LeishMANIAdb
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DUF1330 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
DUF1330 domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
Q4Q717_LEIMA
TriTrypDb:
LmjF.30.2765 , LMJLV39_300035200 * , LMJSD75_300034600
Length:
109

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 5
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q717
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q717

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 69 73 PF00656 0.472
CLV_PCSK_SKI1_1 18 22 PF00082 0.436
DOC_MAPK_gen_1 15 24 PF00069 0.505
DOC_MAPK_HePTP_8 12 24 PF00069 0.499
DOC_MAPK_MEF2A_6 15 24 PF00069 0.542
DOC_PP2B_LxvP_1 77 80 PF13499 0.509
DOC_PP4_MxPP_1 1 4 PF00568 0.616
DOC_USP7_MATH_1 35 39 PF00917 0.549
DOC_WW_Pin1_4 83 88 PF00397 0.479
LIG_Actin_WH2_2 89 107 PF00022 0.577
LIG_FHA_1 19 25 PF00498 0.475
LIG_FHA_1 58 64 PF00498 0.439
LIG_FHA_1 99 105 PF00498 0.545
LIG_FHA_2 14 20 PF00498 0.539
LIG_FHA_2 92 98 PF00498 0.498
LIG_LIR_Gen_1 25 34 PF02991 0.611
LIG_LIR_Gen_1 5 12 PF02991 0.527
LIG_LIR_Gen_1 60 68 PF02991 0.487
LIG_LIR_Nem_3 5 11 PF02991 0.529
LIG_LIR_Nem_3 60 64 PF02991 0.500
LIG_LIR_Nem_3 78 84 PF02991 0.462
LIG_SH2_CRK 8 12 PF00017 0.413
LIG_SH2_GRB2like 26 29 PF00017 0.551
LIG_SH2_STAP1 26 30 PF00017 0.532
LIG_SH2_STAP1 8 12 PF00017 0.398
LIG_SH3_3 81 87 PF00018 0.474
LIG_SH3_5 87 91 PF00018 0.487
LIG_SUMO_SIM_par_1 19 25 PF11976 0.496
MOD_CK1_1 86 92 PF00069 0.503
MOD_CK2_1 13 19 PF00069 0.543
MOD_CK2_1 91 97 PF00069 0.492
MOD_GlcNHglycan 97 101 PF01048 0.536
MOD_GSK3_1 14 21 PF00069 0.577
MOD_GSK3_1 2 9 PF00069 0.523
MOD_N-GLC_1 13 18 PF02516 0.464
MOD_PKA_2 91 97 PF00069 0.482
MOD_Plk_1 18 24 PF00069 0.583
MOD_Plk_1 30 36 PF00069 0.528
MOD_Plk_4 18 24 PF00069 0.513
MOD_Plk_4 35 41 PF00069 0.357
MOD_Plk_4 6 12 PF00069 0.518
MOD_ProDKin_1 83 89 PF00069 0.479
TRG_ENDOCYTIC_2 26 29 PF00928 0.539
TRG_ENDOCYTIC_2 8 11 PF00928 0.422

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IJF7 Leptomonas seymouri 52% 100%
A0A1X0P1G7 Trypanosomatidae 35% 100%
A0A1X0P1L4 Trypanosomatidae 32% 97%
A0A3Q8IEZ6 Leishmania donovani 97% 100%
A0A3S5IRF6 Trypanosoma rangeli 35% 97%
A4HIK9 Leishmania braziliensis 58% 100%
A4I5V4 Leishmania infantum 97% 100%
C9ZR72 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 33% 100%
E9B149 Leishmania mexicana (strain MHOM/GT/2001/U1103) 84% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS