Phosphoinositide phospholipase C

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phospholipase c-like protein

Species:

Leishmania major

UniProt:

Q4Q6Z7_LEIMA

TriTrypDb:

LmjF.30.2950 , LMJLV39_300037500 , LMJSD75_300036600

Length:

737

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q6Z7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6Z7

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	7
GO:0007165	signal transduction	2	7
GO:0008152	metabolic process	1	7
GO:0009056	catabolic process	2	7
GO:0009987	cellular process	1	7
GO:0016042	lipid catabolic process	4	7
GO:0035556	intracellular signal transduction	3	7
GO:0044238	primary metabolic process	2	7
GO:0048015	phosphatidylinositol-mediated signaling	5	2
GO:0048017	inositol lipid-mediated signaling	4	2
GO:0050789	regulation of biological process	2	7
GO:0050794	regulation of cellular process	3	7
GO:0065007	biological regulation	1	7
GO:0071704	organic substance metabolic process	2	7
GO:1901575	organic substance catabolic process	3	7

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004435	phosphatidylinositol phospholipase C activity	7	7
GO:0004620	phospholipase activity	5	7
GO:0004629	phospholipase C activity	6	7
GO:0005488	binding	1	7
GO:0005509	calcium ion binding	5	7
GO:0008081	phosphoric diester hydrolase activity	5	7
GO:0016298	lipase activity	4	7
GO:0016787	hydrolase activity	2	7
GO:0016788	hydrolase activity, acting on ester bonds	3	7
GO:0042578	phosphoric ester hydrolase activity	4	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	164	168	PF00656	0.544
CLV_C14_Caspase3-7	348	352	PF00656	0.464
CLV_C14_Caspase3-7	454	458	PF00656	0.762
CLV_C14_Caspase3-7	686	690	PF00656	0.348
CLV_NRD_NRD_1	195	197	PF00675	0.464
CLV_NRD_NRD_1	332	334	PF00675	0.381
CLV_NRD_NRD_1	376	378	PF00675	0.397
CLV_NRD_NRD_1	46	48	PF00675	0.458
CLV_NRD_NRD_1	64	66	PF00675	0.567
CLV_PCSK_KEX2_1	332	334	PF00082	0.393
CLV_PCSK_KEX2_1	376	378	PF00082	0.397
CLV_PCSK_KEX2_1	41	43	PF00082	0.496
CLV_PCSK_KEX2_1	46	48	PF00082	0.447
CLV_PCSK_KEX2_1	639	641	PF00082	0.464
CLV_PCSK_KEX2_1	68	70	PF00082	0.515
CLV_PCSK_PC1ET2_1	41	43	PF00082	0.560
CLV_PCSK_PC1ET2_1	639	641	PF00082	0.464
CLV_PCSK_PC1ET2_1	68	70	PF00082	0.467
CLV_PCSK_PC7_1	42	48	PF00082	0.526
CLV_PCSK_SKI1_1	173	177	PF00082	0.499
CLV_PCSK_SKI1_1	209	213	PF00082	0.446
CLV_PCSK_SKI1_1	225	229	PF00082	0.437
CLV_PCSK_SKI1_1	332	336	PF00082	0.339
CLV_PCSK_SKI1_1	377	381	PF00082	0.397
CLV_PCSK_SKI1_1	408	412	PF00082	0.384
CLV_PCSK_SKI1_1	65	69	PF00082	0.558
CLV_PCSK_SKI1_1	91	95	PF00082	0.603
DEG_APCC_DBOX_1	407	415	PF00400	0.464
DOC_CKS1_1	425	430	PF01111	0.464
DOC_CYCLIN_RxL_1	511	522	PF00134	0.397
DOC_CYCLIN_RxL_1	65	76	PF00134	0.351
DOC_CYCLIN_yClb5_NLxxxL_5	21	30	PF00134	0.554
DOC_MAPK_gen_1	108	117	PF00069	0.558
DOC_MAPK_gen_1	176	184	PF00069	0.397
DOC_MAPK_gen_1	263	272	PF00069	0.491
DOC_MAPK_gen_1	46	52	PF00069	0.494
DOC_MAPK_gen_1	65	74	PF00069	0.278
DOC_MAPK_HePTP_8	170	182	PF00069	0.513
DOC_MAPK_HePTP_8	206	218	PF00069	0.264
DOC_MAPK_MEF2A_6	173	182	PF00069	0.553
DOC_MAPK_MEF2A_6	209	218	PF00069	0.264
DOC_MAPK_MEF2A_6	670	679	PF00069	0.397
DOC_PP1_RVXF_1	267	273	PF00149	0.404
DOC_PP1_RVXF_1	363	369	PF00149	0.397
DOC_USP7_MATH_1	162	166	PF00917	0.559
DOC_USP7_MATH_1	470	474	PF00917	0.644
DOC_USP7_MATH_1	618	622	PF00917	0.397
DOC_USP7_MATH_1	666	670	PF00917	0.464
DOC_USP7_MATH_1	687	691	PF00917	0.464
DOC_USP7_MATH_1	720	724	PF00917	0.529
DOC_USP7_UBL2_3	169	173	PF12436	0.527
DOC_USP7_UBL2_3	434	438	PF12436	0.352
DOC_USP7_UBL2_3	62	66	PF12436	0.508
DOC_USP7_UBL2_3	88	92	PF12436	0.536
DOC_WW_Pin1_4	278	283	PF00397	0.430
DOC_WW_Pin1_4	380	385	PF00397	0.397
DOC_WW_Pin1_4	424	429	PF00397	0.343
DOC_WW_Pin1_4	462	467	PF00397	0.733
DOC_WW_Pin1_4	600	605	PF00397	0.484
LIG_14-3-3_CanoR_1	269	279	PF00244	0.380
LIG_14-3-3_CanoR_1	377	387	PF00244	0.397
LIG_14-3-3_CanoR_1	47	53	PF00244	0.472
LIG_14-3-3_CanoR_1	483	489	PF00244	0.457
LIG_14-3-3_CanoR_1	714	720	PF00244	0.465
LIG_Actin_WH2_2	687	704	PF00022	0.397
LIG_APCC_ABBA_1	71	76	PF00400	0.410
LIG_BIR_III_2	499	503	PF00653	0.397
LIG_BIR_III_4	199	203	PF00653	0.397
LIG_deltaCOP1_diTrp_1	236	243	PF00928	0.467
LIG_EVH1_1	10	14	PF00568	0.526
LIG_FHA_1	150	156	PF00498	0.562
LIG_FHA_1	211	217	PF00498	0.427
LIG_FHA_1	271	277	PF00498	0.456
LIG_FHA_1	292	298	PF00498	0.479
LIG_FHA_1	299	305	PF00498	0.328
LIG_FHA_1	361	367	PF00498	0.322
LIG_FHA_1	47	53	PF00498	0.550
LIG_FHA_1	604	610	PF00498	0.397
LIG_FHA_1	62	68	PF00498	0.371
LIG_FHA_1	645	651	PF00498	0.345
LIG_FHA_1	660	666	PF00498	0.352
LIG_FHA_1	674	680	PF00498	0.242
LIG_FHA_1	97	103	PF00498	0.503
LIG_FHA_2	14	20	PF00498	0.494
LIG_FHA_2	162	168	PF00498	0.526
LIG_FHA_2	217	223	PF00498	0.463
LIG_FHA_2	237	243	PF00498	0.411
LIG_FHA_2	393	399	PF00498	0.464
LIG_FHA_2	415	421	PF00498	0.464
LIG_FHA_2	452	458	PF00498	0.696
LIG_FHA_2	564	570	PF00498	0.397
LIG_FHA_2	7	13	PF00498	0.555
LIG_FHA_2	79	85	PF00498	0.559
LIG_IBAR_NPY_1	656	658	PF08397	0.464
LIG_Integrin_isoDGR_2	267	269	PF01839	0.344
LIG_LIR_Gen_1	125	134	PF02991	0.515
LIG_LIR_Gen_1	210	218	PF02991	0.321
LIG_LIR_Gen_1	242	249	PF02991	0.400
LIG_LIR_Gen_1	256	264	PF02991	0.435
LIG_LIR_Gen_1	271	280	PF02991	0.235
LIG_LIR_Gen_1	629	637	PF02991	0.344
LIG_LIR_Nem_3	210	214	PF02991	0.321
LIG_LIR_Nem_3	242	246	PF02991	0.402
LIG_LIR_Nem_3	256	262	PF02991	0.424
LIG_LIR_Nem_3	271	275	PF02991	0.263
LIG_LIR_Nem_3	383	388	PF02991	0.344
LIG_LIR_Nem_3	629	635	PF02991	0.398
LIG_LIR_Nem_3	703	708	PF02991	0.510
LIG_MAD2	434	442	PF02301	0.343
LIG_MYND_1	282	286	PF01753	0.467
LIG_NRBOX	477	483	PF00104	0.586
LIG_PCNA_yPIPBox_3	469	482	PF02747	0.658
LIG_PCNA_yPIPBox_3	688	702	PF02747	0.414
LIG_Pex14_1	113	117	PF04695	0.446
LIG_Pex14_1	659	663	PF04695	0.343
LIG_Pex14_2	211	215	PF04695	0.343
LIG_PTB_Apo_2	420	427	PF02174	0.385
LIG_PTB_Phospho_1	420	426	PF10480	0.385
LIG_SH2_CRK	705	709	PF00017	0.392
LIG_SH2_GRB2like	636	639	PF00017	0.414
LIG_SH2_PTP2	632	635	PF00017	0.397
LIG_SH2_STAT3	503	506	PF00017	0.343
LIG_SH2_STAT5	278	281	PF00017	0.490
LIG_SH2_STAT5	307	310	PF00017	0.343
LIG_SH2_STAT5	316	319	PF00017	0.343
LIG_SH2_STAT5	426	429	PF00017	0.397
LIG_SH2_STAT5	504	507	PF00017	0.352
LIG_SH2_STAT5	508	511	PF00017	0.333
LIG_SH2_STAT5	586	589	PF00017	0.343
LIG_SH2_STAT5	592	595	PF00017	0.417
LIG_SH2_STAT5	632	635	PF00017	0.343
LIG_SH2_STAT5	636	639	PF00017	0.343
LIG_SH3_3	584	590	PF00018	0.343
LIG_SH3_3	728	734	PF00018	0.538
LIG_SH3_3	8	14	PF00018	0.497
LIG_SH3_4	619	626	PF00018	0.464
LIG_SH3_4	62	69	PF00018	0.556
LIG_SH3_5	303	307	PF00018	0.464
LIG_SUMO_SIM_anti_2	608	613	PF11976	0.464
LIG_SUMO_SIM_par_1	385	390	PF11976	0.349
LIG_SUMO_SIM_par_1	48	55	PF11976	0.563
LIG_SUMO_SIM_par_1	605	610	PF11976	0.464
LIG_SxIP_EBH_1	610	624	PF03271	0.397
LIG_TRAF2_1	16	19	PF00917	0.553
LIG_TRFH_1	278	282	PF08558	0.418
LIG_TRFH_1	586	590	PF08558	0.343
LIG_TYR_ITSM	701	708	PF00017	0.464
LIG_UBA3_1	190	197	PF00899	0.464
LIG_UBA3_1	258	266	PF00899	0.559
LIG_UBA3_1	410	419	PF00899	0.352
LIG_UBA3_1	577	582	PF00899	0.464
LIG_WRC_WIRS_1	228	233	PF05994	0.549
LIG_WRC_WIRS_1	660	665	PF05994	0.464
MOD_CDK_SPxxK_3	462	469	PF00069	0.702
MOD_CK1_1	122	128	PF00069	0.524
MOD_CK1_1	312	318	PF00069	0.343
MOD_CK1_1	51	57	PF00069	0.508
MOD_CK2_1	13	19	PF00069	0.508
MOD_CK2_1	216	222	PF00069	0.400
MOD_CK2_1	236	242	PF00069	0.400
MOD_CK2_1	323	329	PF00069	0.464
MOD_CK2_1	392	398	PF00069	0.464
MOD_CK2_1	504	510	PF00069	0.397
MOD_CK2_1	687	693	PF00069	0.464
MOD_GlcNHglycan	118	124	PF01048	0.478
MOD_GlcNHglycan	141	144	PF01048	0.562
MOD_GlcNHglycan	199	203	PF01048	0.343
MOD_GlcNHglycan	317	320	PF01048	0.432
MOD_GlcNHglycan	471	475	PF01048	0.631
MOD_GlcNHglycan	596	599	PF01048	0.521
MOD_GlcNHglycan	612	615	PF01048	0.247
MOD_GlcNHglycan	685	688	PF01048	0.464
MOD_GSK3_1	2	9	PF00069	0.686
MOD_GSK3_1	25	32	PF00069	0.409
MOD_GSK3_1	308	315	PF00069	0.397
MOD_GSK3_1	393	400	PF00069	0.397
MOD_GSK3_1	46	53	PF00069	0.512
MOD_GSK3_1	504	511	PF00069	0.464
MOD_GSK3_1	537	544	PF00069	0.404
MOD_GSK3_1	547	554	PF00069	0.343
MOD_GSK3_1	603	610	PF00069	0.464
MOD_GSK3_1	640	647	PF00069	0.354
MOD_GSK3_1	683	690	PF00069	0.464
MOD_N-GLC_1	309	314	PF02516	0.329
MOD_N-GLC_1	687	692	PF02516	0.414
MOD_NEK2_1	227	232	PF00069	0.525
MOD_NEK2_1	258	263	PF00069	0.475
MOD_NEK2_1	30	35	PF00069	0.565
MOD_NEK2_1	308	313	PF00069	0.362
MOD_NEK2_1	322	327	PF00069	0.397
MOD_NEK2_1	414	419	PF00069	0.464
MOD_NEK2_1	612	617	PF00069	0.397
MOD_NEK2_2	673	678	PF00069	0.264
MOD_PIKK_1	216	222	PF00454	0.533
MOD_PIKK_1	270	276	PF00454	0.504
MOD_PIKK_1	464	470	PF00454	0.734
MOD_PIKK_1	612	618	PF00454	0.397
MOD_PKA_1	46	52	PF00069	0.474
MOD_PKA_2	268	274	PF00069	0.396
MOD_PKA_2	361	367	PF00069	0.397
MOD_PKA_2	37	43	PF00069	0.568
MOD_PKA_2	46	52	PF00069	0.415
MOD_Plk_1	209	215	PF00069	0.407
MOD_Plk_1	397	403	PF00069	0.464
MOD_Plk_1	687	693	PF00069	0.419
MOD_Plk_4	122	128	PF00069	0.455
MOD_Plk_4	210	216	PF00069	0.375
MOD_Plk_4	312	318	PF00069	0.343
MOD_Plk_4	397	403	PF00069	0.464
MOD_Plk_4	504	510	PF00069	0.464
MOD_Plk_4	607	613	PF00069	0.483
MOD_Plk_4	645	651	PF00069	0.369
MOD_Plk_4	720	726	PF00069	0.516
MOD_ProDKin_1	278	284	PF00069	0.430
MOD_ProDKin_1	380	386	PF00069	0.397
MOD_ProDKin_1	424	430	PF00069	0.343
MOD_ProDKin_1	462	468	PF00069	0.728
MOD_ProDKin_1	600	606	PF00069	0.483
MOD_SUMO_rev_2	163	170	PF00179	0.475
MOD_SUMO_rev_2	171	178	PF00179	0.419
MOD_SUMO_rev_2	201	211	PF00179	0.264
MOD_SUMO_rev_2	51	59	PF00179	0.538
MOD_SUMO_rev_2	641	648	PF00179	0.414
TRG_DiLeu_BaEn_2	241	247	PF01217	0.391
TRG_ENDOCYTIC_2	632	635	PF00928	0.343
TRG_ENDOCYTIC_2	705	708	PF00928	0.382
TRG_ER_diArg_1	331	333	PF00400	0.381
TRG_ER_diArg_1	375	377	PF00400	0.397
TRG_ER_diArg_1	45	47	PF00400	0.534
TRG_NES_CRM1_1	207	220	PF08389	0.464
TRG_NLS_Bipartite_1	47	69	PF00514	0.585
TRG_NLS_MonoExtC_3	64	69	PF00514	0.633
TRG_NLS_MonoExtN_4	62	69	PF00514	0.636
TRG_NLS_MonoExtN_4	88	95	PF00514	0.553
TRG_Pf-PMV_PEXEL_1	65	70	PF00026	0.515
TRG_Pf-PMV_PEXEL_1	75	79	PF00026	0.494

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWX7	Leptomonas seymouri	35%	100%
A0A0N1I1N0	Leptomonas seymouri	63%	100%
A0A0N1IKD7	Leptomonas seymouri	33%	98%
A0A0S4ITT3	Bodo saltans	32%	84%
A0A0S4J9Y4	Bodo saltans	36%	100%
A0A0S4JUS2	Bodo saltans	34%	100%
A0A1X0P2K1	Trypanosomatidae	41%	100%
A0A3Q8IF05	Leishmania donovani	95%	100%
A0A3S7X8U7	Leishmania donovani	33%	100%
A0A422N571	Trypanosoma rangeli	35%	100%
A4HCK9	Leishmania braziliensis	35%	100%
A4HM43	Leishmania braziliensis	33%	100%
A4I027	Leishmania infantum	33%	94%
A4I5X4	Leishmania infantum	95%	100%
A4IAQ5	Leishmania infantum	33%	100%
A5D6R3	Danio rerio	34%	94%
D0A7A3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AEI1	Leishmania major	33%	100%
E9B168	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
E9B5P2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
P10688	Rattus norvegicus	32%	97%
P10895	Bos taurus	32%	97%
P40977	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	82%
P51178	Homo sapiens	32%	97%
Q02158	Dictyostelium discoideum	35%	92%
Q15111	Homo sapiens	28%	67%
Q1RML2	Bos taurus	32%	100%
Q2VRL0	Gallus gallus	33%	100%
Q32NH8	Xenopus laevis	35%	97%
Q39032	Arabidopsis thaliana	29%	100%
Q39033	Arabidopsis thaliana	30%	100%
Q3USB7	Mus musculus	27%	67%
Q4QBH9	Leishmania major	32%	100%
Q5FX52	Rattus norvegicus	31%	100%
Q5RET0	Pongo abelii	37%	97%
Q62711	Rattus norvegicus	37%	95%
Q7YRU3	Sus scrofa	30%	100%
Q86YW0	Homo sapiens	32%	100%
Q8GV43	Arabidopsis thaliana	29%	100%
Q8K2J0	Mus musculus	38%	94%
Q8K4D7	Mus musculus	31%	100%
Q8N3E9	Homo sapiens	38%	93%
Q8R3B1	Mus musculus	32%	97%
Q8SPR7	Sus scrofa	36%	95%
Q944C1	Arabidopsis thaliana	30%	100%
Q944C2	Arabidopsis thaliana	28%	100%
Q95JS1	Macaca fascicularis	31%	100%
Q9BRC7	Homo sapiens	37%	97%
Q9LY51	Arabidopsis thaliana	30%	100%