GTPase activator-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

GTPase activator-like protein

Species:

Leishmania major

UniProt:

Q4Q709_LEIMA

TriTrypDb:

LmjF.30.2840 , LMJLV39_300036000 , LMJSD75_300035400

Length:

324

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q709

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q709

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0006886	intracellular protein transport	4	2
GO:0008104	protein localization	4	2
GO:0009987	cellular process	1	2
GO:0015031	protein transport	4	2
GO:0033036	macromolecule localization	2	2
GO:0043085	positive regulation of catalytic activity	4	2
GO:0043087	regulation of GTPase activity	5	2
GO:0043547	positive regulation of GTPase activity	6	2
GO:0044093	positive regulation of molecular function	3	2
GO:0045184	establishment of protein localization	3	2
GO:0046907	intracellular transport	3	2
GO:0050790	regulation of catalytic activity	3	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051336	regulation of hydrolase activity	4	2
GO:0051345	positive regulation of hydrolase activity	5	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0065007	biological regulation	1	2
GO:0065009	regulation of molecular function	2	2
GO:0070727	cellular macromolecule localization	3	2
GO:0071702	organic substance transport	4	2
GO:0071705	nitrogen compound transport	4	2
GO:0090630	activation of GTPase activity	7	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0003924	GTPase activity	7	5
GO:0003925	G protein activity	2	5
GO:0005096	GTPase activator activity	4	2
GO:0008047	enzyme activator activity	3	2
GO:0016462	pyrophosphatase activity	5	5
GO:0016787	hydrolase activity	2	5
GO:0016817	hydrolase activity, acting on acid anhydrides	3	5
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	5
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	5
GO:0030234	enzyme regulator activity	2	2
GO:0030695	GTPase regulator activity	4	2
GO:0060589	nucleoside-triphosphatase regulator activity	3	2
GO:0098772	molecular function regulator activity	1	5
GO:0140677	molecular function activator activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	90	92	PF00675	0.335
CLV_PCSK_KEX2_1	9	11	PF00082	0.590
CLV_PCSK_KEX2_1	90	92	PF00082	0.335
CLV_PCSK_PC1ET2_1	9	11	PF00082	0.603
CLV_PCSK_SKI1_1	272	276	PF00082	0.463
CLV_PCSK_SKI1_1	90	94	PF00082	0.359
DEG_APCC_DBOX_1	271	279	PF00400	0.491
DOC_CYCLIN_yClb1_LxF_4	171	177	PF00134	0.447
DOC_MAPK_MEF2A_6	53	60	PF00069	0.428
DOC_PP4_FxxP_1	176	179	PF00568	0.355
DOC_USP7_MATH_1	33	37	PF00917	0.556
DOC_USP7_MATH_1	63	67	PF00917	0.363
DOC_USP7_MATH_1	99	103	PF00917	0.473
DOC_USP7_UBL2_3	276	280	PF12436	0.511
DOC_WW_Pin1_4	290	295	PF00397	0.470
DOC_WW_Pin1_4	80	85	PF00397	0.350
LIG_BRCT_BRCA1_1	153	157	PF00533	0.393
LIG_BRCT_BRCA1_1	56	60	PF00533	0.378
LIG_FHA_1	127	133	PF00498	0.408
LIG_FHA_1	164	170	PF00498	0.461
LIG_FHA_1	74	80	PF00498	0.460
LIG_LIR_Gen_1	180	190	PF02991	0.378
LIG_LIR_Gen_1	282	291	PF02991	0.484
LIG_LIR_Gen_1	44	52	PF02991	0.402
LIG_LIR_Gen_1	8	19	PF02991	0.467
LIG_LIR_Nem_3	135	140	PF02991	0.336
LIG_LIR_Nem_3	180	185	PF02991	0.378
LIG_LIR_Nem_3	186	190	PF02991	0.390
LIG_LIR_Nem_3	21	25	PF02991	0.429
LIG_LIR_Nem_3	282	286	PF02991	0.477
LIG_LIR_Nem_3	44	49	PF02991	0.473
LIG_LIR_Nem_3	8	14	PF02991	0.497
LIG_PDZ_Class_1	319	324	PF00595	0.641
LIG_Pex14_1	277	281	PF04695	0.400
LIG_Pex14_2	151	155	PF04695	0.445
LIG_Pex14_2	204	208	PF04695	0.355
LIG_Pex14_2	219	223	PF04695	0.355
LIG_PTB_Apo_2	226	233	PF02174	0.441
LIG_SH2_CRK	22	26	PF00017	0.535
LIG_SH2_STAP1	195	199	PF00017	0.335
LIG_SH2_STAT5	105	108	PF00017	0.335
LIG_SH2_STAT5	112	115	PF00017	0.335
LIG_SH2_STAT5	146	149	PF00017	0.408
LIG_SH2_STAT5	187	190	PF00017	0.466
LIG_SH3_3	288	294	PF00018	0.463
LIG_SH3_3	46	52	PF00018	0.383
LIG_TYR_ITIM	185	190	PF00017	0.402
LIG_UBA3_1	269	276	PF00899	0.479
LIG_UBA3_1	285	290	PF00899	0.396
LIG_WRC_WIRS_1	220	225	PF05994	0.335
MOD_CK1_1	126	132	PF00069	0.424
MOD_CK1_1	245	251	PF00069	0.482
MOD_CK2_1	33	39	PF00069	0.558
MOD_CK2_1	63	69	PF00069	0.430
MOD_CK2_1	72	78	PF00069	0.391
MOD_GlcNHglycan	247	250	PF01048	0.557
MOD_GSK3_1	241	248	PF00069	0.434
MOD_GSK3_1	315	322	PF00069	0.529
MOD_GSK3_1	63	70	PF00069	0.364
MOD_N-GLC_1	126	131	PF02516	0.408
MOD_N-GLC_1	99	104	PF02516	0.480
MOD_NEK2_1	163	168	PF00069	0.461
MOD_NEK2_1	219	224	PF00069	0.355
MOD_NEK2_1	242	247	PF00069	0.391
MOD_NEK2_1	300	305	PF00069	0.566
MOD_NEK2_1	93	98	PF00069	0.432
MOD_PIKK_1	202	208	PF00454	0.298
MOD_PIKK_1	82	88	PF00454	0.378
MOD_PKA_2	242	248	PF00069	0.417
MOD_PKA_2	300	306	PF00069	0.558
MOD_Plk_1	63	69	PF00069	0.398
MOD_Plk_1	99	105	PF00069	0.480
MOD_Plk_4	133	139	PF00069	0.388
MOD_Plk_4	142	148	PF00069	0.313
MOD_Plk_4	177	183	PF00069	0.480
MOD_Plk_4	242	248	PF00069	0.403
MOD_Plk_4	315	321	PF00069	0.572
MOD_ProDKin_1	290	296	PF00069	0.466
MOD_ProDKin_1	80	86	PF00069	0.350
MOD_SUMO_rev_2	282	292	PF00179	0.459
TRG_DiLeu_BaLyEn_6	254	259	PF01217	0.491
TRG_ENDOCYTIC_2	187	190	PF00928	0.488
TRG_ENDOCYTIC_2	22	25	PF00928	0.433
TRG_ER_diArg_1	89	91	PF00400	0.335

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1N7	Leptomonas seymouri	66%	100%
A0A0S4ITU5	Bodo saltans	40%	79%
A0A1X0P1K5	Trypanosomatidae	47%	81%
A0A3S7X3S6	Leishmania donovani	95%	100%
A4HIL7	Leishmania braziliensis	81%	100%
A4I5W2	Leishmania infantum	95%	100%
C9ZR83	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	82%
E9B157	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5B7A5	Trypanosoma cruzi	50%	100%