435	438	PF00017	0.454
LIG_SH2_STAT5	485	488	PF00017	0.524
LIG_SH2_STAT5	495	498	PF00017	0.434
LIG_SH2_STAT5	589	592	PF00017	0.546
LIG_SH2_STAT5	604	607	PF00017	0.546
LIG_SH2_STAT5	61	64	PF00017	0.626
LIG_SH2_STAT5	720	723	PF00017	0.404
LIG_SH2_STAT5	727	730	PF00017	0.462
LIG_SH3_3	15	21	PF00018	0.651
LIG_SH3_3	284	290	PF00018	0.675
LIG_SH3_3	303	309	PF00018	0.493
LIG_SH3_3	421	427	PF00018	0.459
LIG_SH3_3	730	736	PF00018	0.647
LIG_SH3_3	96	102	PF00018	0.732
LIG_SUMO_SIM_anti_2	64	69	PF11976	0.682
LIG_SUMO_SIM_anti_2	721	726	PF11976	0.557
LIG_TRAF2_1	193	196	PF00917	0.745
LIG_TRAF2_1	54	57	PF00917	0.638
LIG_TRAF2_1	71	74	PF00917	0.611
LIG_UBA3_1	541	550	PF00899	0.549
LIG_UBA3_1	551	557	PF00899	0.541
LIG_UBA3_1	623	630	PF00899	0.619
LIG_WRC_WIRS_1	212	217	PF05994	0.499
LIG_WRC_WIRS_1	740	745	PF05994	0.625
LIG_WW_1	23	26	PF00397	0.639
MOD_CDK_SPxxK_3	247	254	PF00069	0.606
MOD_CDK_SPxxK_3	789	796	PF00069	0.507
MOD_CK1_1	129	135	PF00069	0.699
MOD_CK1_1	147	153	PF00069	0.494
MOD_CK1_1	247	253	PF00069	0.684
MOD_CK1_1	259	265	PF00069	0.752
MOD_CK1_1	324	330	PF00069	0.821
MOD_CK1_1	43	49	PF00069	0.549
MOD_CK1_1	514	520	PF00069	0.505
MOD_CK1_1	526	532	PF00069	0.562
MOD_CK1_1	591	597	PF00069	0.507
MOD_CK1_1	631	637	PF00069	0.619
MOD_CK1_1	655	661	PF00069	0.737
MOD_CK1_1	741	747	PF00069	0.523
MOD_CK2_1	225	231	PF00069	0.718
MOD_CK2_1	324	330	PF00069	0.766
MOD_CK2_1	526	532	PF00069	0.619
MOD_CK2_1	631	637	PF00069	0.546
MOD_CK2_1	68	74	PF00069	0.711
MOD_CK2_1	79	85	PF00069	0.562
MOD_GlcNHglycan	131	134	PF01048	0.699
MOD_GlcNHglycan	146	149	PF01048	0.522
MOD_GlcNHglycan	152	155	PF01048	0.682
MOD_GlcNHglycan	168	171	PF01048	0.629
MOD_GlcNHglycan	227	230	PF01048	0.745
MOD_GlcNHglycan	235	238	PF01048	0.824
MOD_GlcNHglycan	271	274	PF01048	0.750
MOD_GlcNHglycan	300	303	PF01048	0.730
MOD_GlcNHglycan	330	334	PF01048	0.847
MOD_GlcNHglycan	344	347	PF01048	0.577
MOD_GlcNHglycan	37	40	PF01048	0.717
MOD_GlcNHglycan	444	447	PF01048	0.547
MOD_GlcNHglycan	489	492	PF01048	0.563
MOD_GlcNHglycan	648	651	PF01048	0.679
MOD_GlcNHglycan	654	657	PF01048	0.674
MOD_GlcNHglycan	748	751	PF01048	0.537
MOD_GlcNHglycan	835	838	PF01048	0.597
MOD_GSK3_1	118	125	PF00069	0.674
MOD_GSK3_1	129	136	PF00069	0.669
MOD_GSK3_1	256	263	PF00069	0.753
MOD_GSK3_1	269	276	PF00069	0.609
MOD_GSK3_1	298	305	PF00069	0.768
MOD_GSK3_1	319	326	PF00069	0.837
MOD_GSK3_1	337	344	PF00069	0.667
MOD_GSK3_1	378	385	PF00069	0.738
MOD_GSK3_1	394	401	PF00069	0.367
MOD_GSK3_1	640	647	PF00069	0.730
MOD_GSK3_1	69	76	PF00069	0.612
MOD_GSK3_1	746	753	PF00069	0.530
MOD_GSK3_1	826	833	PF00069	0.398
MOD_N-GLC_1	233	238	PF02516	0.742
MOD_N-GLC_1	273	278	PF02516	0.656
MOD_N-GLC_1	439	444	PF02516	0.635
MOD_N-GLC_1	628	633	PF02516	0.393
MOD_N-GLC_1	652	657	PF02516	0.762
MOD_N-GLC_1	68	73	PF02516	0.612
MOD_N-GLC_1	93	98	PF02516	0.658
MOD_NEK2_1	122	127	PF00069	0.712
MOD_NEK2_1	200	205	PF00069	0.665
MOD_NEK2_1	208	213	PF00069	0.613
MOD_NEK2_1	257	262	PF00069	0.716
MOD_NEK2_1	329	334	PF00069	0.741
MOD_NEK2_1	503	508	PF00069	0.514
MOD_NEK2_1	646	651	PF00069	0.639
MOD_NEK2_1	690	695	PF00069	0.572
MOD_NEK2_1	718	723	PF00069	0.440
MOD_NEK2_1	739	744	PF00069	0.514
MOD_NEK2_1	755	760	PF00069	0.506
MOD_NEK2_1	830	835	PF00069	0.503
MOD_NEK2_2	273	278	PF00069	0.757
MOD_PIKK_1	319	325	PF00454	0.767
MOD_PIKK_1	370	376	PF00454	0.630
MOD_PIKK_1	43	49	PF00454	0.759
MOD_PK_1	124	130	PF00069	0.679
MOD_PKA_1	398	404	PF00069	0.571
MOD_PKA_1	641	647	PF00069	0.634
MOD_PKA_2	106	112	PF00069	0.608
MOD_PKA_2	35	41	PF00069	0.679
MOD_PKA_2	398	404	PF00069	0.571
MOD_PKA_2	523	529	PF00069	0.513
MOD_PKA_2	640	646	PF00069	0.724
MOD_Plk_1	118	124	PF00069	0.662
MOD_Plk_1	273	279	PF00069	0.756
MOD_Plk_1	628	634	PF00069	0.580
MOD_Plk_1	73	79	PF00069	0.647
MOD_Plk_1	93	99	PF00069	0.540
MOD_Plk_4	211	217	PF00069	0.633
MOD_Plk_4	244	250	PF00069	0.731
MOD_Plk_4	415	421	PF00069	0.462
MOD_Plk_4	526	532	PF00069	0.546
MOD_Plk_4	628	634	PF00069	0.619
MOD_Plk_4	690	696	PF00069	0.578
MOD_Plk_4	718	724	PF00069	0.405
MOD_Plk_4	756	762	PF00069	0.511
MOD_ProDKin_1	247	253	PF00069	0.744
MOD_ProDKin_1	286	292	PF00069	0.581
MOD_ProDKin_1	302	308	PF00069	0.656
MOD_ProDKin_1	511	517	PF00069	0.532
MOD_ProDKin_1	789	795	PF00069	0.632
MOD_ProDKin_1	831	837	PF00069	0.608
MOD_SUMO_for_1	116	119	PF00179	0.671
MOD_SUMO_rev_2	622	632	PF00179	0.619
MOD_SUMO_rev_2	808	814	PF00179	0.415
MOD_SUMO_rev_2	851	859	PF00179	0.486
TRG_DiLeu_BaEn_1	548	553	PF01217	0.546
TRG_DiLeu_BaEn_1	773	778	PF01217	0.464
TRG_DiLeu_BaLyEn_6	204	209	PF01217	0.619
TRG_ENDOCYTIC_2	180	183	PF00928	0.578
TRG_ENDOCYTIC_2	26	29	PF00928	0.616
TRG_ENDOCYTIC_2	458	461	PF00928	0.468
TRG_ENDOCYTIC_2	485	488	PF00928	0.491
TRG_ENDOCYTIC_2	589	592	PF00928	0.546
TRG_ENDOCYTIC_2	687	690	PF00928	0.472
TRG_ENDOCYTIC_2	720	723	PF00928	0.440
TRG_ENDOCYTIC_2	740	743	PF00928	0.521
TRG_ER_diArg_1	52	54	PF00400	0.731
TRG_ER_diArg_1	710	713	PF00400	0.394
TRG_ER_diArg_1	815	817	PF00400	0.448

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P522	Leptomonas seymouri	57%	88%
A0A3S7X3N9	Leishmania donovani	91%	100%
A4HIK5	Leishmania braziliensis	73%	100%
A4I5V0	Leishmania infantum	92%	93%
E9B145	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%