TPH domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q710_LEIMA

TriTrypDb:

LmjF.30.2830 , LMJLV39_300035900 , LMJSD75_300035300

Length:

799

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	2
GO:0036064	ciliary basal body	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q710

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q710

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	3	7	PF00656	0.680
CLV_C14_Caspase3-7	759	763	PF00656	0.654
CLV_NRD_NRD_1	14	16	PF00675	0.746
CLV_NRD_NRD_1	268	270	PF00675	0.531
CLV_NRD_NRD_1	278	280	PF00675	0.535
CLV_NRD_NRD_1	323	325	PF00675	0.498
CLV_NRD_NRD_1	331	333	PF00675	0.505
CLV_NRD_NRD_1	386	388	PF00675	0.545
CLV_NRD_NRD_1	413	415	PF00675	0.575
CLV_NRD_NRD_1	422	424	PF00675	0.573
CLV_NRD_NRD_1	448	450	PF00675	0.612
CLV_NRD_NRD_1	456	458	PF00675	0.658
CLV_NRD_NRD_1	587	589	PF00675	0.498
CLV_NRD_NRD_1	608	610	PF00675	0.589
CLV_NRD_NRD_1	61	63	PF00675	0.708
CLV_NRD_NRD_1	618	620	PF00675	0.474
CLV_NRD_NRD_1	736	738	PF00675	0.554
CLV_PCSK_FUR_1	265	269	PF00082	0.639
CLV_PCSK_FUR_1	321	325	PF00082	0.530
CLV_PCSK_FUR_1	329	333	PF00082	0.506
CLV_PCSK_FUR_1	384	388	PF00082	0.508
CLV_PCSK_KEX2_1	145	147	PF00082	0.594
CLV_PCSK_KEX2_1	188	190	PF00082	0.593
CLV_PCSK_KEX2_1	265	267	PF00082	0.548
CLV_PCSK_KEX2_1	268	270	PF00082	0.524
CLV_PCSK_KEX2_1	278	280	PF00082	0.521
CLV_PCSK_KEX2_1	323	325	PF00082	0.515
CLV_PCSK_KEX2_1	331	333	PF00082	0.476
CLV_PCSK_KEX2_1	386	388	PF00082	0.507
CLV_PCSK_KEX2_1	413	415	PF00082	0.575
CLV_PCSK_KEX2_1	422	424	PF00082	0.573
CLV_PCSK_KEX2_1	448	450	PF00082	0.614
CLV_PCSK_KEX2_1	471	473	PF00082	0.580
CLV_PCSK_KEX2_1	587	589	PF00082	0.495
CLV_PCSK_KEX2_1	608	610	PF00082	0.546
CLV_PCSK_KEX2_1	61	63	PF00082	0.755
CLV_PCSK_KEX2_1	701	703	PF00082	0.486
CLV_PCSK_KEX2_1	736	738	PF00082	0.564
CLV_PCSK_PC1ET2_1	145	147	PF00082	0.594
CLV_PCSK_PC1ET2_1	188	190	PF00082	0.594
CLV_PCSK_PC1ET2_1	471	473	PF00082	0.580
CLV_PCSK_PC1ET2_1	61	63	PF00082	0.775
CLV_PCSK_PC1ET2_1	701	703	PF00082	0.478
CLV_PCSK_SKI1_1	165	169	PF00082	0.559
CLV_PCSK_SKI1_1	298	302	PF00082	0.515
CLV_PCSK_SKI1_1	315	319	PF00082	0.476
CLV_PCSK_SKI1_1	343	347	PF00082	0.573
CLV_PCSK_SKI1_1	351	355	PF00082	0.484
CLV_PCSK_SKI1_1	367	371	PF00082	0.394
CLV_PCSK_SKI1_1	413	417	PF00082	0.717
CLV_PCSK_SKI1_1	587	591	PF00082	0.487
CLV_PCSK_SKI1_1	609	613	PF00082	0.477
CLV_PCSK_SKI1_1	619	623	PF00082	0.462
CLV_PCSK_SKI1_1	711	715	PF00082	0.501
CLV_PCSK_SKI1_1	792	796	PF00082	0.538
DEG_APCC_DBOX_1	440	448	PF00400	0.692
DEG_APCC_DBOX_1	608	616	PF00400	0.532
DEG_APCC_DBOX_1	791	799	PF00400	0.550
DEG_SPOP_SBC_1	75	79	PF00917	0.692
DOC_CDC14_PxL_1	4	12	PF14671	0.650
DOC_CYCLIN_RxL_1	616	623	PF00134	0.561
DOC_MAPK_gen_1	422	429	PF00069	0.473
DOC_PP4_FxxP_1	105	108	PF00568	0.700
DOC_USP7_MATH_1	108	112	PF00917	0.752
DOC_USP7_MATH_1	218	222	PF00917	0.700
DOC_USP7_MATH_1	42	46	PF00917	0.810
DOC_USP7_MATH_1	54	58	PF00917	0.655
DOC_USP7_MATH_1	575	579	PF00917	0.612
DOC_USP7_MATH_1	652	656	PF00917	0.649
DOC_USP7_MATH_1	671	675	PF00917	0.358
DOC_USP7_MATH_1	742	746	PF00917	0.584
DOC_USP7_MATH_1	75	79	PF00917	0.676
DOC_USP7_UBL2_3	59	63	PF12436	0.723
DOC_USP7_UBL2_3	697	701	PF12436	0.534
DOC_WW_Pin1_4	118	123	PF00397	0.741
DOC_WW_Pin1_4	125	130	PF00397	0.737
DOC_WW_Pin1_4	8	13	PF00397	0.672
LIG_14-3-3_CanoR_1	146	152	PF00244	0.599
LIG_14-3-3_CanoR_1	15	21	PF00244	0.743
LIG_14-3-3_CanoR_1	273	278	PF00244	0.611
LIG_14-3-3_CanoR_1	526	530	PF00244	0.590
LIG_14-3-3_CanoR_1	690	696	PF00244	0.598
LIG_BIR_II_1	1	5	PF00653	0.695
LIG_CaM_IQ_9	527	543	PF13499	0.549
LIG_FHA_1	428	434	PF00498	0.683
LIG_FHA_1	664	670	PF00498	0.589
LIG_FHA_2	148	154	PF00498	0.645
LIG_FHA_2	366	372	PF00498	0.531
LIG_LIR_Apic_2	103	108	PF02991	0.766
LIG_LIR_Apic_2	26	32	PF02991	0.649
LIG_LIR_Gen_1	19	25	PF02991	0.597
LIG_LIR_Gen_1	299	309	PF02991	0.516
LIG_LIR_Gen_1	623	634	PF02991	0.466
LIG_LIR_Gen_1	730	739	PF02991	0.640
LIG_LIR_Nem_3	19	23	PF02991	0.609
LIG_LIR_Nem_3	299	304	PF02991	0.518
LIG_LIR_Nem_3	363	369	PF02991	0.533
LIG_LIR_Nem_3	623	629	PF02991	0.465
LIG_LIR_Nem_3	730	735	PF02991	0.632
LIG_MYND_1	8	12	PF01753	0.715
LIG_PCNA_yPIPBox_3	535	548	PF02747	0.544
LIG_SH2_CRK	148	152	PF00017	0.671
LIG_SH2_CRK	597	601	PF00017	0.586
LIG_SH2_NCK_1	148	152	PF00017	0.629
LIG_SH2_PTP2	29	32	PF00017	0.616
LIG_SH2_STAP1	101	105	PF00017	0.676
LIG_SH2_STAP1	25	29	PF00017	0.684
LIG_SH2_STAT3	440	443	PF00017	0.545
LIG_SH2_STAT5	114	117	PF00017	0.732
LIG_SH2_STAT5	29	32	PF00017	0.631
LIG_SH3_3	127	133	PF00018	0.667
LIG_SH3_3	69	75	PF00018	0.690
LIG_TRAF2_1	150	153	PF00917	0.616
LIG_TRAF2_1	280	283	PF00917	0.607
LIG_TRAF2_1	417	420	PF00917	0.636
LIG_TRAF2_1	507	510	PF00917	0.714
LIG_TRAF2_1	674	677	PF00917	0.480
LIG_TRAF2_1	744	747	PF00917	0.595
LIG_WRC_WIRS_1	366	371	PF05994	0.591
LIG_WRC_WIRS_1	576	581	PF05994	0.614
MOD_CDK_SPxxK_3	125	132	PF00069	0.660
MOD_CDK_SPxxK_3	8	15	PF00069	0.714
MOD_CK1_1	11	17	PF00069	0.740
MOD_CK1_1	117	123	PF00069	0.690
MOD_CK1_1	43	49	PF00069	0.765
MOD_CK1_1	554	560	PF00069	0.550
MOD_CK1_1	57	63	PF00069	0.511
MOD_CK1_1	577	583	PF00069	0.495
MOD_CK1_1	685	691	PF00069	0.634
MOD_CK1_1	77	83	PF00069	0.647
MOD_CK2_1	147	153	PF00069	0.627
MOD_CK2_1	256	262	PF00069	0.716
MOD_CK2_1	365	371	PF00069	0.590
MOD_CK2_1	496	502	PF00069	0.682
MOD_CK2_1	671	677	PF00069	0.582
MOD_CK2_1	727	733	PF00069	0.611
MOD_CK2_1	741	747	PF00069	0.438
MOD_GlcNHglycan	220	223	PF01048	0.662
MOD_GlcNHglycan	434	439	PF01048	0.589
MOD_GlcNHglycan	85	88	PF01048	0.679
MOD_GSK3_1	113	120	PF00069	0.724
MOD_GSK3_1	228	235	PF00069	0.782
MOD_GSK3_1	40	47	PF00069	0.709
MOD_GSK3_1	508	515	PF00069	0.692
MOD_GSK3_1	6	13	PF00069	0.632
MOD_GSK3_1	685	692	PF00069	0.634
MOD_GSK3_1	74	81	PF00069	0.654
MOD_LATS_1	271	277	PF00433	0.610
MOD_N-GLC_1	304	309	PF02516	0.471
MOD_N-GLC_1	496	501	PF02516	0.676
MOD_NEK2_1	147	152	PF00069	0.672
MOD_NEK2_1	304	309	PF00069	0.471
MOD_NEK2_1	427	432	PF00069	0.651
MOD_NEK2_1	512	517	PF00069	0.599
MOD_NEK2_1	574	579	PF00069	0.537
MOD_PIKK_1	211	217	PF00454	0.655
MOD_PIKK_1	551	557	PF00454	0.551
MOD_PIKK_1	742	748	PF00454	0.635
MOD_PK_1	682	688	PF00069	0.586
MOD_PKA_2	391	397	PF00069	0.596
MOD_PKA_2	525	531	PF00069	0.590
MOD_PKA_2	54	60	PF00069	0.762
MOD_PKA_2	689	695	PF00069	0.587
MOD_Plk_1	304	310	PF00069	0.471
MOD_Plk_1	496	502	PF00069	0.725
MOD_Plk_1	652	658	PF00069	0.595
MOD_Plk_4	304	310	PF00069	0.495
MOD_Plk_4	525	531	PF00069	0.634
MOD_Plk_4	652	658	PF00069	0.595
MOD_ProDKin_1	118	124	PF00069	0.742
MOD_ProDKin_1	125	131	PF00069	0.738
MOD_ProDKin_1	8	14	PF00069	0.670
MOD_SUMO_for_1	167	170	PF00179	0.613
MOD_SUMO_for_1	317	320	PF00179	0.505
MOD_SUMO_for_1	415	418	PF00179	0.728
MOD_SUMO_for_1	570	573	PF00179	0.602
MOD_SUMO_for_1	681	684	PF00179	0.511
MOD_SUMO_for_1	696	699	PF00179	0.525
MOD_SUMO_rev_2	139	147	PF00179	0.584
MOD_SUMO_rev_2	347	355	PF00179	0.560
MOD_SUMO_rev_2	360	366	PF00179	0.470
MOD_SUMO_rev_2	545	554	PF00179	0.507
MOD_SUMO_rev_2	614	622	PF00179	0.468
MOD_SUMO_rev_2	674	681	PF00179	0.580
MOD_SUMO_rev_2	698	703	PF00179	0.489
TRG_AP2beta_CARGO_1	363	373	PF09066	0.624
TRG_DiLeu_BaEn_1	312	317	PF01217	0.477
TRG_DiLeu_BaEn_1	724	729	PF01217	0.504
TRG_DiLeu_LyEn_5	312	317	PF01217	0.477
TRG_ENDOCYTIC_2	148	151	PF00928	0.627
TRG_ENDOCYTIC_2	597	600	PF00928	0.485
TRG_ER_diArg_1	180	183	PF00400	0.663
TRG_ER_diArg_1	265	268	PF00400	0.545
TRG_ER_diArg_1	277	279	PF00400	0.530
TRG_ER_diArg_1	322	324	PF00400	0.547
TRG_ER_diArg_1	384	387	PF00400	0.595
TRG_ER_diArg_1	447	449	PF00400	0.639
TRG_ER_diArg_1	562	565	PF00400	0.476
TRG_ER_diArg_1	608	610	PF00400	0.546
TRG_ER_diArg_1	672	675	PF00400	0.579
TRG_ER_diArg_1	735	737	PF00400	0.558
TRG_ER_diArg_1	748	751	PF00400	0.697
TRG_NLS_Bipartite_1	50	66	PF00514	0.734
TRG_NLS_MonoCore_2	60	65	PF00514	0.779
TRG_NLS_MonoExtC_3	57	62	PF00514	0.733
TRG_NLS_MonoExtN_4	48	54	PF00514	0.687
TRG_NLS_MonoExtN_4	55	62	PF00514	0.685
TRG_Pf-PMV_PEXEL_1	189	194	PF00026	0.583
TRG_Pf-PMV_PEXEL_1	315	319	PF00026	0.476
TRG_Pf-PMV_PEXEL_1	326	330	PF00026	0.490
TRG_Pf-PMV_PEXEL_1	343	347	PF00026	0.587
TRG_Pf-PMV_PEXEL_1	387	391	PF00026	0.601
TRG_Pf-PMV_PEXEL_1	400	404	PF00026	0.530
TRG_Pf-PMV_PEXEL_1	521	525	PF00026	0.634
TRG_Pf-PMV_PEXEL_1	535	539	PF00026	0.440
TRG_Pf-PMV_PEXEL_1	619	623	PF00026	0.561

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC64	Leptomonas seymouri	72%	100%
A0A1X0P1G0	Trypanosomatidae	42%	99%
A0A3R7M5L7	Trypanosoma rangeli	44%	100%
A0A3S7X3P7	Leishmania donovani	94%	100%
A4HIL6	Leishmania braziliensis	84%	100%
A4I5W1	Leishmania infantum	94%	100%
C9ZR81	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9B156	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%