Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q703_LEIMA

TriTrypDb:

LmjF.30.2890 , LMJLV39_300036800 , LMJSD75_300036000

Length:

457

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	3
GO:0016020	membrane	2	1

Expansion

Sequence features

Q4Q703

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q703

PDB structure(s): 7aih_BM , 7am2_BM , 7ane_BM

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	141	143	PF00675	0.366
CLV_NRD_NRD_1	212	214	PF00675	0.436
CLV_NRD_NRD_1	270	272	PF00675	0.301
CLV_NRD_NRD_1	45	47	PF00675	0.349
CLV_NRD_NRD_1	79	81	PF00675	0.318
CLV_PCSK_KEX2_1	140	142	PF00082	0.411
CLV_PCSK_KEX2_1	411	413	PF00082	0.370
CLV_PCSK_KEX2_1	79	81	PF00082	0.318
CLV_PCSK_PC1ET2_1	411	413	PF00082	0.353
CLV_PCSK_PC7_1	137	143	PF00082	0.541
CLV_PCSK_SKI1_1	17	21	PF00082	0.307
CLV_PCSK_SKI1_1	182	186	PF00082	0.381
CLV_PCSK_SKI1_1	389	393	PF00082	0.495
CLV_PCSK_SKI1_1	47	51	PF00082	0.344
CLV_PCSK_SKI1_1	89	93	PF00082	0.380
CLV_PCSK_SKI1_1	98	102	PF00082	0.478
DEG_APCC_DBOX_1	16	24	PF00400	0.339
DOC_CDC14_PxL_1	20	28	PF14671	0.340
DOC_MAPK_DCC_7	339	349	PF00069	0.409
DOC_MAPK_gen_1	188	197	PF00069	0.473
DOC_PP2B_LxvP_1	353	356	PF13499	0.441
DOC_USP7_MATH_1	288	292	PF00917	0.368
DOC_WW_Pin1_4	116	121	PF00397	0.476
DOC_WW_Pin1_4	327	332	PF00397	0.324
LIG_14-3-3_CanoR_1	282	286	PF00244	0.438
LIG_14-3-3_CanoR_1	71	78	PF00244	0.307
LIG_14-3-3_CanoR_1	89	94	PF00244	0.348
LIG_APCC_ABBAyCdc20_2	79	85	PF00400	0.327
LIG_BIR_II_1	1	5	PF00653	0.469
LIG_FHA_1	117	123	PF00498	0.481
LIG_FHA_1	338	344	PF00498	0.468
LIG_FHA_1	378	384	PF00498	0.563
LIG_FHA_2	327	333	PF00498	0.392
LIG_FHA_2	437	443	PF00498	0.587
LIG_FHA_2	90	96	PF00498	0.362
LIG_LIR_Gen_1	154	162	PF02991	0.293
LIG_LIR_Gen_1	226	233	PF02991	0.373
LIG_LIR_Gen_1	368	378	PF02991	0.337
LIG_LIR_Gen_1	54	62	PF02991	0.326
LIG_LIR_Nem_3	13	19	PF02991	0.276
LIG_LIR_Nem_3	2	7	PF02991	0.480
LIG_LIR_Nem_3	226	230	PF02991	0.382
LIG_LIR_Nem_3	368	374	PF02991	0.340
LIG_LIR_Nem_3	54	59	PF02991	0.312
LIG_PCNA_yPIPBox_3	213	223	PF02747	0.504
LIG_Pex14_1	266	270	PF04695	0.287
LIG_SH2_CRK	227	231	PF00017	0.428
LIG_SH2_NCK_1	227	231	PF00017	0.428
LIG_SH2_NCK_1	328	332	PF00017	0.311
LIG_SH2_NCK_1	72	76	PF00017	0.291
LIG_SH2_STAP1	124	128	PF00017	0.379
LIG_SH2_STAP1	402	406	PF00017	0.439
LIG_SH2_STAP1	72	76	PF00017	0.323
LIG_SH2_STAP1	83	87	PF00017	0.341
LIG_SH2_STAT3	322	325	PF00017	0.346
LIG_SH2_STAT5	155	158	PF00017	0.386
LIG_SH2_STAT5	179	182	PF00017	0.346
LIG_SH2_STAT5	279	282	PF00017	0.401
LIG_SH2_STAT5	326	329	PF00017	0.342
LIG_SH2_STAT5	72	75	PF00017	0.314
LIG_SH2_STAT5	77	80	PF00017	0.301
LIG_SH3_3	35	41	PF00018	0.453
LIG_SH3_3	416	422	PF00018	0.478
LIG_SUMO_SIM_par_1	237	242	PF11976	0.438
LIG_TRAF2_1	27	30	PF00917	0.334
LIG_TYR_ITIM	70	75	PF00017	0.279
LIG_UBA3_1	316	321	PF00899	0.381
MOD_CDK_SPK_2	116	121	PF00069	0.476
MOD_CK1_1	297	303	PF00069	0.440
MOD_CK2_1	420	426	PF00069	0.441
MOD_CK2_1	436	442	PF00069	0.482
MOD_CK2_1	89	95	PF00069	0.436
MOD_GlcNHglycan	104	107	PF01048	0.404
MOD_GlcNHglycan	201	204	PF01048	0.638
MOD_GlcNHglycan	290	293	PF01048	0.395
MOD_GlcNHglycan	296	299	PF01048	0.450
MOD_GlcNHglycan	398	401	PF01048	0.544
MOD_GlcNHglycan	442	446	PF01048	0.680
MOD_GSK3_1	102	109	PF00069	0.420
MOD_GSK3_1	422	429	PF00069	0.469
MOD_GSK3_1	437	444	PF00069	0.558
MOD_GSK3_1	89	96	PF00069	0.370
MOD_NEK2_1	19	24	PF00069	0.337
MOD_NEK2_1	383	388	PF00069	0.408
MOD_NEK2_1	70	75	PF00069	0.294
MOD_NEK2_1	93	98	PF00069	0.392
MOD_PKA_2	245	251	PF00069	0.375
MOD_PKA_2	281	287	PF00069	0.402
MOD_PKA_2	288	294	PF00069	0.355
MOD_PKA_2	426	432	PF00069	0.622
MOD_PKA_2	70	76	PF00069	0.302
MOD_Plk_1	239	245	PF00069	0.306
MOD_Plk_4	281	287	PF00069	0.346
MOD_Plk_4	383	389	PF00069	0.377
MOD_Plk_4	89	95	PF00069	0.398
MOD_ProDKin_1	116	122	PF00069	0.470
MOD_ProDKin_1	327	333	PF00069	0.326
MOD_SUMO_rev_2	183	189	PF00179	0.343
MOD_SUMO_rev_2	212	219	PF00179	0.391
TRG_DiLeu_BaLyEn_6	342	347	PF01217	0.389
TRG_DiLeu_BaLyEn_6	348	353	PF01217	0.402
TRG_ENDOCYTIC_2	155	158	PF00928	0.307
TRG_ENDOCYTIC_2	16	19	PF00928	0.425
TRG_ENDOCYTIC_2	227	230	PF00928	0.396
TRG_ENDOCYTIC_2	72	75	PF00928	0.280
TRG_ENDOCYTIC_2	83	86	PF00928	0.311
TRG_ER_diArg_1	139	142	PF00400	0.410
TRG_ER_diArg_1	78	80	PF00400	0.310
TRG_Pf-PMV_PEXEL_1	142	147	PF00026	0.531
TRG_Pf-PMV_PEXEL_1	31	35	PF00026	0.323
TRG_Pf-PMV_PEXEL_1	389	393	PF00026	0.477
TRG_Pf-PMV_PEXEL_1	80	84	PF00026	0.330

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJE9	Leptomonas seymouri	76%	100%
A0A0S4IPF0	Bodo saltans	44%	100%
A0A1X0P1F2	Trypanosomatidae	56%	100%
A0A3Q8IFT4	Leishmania donovani	97%	100%
A0A422N0P2	Trypanosoma rangeli	58%	100%
A4HIM3	Leishmania braziliensis	86%	100%
A4I5W8	Leishmania infantum	98%	100%
C9ZR91	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	83%
E9B162	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
V5BMU7	Trypanosoma cruzi	58%	100%