DUF2817 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF2817), putative

Species:

Leishmania major

UniProt:

Q4Q6Z3_LEIMA

TriTrypDb:

LmjF.30.2990 , LMJLV39_300038000 , LMJSD75_300037100

Length:

439

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 7
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

Q4Q6Z3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6Z3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	124	126	PF00675	0.576
CLV_NRD_NRD_1	180	182	PF00675	0.528
CLV_NRD_NRD_1	322	324	PF00675	0.542
CLV_PCSK_KEX2_1	108	110	PF00082	0.573
CLV_PCSK_KEX2_1	124	126	PF00082	0.480
CLV_PCSK_KEX2_1	180	182	PF00082	0.560
CLV_PCSK_KEX2_1	250	252	PF00082	0.501
CLV_PCSK_KEX2_1	416	418	PF00082	0.557
CLV_PCSK_KEX2_1	421	423	PF00082	0.606
CLV_PCSK_PC1ET2_1	108	110	PF00082	0.570
CLV_PCSK_PC1ET2_1	124	126	PF00082	0.504
CLV_PCSK_PC1ET2_1	250	252	PF00082	0.560
CLV_PCSK_PC1ET2_1	416	418	PF00082	0.557
CLV_PCSK_PC1ET2_1	421	423	PF00082	0.606
CLV_PCSK_PC7_1	417	423	PF00082	0.548
CLV_PCSK_SKI1_1	216	220	PF00082	0.588
CLV_PCSK_SKI1_1	230	234	PF00082	0.457
CLV_PCSK_SKI1_1	250	254	PF00082	0.362
CLV_PCSK_SKI1_1	279	283	PF00082	0.515
CLV_PCSK_SKI1_1	323	327	PF00082	0.525
CLV_PCSK_SKI1_1	405	409	PF00082	0.525
CLV_PCSK_SKI1_1	416	420	PF00082	0.525
DEG_APCC_DBOX_1	229	237	PF00400	0.315
DEG_MDM2_SWIB_1	427	434	PF02201	0.384
DOC_MAPK_gen_1	124	131	PF00069	0.305
DOC_MAPK_gen_1	421	427	PF00069	0.374
DOC_PP2B_LxvP_1	218	221	PF13499	0.327
DOC_USP7_MATH_1	348	352	PF00917	0.287
DOC_USP7_UBL2_3	124	128	PF12436	0.360
LIG_14-3-3_CanoR_1	191	199	PF00244	0.315
LIG_14-3-3_CanoR_1	417	421	PF00244	0.357
LIG_BIR_II_1	1	5	PF00653	0.554
LIG_BIR_III_3	1	5	PF00653	0.554
LIG_BRCT_BRCA1_1	163	167	PF00533	0.301
LIG_BRCT_BRCA1_1	34	38	PF00533	0.415
LIG_BRCT_BRCA1_1	423	427	PF00533	0.417
LIG_Clathr_ClatBox_1	50	54	PF01394	0.357
LIG_FHA_1	134	140	PF00498	0.352
LIG_FHA_1	290	296	PF00498	0.356
LIG_FHA_1	360	366	PF00498	0.312
LIG_FHA_1	46	52	PF00498	0.363
LIG_FHA_1	67	73	PF00498	0.431
LIG_FHA_2	304	310	PF00498	0.302
LIG_KLC1_Yacidic_2	293	298	PF13176	0.398
LIG_LIR_Apic_2	255	261	PF02991	0.325
LIG_LIR_Gen_1	196	207	PF02991	0.385
LIG_LIR_Gen_1	229	238	PF02991	0.303
LIG_LIR_Gen_1	293	303	PF02991	0.327
LIG_LIR_Gen_1	3	13	PF02991	0.554
LIG_LIR_Gen_1	41	51	PF02991	0.405
LIG_LIR_Nem_3	196	202	PF02991	0.301
LIG_LIR_Nem_3	229	234	PF02991	0.303
LIG_LIR_Nem_3	293	299	PF02991	0.327
LIG_LIR_Nem_3	3	9	PF02991	0.556
LIG_LIR_Nem_3	366	372	PF02991	0.312
LIG_LIR_Nem_3	41	46	PF02991	0.405
LIG_MYND_1	217	221	PF01753	0.315
LIG_PDZ_Class_1	434	439	PF00595	0.415
LIG_Pex14_2	427	431	PF04695	0.348
LIG_Pex14_2	5	9	PF04695	0.556
LIG_PTB_Apo_2	370	377	PF02174	0.388
LIG_PTB_Apo_2	382	389	PF02174	0.312
LIG_PTB_Phospho_1	382	388	PF10480	0.353
LIG_Rb_LxCxE_1	69	88	PF01857	0.388
LIG_SH2_NCK_1	345	349	PF00017	0.398
LIG_SH2_PTP2	231	234	PF00017	0.370
LIG_SH2_PTP2	296	299	PF00017	0.315
LIG_SH2_SRC	296	299	PF00017	0.385
LIG_SH2_SRC	395	398	PF00017	0.317
LIG_SH2_STAP1	68	72	PF00017	0.455
LIG_SH2_STAP1	79	83	PF00017	0.299
LIG_SH2_STAT5	142	145	PF00017	0.300
LIG_SH2_STAT5	193	196	PF00017	0.360
LIG_SH2_STAT5	231	234	PF00017	0.324
LIG_SH2_STAT5	235	238	PF00017	0.327
LIG_SH2_STAT5	296	299	PF00017	0.360
LIG_SH2_STAT5	395	398	PF00017	0.298
LIG_SH2_STAT5	433	436	PF00017	0.362
LIG_SH2_STAT5	68	71	PF00017	0.431
LIG_SH3_2	221	226	PF14604	0.360
LIG_SH3_3	218	224	PF00018	0.334
LIG_SH3_3	404	410	PF00018	0.342
LIG_SH3_CIN85_PxpxPR_1	221	226	PF14604	0.287
LIG_SUMO_SIM_anti_2	274	280	PF11976	0.325
LIG_SUMO_SIM_par_1	361	368	PF11976	0.318
LIG_SUMO_SIM_par_1	43	48	PF11976	0.391
LIG_TRAF2_1	195	198	PF00917	0.398
LIG_TRAF2_1	315	318	PF00917	0.342
LIG_TRAF2_1	57	60	PF00917	0.373
LIG_WW_3	223	227	PF00397	0.360
MOD_CK1_1	161	167	PF00069	0.354
MOD_CK1_1	339	345	PF00069	0.356
MOD_CK2_1	192	198	PF00069	0.378
MOD_CK2_1	312	318	PF00069	0.326
MOD_CMANNOS	428	431	PF00535	0.624
MOD_Cter_Amidation	122	125	PF01082	0.560
MOD_GlcNHglycan	133	136	PF01048	0.525
MOD_GlcNHglycan	144	147	PF01048	0.522
MOD_GlcNHglycan	160	163	PF01048	0.501
MOD_GlcNHglycan	338	341	PF01048	0.530
MOD_GlcNHglycan	40	43	PF01048	0.422
MOD_GlcNHglycan	69	72	PF01048	0.547
MOD_GSK3_1	20	27	PF00069	0.728
MOD_GSK3_1	303	310	PF00069	0.312
MOD_GSK3_1	331	338	PF00069	0.362
MOD_GSK3_1	359	366	PF00069	0.315
MOD_N-GLC_1	155	160	PF02516	0.501
MOD_N-GLC_1	66	71	PF02516	0.598
MOD_NEK2_1	130	135	PF00069	0.388
MOD_NEK2_1	312	317	PF00069	0.321
MOD_NEK2_1	38	43	PF00069	0.443
MOD_NEK2_1	434	439	PF00069	0.415
MOD_NEK2_1	58	63	PF00069	0.351
MOD_NEK2_2	348	353	PF00069	0.287
MOD_PIKK_1	20	26	PF00454	0.553
MOD_PIKK_1	313	319	PF00454	0.342
MOD_PIKK_1	331	337	PF00454	0.398
MOD_PK_1	273	279	PF00069	0.398
MOD_PK_1	421	427	PF00069	0.374
MOD_PKA_1	416	422	PF00069	0.357
MOD_PKA_2	391	397	PF00069	0.337
MOD_PKA_2	416	422	PF00069	0.357
MOD_Plk_1	155	161	PF00069	0.360
MOD_Plk_1	411	417	PF00069	0.354
MOD_Plk_4	161	167	PF00069	0.300
MOD_Plk_4	307	313	PF00069	0.344
MOD_Plk_4	391	397	PF00069	0.298
MOD_Plk_4	399	405	PF00069	0.288
MOD_Plk_4	58	64	PF00069	0.430
MOD_SUMO_rev_2	269	275	PF00179	0.398
TRG_DiLeu_BaEn_4	184	190	PF01217	0.346
TRG_DiLeu_BaLyEn_6	214	219	PF01217	0.315
TRG_ENDOCYTIC_2	212	215	PF00928	0.300
TRG_ENDOCYTIC_2	231	234	PF00928	0.197
TRG_ENDOCYTIC_2	296	299	PF00928	0.360
TRG_ER_diArg_1	179	181	PF00400	0.360
TRG_Pf-PMV_PEXEL_1	150	154	PF00026	0.522

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKP4	Leptomonas seymouri	69%	100%
A0A1X0P1D9	Trypanosomatidae	50%	100%
A0A3Q8II59	Leishmania donovani	96%	100%
A4HIN1	Leishmania braziliensis	82%	100%
A4I5X8	Leishmania infantum	96%	100%
C9ZRA5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9B171	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%