Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q700_LEIMA

TriTrypDb:

LmjF.30.2920 , LMJLV39_300037100 , LMJSD75_300036300

Length:

456

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q700

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q700

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	104	106	PF00675	0.736
CLV_NRD_NRD_1	149	151	PF00675	0.478
CLV_NRD_NRD_1	152	154	PF00675	0.446
CLV_NRD_NRD_1	230	232	PF00675	0.469
CLV_NRD_NRD_1	315	317	PF00675	0.429
CLV_PCSK_KEX2_1	104	106	PF00082	0.736
CLV_PCSK_KEX2_1	149	151	PF00082	0.524
CLV_PCSK_SKI1_1	154	158	PF00082	0.446
CLV_PCSK_SKI1_1	372	376	PF00082	0.554
CLV_PCSK_SKI1_1	428	432	PF00082	0.636
DEG_APCC_DBOX_1	152	160	PF00400	0.418
DOC_CKS1_1	429	434	PF01111	0.623
DOC_CYCLIN_RxL_1	149	162	PF00134	0.391
DOC_CYCLIN_RxL_1	239	249	PF00134	0.453
DOC_MAPK_gen_1	149	159	PF00069	0.479
DOC_MAPK_MEF2A_6	414	422	PF00069	0.525
DOC_MAPK_MEF2A_6	9	16	PF00069	0.453
DOC_PP4_FxxP_1	42	45	PF00568	0.510
DOC_USP7_MATH_1	179	183	PF00917	0.566
DOC_USP7_MATH_1	214	218	PF00917	0.563
DOC_USP7_MATH_1	271	275	PF00917	0.637
DOC_USP7_MATH_1	57	61	PF00917	0.498
DOC_USP7_MATH_1	88	92	PF00917	0.510
DOC_WW_Pin1_4	267	272	PF00397	0.606
DOC_WW_Pin1_4	286	291	PF00397	0.575
DOC_WW_Pin1_4	414	419	PF00397	0.677
DOC_WW_Pin1_4	428	433	PF00397	0.576
DOC_WW_Pin1_4	436	441	PF00397	0.623
DOC_WW_Pin1_4	450	455	PF00397	0.559
DOC_WW_Pin1_4	62	67	PF00397	0.514
LIG_14-3-3_CanoR_1	247	251	PF00244	0.568
LIG_14-3-3_CanoR_1	281	288	PF00244	0.631
LIG_14-3-3_CanoR_1	339	343	PF00244	0.501
LIG_14-3-3_CanoR_1	441	451	PF00244	0.700
LIG_APCC_ABBA_1	12	17	PF00400	0.452
LIG_BIR_II_1	1	5	PF00653	0.487
LIG_BIR_III_4	263	267	PF00653	0.629
LIG_CaM_IQ_9	311	326	PF13499	0.430
LIG_FHA_1	306	312	PF00498	0.378
LIG_FHA_1	343	349	PF00498	0.445
LIG_FHA_1	443	449	PF00498	0.623
LIG_FHA_2	142	148	PF00498	0.419
LIG_FHA_2	26	32	PF00498	0.474
LIG_FHA_2	77	83	PF00498	0.560
LIG_GBD_Chelix_1	219	227	PF00786	0.497
LIG_LIR_Apic_2	41	45	PF02991	0.556
LIG_LIR_Gen_1	80	90	PF02991	0.498
LIG_LIR_Nem_3	80	86	PF02991	0.524
LIG_SH2_STAP1	83	87	PF00017	0.493
LIG_SH3_3	118	124	PF00018	0.593
LIG_SH3_3	265	271	PF00018	0.611
LIG_SH3_3	412	418	PF00018	0.641
LIG_SH3_3	434	440	PF00018	0.640
LIG_SUMO_SIM_anti_2	155	160	PF11976	0.472
LIG_TRAF2_1	21	24	PF00917	0.467
LIG_WRC_WIRS_1	39	44	PF05994	0.550
MOD_CDC14_SPxK_1	453	456	PF00782	0.600
MOD_CDK_SPK_2	267	272	PF00069	0.606
MOD_CDK_SPK_2	436	441	PF00069	0.634
MOD_CDK_SPxK_1	450	456	PF00069	0.609
MOD_CDK_SPxxK_3	414	421	PF00069	0.583
MOD_CDK_SPxxK_3	436	443	PF00069	0.636
MOD_CK1_1	249	255	PF00069	0.604
MOD_CK1_1	280	286	PF00069	0.646
MOD_CK1_1	38	44	PF00069	0.546
MOD_CK1_1	382	388	PF00069	0.469
MOD_CK1_1	395	401	PF00069	0.579
MOD_CK1_1	59	65	PF00069	0.508
MOD_CK2_1	141	147	PF00069	0.421
MOD_CK2_1	18	24	PF00069	0.467
MOD_CK2_1	209	215	PF00069	0.612
MOD_CK2_1	25	31	PF00069	0.482
MOD_CK2_1	76	82	PF00069	0.536
MOD_DYRK1A_RPxSP_1	414	418	PF00069	0.521
MOD_GlcNHglycan	135	138	PF01048	0.425
MOD_GlcNHglycan	168	171	PF01048	0.534
MOD_GlcNHglycan	20	23	PF01048	0.454
MOD_GlcNHglycan	215	219	PF01048	0.550
MOD_GlcNHglycan	251	254	PF01048	0.562
MOD_GlcNHglycan	263	267	PF01048	0.707
MOD_GlcNHglycan	290	293	PF01048	0.690
MOD_GlcNHglycan	328	331	PF01048	0.423
MOD_GlcNHglycan	394	397	PF01048	0.564
MOD_GlcNHglycan	61	64	PF01048	0.557
MOD_GSK3_1	162	169	PF00069	0.510
MOD_GSK3_1	189	196	PF00069	0.640
MOD_GSK3_1	209	216	PF00069	0.651
MOD_GSK3_1	262	269	PF00069	0.619
MOD_GSK3_1	277	284	PF00069	0.553
MOD_GSK3_1	338	345	PF00069	0.481
MOD_GSK3_1	384	391	PF00069	0.525
MOD_GSK3_1	416	423	PF00069	0.649
MOD_GSK3_1	428	435	PF00069	0.576
MOD_GSK3_1	53	60	PF00069	0.534
MOD_N-GLC_1	179	184	PF02516	0.582
MOD_NEK2_1	16	21	PF00069	0.457
MOD_NEK2_1	193	198	PF00069	0.616
MOD_NEK2_1	246	251	PF00069	0.505
MOD_NEK2_1	25	30	PF00069	0.370
MOD_NEK2_1	342	347	PF00069	0.426
MOD_NEK2_1	360	365	PF00069	0.443
MOD_NEK2_1	40	45	PF00069	0.527
MOD_NEK2_1	5	10	PF00069	0.468
MOD_NEK2_1	67	72	PF00069	0.521
MOD_PIKK_1	218	224	PF00454	0.691
MOD_PIKK_1	347	353	PF00454	0.423
MOD_PIKK_1	379	385	PF00454	0.497
MOD_PIKK_1	388	394	PF00454	0.711
MOD_PIKK_1	88	94	PF00454	0.448
MOD_PK_1	281	287	PF00069	0.596
MOD_PKA_2	100	106	PF00069	0.642
MOD_PKA_2	138	144	PF00069	0.584
MOD_PKA_2	246	252	PF00069	0.511
MOD_PKA_2	271	277	PF00069	0.602
MOD_PKA_2	280	286	PF00069	0.583
MOD_PKA_2	338	344	PF00069	0.425
MOD_PKA_2	35	41	PF00069	0.480
MOD_PKA_2	401	407	PF00069	0.578
MOD_PKA_2	420	426	PF00069	0.622
MOD_PKA_2	53	59	PF00069	0.538
MOD_PKB_1	377	385	PF00069	0.449
MOD_PKB_1	386	394	PF00069	0.522
MOD_Plk_1	141	147	PF00069	0.431
MOD_Plk_1	16	22	PF00069	0.458
MOD_Plk_1	170	176	PF00069	0.625
MOD_Plk_1	214	220	PF00069	0.524
MOD_Plk_1	305	311	PF00069	0.408
MOD_Plk_1	342	348	PF00069	0.418
MOD_Plk_2-3	338	344	PF00069	0.423
MOD_Plk_4	170	176	PF00069	0.591
MOD_Plk_4	189	195	PF00069	0.523
MOD_Plk_4	35	41	PF00069	0.509
MOD_ProDKin_1	267	273	PF00069	0.606
MOD_ProDKin_1	286	292	PF00069	0.572
MOD_ProDKin_1	414	420	PF00069	0.677
MOD_ProDKin_1	428	434	PF00069	0.576
MOD_ProDKin_1	436	442	PF00069	0.624
MOD_ProDKin_1	450	456	PF00069	0.561
MOD_ProDKin_1	62	68	PF00069	0.513
MOD_SUMO_for_1	303	306	PF00179	0.464
MOD_SUMO_for_1	335	338	PF00179	0.468
MOD_SUMO_rev_2	368	374	PF00179	0.444
TRG_DiLeu_BaEn_1	239	244	PF01217	0.464
TRG_DiLeu_BaEn_1	306	311	PF01217	0.439
TRG_DiLeu_BaEn_1	370	375	PF01217	0.495
TRG_DiLeu_BaEn_1	82	87	PF01217	0.487
TRG_DiLeu_LyEn_5	239	244	PF01217	0.441
TRG_ENDOCYTIC_2	83	86	PF00928	0.493
TRG_ER_diArg_1	104	106	PF00400	0.637
TRG_ER_diArg_1	377	380	PF00400	0.489
TRG_NES_CRM1_1	369	384	PF08389	0.497
TRG_Pf-PMV_PEXEL_1	129	133	PF00026	0.508
TRG_Pf-PMV_PEXEL_1	372	376	PF00026	0.473
TRG_Pf-PMV_PEXEL_1	379	383	PF00026	0.415
TRG_Pf-PMV_PEXEL_1	424	429	PF00026	0.637

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUI5	Leptomonas seymouri	46%	71%
A0A3Q8IEH0	Leishmania donovani	88%	100%
A4HIM6	Leishmania braziliensis	69%	71%
A4I5X1	Leishmania infantum	88%	100%
E9B165	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%