Dirigent protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Dirigent protein

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q6Z8_LEIMA

TriTrypDb:

LmjF.30.2940 , LMJLV39_300037400 , LMJSD75_300036500

Length:

340

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 12, no: 0
NetGPI	no	yes: 0, no: 12

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q6Z8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6Z8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	325	329	PF00656	0.450
CLV_NRD_NRD_1	280	282	PF00675	0.512
CLV_NRD_NRD_1	297	299	PF00675	0.575
CLV_NRD_NRD_1	50	52	PF00675	0.533
CLV_PCSK_FUR_1	51	55	PF00082	0.538
CLV_PCSK_KEX2_1	297	299	PF00082	0.604
CLV_PCSK_KEX2_1	53	55	PF00082	0.497
CLV_PCSK_PC1ET2_1	53	55	PF00082	0.536
CLV_PCSK_SKI1_1	222	226	PF00082	0.484
CLV_PCSK_SKI1_1	298	302	PF00082	0.527
CLV_PCSK_SKI1_1	58	62	PF00082	0.455
DEG_APCC_DBOX_1	305	313	PF00400	0.555
DEG_APCC_DBOX_1	53	61	PF00400	0.462
DEG_APCC_KENBOX_2	315	319	PF00400	0.586
DEG_Nend_Nbox_1	1	3	PF02207	0.672
DEG_SCF_FBW7_1	238	245	PF00400	0.329
DOC_CYCLIN_yClb1_LxF_4	309	315	PF00134	0.570
DOC_CYCLIN_yClb5_NLxxxL_5	53	61	PF00134	0.463
DOC_MAPK_gen_1	281	289	PF00069	0.497
DOC_MAPK_gen_1	51	59	PF00069	0.473
DOC_MAPK_MEF2A_6	281	289	PF00069	0.574
DOC_MAPK_MEF2A_6	51	59	PF00069	0.438
DOC_MAPK_NFAT4_5	52	60	PF00069	0.552
DOC_PP1_RVXF_1	235	241	PF00149	0.552
DOC_USP7_MATH_1	135	139	PF00917	0.582
DOC_USP7_MATH_1	190	194	PF00917	0.632
DOC_USP7_MATH_1	242	246	PF00917	0.555
DOC_WW_Pin1_4	238	243	PF00397	0.544
LIG_14-3-3_CanoR_1	126	131	PF00244	0.501
LIG_14-3-3_CanoR_1	298	308	PF00244	0.608
LIG_14-3-3_CanoR_1	8	16	PF00244	0.437
LIG_FHA_1	109	115	PF00498	0.565
LIG_FHA_1	146	152	PF00498	0.502
LIG_FHA_1	223	229	PF00498	0.491
LIG_FHA_1	284	290	PF00498	0.508
LIG_FHA_2	105	111	PF00498	0.609
LIG_FHA_2	249	255	PF00498	0.485
LIG_FHA_2	61	67	PF00498	0.560
LIG_LIR_Gen_1	256	265	PF02991	0.579
LIG_LIR_Gen_1	91	101	PF02991	0.464
LIG_LIR_Nem_3	256	261	PF02991	0.566
LIG_LIR_Nem_3	286	291	PF02991	0.448
LIG_LIR_Nem_3	80	86	PF02991	0.563
LIG_LIR_Nem_3	91	96	PF02991	0.501
LIG_Pex14_1	288	292	PF04695	0.400
LIG_PTB_Apo_2	178	185	PF02174	0.567
LIG_PTB_Apo_2	196	203	PF02174	0.439
LIG_PTB_Phospho_1	196	202	PF10480	0.588
LIG_SH2_CRK	202	206	PF00017	0.548
LIG_SH2_CRK	258	262	PF00017	0.579
LIG_SH2_NCK_1	258	262	PF00017	0.566
LIG_SH2_SRC	202	205	PF00017	0.448
LIG_SH2_STAT5	105	108	PF00017	0.555
LIG_SH2_STAT5	127	130	PF00017	0.425
LIG_SH2_STAT5	219	222	PF00017	0.564
LIG_SH2_STAT5	258	261	PF00017	0.541
LIG_SH2_STAT5	311	314	PF00017	0.588
LIG_SH3_3	1	7	PF00018	0.654
LIG_SH3_3	194	200	PF00018	0.591
LIG_SH3_3	229	235	PF00018	0.566
LIG_SUMO_SIM_par_1	171	176	PF11976	0.417
LIG_WRC_WIRS_1	311	316	PF05994	0.641
LIG_WRC_WIRS_1	90	95	PF05994	0.536
MOD_CK1_1	120	126	PF00069	0.466
MOD_CK1_1	136	142	PF00069	0.471
MOD_CK1_1	147	153	PF00069	0.425
MOD_CK1_1	193	199	PF00069	0.516
MOD_CK1_1	256	262	PF00069	0.560
MOD_CK1_1	91	97	PF00069	0.541
MOD_CK2_1	104	110	PF00069	0.591
MOD_CK2_1	60	66	PF00069	0.555
MOD_GlcNHglycan	109	114	PF01048	0.520
MOD_GlcNHglycan	244	247	PF01048	0.482
MOD_GlcNHglycan	302	305	PF01048	0.468
MOD_GlcNHglycan	9	12	PF01048	0.678
MOD_GSK3_1	100	107	PF00069	0.422
MOD_GSK3_1	109	116	PF00069	0.438
MOD_GSK3_1	238	245	PF00069	0.560
MOD_GSK3_1	283	290	PF00069	0.435
MOD_GSK3_1	322	329	PF00069	0.591
MOD_N-GLC_1	136	141	PF02516	0.478
MOD_N-GLC_1	208	213	PF02516	0.634
MOD_N-GLC_1	222	227	PF02516	0.528
MOD_N-GLC_1	333	338	PF02516	0.700
MOD_N-GLC_1	67	72	PF02516	0.562
MOD_N-GLC_2	218	220	PF02516	0.519
MOD_NEK2_1	100	105	PF00069	0.421
MOD_NEK2_1	133	138	PF00069	0.487
MOD_NEK2_1	283	288	PF00069	0.543
MOD_NEK2_1	60	65	PF00069	0.546
MOD_OFUCOSY	33	39	PF10250	0.581
MOD_PIKK_1	24	30	PF00454	0.549
MOD_PIKK_1	70	76	PF00454	0.606
MOD_PK_1	126	132	PF00069	0.460
MOD_PKA_2	7	13	PF00069	0.444
MOD_Plk_1	136	142	PF00069	0.519
MOD_Plk_1	193	199	PF00069	0.538
MOD_Plk_1	222	228	PF00069	0.568
MOD_Plk_1	67	73	PF00069	0.534
MOD_Plk_2-3	117	123	PF00069	0.524
MOD_Plk_2-3	248	254	PF00069	0.476
MOD_Plk_4	126	132	PF00069	0.449
MOD_Plk_4	136	142	PF00069	0.441
MOD_Plk_4	147	153	PF00069	0.461
MOD_Plk_4	168	174	PF00069	0.434
MOD_Plk_4	228	234	PF00069	0.584
MOD_Plk_4	253	259	PF00069	0.618
MOD_Plk_4	283	289	PF00069	0.436
MOD_Plk_4	310	316	PF00069	0.613
MOD_Plk_4	326	332	PF00069	0.604
MOD_ProDKin_1	238	244	PF00069	0.543
TRG_ENDOCYTIC_2	127	130	PF00928	0.458
TRG_ENDOCYTIC_2	202	205	PF00928	0.635
TRG_ENDOCYTIC_2	258	261	PF00928	0.541
TRG_ENDOCYTIC_2	311	314	PF00928	0.552
TRG_ER_diArg_1	296	298	PF00400	0.585
TRG_NLS_MonoCore_2	50	55	PF00514	0.569
TRG_NLS_MonoExtN_4	51	56	PF00514	0.511

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4A9	Leptomonas seymouri	45%	94%
A0A1X0P1Q5	Trypanosomatidae	23%	100%
A0A1X0P2Z8	Trypanosomatidae	37%	89%
A0A3R7LKG2	Trypanosoma rangeli	41%	100%
A0A3S7X3Q6	Leishmania donovani	94%	100%
A4HIM8	Leishmania braziliensis	66%	100%
A4I5X3	Leishmania infantum	93%	100%
B6DTB5	Bodo saltans	31%	100%
C9ZR97	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
C9ZR98	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9B167	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%