C3H1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zinc finger C-x8-C-x5-C-x3-H type (and similar), putative

Species:

Leishmania major

UniProt:

Q4Q715_LEIMA

TriTrypDb:

LmjF.30.2780 , LMJLV39_300035400 , LMJSD75_300034800

Length:

338

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005681	spliceosomal complex	3	2
GO:0005689	U12-type spliceosomal complex	4	2
GO:0032991	protein-containing complex	1	2
GO:0140513	nuclear protein-containing complex	2	2
GO:1990904	ribonucleoprotein complex	2	2

Expansion

Sequence features

Q4Q715

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q715

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0005488	binding	1	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	173	175	PF00675	0.625
CLV_NRD_NRD_1	227	229	PF00675	0.689
CLV_NRD_NRD_1	251	253	PF00675	0.666
CLV_PCSK_KEX2_1	173	175	PF00082	0.625
CLV_PCSK_KEX2_1	227	229	PF00082	0.689
CLV_PCSK_KEX2_1	251	253	PF00082	0.666
DEG_SPOP_SBC_1	142	146	PF00917	0.645
DEG_SPOP_SBC_1	279	283	PF00917	0.517
DOC_PP1_RVXF_1	226	233	PF00149	0.624
DOC_USP7_MATH_1	150	154	PF00917	0.800
DOC_USP7_MATH_1	71	75	PF00917	0.446
DOC_USP7_MATH_2	141	147	PF00917	0.566
DOC_USP7_UBL2_3	297	301	PF12436	0.241
DOC_WW_Pin1_4	256	261	PF00397	0.623
DOC_WW_Pin1_4	273	278	PF00397	0.598
DOC_WW_Pin1_4	95	100	PF00397	0.603
LIG_14-3-3_CanoR_1	15	24	PF00244	0.580
LIG_14-3-3_CanoR_1	166	172	PF00244	0.605
LIG_14-3-3_CanoR_1	191	199	PF00244	0.556
LIG_14-3-3_CanoR_1	227	231	PF00244	0.636
LIG_14-3-3_CanoR_1	308	312	PF00244	0.411
LIG_14-3-3_CanoR_1	70	74	PF00244	0.394
LIG_APCC_ABBA_1	210	215	PF00400	0.633
LIG_BRCT_BRCA1_1	219	223	PF00533	0.658
LIG_BRCT_BRCA1_1	228	232	PF00533	0.598
LIG_FHA_1	11	17	PF00498	0.569
LIG_FHA_1	279	285	PF00498	0.739
LIG_FHA_1	294	300	PF00498	0.543
LIG_FHA_1	57	63	PF00498	0.610
LIG_FHA_2	100	106	PF00498	0.597
LIG_FHA_2	143	149	PF00498	0.712
LIG_FHA_2	21	27	PF00498	0.360
LIG_FHA_2	281	287	PF00498	0.528
LIG_KLC1_Yacidic_2	211	215	PF13176	0.589
LIG_LIR_Apic_2	93	99	PF02991	0.529
LIG_LIR_Nem_3	23	27	PF02991	0.465
LIG_SH2_SRC	27	30	PF00017	0.438
LIG_SH2_STAT5	213	216	PF00017	0.718
LIG_SH2_STAT5	27	30	PF00017	0.485
LIG_SH3_3	136	142	PF00018	0.682
LIG_SH3_3	259	265	PF00018	0.584
LIG_SH3_3	271	277	PF00018	0.545
LIG_SH3_3	98	104	PF00018	0.564
LIG_TRAF2_1	110	113	PF00917	0.626
MOD_CK1_1	128	134	PF00069	0.641
MOD_CK1_1	144	150	PF00069	0.613
MOD_CK1_1	176	182	PF00069	0.661
MOD_CK1_1	183	189	PF00069	0.581
MOD_CK1_1	234	240	PF00069	0.609
MOD_CK1_1	48	54	PF00069	0.415
MOD_CK2_1	142	148	PF00069	0.711
MOD_CK2_1	20	26	PF00069	0.465
MOD_CK2_1	280	286	PF00069	0.561
MOD_CK2_1	36	42	PF00069	0.315
MOD_CK2_1	77	83	PF00069	0.488
MOD_CK2_1	99	105	PF00069	0.599
MOD_Cter_Amidation	171	174	PF01082	0.632
MOD_DYRK1A_RPxSP_1	256	260	PF00069	0.622
MOD_GlcNHglycan	158	161	PF01048	0.660
MOD_GlcNHglycan	178	181	PF01048	0.619
MOD_GlcNHglycan	29	32	PF01048	0.463
MOD_GlcNHglycan	34	37	PF01048	0.483
MOD_GlcNHglycan	47	50	PF01048	0.334
MOD_GSK3_1	10	17	PF00069	0.578
MOD_GSK3_1	176	183	PF00069	0.730
MOD_GSK3_1	191	198	PF00069	0.637
MOD_GSK3_1	254	261	PF00069	0.746
MOD_GSK3_1	303	310	PF00069	0.309
MOD_GSK3_1	32	39	PF00069	0.489
MOD_GSK3_1	95	102	PF00069	0.567
MOD_N-GLC_1	237	242	PF02516	0.631
MOD_NEK2_1	164	169	PF00069	0.566
MOD_NEK2_1	20	25	PF00069	0.448
MOD_NEK2_1	303	308	PF00069	0.326
MOD_PKA_1	173	179	PF00069	0.615
MOD_PKA_2	14	20	PF00069	0.487
MOD_PKA_2	173	179	PF00069	0.621
MOD_PKA_2	226	232	PF00069	0.634
MOD_PKA_2	307	313	PF00069	0.381
MOD_PKA_2	69	75	PF00069	0.401
MOD_Plk_4	183	189	PF00069	0.564
MOD_ProDKin_1	256	262	PF00069	0.620
MOD_ProDKin_1	273	279	PF00069	0.592
MOD_ProDKin_1	95	101	PF00069	0.598
MOD_SUMO_rev_2	146	155	PF00179	0.648
MOD_SUMO_rev_2	170	179	PF00179	0.620
TRG_DiLeu_BaEn_1	42	47	PF01217	0.425
TRG_DiLeu_BaEn_2	285	291	PF01217	0.595
TRG_DiLeu_BaLyEn_6	159	164	PF01217	0.529
TRG_Pf-PMV_PEXEL_1	138	143	PF00026	0.561

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD74	Leptomonas seymouri	32%	99%
A0A3S7X3N7	Leishmania donovani	90%	100%
A4HIL1	Leishmania braziliensis	67%	72%
A4I5V6	Leishmania infantum	90%	100%
E9B151	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%