zf-CHCC domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q6Z6_LEIMA

TriTrypDb:

LmjF.30.2960 , LMJLV39_300037600 , LMJSD75_300036700

Length:

225

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q6Z6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6Z6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	10	14	PF00656	0.651
CLV_NRD_NRD_1	68	70	PF00675	0.598
CLV_PCSK_KEX2_1	2	4	PF00082	0.498
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.617
CLV_PCSK_SKI1_1	188	192	PF00082	0.549
DEG_Nend_UBRbox_1	1	4	PF02207	0.556
DEG_SCF_FBW7_2	150	157	PF00400	0.663
DOC_MAPK_MEF2A_6	15	24	PF00069	0.628
DOC_PP1_RVXF_1	125	131	PF00149	0.412
DOC_PP1_RVXF_1	34	41	PF00149	0.531
DOC_PP2B_PxIxI_1	108	114	PF00149	0.416
DOC_PP4_FxxP_1	40	43	PF00568	0.532
DOC_USP7_MATH_2	25	31	PF00917	0.492
DOC_USP7_UBL2_3	199	203	PF12436	0.615
DOC_WW_Pin1_4	150	155	PF00397	0.536
DOC_WW_Pin1_4	171	176	PF00397	0.605
DOC_WW_Pin1_4	68	73	PF00397	0.558
LIG_FHA_1	2	8	PF00498	0.614
LIG_FHA_1	69	75	PF00498	0.589
LIG_FHA_2	133	139	PF00498	0.447
LIG_FHA_2	150	156	PF00498	0.604
LIG_FHA_2	50	56	PF00498	0.638
LIG_FHA_2	8	14	PF00498	0.649
LIG_PTB_Apo_2	170	177	PF02174	0.637
LIG_SH2_CRK	18	22	PF00017	0.542
LIG_SH2_CRK	187	191	PF00017	0.510
LIG_SH2_STAP1	28	32	PF00017	0.498
LIG_SH2_STAT5	48	51	PF00017	0.615
LIG_SH2_STAT5	76	79	PF00017	0.630
LIG_SH3_3	187	193	PF00018	0.504
LIG_SH3_3	19	25	PF00018	0.533
LIG_SH3_3	40	46	PF00018	0.536
LIG_SH3_3	84	90	PF00018	0.434
LIG_WRC_WIRS_1	8	13	PF05994	0.536
LIG_WW_1	20	23	PF00397	0.524
MOD_CK1_1	30	36	PF00069	0.607
MOD_CK2_1	131	137	PF00069	0.496
MOD_CK2_1	149	155	PF00069	0.507
MOD_CK2_1	214	220	PF00069	0.581
MOD_Cter_Amidation	67	70	PF01082	0.601
MOD_GlcNHglycan	216	219	PF01048	0.637
MOD_GSK3_1	149	156	PF00069	0.570
MOD_N-GLC_1	131	136	PF02516	0.409
MOD_N-GLC_1	74	79	PF02516	0.656
MOD_NEK2_1	1	6	PF00069	0.530
MOD_NEK2_1	38	43	PF00069	0.554
MOD_NEK2_1	7	12	PF00069	0.542
MOD_NEK2_1	74	79	PF00069	0.686
MOD_PKA_1	214	220	PF00069	0.577
MOD_PKA_2	30	36	PF00069	0.514
MOD_Plk_1	55	61	PF00069	0.598
MOD_ProDKin_1	150	156	PF00069	0.533
MOD_ProDKin_1	171	177	PF00069	0.608
MOD_ProDKin_1	68	74	PF00069	0.556
MOD_SUMO_rev_2	141	151	PF00179	0.524
MOD_SUMO_rev_2	174	182	PF00179	0.670
TRG_DiLeu_BaLyEn_6	3	8	PF01217	0.621
TRG_ENDOCYTIC_2	187	190	PF00928	0.514
TRG_ENDOCYTIC_2	23	26	PF00928	0.503
TRG_ER_diArg_1	92	95	PF00400	0.514

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4Q1	Leptomonas seymouri	81%	99%
A0A0S4ITD8	Bodo saltans	66%	96%
A0A1X0P1R4	Trypanosomatidae	78%	99%
A0A3S7X3U1	Leishmania donovani	99%	100%
A4HIM9	Leishmania braziliensis	89%	97%
A4I5X5	Leishmania infantum	99%	100%
C9ZR99	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	79%	95%
E9B169	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
V5BSK1	Trypanosoma cruzi	78%	100%