Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q713_LEIMA

TriTrypDb:

LmjF.30.2800 , LMJLV39_300035600 , LMJSD75_300035000

Length:

274

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

Q4Q713

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q713

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	261	265	PF00656	0.631
CLV_NRD_NRD_1	124	126	PF00675	0.443
CLV_NRD_NRD_1	2	4	PF00675	0.507
CLV_NRD_NRD_1	267	269	PF00675	0.402
CLV_PCSK_KEX2_1	267	269	PF00082	0.377
CLV_PCSK_SKI1_1	125	129	PF00082	0.391
CLV_PCSK_SKI1_1	4	8	PF00082	0.455
DEG_APCC_DBOX_1	124	132	PF00400	0.575
DEG_Nend_Nbox_1	1	3	PF02207	0.695
DEG_SPOP_SBC_1	255	259	PF00917	0.599
DOC_MAPK_MEF2A_6	196	203	PF00069	0.601
DOC_PP1_RVXF_1	124	131	PF00149	0.590
DOC_PP1_RVXF_1	235	242	PF00149	0.612
DOC_PP1_RVXF_1	35	41	PF00149	0.794
DOC_PP2B_LxvP_1	142	145	PF13499	0.484
DOC_PP2B_LxvP_1	7	10	PF13499	0.701
DOC_USP7_MATH_1	165	169	PF00917	0.369
DOC_USP7_MATH_1	227	231	PF00917	0.581
DOC_USP7_MATH_1	255	259	PF00917	0.607
DOC_USP7_MATH_1	32	36	PF00917	0.777
DOC_WW_Pin1_4	148	153	PF00397	0.426
LIG_14-3-3_CanoR_1	219	223	PF00244	0.608
LIG_14-3-3_CanoR_1	240	246	PF00244	0.656
LIG_14-3-3_CanoR_1	251	255	PF00244	0.589
LIG_14-3-3_CanoR_1	256	263	PF00244	0.475
LIG_14-3-3_CanoR_1	31	40	PF00244	0.725
LIG_Actin_WH2_2	226	242	PF00022	0.595
LIG_eIF4E_1	133	139	PF01652	0.443
LIG_FHA_1	133	139	PF00498	0.400
LIG_FHA_1	257	263	PF00498	0.584
LIG_FHA_2	13	19	PF00498	0.605
LIG_FHA_2	187	193	PF00498	0.646
LIG_LIR_Gen_1	200	211	PF02991	0.629
LIG_LIR_Nem_3	168	174	PF02991	0.420
LIG_LIR_Nem_3	200	206	PF02991	0.581
LIG_LIR_Nem_3	213	218	PF02991	0.493
LIG_LIR_Nem_3	269	273	PF02991	0.569
LIG_LYPXL_yS_3	211	214	PF13949	0.555
LIG_NRBOX	133	139	PF00104	0.443
LIG_Pex14_2	270	274	PF04695	0.611
LIG_PTB_Apo_2	126	133	PF02174	0.561
LIG_SH2_STAT3	154	157	PF00017	0.478
LIG_SH2_STAT5	133	136	PF00017	0.410
LIG_SH2_STAT5	154	157	PF00017	0.453
LIG_SH2_STAT5	171	174	PF00017	0.345
LIG_SH3_3	115	121	PF00018	0.742
LIG_SUMO_SIM_anti_2	135	142	PF11976	0.363
LIG_TRAF2_1	54	57	PF00917	0.740
MOD_CK2_1	12	18	PF00069	0.709
MOD_CK2_1	177	183	PF00069	0.492
MOD_CK2_1	186	192	PF00069	0.614
MOD_CK2_1	218	224	PF00069	0.628
MOD_CK2_1	50	56	PF00069	0.713
MOD_GlcNHglycan	167	170	PF01048	0.400
MOD_GlcNHglycan	21	24	PF01048	0.489
MOD_GlcNHglycan	229	232	PF01048	0.366
MOD_GlcNHglycan	234	237	PF01048	0.413
MOD_GlcNHglycan	52	55	PF01048	0.563
MOD_GlcNHglycan	7	10	PF01048	0.541
MOD_GSK3_1	148	155	PF00069	0.440
MOD_GSK3_1	227	234	PF00069	0.599
MOD_GSK3_1	250	257	PF00069	0.704
MOD_GSK3_1	32	39	PF00069	0.728
MOD_GSK3_1	46	53	PF00069	0.724
MOD_N-GLC_1	41	46	PF02516	0.562
MOD_NEK2_1	11	16	PF00069	0.755
MOD_NEK2_1	132	137	PF00069	0.369
MOD_NEK2_1	241	246	PF00069	0.558
MOD_NEK2_1	33	38	PF00069	0.689
MOD_PIKK_1	205	211	PF00454	0.597
MOD_PIKK_1	218	224	PF00454	0.527
MOD_PIKK_1	46	52	PF00454	0.803
MOD_PKA_2	218	224	PF00069	0.628
MOD_PKA_2	250	256	PF00069	0.633
MOD_PKA_2	36	42	PF00069	0.740
MOD_Plk_4	133	139	PF00069	0.295
MOD_Plk_4	210	216	PF00069	0.571
MOD_Plk_4	241	247	PF00069	0.611
MOD_ProDKin_1	148	154	PF00069	0.430
MOD_SUMO_for_1	187	190	PF00179	0.576
TRG_ENDOCYTIC_2	171	174	PF00928	0.400
TRG_ENDOCYTIC_2	211	214	PF00928	0.555
TRG_ER_diArg_1	266	268	PF00400	0.588
TRG_Pf-PMV_PEXEL_1	66	70	PF00026	0.446

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4B3	Leptomonas seymouri	67%	100%
A0A0S4IU47	Bodo saltans	36%	75%
A0A1X0P2M0	Trypanosomatidae	48%	100%
A0A3R7L2S3	Trypanosoma rangeli	47%	100%
A0A3S7X3P3	Leishmania donovani	93%	100%
A4HIL3	Leishmania braziliensis	82%	100%
A4I5V8	Leishmania infantum	93%	100%
E9B153	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%