AflR domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q6Z2_LEIMA

TriTrypDb:

LmjF.30.3000 , LMJLV39_300038100 , LMJSD75_300037200

Length:

204

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q6Z2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q6Z2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	114	116	PF00675	0.512
CLV_PCSK_KEX2_1	114	116	PF00082	0.512
CLV_PCSK_SKI1_1	100	104	PF00082	0.406
CLV_PCSK_SKI1_1	115	119	PF00082	0.466
CLV_PCSK_SKI1_1	31	35	PF00082	0.521
CLV_PCSK_SKI1_1	91	95	PF00082	0.514
CLV_Separin_Metazoa	178	182	PF03568	0.594
DEG_APCC_DBOX_1	30	38	PF00400	0.521
DEG_APCC_DBOX_1	99	107	PF00400	0.484
DEG_SCF_FBW7_1	60	67	PF00400	0.558
DOC_CKS1_1	61	66	PF01111	0.555
DOC_CYCLIN_yCln2_LP_2	58	61	PF00134	0.554
DOC_MAPK_gen_1	158	166	PF00069	0.551
DOC_MAPK_MEF2A_6	160	168	PF00069	0.636
DOC_MAPK_MEF2A_6	189	197	PF00069	0.489
DOC_MAPK_MEF2A_6	27	36	PF00069	0.565
DOC_MAPK_MEF2A_6	86	94	PF00069	0.456
DOC_PP2B_LxvP_1	130	133	PF13499	0.545
DOC_PP2B_LxvP_1	4	7	PF13499	0.651
DOC_PP2B_LxvP_1	58	61	PF13499	0.653
DOC_USP7_MATH_1	41	45	PF00917	0.607
DOC_USP7_MATH_1	64	68	PF00917	0.565
DOC_WW_Pin1_4	10	15	PF00397	0.659
DOC_WW_Pin1_4	2	7	PF00397	0.794
DOC_WW_Pin1_4	60	65	PF00397	0.656
LIG_14-3-3_CanoR_1	114	118	PF00244	0.590
LIG_14-3-3_CanoR_1	31	37	PF00244	0.529
LIG_14-3-3_CanoR_1	82	90	PF00244	0.452
LIG_Actin_WH2_2	165	183	PF00022	0.525
LIG_Actin_WH2_2	87	102	PF00022	0.522
LIG_FHA_1	175	181	PF00498	0.535
LIG_FHA_2	173	179	PF00498	0.577
LIG_FHA_2	20	26	PF00498	0.566
LIG_GBD_Chelix_1	140	148	PF00786	0.584
LIG_GSK3_LRP6_1	60	66	PF00069	0.555
LIG_LIR_Gen_1	116	126	PF02991	0.555
LIG_LIR_Gen_1	134	144	PF02991	0.529
LIG_LIR_Gen_1	35	42	PF02991	0.620
LIG_LIR_Nem_3	116	121	PF02991	0.503
LIG_LIR_Nem_3	134	140	PF02991	0.487
LIG_LIR_Nem_3	35	39	PF02991	0.618
LIG_LIR_Nem_3	84	90	PF02991	0.493
LIG_LYPXL_yS_3	87	90	PF13949	0.458
LIG_OCRL_FandH_1	117	129	PF00620	0.470
LIG_SH2_STAT5	98	101	PF00017	0.659
LIG_SH3_3	11	17	PF00018	0.624
LIG_SH3_3	58	64	PF00018	0.551
LIG_WRC_WIRS_1	33	38	PF05994	0.623
MOD_CDK_SPK_2	10	15	PF00069	0.597
MOD_CK1_1	66	72	PF00069	0.743
MOD_CK2_1	148	154	PF00069	0.585
MOD_CK2_1	172	178	PF00069	0.550
MOD_CK2_1	62	68	PF00069	0.576
MOD_CK2_1	70	76	PF00069	0.650
MOD_GlcNHglycan	39	42	PF01048	0.607
MOD_GlcNHglycan	48	51	PF01048	0.550
MOD_GlcNHglycan	78	81	PF01048	0.537
MOD_GlcNHglycan	83	86	PF01048	0.508
MOD_GSK3_1	15	22	PF00069	0.700
MOD_GSK3_1	180	187	PF00069	0.604
MOD_GSK3_1	37	44	PF00069	0.682
MOD_GSK3_1	59	66	PF00069	0.663
MOD_NEK2_1	180	185	PF00069	0.488
MOD_NEK2_1	19	24	PF00069	0.554
MOD_NEK2_2	113	118	PF00069	0.574
MOD_NEK2_2	191	196	PF00069	0.601
MOD_PIKK_1	172	178	PF00454	0.612
MOD_PKA_2	113	119	PF00069	0.535
MOD_PKA_2	180	186	PF00069	0.548
MOD_PKA_2	26	32	PF00069	0.658
MOD_PKA_2	81	87	PF00069	0.464
MOD_Plk_4	15	21	PF00069	0.705
MOD_Plk_4	32	38	PF00069	0.532
MOD_ProDKin_1	10	16	PF00069	0.658
MOD_ProDKin_1	2	8	PF00069	0.793
MOD_ProDKin_1	60	66	PF00069	0.657
TRG_DiLeu_BaEn_1	89	94	PF01217	0.561
TRG_DiLeu_BaLyEn_6	29	34	PF01217	0.558
TRG_ENDOCYTIC_2	87	90	PF00928	0.458
TRG_Pf-PMV_PEXEL_1	104	108	PF00026	0.510

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5Z8	Leptomonas seymouri	65%	91%
A0A1X0P230	Trypanosomatidae	29%	100%
A0A3Q8IF51	Leishmania donovani	92%	100%
A0A3R7N1I2	Trypanosoma rangeli	30%	100%
A4HIN2	Leishmania braziliensis	80%	99%
A4I5X9	Leishmania infantum	93%	100%
C9ZRA6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%