Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q704_LEIMA

TriTrypDb:

LmjF.30.2880 , LMJLV39_300036700 , LMJSD75_300035900

Length:

673

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q704

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q704

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	425	429	PF00656	0.563
CLV_C14_Caspase3-7	493	497	PF00656	0.573
CLV_C14_Caspase3-7	603	607	PF00656	0.584
CLV_NRD_NRD_1	28	30	PF00675	0.465
CLV_NRD_NRD_1	39	41	PF00675	0.529
CLV_NRD_NRD_1	54	56	PF00675	0.686
CLV_NRD_NRD_1	640	642	PF00675	0.557
CLV_PCSK_KEX2_1	28	30	PF00082	0.476
CLV_PCSK_KEX2_1	39	41	PF00082	0.529
CLV_PCSK_KEX2_1	53	55	PF00082	0.691
CLV_PCSK_KEX2_1	640	642	PF00082	0.577
CLV_PCSK_PC7_1	50	56	PF00082	0.722
CLV_PCSK_SKI1_1	28	32	PF00082	0.486
CLV_PCSK_SKI1_1	308	312	PF00082	0.513
CLV_PCSK_SKI1_1	39	43	PF00082	0.564
CLV_PCSK_SKI1_1	652	656	PF00082	0.486
DEG_Nend_UBRbox_1	1	4	PF02207	0.649
DEG_SPOP_SBC_1	193	197	PF00917	0.598
DEG_SPOP_SBC_1	81	85	PF00917	0.652
DOC_CYCLIN_RxL_1	305	313	PF00134	0.548
DOC_CYCLIN_yCln2_LP_2	320	326	PF00134	0.479
DOC_MAPK_DCC_7	535	543	PF00069	0.523
DOC_MAPK_MEF2A_6	592	599	PF00069	0.533
DOC_PP4_FxxP_1	131	134	PF00568	0.719
DOC_PP4_FxxP_1	166	169	PF00568	0.654
DOC_USP7_MATH_1	386	390	PF00917	0.505
DOC_USP7_MATH_1	43	47	PF00917	0.679
DOC_USP7_MATH_1	431	435	PF00917	0.508
DOC_USP7_MATH_1	48	52	PF00917	0.724
DOC_USP7_MATH_1	566	570	PF00917	0.544
DOC_USP7_MATH_1	586	590	PF00917	0.196
DOC_USP7_MATH_1	639	643	PF00917	0.574
DOC_USP7_MATH_1	81	85	PF00917	0.745
DOC_USP7_MATH_1	93	97	PF00917	0.661
DOC_WW_Pin1_4	169	174	PF00397	0.619
DOC_WW_Pin1_4	221	226	PF00397	0.458
DOC_WW_Pin1_4	370	375	PF00397	0.449
DOC_WW_Pin1_4	641	646	PF00397	0.519
DOC_WW_Pin1_4	656	661	PF00397	0.502
LIG_14-3-3_CanoR_1	128	132	PF00244	0.613
LIG_14-3-3_CanoR_1	161	169	PF00244	0.765
LIG_14-3-3_CanoR_1	183	193	PF00244	0.585
LIG_14-3-3_CanoR_1	387	393	PF00244	0.561
LIG_14-3-3_CanoR_1	441	449	PF00244	0.534
LIG_14-3-3_CanoR_1	55	64	PF00244	0.770
LIG_14-3-3_CterR_2	668	673	PF00244	0.549
LIG_Actin_WH2_2	13	30	PF00022	0.482
LIG_BRCT_BRCA1_1	162	166	PF00533	0.752
LIG_BRCT_BRCA1_1	630	634	PF00533	0.506
LIG_CaM_IQ_9	343	359	PF13499	0.549
LIG_eIF4E_1	289	295	PF01652	0.435
LIG_FHA_1	127	133	PF00498	0.701
LIG_FHA_1	193	199	PF00498	0.596
LIG_FHA_1	254	260	PF00498	0.474
LIG_FHA_1	331	337	PF00498	0.442
LIG_FHA_1	353	359	PF00498	0.532
LIG_FHA_1	395	401	PF00498	0.551
LIG_FHA_1	653	659	PF00498	0.520
LIG_FHA_1	72	78	PF00498	0.694
LIG_FHA_2	150	156	PF00498	0.566
LIG_FHA_2	32	38	PF00498	0.531
LIG_FHA_2	401	407	PF00498	0.531
LIG_FHA_2	474	480	PF00498	0.487
LIG_FHA_2	491	497	PF00498	0.424
LIG_FHA_2	601	607	PF00498	0.573
LIG_FHA_2	642	648	PF00498	0.451
LIG_LIR_Apic_2	129	134	PF02991	0.709
LIG_LIR_Apic_2	163	169	PF02991	0.662
LIG_LIR_Gen_1	364	374	PF02991	0.555
LIG_LIR_Gen_1	434	443	PF02991	0.423
LIG_LIR_LC3C_4	270	275	PF02991	0.491
LIG_LIR_Nem_3	364	369	PF02991	0.462
LIG_LIR_Nem_3	434	439	PF02991	0.415
LIG_LIR_Nem_3	442	446	PF02991	0.405
LIG_NRBOX	229	235	PF00104	0.483
LIG_NRBOX	6	12	PF00104	0.480
LIG_Rb_LxCxE_1	278	290	PF01857	0.628
LIG_REV1ctd_RIR_1	363	372	PF16727	0.422
LIG_SH2_CRK	436	440	PF00017	0.399
LIG_SH2_STAP1	418	422	PF00017	0.467
LIG_SH2_STAP1	613	617	PF00017	0.533
LIG_SH2_STAT3	220	223	PF00017	0.521
LIG_SH2_STAT3	350	353	PF00017	0.593
LIG_SH2_STAT5	220	223	PF00017	0.533
LIG_SH2_STAT5	297	300	PF00017	0.504
LIG_SH3_3	219	225	PF00018	0.446
LIG_SH3_3	290	296	PF00018	0.423
LIG_SH3_3	571	577	PF00018	0.455
LIG_SUMO_SIM_anti_2	397	403	PF11976	0.499
LIG_SUMO_SIM_par_1	473	479	PF11976	0.389
LIG_TRAF2_1	34	37	PF00917	0.587
LIG_TYR_ITIM	295	300	PF00017	0.285
LIG_UBA3_1	510	516	PF00899	0.441
LIG_WRC_WIRS_1	440	445	PF05994	0.407
MOD_CDK_SPxxK_3	641	648	PF00069	0.515
MOD_CK1_1	184	190	PF00069	0.575
MOD_CK1_1	301	307	PF00069	0.595
MOD_CK1_1	457	463	PF00069	0.524
MOD_CK1_1	489	495	PF00069	0.475
MOD_CK1_1	503	509	PF00069	0.514
MOD_CK1_1	56	62	PF00069	0.742
MOD_CK1_1	65	71	PF00069	0.754
MOD_CK1_1	79	85	PF00069	0.751
MOD_CK1_1	87	93	PF00069	0.710
MOD_CK2_1	149	155	PF00069	0.566
MOD_CK2_1	31	37	PF00069	0.547
MOD_CK2_1	473	479	PF00069	0.489
MOD_DYRK1A_RPxSP_1	641	645	PF00069	0.569
MOD_DYRK1A_RPxSP_1	656	660	PF00069	0.584
MOD_GlcNHglycan	163	166	PF01048	0.726
MOD_GlcNHglycan	189	192	PF01048	0.656
MOD_GlcNHglycan	269	272	PF01048	0.421
MOD_GlcNHglycan	300	303	PF01048	0.445
MOD_GlcNHglycan	312	315	PF01048	0.435
MOD_GlcNHglycan	443	446	PF01048	0.513
MOD_GlcNHglycan	479	483	PF01048	0.491
MOD_GlcNHglycan	496	499	PF01048	0.456
MOD_GlcNHglycan	58	61	PF01048	0.717
MOD_GlcNHglycan	588	591	PF01048	0.427
MOD_GlcNHglycan	79	82	PF01048	0.764
MOD_GlcNHglycan	89	92	PF01048	0.746
MOD_GlcNHglycan	95	98	PF01048	0.735
MOD_GSK3_1	156	163	PF00069	0.797
MOD_GSK3_1	181	188	PF00069	0.496
MOD_GSK3_1	201	208	PF00069	0.497
MOD_GSK3_1	39	46	PF00069	0.657
MOD_GSK3_1	431	438	PF00069	0.493
MOD_GSK3_1	486	493	PF00069	0.506
MOD_GSK3_1	500	507	PF00069	0.573
MOD_GSK3_1	652	659	PF00069	0.514
MOD_GSK3_1	71	78	PF00069	0.748
MOD_GSK3_1	80	87	PF00069	0.705
MOD_N-GLC_1	611	616	PF02516	0.403
MOD_N-GLC_2	21	23	PF02516	0.437
MOD_NEK2_1	11	16	PF00069	0.554
MOD_NEK2_1	127	132	PF00069	0.645
MOD_NEK2_1	181	186	PF00069	0.585
MOD_NEK2_1	192	197	PF00069	0.579
MOD_NEK2_1	201	206	PF00069	0.501
MOD_NEK2_1	228	233	PF00069	0.445
MOD_NEK2_1	253	258	PF00069	0.505
MOD_NEK2_1	298	303	PF00069	0.454
MOD_NEK2_1	31	36	PF00069	0.301
MOD_NEK2_1	310	315	PF00069	0.368
MOD_NEK2_1	426	431	PF00069	0.517
MOD_NEK2_1	439	444	PF00069	0.325
MOD_NEK2_1	494	499	PF00069	0.484
MOD_NEK2_1	501	506	PF00069	0.523
MOD_NEK2_1	600	605	PF00069	0.499
MOD_NEK2_1	77	82	PF00069	0.770
MOD_NEK2_1	86	91	PF00069	0.719
MOD_NEK2_1	92	97	PF00069	0.520
MOD_NEK2_2	48	53	PF00069	0.726
MOD_PIKK_1	349	355	PF00454	0.554
MOD_PIKK_1	400	406	PF00454	0.496
MOD_PIKK_1	501	507	PF00454	0.405
MOD_PIKK_1	566	572	PF00454	0.549
MOD_PIKK_1	611	617	PF00454	0.434
MOD_PKA_1	39	45	PF00069	0.622
MOD_PKA_1	53	59	PF00069	0.504
MOD_PKA_2	127	133	PF00069	0.683
MOD_PKA_2	160	166	PF00069	0.776
MOD_PKA_2	182	188	PF00069	0.569
MOD_PKA_2	386	392	PF00069	0.558
MOD_PKA_2	39	45	PF00069	0.694
MOD_PKA_2	53	59	PF00069	0.528
MOD_PKA_2	639	645	PF00069	0.534
MOD_Plk_1	394	400	PF00069	0.474
MOD_Plk_1	463	469	PF00069	0.550
MOD_Plk_1	628	634	PF00069	0.513
MOD_Plk_2-3	473	479	PF00069	0.513
MOD_Plk_4	11	17	PF00069	0.580
MOD_Plk_4	127	133	PF00069	0.614
MOD_Plk_4	229	235	PF00069	0.422
MOD_Plk_4	435	441	PF00069	0.452
MOD_Plk_4	454	460	PF00069	0.311
MOD_Plk_4	490	496	PF00069	0.465
MOD_ProDKin_1	169	175	PF00069	0.609
MOD_ProDKin_1	221	227	PF00069	0.460
MOD_ProDKin_1	370	376	PF00069	0.447
MOD_ProDKin_1	641	647	PF00069	0.512
MOD_ProDKin_1	656	662	PF00069	0.493
MOD_SUMO_rev_2	389	393	PF00179	0.575
TRG_DiLeu_BaEn_1	354	359	PF01217	0.584
TRG_ENDOCYTIC_2	297	300	PF00928	0.496
TRG_ENDOCYTIC_2	436	439	PF00928	0.404
TRG_ER_diArg_1	27	29	PF00400	0.460
TRG_ER_diArg_1	39	41	PF00400	0.527
TRG_ER_diArg_1	52	55	PF00400	0.688
TRG_ER_diArg_1	639	641	PF00400	0.581
TRG_Pf-PMV_PEXEL_1	260	264	PF00026	0.526
TRG_Pf-PMV_PEXEL_1	308	312	PF00026	0.546

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I481	Leptomonas seymouri	70%	98%
A0A0S4IPG5	Bodo saltans	36%	100%
A0A1X0P1H7	Trypanosomatidae	49%	100%
A0A3Q8IG13	Leishmania donovani	96%	100%
A0A3R7JPV2	Trypanosoma rangeli	49%	100%
A4HIM2	Leishmania braziliensis	85%	100%
A4I5W7	Leishmania infantum	96%	100%
C9ZR90	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9B161	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5B7A2	Trypanosoma cruzi	49%	100%