Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q719_LEIMA

TriTrypDb:

LmjF.30.2750 , LMJLV39_300035100 , LMJSD75_300034500

Length:

234

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000315	organellar large ribosomal subunit	5	2
GO:0005762	mitochondrial large ribosomal subunit	3	2
GO:0015934	large ribosomal subunit	4	2
GO:0032991	protein-containing complex	1	2
GO:0044391	ribosomal subunit	3	2
GO:0098798	mitochondrial protein-containing complex	2	2
GO:1990904	ribonucleoprotein complex	2	2
GO:0005840	ribosome	5	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q719

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q719

PDB structure(s): 7aih_Q , 7am2_Q , 7ane_Q

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	12
GO:0005198	structural molecule activity	1	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	195	199	PF00656	0.440
CLV_NRD_NRD_1	157	159	PF00675	0.384
CLV_NRD_NRD_1	222	224	PF00675	0.454
CLV_PCSK_FUR_1	155	159	PF00082	0.388
CLV_PCSK_KEX2_1	142	144	PF00082	0.376
CLV_PCSK_KEX2_1	157	159	PF00082	0.390
CLV_PCSK_KEX2_1	212	214	PF00082	0.475
CLV_PCSK_KEX2_1	217	219	PF00082	0.445
CLV_PCSK_PC1ET2_1	142	144	PF00082	0.355
CLV_PCSK_PC1ET2_1	212	214	PF00082	0.490
CLV_PCSK_PC1ET2_1	217	219	PF00082	0.471
CLV_PCSK_PC7_1	213	219	PF00082	0.490
CLV_PCSK_SKI1_1	158	162	PF00082	0.404
CLV_PCSK_SKI1_1	51	55	PF00082	0.426
CLV_PCSK_SKI1_1	63	67	PF00082	0.317
CLV_PCSK_SKI1_1	97	101	PF00082	0.374
DEG_APCC_DBOX_1	50	58	PF00400	0.403
DEG_Nend_Nbox_1	1	3	PF02207	0.539
DOC_MAPK_gen_1	155	162	PF00069	0.391
DOC_USP7_MATH_1	17	21	PF00917	0.462
DOC_USP7_UBL2_3	165	169	PF12436	0.422
DOC_WW_Pin1_4	58	63	PF00397	0.538
LIG_14-3-3_CanoR_1	149	153	PF00244	0.381
LIG_14-3-3_CanoR_1	223	227	PF00244	0.571
LIG_14-3-3_CanoR_1	3	8	PF00244	0.476
LIG_14-3-3_CanoR_1	33	38	PF00244	0.362
LIG_14-3-3_CanoR_1	56	62	PF00244	0.443
LIG_14-3-3_CanoR_1	85	92	PF00244	0.400
LIG_Actin_WH2_2	133	151	PF00022	0.376
LIG_FHA_1	10	16	PF00498	0.468
LIG_FHA_2	149	155	PF00498	0.390
LIG_FHA_2	182	188	PF00498	0.538
LIG_FHA_2	190	196	PF00498	0.594
LIG_LIR_Gen_1	115	125	PF02991	0.381
LIG_LIR_Gen_1	133	141	PF02991	0.256
LIG_LIR_Nem_3	115	120	PF02991	0.391
LIG_LIR_Nem_3	133	139	PF02991	0.255
LIG_LIR_Nem_3	209	214	PF02991	0.577
LIG_LYPXL_yS_3	101	104	PF13949	0.364
LIG_SH2_CRK	96	100	PF00017	0.376
LIG_SH2_STAP1	110	114	PF00017	0.369
LIG_SH2_STAT5	34	37	PF00017	0.351
LIG_SH3_2	23	28	PF14604	0.420
LIG_SH3_3	115	121	PF00018	0.358
LIG_SH3_3	20	26	PF00018	0.426
LIG_SH3_3	64	70	PF00018	0.391
LIG_TRAF2_1	192	195	PF00917	0.567
LIG_TRFH_1	13	17	PF08558	0.444
LIG_TYR_ITIM	99	104	PF00017	0.363
LIG_UBA3_1	127	132	PF00899	0.501
LIG_WRC_WIRS_1	10	15	PF05994	0.428
LIG_WW_3	25	29	PF00397	0.406
MOD_CDK_SPK_2	58	63	PF00069	0.538
MOD_CK1_1	58	64	PF00069	0.452
MOD_CK2_1	141	147	PF00069	0.400
MOD_CK2_1	148	154	PF00069	0.378
MOD_CK2_1	181	187	PF00069	0.497
MOD_CK2_1	189	195	PF00069	0.500
MOD_CMANNOS	42	45	PF00535	0.347
MOD_GlcNHglycan	143	146	PF01048	0.396
MOD_NEK2_1	103	108	PF00069	0.447
MOD_NEK2_1	141	146	PF00069	0.399
MOD_NEK2_1	148	153	PF00069	0.376
MOD_NEK2_1	2	7	PF00069	0.498
MOD_NEK2_1	8	13	PF00069	0.443
MOD_PIKK_1	164	170	PF00454	0.470
MOD_PIKK_1	181	187	PF00454	0.296
MOD_PKA_2	148	154	PF00069	0.371
MOD_PKA_2	2	8	PF00069	0.491
MOD_PKA_2	222	228	PF00069	0.571
MOD_PKA_2	55	61	PF00069	0.401
MOD_PKA_2	86	92	PF00069	0.401
MOD_PKB_1	83	91	PF00069	0.398
MOD_Plk_4	3	9	PF00069	0.614
MOD_ProDKin_1	58	64	PF00069	0.533
MOD_SUMO_rev_2	207	214	PF00179	0.475
TRG_AP2beta_CARGO_1	133	143	PF09066	0.364
TRG_AP2beta_CARGO_1	209	218	PF09066	0.487
TRG_DiLeu_BaEn_1	210	215	PF01217	0.483
TRG_ENDOCYTIC_2	101	104	PF00928	0.364
TRG_ENDOCYTIC_2	34	37	PF00928	0.351
TRG_ENDOCYTIC_2	96	99	PF00928	0.380
TRG_ER_diArg_1	155	158	PF00400	0.369
TRG_Pf-PMV_PEXEL_1	178	182	PF00026	0.448

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5G2	Leptomonas seymouri	86%	99%
A0A0S4IPI6	Bodo saltans	65%	98%
A0A1X0P1J1	Trypanosomatidae	72%	99%
A0A3Q8IEF6	Leishmania donovani	96%	100%
A0A3R7NH11	Trypanosoma rangeli	77%	98%
A4HIK7	Leishmania braziliensis	94%	100%
A4I5V2	Leishmania infantum	96%	100%
C9ZR74	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	72%	97%
E9B147	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
V5B7A9	Trypanosoma cruzi	70%	83%