Putative superoxide dismutase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

superoxide dismutase, putative

Species:

Leishmania major

UniProt:

Q4Q716_LEIMA

TriTrypDb:

LmjF.30.2770 , LMJLV39_300035300 , LMJSD75_300034700

Length:

268

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q716

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q716

PDB structure(s): 7ane_x

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	19
GO:0004784	superoxide dismutase activity	2	19
GO:0005488	binding	1	19
GO:0016209	antioxidant activity	1	19
GO:0016491	oxidoreductase activity	2	19
GO:0016721	oxidoreductase activity, acting on superoxide radicals as acceptor	3	19
GO:0043167	ion binding	2	19
GO:0043169	cation binding	3	19
GO:0046872	metal ion binding	4	19

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	7	9	PF00675	0.490
CLV_NRD_NRD_1	73	75	PF00675	0.402
CLV_PCSK_KEX2_1	7	9	PF00082	0.459
CLV_PCSK_SKI1_1	172	176	PF00082	0.230
CLV_PCSK_SKI1_1	247	251	PF00082	0.399
CLV_PCSK_SKI1_1	49	53	PF00082	0.460
DEG_Nend_UBRbox_1	1	4	PF02207	0.522
DOC_CKS1_1	25	30	PF01111	0.387
DOC_MAPK_gen_1	149	156	PF00069	0.466
DOC_PP4_FxxP_1	55	58	PF00568	0.270
DOC_USP7_MATH_1	124	128	PF00917	0.345
DOC_USP7_MATH_1	208	212	PF00917	0.296
DOC_USP7_MATH_1	70	74	PF00917	0.343
DOC_WW_Pin1_4	24	29	PF00397	0.456
LIG_14-3-3_CanoR_1	111	116	PF00244	0.312
LIG_14-3-3_CanoR_1	172	177	PF00244	0.335
LIG_14-3-3_CanoR_1	2	6	PF00244	0.506
LIG_BIR_III_4	50	54	PF00653	0.358
LIG_BRCT_BRCA1_1	126	130	PF00533	0.356
LIG_FHA_1	204	210	PF00498	0.334
LIG_LIR_Gen_1	78	89	PF02991	0.267
LIG_LIR_Nem_3	252	258	PF02991	0.310
LIG_LIR_Nem_3	78	84	PF02991	0.255
LIG_Pex14_2	130	134	PF04695	0.282
LIG_Pex14_2	245	249	PF04695	0.247
LIG_PTB_Apo_2	109	116	PF02174	0.399
LIG_REV1ctd_RIR_1	247	255	PF16727	0.356
LIG_SH2_CRK	136	140	PF00017	0.264
LIG_SH2_CRK	228	232	PF00017	0.412
LIG_SH2_SRC	228	231	PF00017	0.247
LIG_SH2_STAT3	261	264	PF00017	0.373
LIG_SH2_STAT5	12	15	PF00017	0.366
LIG_SH2_STAT5	132	135	PF00017	0.264
LIG_SH2_STAT5	189	192	PF00017	0.302
LIG_SH2_STAT5	261	264	PF00017	0.374
LIG_SH2_STAT5	56	59	PF00017	0.392
LIG_SH3_3	22	28	PF00018	0.380
LIG_SH3_5	58	62	PF00018	0.399
LIG_SUMO_SIM_par_1	215	221	PF11976	0.454
MOD_CK1_1	180	186	PF00069	0.360
MOD_CK1_1	24	30	PF00069	0.478
MOD_CK2_1	96	102	PF00069	0.252
MOD_GlcNHglycan	182	185	PF01048	0.290
MOD_GlcNHglycan	223	226	PF01048	0.277
MOD_GSK3_1	111	118	PF00069	0.308
MOD_GSK3_1	156	163	PF00069	0.533
MOD_N-GLC_1	111	116	PF02516	0.410
MOD_N-GLC_1	160	165	PF02516	0.491
MOD_N-GLC_2	131	133	PF02516	0.222
MOD_NEK2_1	1	6	PF00069	0.518
MOD_NEK2_1	115	120	PF00069	0.260
MOD_NEK2_1	156	161	PF00069	0.501
MOD_NEK2_1	190	195	PF00069	0.306
MOD_NEK2_1	249	254	PF00069	0.360
MOD_NEK2_2	135	140	PF00069	0.419
MOD_PIKK_1	156	162	PF00454	0.383
MOD_PIKK_1	16	22	PF00454	0.594
MOD_PIKK_1	177	183	PF00454	0.399
MOD_PKA_2	1	7	PF00069	0.472
MOD_PKA_2	110	116	PF00069	0.335
MOD_PKA_2	35	41	PF00069	0.388
MOD_Plk_1	111	117	PF00069	0.383
MOD_Plk_4	1	7	PF00069	0.592
MOD_ProDKin_1	24	30	PF00069	0.446
MOD_SUMO_for_1	150	153	PF00179	0.479
MOD_SUMO_rev_2	46	54	PF00179	0.356
TRG_DiLeu_BaEn_2	240	246	PF01217	0.452
TRG_DiLeu_BaLyEn_6	212	217	PF01217	0.222
TRG_ENDOCYTIC_2	136	139	PF00928	0.316
TRG_ENDOCYTIC_2	81	84	PF00928	0.279
TRG_ER_diArg_1	6	8	PF00400	0.483

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4B5	Leptomonas seymouri	75%	100%
A0A0N0P8Z4	Leptomonas seymouri	27%	85%
A0A0N0P9F1	Leptomonas seymouri	26%	100%
A0A0S4IVC2	Bodo saltans	42%	95%
A0A0S4JBZ0	Bodo saltans	30%	100%
A0A0S4JFS7	Bodo saltans	29%	100%
A0A0S4JY21	Bodo saltans	29%	90%
A0A1X0NP16	Trypanosomatidae	28%	100%
A0A1X0NRJ7	Trypanosomatidae	30%	87%
A0A1X0P269	Trypanosomatidae	56%	100%
A0A3Q8II48	Leishmania donovani	97%	100%
A0A3R7MQ43	Trypanosoma rangeli	54%	100%
A0A3S5IRU3	Trypanosoma rangeli	25%	100%
A0A3S7X5U1	Leishmania donovani	28%	99%
A4H599	Leishmania braziliensis	27%	100%
A4HIL0	Leishmania braziliensis	85%	100%
A4HKH0	Leishmania braziliensis	26%	100%
A4HKH1	Leishmania braziliensis	26%	100%
A4HKQ4	Leishmania braziliensis	29%	99%
A4HTI0	Leishmania infantum	27%	100%
A4I5V5	Leishmania infantum	97%	100%
A4I884	Leishmania infantum	28%	99%
C9ZPK4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
C9ZR73	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
D0AAF4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	87%
D3KVM5	Burkholderia sp.	25%	100%
E9AMA8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9B150	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
E9B342	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	99%
O13401	Candida albicans	25%	100%
P0A2F4	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	24%	100%
P0A2F5	Salmonella typhi	24%	100%
P0AGD3	Escherichia coli (strain K12)	23%	100%
P0AGD4	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	23%	100%
P0AGD5	Escherichia coli O157:H7	23%	100%
P0AGD6	Shigella flexneri	23%	100%
P18655	Synechococcus elongatus (strain PCC 7942 / FACHB-805)	24%	100%
P19685	Coxiella burnetii (strain RSA 493 / Nine Mile phase I)	23%	100%
P21276	Arabidopsis thaliana	23%	100%
P22302	Nicotiana plumbaginifolia	26%	100%
P37369	Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)	25%	100%
P50061	Leptolyngbya boryana	29%	100%
P77968	Synechocystis sp. (strain PCC 6803 / Kazusa)	25%	100%
Q1RH88	Rickettsia bellii (strain RML369-C)	25%	100%
Q49XZ6	Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41)	21%	100%
Q4Q512	Leishmania major	28%	100%
Q4QIE0	Leishmania major	25%	100%
Q4ULI1	Rickettsia felis (strain ATCC VR-1525 / URRWXCal2)	27%	100%
Q5VRL3	Oryza sativa subsp. japonica	29%	69%
Q68WK0	Rickettsia typhi (strain ATCC VR-144 / Wilmington)	26%	100%
Q71S86	Leishmania donovani	27%	100%
Q8VQ15	Staphylococcus epidermidis	22%	100%
Q92HJ3	Rickettsia conorii (strain ATCC VR-613 / Malish 7)	26%	100%
Q9K4V3	Staphylococcus xylosus	22%	100%
Q9LU64	Arabidopsis thaliana	25%	88%
Q9ZD15	Rickettsia prowazekii (strain Madrid E)	25%	100%
V5AUS6	Trypanosoma cruzi	29%	89%
V5DNY0	Trypanosoma cruzi	56%	85%