Putative aldehyde dehydrogenase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

aldehyde dehydrogenase, putative

Species:

Leishmania major

UniProt:

Q4Q702_LEIMA

TriTrypDb:

LmjF.30.2900 , LMJLV39_300036900 , LMJSD75_300036100

Length:

585

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q702

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q702

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004029	aldehyde dehydrogenase (NAD+) activity	6	7
GO:0004030	aldehyde dehydrogenase [NAD(P)+] activity	5	7
GO:0016491	oxidoreductase activity	2	12
GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	4	12
GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	3	12
GO:0043878	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity	5	7

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	139	143	PF00656	0.419
CLV_C14_Caspase3-7	441	445	PF00656	0.480
CLV_NRD_NRD_1	110	112	PF00675	0.207
CLV_NRD_NRD_1	95	97	PF00675	0.293
CLV_PCSK_KEX2_1	110	112	PF00082	0.233
CLV_PCSK_KEX2_1	180	182	PF00082	0.232
CLV_PCSK_PC1ET2_1	180	182	PF00082	0.219
CLV_PCSK_SKI1_1	111	115	PF00082	0.226
CLV_PCSK_SKI1_1	357	361	PF00082	0.256
CLV_PCSK_SKI1_1	81	85	PF00082	0.280

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0E3T3B5	Malus domestica	31%	100%
A0A0E3T552	Malus domestica	30%	100%
A0A0N0P2K9	Leptomonas seymouri	31%	100%
A0A0N1HV25	Leptomonas seymouri	24%	100%
A0A0N1I2U5	Leptomonas seymouri	33%	100%
A0A0N1IL67	Leptomonas seymouri	30%	100%
A0A0N1PB61	Leptomonas seymouri	85%	100%
A0A0S4IS93	Bodo saltans	25%	100%
A0A0S4ITF6	Bodo saltans	71%	100%
A0A0S4IZS0	Bodo saltans	25%	100%

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